Abstract:
:Bisphenol A (BPA) accumulates in the maturing gut and liver in utero and is known to alter gut bacterial profiles in offspring. Gut bacterial dysbiosis may contribute to chronic colonic and systemic inflammation. We hypothesized that perinatal BPA exposure-induced intestinal (and liver) inflammation in offspring is due to alterations in the microbiome and colonic metabolome. The 16S rRNA amplicon sequencing analysis revealed differences in beta diversity with a significant reduction in the relative abundances of short-chain fatty acid (SCFA) producers such as Oscillospira and Ruminococcaceae due to BPA exposure. Furthermore, BPA exposure reduced fecal SCFA levels and increased systemic lipopolysaccharide (LPS) levels. BPA exposure-increased intestinal permeability was ameliorated by the addition of SCFA in vitro. Metabolic fingerprints revealed alterations in global metabolism and amino acid metabolism. Thus, our findings indicate that perinatal BPA exposure may cause gut bacterial dysbiosis and altered metabolite profiles, particularly SCFA profiles, leading to chronic colon and liver inflammation. IMPORTANCE Emerging evidence suggests that environmental toxicants may influence inflammation-promoted chronic disease susceptibility during early life. BPA, an environmental endocrine disruptor, can transfer across the placenta and accumulate in fetal gut and liver. However, underlying mechanisms for BPA-induced colonic and liver inflammation are not fully elucidated. In this report, we show how perinatal BPA exposure in rabbits alters gut microbiota and their metabolite profiles, which leads to colonic and liver inflammation as well as to increased gut permeability as measured by elevated serum lipopolysaccharide (LPS) levels in the offspring. Also, perinatal BPA exposure leads to reduced levels of gut bacterial diversity and bacterial metabolites (short-chain fatty acids [SCFA]) and elevated gut permeability-three common early biomarkers of inflammation-promoted chronic diseases. In addition, we showed that SCFA ameliorated BPA-induced intestinal permeability in vitro. Thus, our study results suggest that correcting environmental toxicant-induced bacterial dysbiosis early in life may reduce the risk of chronic diseases later in life.
journal_name
mSystemsjournal_title
mSystemsauthors
Reddivari L,Veeramachaneni DNR,Walters WA,Lozupone C,Palmer J,Hewage MKK,Bhatnagar R,Amir A,Kennett MJ,Knight R,Vanamala JKPdoi
10.1128/mSystems.00093-17subject
Has Abstractpub_date
2017-10-10 00:00:00issue
5issn
2379-5077pii
mSystems00093-17journal_volume
2pub_type
杂志文章相关文献
mSystems文献大全abstract::Dimorphic plant and human mycopathogens require a switch from the usual yeast growth to filamentous growth for host tissue penetration, and the switch is controlled by multiple signaling systems other than the central developmental pathway. Unlike these fungi, dimorphic insect mycopathogens usually grow by hyphal exte...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00140-19
更新日期:2019-07-09 00:00:00
abstract::The reactive intermediate deaminase RidA (EC 3.5.99.10) is conserved across all domains of life and deaminates reactive enamine species. When Salmonella entericaridA mutants are grown in minimal medium, 2-aminoacrylate (2AA) accumulates, damages several pyridoxal 5'-phosphate (PLP)-dependent enzymes, and elicits an ob...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00843-19
更新日期:2020-03-10 00:00:00
abstract::Methylobacter species, members of the Methylococcales, have recently emerged as some of the globally widespread, cosmopolitan species that play a key role in the environmental consumption of methane across gradients of dioxygen tensions. In this work, we approached the question of how Methylobacter copes with hypoxia,...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00770-19
更新日期:2020-01-21 00:00:00
abstract::As the most ancient metazoan, sponges have established close relationships with particular microbial symbionts. However, the characteristics and physiology of thioautotrophic symbionts in deep-sea sponges are largely unknown. Using a tailored "differential coverage binning" method on 22-Gb metagenomic sequences, we re...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00184-16
更新日期:2017-03-21 00:00:00
abstract::Marine oil spills can impact both coastal and offshore marine environments, but little information is available on how the microbial response to oil and dispersants might differ between these biomes. Here, we describe the compositional and functional response of microbial communities to different concentrations of oil...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00668-20
更新日期:2020-08-25 00:00:00
abstract::Apoptosis is generally considered the first line of defense against viral infection. However, the role of apoptosis in the interactions between plant viruses and their insect vectors has rarely been investigated. By studying plant DNA viruses of the genus Begomovirus within the family Geminiviridae, which are transmit...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00433-20
更新日期:2020-09-22 00:00:00
abstract::Networks encode the interactions between the components in complex systems and play an essential role in understanding complex systems. Microbial ecological networks provide a system-level insight for comprehensively understanding complex microbial interactions, which play important roles in microbial community assemb...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00124-19
更新日期:2019-05-21 00:00:00
abstract::A diverse set of prophage-mediated mechanisms protecting bacterial hosts from infection has been recently uncovered within cluster N mycobacteriophages isolated on the host, Mycobacterium smegmatis mc2155. In that context, we unveil a novel defense mechanism in cluster N prophage Butters. By using bioinformatics analy...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00534-20
更新日期:2020-10-06 00:00:00
abstract::Increasing rates of antibiotic-resistant bacterial infection are one of the most pressing contemporary global health concerns. The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) have been identified as the...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00024-18
更新日期:2018-04-17 00:00:00
abstract::Sulfur is an essential nutrient that contributes to cellular redox homeostasis, transcriptional regulation, and translation initiation when incorporated into different biomolecules. Transport and reduction of extracellular sulfate followed by cysteine biosynthesis is a major pathway of bacterial sulfur assimilation. F...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00285-19
更新日期:2019-08-06 00:00:00
abstract::Given the complexity of host-microbiota symbioses, scientists and philosophers are asking questions at new biological levels of hierarchical organization-what is a holobiont and hologenome? When should this vocabulary be applied? Are these concepts a null hypothesis for host-microbe systems or limited to a certain spe...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00028-16
更新日期:2016-03-29 00:00:00
abstract::It is important to expedite our understanding of antibiotic resistance to address the increasing numbers of fatalities and environmental pollution due to the emergence of antibiotic resistance and multidrug-resistant strains. Here, we combined the CRISPR-enabled trackable genome engineering (CREATE) technology and tra...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00232-20
更新日期:2020-04-21 00:00:00
abstract::Microbial and plant specialized metabolites, also known as natural products, are key mediators of microbe-microbe and host-microbe interactions and constitute a rich resource for drug development. In the past decade, genome mining has emerged as a prominent strategy for natural product discovery. Initially, such minin...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00182-17
更新日期:2018-03-06 00:00:00
abstract::Here, the role of the dairy-processing chain as a reservoir of antimicrobial resistance (AR) determinants and a source of novel biocontrol quorum-sensing inhibitors is assessed through a functional metagenomics approach. A metagenomic library comprising ∼22,000 recombinant clones was built from DNA isolated from raw m...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00723-19
更新日期:2020-02-18 00:00:00
abstract::The human gut microbiome plays a vital role in both health and disease states and as a mediator of cognitive and physical performance. Despite major advances in our understanding of the role of gut microbes in host physiology, mechanisms underlying human-microbiome dynamics have yet to be fully elucidated. This knowle...
journal_title:mSystems
pub_type: 杂志文章,评审
doi:10.1128/mSystems.00487-20
更新日期:2020-10-27 00:00:00
abstract::ABSRTACTKlebsiella pneumoniae is a common cause of human-pneumonia-derived sepsis with high morbidity and mortality. The microbiota promotes and maintains host immune homeostasis. The mechanisms by which the gut microbiota affects the host defenses in the respiratory system systematically, however, remain poorly under...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00587-20
更新日期:2020-11-03 00:00:00
abstract::Intestinal bacterial dysbiosis has been increasingly linked to ankylosing spondylitis (AS), which is a prototypic and best studied subtype of spondyloarthritis (SpA). Fungi and bacteria coexist in the human gut and interact with each other. Although they have been shown to contribute actively to health or disease, no ...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00176-18
更新日期:2019-03-26 00:00:00
abstract::The mechanisms by which microbes interact in communities remain poorly understood. Here, we interrogated specific interactions between photoautotrophic and heterotrophic members of a model consortium to infer mechanisms that mediate metabolic coupling and acclimation to partnership. This binary consortium was composed...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00181-16
更新日期:2017-03-07 00:00:00
abstract::Bacterial motility is thought to play an important role in virulence. We have previously shown that proficient bacterial swimming and swarming in vitro is correlated with the persistent intramammary infection phenotype observed in cattle. However, little is known about the gene regulation differences important for dif...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00064-16
更新日期:2016-08-09 00:00:00
abstract::Although a few studies have investigated the intestinal microbiota of women with polycystic ovary syndrome (PCOS), the functional and metabolic mechanisms of the microbes associated with PCOS, as well as potential microbial biomarkers, have not yet been identified. To address this gap, we designed a two-phase experime...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00017-19
更新日期:2019-04-16 00:00:00
abstract::Environmental strains of the soil bacterium Bacillus subtilis have valuable applications in agriculture, industry, and biotechnology; however, environmental strains are genetically less accessible. This reduced accessibility is in sharp contrast to laboratory strains, which are well known for their natural competence,...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00539-20
更新日期:2020-09-01 00:00:00
abstract::Globally, dental caries is the most prevalent chronic oral disease and affects roughly half of all children. The aim of this report was to use metagenomic analyses to investigate the relationship between the oral microbiome and caries in preschool children. A total of 25 preschoolers, aged 3 to 5 years old with severe...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00450-19
更新日期:2019-11-05 00:00:00
abstract::Single mutations frequently alter several aspects of cell behavior but rarely reveal whether a particular statistically significant change is biologically significant. To determine which behavioral changes are most important for multicellular self-organization, we devised a new methodology using Myxococcus xanthus as ...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00518-20
更新日期:2020-07-14 00:00:00
abstract::Marine microbes are known to degrade hydrocarbons; however, microbes inhabiting deep-sea sediments remain largely unexplored. Previous studies into the classical pathways of marine microbial metabolism reveal diverse chemistries; however, metabolic profiling of marine microbes cultured with hydrocarbons is limited. In...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00824-20
更新日期:2020-11-10 00:00:00
abstract::Estimations of microbial community diversity based on metagenomic data sets are affected, often to an unknown degree, by biases derived from insufficient coverage and reference database-dependent estimations of diversity. For instance, the completeness of reference databases cannot be generally estimated since it depe...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00039-18
更新日期:2018-04-10 00:00:00
abstract::Thaumarchaeota are frequently reported to associate with marine sponges (phylum Porifera); however, little is known about the features that distinguish them from their free-living thaumarchaeal counterparts. In this study, thaumarchaeal metagenome-assembled genomes (MAGs) were reconstructed from metagenomic data sets ...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00288-19
更新日期:2019-08-13 00:00:00
abstract::GapMind is a Web-based tool for annotating amino acid biosynthesis in bacteria and archaea (http://papers.genomics.lbl.gov/gaps). GapMind incorporates many variant pathways and 130 different reactions, and it analyzes a genome in just 15 s. To avoid error-prone transitive annotations, GapMind relies primarily on a dat...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00291-20
更新日期:2020-06-23 00:00:00
abstract::Pullorum disease is one of the most common diarrhea-related diseases caused by Salmonella enterica subspecies enterica serovar Gallinarum biovar Pullorum (S Pullorum); it negatively affects the poultry industry. However, limited studies have explored the association between the gut microbiota and S Pullorum infection ...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.01192-20
更新日期:2021-01-05 00:00:00
abstract::The identification of ancestral traits is essential to understanding the evolution of any group. In the case of parasitic groups, this helps us understand the adaptation to this lifestyle and a particular host. Most diplomonads are parasites, but there are free-living members of the group nested among the host-associa...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00774-20
更新日期:2020-12-22 00:00:00
abstract::Primary production by Prochlorococcus, the smallest known free-living photosynthetic organism in terms of both physical and genomic size, is thought to have a significant role in global carbon cycles. Despite its small size and low growth rate, Prochlorococcus numerically dominates the phytoplankton community in the n...
journal_title:mSystems
pub_type: 杂志文章
doi:10.1128/mSystems.00254-18
更新日期:2019-02-26 00:00:00