Abstract:
BACKGROUND AND OBJECTIVES:Despite the favorable efficacy of new antiplatelet agents demonstrated in randomized controlled trials, their clinical implications in Korea are unclear. The purpose of this study was to investigate trends in antiplatelet agent use for acute myocardial infarction (AMI) and their impact on 30-day clinical outcomes. METHODS:AMI patients undergoing percutaneous coronary intervention between 2010 and 2015 were assessed using claim data from the Health Insurance Review and Assessment Service. RESULTS:The use of new antiplatelet agents has rapidly increased since 2013 and has been preferred over clopidogrel (Plavix; Bristol-Myers Squibb/Sanofi Pharmaceuticals) since 2015. Both prasugrel (Effient; Eli Lilly and Company) (odds ratio [OR], 0.45; 95% confidence interval [CI], 0.31-0.67; p<0.001) and ticagrelor (Brilinta; AstraZeneca Pharmaceuticals LP) (OR, 0.84; 95% CI, 0.71-0.98; p=0.032) had an independent effect on lowering 30-day mortality in a weighted multivariable logistic regression model. However, new antiplatelet agents had no significant effect on other clinical outcomes including myocardial infarction, stroke, bleeding, and readmission within 30 days. CONCLUSION:The use of new antiplatelet agents is rapidly increasing, and they have been used more commonly than clopidogrel since 2015. We demonstrated that new antiplatelet agents have a favorable effect on reducing 30-day mortality in AMI patients in Korea.
journal_name
Korean Circ Jjournal_title
Korean circulation journalauthors
Kim C,Shin DH,Ahn CM,Kim JS,Kim BK,Ko YG,Choi D,Hong MK,Park J,Lee H,Choi YJ,Choi YS,Oh SK,Jang Ydoi
10.4070/kcj.2017.0072subject
Has Abstractpub_date
2017-11-01 00:00:00pages
888-897issue
6eissn
1738-5520issn
1738-5555pii
47.e316journal_volume
47pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:The drug-eluting balloon (DEB) catheter system was developed to treat restenosis. Furthermore, DEB angioplasty has been shown to reduce restenosis risk when compared to drug-eluting stents (DES) in patients with in-stent restenosis (ISR) or small vessel disease (SVD). In addition, DEB angiopla...
journal_title:Korean circulation journal
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journal_title:Korean circulation journal
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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abstract::There have been great advances in ventricular assist device (VAD) treatment for pediatric patients with advanced heart failure. VAD support provides more time for the patient in the heart transplant waiting list. Augmented cardiac output improves heart failure symptoms, end-organ function, and general condition, and c...
journal_title:Korean circulation journal
pub_type: 杂志文章,评审
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journal_title:Korean circulation journal
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journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2016.46.3.417
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journal_title:Korean circulation journal
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journal_title:Korean circulation journal
pub_type: 杂志文章
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journal_title:Korean circulation journal
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pub_type: 杂志文章
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