The Use Pattern and Clinical Impact of New Antiplatelet Agents Including Prasugrel and Ticagrelor on 30-day Outcomes after Acute Myocardial Infarction in Korea: Korean Health Insurance Review and Assessment Data.

Abstract:

BACKGROUND AND OBJECTIVES:Despite the favorable efficacy of new antiplatelet agents demonstrated in randomized controlled trials, their clinical implications in Korea are unclear. The purpose of this study was to investigate trends in antiplatelet agent use for acute myocardial infarction (AMI) and their impact on 30-day clinical outcomes. METHODS:AMI patients undergoing percutaneous coronary intervention between 2010 and 2015 were assessed using claim data from the Health Insurance Review and Assessment Service. RESULTS:The use of new antiplatelet agents has rapidly increased since 2013 and has been preferred over clopidogrel (Plavix; Bristol-Myers Squibb/Sanofi Pharmaceuticals) since 2015. Both prasugrel (Effient; Eli Lilly and Company) (odds ratio [OR], 0.45; 95% confidence interval [CI], 0.31-0.67; p<0.001) and ticagrelor (Brilinta; AstraZeneca Pharmaceuticals LP) (OR, 0.84; 95% CI, 0.71-0.98; p=0.032) had an independent effect on lowering 30-day mortality in a weighted multivariable logistic regression model. However, new antiplatelet agents had no significant effect on other clinical outcomes including myocardial infarction, stroke, bleeding, and readmission within 30 days. CONCLUSION:The use of new antiplatelet agents is rapidly increasing, and they have been used more commonly than clopidogrel since 2015. We demonstrated that new antiplatelet agents have a favorable effect on reducing 30-day mortality in AMI patients in Korea.

journal_name

Korean Circ J

authors

Kim C,Shin DH,Ahn CM,Kim JS,Kim BK,Ko YG,Choi D,Hong MK,Park J,Lee H,Choi YJ,Choi YS,Oh SK,Jang Y

doi

10.4070/kcj.2017.0072

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

888-897

issue

6

eissn

1738-5520

issn

1738-5555

pii

47.e316

journal_volume

47

pub_type

杂志文章
  • Analysis of potential cost-savings after introduction of drug-eluting balloon angioplasty for in-stent restenosis or small vessel disease.

    abstract:BACKGROUND AND OBJECTIVES:The drug-eluting balloon (DEB) catheter system was developed to treat restenosis. Furthermore, DEB angioplasty has been shown to reduce restenosis risk when compared to drug-eluting stents (DES) in patients with in-stent restenosis (ISR) or small vessel disease (SVD). In addition, DEB angiopla...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2011.41.12.705

    authors: Park K,Kim TE,Park KW,Kang HJ,Koo BK,Kim HS

    更新日期:2011-12-01 00:00:00

  • Sacubitril/Valsartan in Asian Patients with Heart Failure with Reduced Ejection Fraction.

    abstract::The Prospective comparison of Angiotensin Receptor-neprilysin inhibitor (ARNI) with Angiotensin converting enzyme inhibitor (ACEI) to Determine Impact on Global Mortality and morbidity in Heart Failure (HF) trial (PARADIGM-HF) showed that adding a neprilysin inhibitor (sacubitril) to a renin-angiotensin system blocker...

    journal_title:Korean circulation journal

    pub_type: 杂志文章,评审

    doi:10.4070/kcj.2019.0136

    authors: Dewan P,Docherty KF,McMurray JJV

    更新日期:2019-06-01 00:00:00

  • The Past, Present and Future of Heart Transplantation.

    abstract::Heart transplantation (HTx) has become standard treatment for selected patients with end-stage heart failure. Improvements in immunosuppressant, donor procurement, surgical techniques, and post-HTx care have resulted in a substantial decrease in acute allograft rejection, which had previously significantly limited sur...

    journal_title:Korean circulation journal

    pub_type: 杂志文章,评审

    doi:10.4070/kcj.2018.0189

    authors: Kim IC,Youn JC,Kobashigawa JA

    更新日期:2018-07-01 00:00:00

  • Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting for the Treatment of Left Main Coronary Artery Disease.

    abstract::Severe stenosis of the left main coronary artery (LMCA) generally occurs as a result of atherosclerosis and compromises the blood supply to a wide area of myocardium, thereby increasing the risk of serious adverse cardiac events. Current revascularization strategies for patients with significant LMCA disease include c...

    journal_title:Korean circulation journal

    pub_type: 杂志文章,评审

    doi:10.4070/kcj.2019.0112

    authors: Cho SC,Park DW,Park SJ

    更新日期:2019-05-01 00:00:00

  • Pediatric Ventricular Assist Device.

    abstract::There have been great advances in ventricular assist device (VAD) treatment for pediatric patients with advanced heart failure. VAD support provides more time for the patient in the heart transplant waiting list. Augmented cardiac output improves heart failure symptoms, end-organ function, and general condition, and c...

    journal_title:Korean circulation journal

    pub_type: 杂志文章,评审

    doi:10.4070/kcj.2019.0163

    authors: Shin YR,Park YH,Park HK

    更新日期:2019-08-01 00:00:00

  • Diagnosis of incomplete kawasaki disease in infants based on an inflammation at the bacille calmette-guérin inoculation site.

    abstract:BACKGROUND AND OBJECTIVES:This study was intended to test how the inflammation at the Bacille Calmette-Guérin (BCG) inoculation site (BCGitis) can be a useful a diagnostic feature of Kawasaki disease (KD). SUBJECTS AND METHODS:All subjects were infants at the time of admission, and had received BCG vaccination during ...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2012.42.12.823

    authors: Seo JH,Yu JJ,Ko HK,Choi HS,Kim YH,Ko JK

    更新日期:2012-12-01 00:00:00

  • Intracardiac echocardiography to guide biopsy for two cases of intracardiac masses.

    abstract::Pathologic diagnosis of a cardiac mass is vital in determining the proper treatment modality. Open heart surgery or transesophageal echocardiography guided biopsy can be feasible methods to confirm the pathology. However, the former is highly invasive and both methods require general anesthesia. The introduction of in...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2015.45.2.165

    authors: Park KI,Kim MJ,Oh JK,Lee JH,Park JH,Choi SW,Jeong JO,Seong IW

    更新日期:2015-03-01 00:00:00

  • Endovascular Treatment of Multilevel Chronic Total Occlusion Using a Stent Puncture Technique in Buerger's Disease.

    abstract::We reported a patient with Buerger's disease who presented with critical limb ischemiawith prior recurrent occlusions after multiple surgical and endovascular treatments. Total occlusion of the whole native femoropopliteal and infrapopliteal arteries was observed. The femoropopliteal bypass graft, as well as a stent t...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2016.46.3.417

    authors: Lee JH,Ko YG,Choi D

    更新日期:2016-05-01 00:00:00

  • Revascularization for Left Main and Multivessel Coronary Artery Disease: Current Status and Future Prospects after the EXCEL and NOBLE Trials.

    abstract::Revascularization of severe left main and multivessel coronary artery disease has been shown to improve survival in both stable ischemic heart disease and acute coronary syndrome. While revascularization with coronary artery bypass surgery for these disease entities carries class I recommendation in most current guide...

    journal_title:Korean circulation journal

    pub_type: 杂志文章,评审

    doi:10.4070/kcj.2018.0078

    authors: Al-Hijji M,El Sabbagh A,Holmes DR

    更新日期:2018-06-01 00:00:00

  • Constrictive Pericarditis Accompanied by Swine-Origin Influenza A (H1N1) Infection.

    abstract::Swine-origin influenza A (H1N1) is caused by a new strain of the influenza virus. The disease has spread rapidly and was declared a pandemic in April, 2009. So far, however, there is a scarcity of information regarding the complications of swine influenza. A report of the disease in the winter of 2009 in the Southern ...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2010.40.10.539

    authors: Jang JY,Chang HJ,Jang Y,Han SH,Bang WD,Cho SS,Oh CM,Yu HT,Shim CY,Ha JW,Chung N

    更新日期:2010-10-01 00:00:00

  • Management of a remnant electrode in a patient with cardioverter-defibrillator infection after refusal of intravascular electrode removal.

    abstract::Treatments of choice for cardiac implantable electronic device (CIED) infections are the removal of the entire CIED system, control of infection, and new device implantation. Occasionally, a complete CIED removal can not be performed for several reasons, such as very old age, severe comobidity, limited life expectancy...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2011.41.1.46

    authors: Hahn S,Kim J,Choi JH,Lim SH,Kang TS,Park BE,Lee MY

    更新日期:2011-01-01 00:00:00

  • Hypercholesterolemia and in-vivo coronary plaque composition in patients with coronary artery disease: a virtual histology - intravascular ultrasound study.

    abstract:BACKGROUND AND OBJECTIVES:Hypercholesterolemia is a key factor in the development of atherosclerosis. We sought to evaluate the relation between hypercholesterolemia and plaque composition in patients with coronary artery disease. SUBJECTS AND METHODS:Study subjects consisted of 323 patients (mean 61.5 years, 226 male...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2013.43.1.23

    authors: Seo YH,Lee CS,Yuk HB,Yang DJ,Park HW,Kim KH,Kim WH,Kwon TG,Bae JH

    更新日期:2013-01-01 00:00:00

  • Catheter Ablation of Ventricular Arrhythmias via the Radial Artery in a Patient With Prior Myocardial Infarction and Peripheral Vascular Disease.

    abstract::Herein, we present a case of a successful catheter ablation of ventricular tachycardia (VT) using a radial artery approach in a post-myocardial infarction patient, who had an implantable cardioverter-defibrillator and peripheral artery disease. Although the patient did not use antiarrhythmic drugs, the patient experie...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2012.42.9.632

    authors: Kim J,Han D,Sohn C,Kim JS,Park YH

    更新日期:2012-09-01 00:00:00

  • Morbidity and Mortality of Very Low Birth Weight Infants with Congenital Heart Disease.

    abstract:BACKGROUND AND OBJECTIVES:This study aimed to provide morbidity and mortality information on very low birth weight (VLBW) infants with congenital heart disease (CHD-VLBWs). METHODS:The study used a 10-year cohort of VLBW infants from a single institution. CHD was classified according to International Classification of...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2020.0135

    authors: Song WS,Kim CY,Lee BS,Kim EAR,Kim KS,Jung E

    更新日期:2020-12-01 00:00:00

  • Comparison of Prolonged Atrial Electromechanical Delays with Different Definitions in the Discrimination of Patients with Non-Valvular Paroxysmal Atrial Fibrillation.

    abstract:BACKGROUND AND OBJECTIVES:Previous studies have evaluated atrial electromechanical delays (AEMDs) with a number of different definitions to discriminate patients with paroxysmal atrial fibrillation (PAF) from controls without PAF. However, their discriminative values for PAF have not previously been directly compared. ...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2015.45.6.479

    authors: Lee DH,Choi SY,Park JS,Seo JM,Choi JH,Cho YR,Park K,Kim MH,Kim YD

    更新日期:2015-11-01 00:00:00

  • Takayasu's Disease in a Patient with Ulcerative Colitis.

    abstract::A 35-year-old Korean man with a 10-year history of ulcerative colitis (UC) presented with pain and swelling of the right neck. The patient was diagnosed with Takayasu's arteritis (TA) and had human leukocyte antigen (HLA) B-52, which is frequently found in patients having both UC and Takayasu's disease concurrently on...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2013.43.2.135

    authors: Chae MJ,Yu CW,Lee SY,Jang DH,Hyun JY,Jeong SJ,Kim MH

    更新日期:2013-02-01 00:00:00

  • Pericardial-esophageal Fistula Complicating Atrial Fibrillation Ablation Successfully Resolved after Pericardial Drainage with Conservative Management.

    abstract::A 40-year-old male patient underwent radiofrequency catheter ablation for symptomatic paroxysmal atrial fibrillation (AF). Although pulmonary vein (PV) isolation was successfully completed without acute complications, the patient began complaining of sustained retrosternal pain. Seventeen days after ablation, the pati...

    journal_title:Korean circulation journal

    pub_type:

    doi:10.4070/kcj.2016.0364

    authors: Seo JM,Park JS,Jeong SS

    更新日期:2017-11-01 00:00:00

  • Carotid intima-media thickness and pulse wave velocity after recovery from kawasaki disease.

    abstract:BACKGROUND AND OBJECTIVES:Kawasaki disease (KD) is an acute inflammatory process affecting the arterial walls that results in panvasculitis. Recent studies have shown that even after resolution of the disease, endothelial dysfunction persists and may progress to atherosclerosis. The pulse wave velocity (PWV) and the an...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2009.39.7.264

    authors: Lee SJ,Ahn HM,You JH,Hong YM

    更新日期:2009-07-01 00:00:00

  • A case of left atrial metastasis from hepatocellular carcinoma: life-saving palliative resection using cardiopulmonary bypass.

    abstract::Hepatocellular carcinoma (HCC) with metastasis to the heart is uncommon. We report a rare case of left atrial metastasis of HCC which was resected palliatively as a live-saving procedure with the use of cardiopulmonary bypass. Despite chemoembolization, which was undertaken 11 times, cardiac metastasis occurred. Moreo...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2011.41.9.542

    authors: Seo JB,Kim JS,Jeong DS,Chung WY,Kim SH,Kim MA,Zo JH

    更新日期:2011-09-01 00:00:00

  • Survival, exercise capacity, and left ventricular remodeling in a rat model of chronic mitral regurgitation: serial echocardiography and pressure-volume analysis.

    abstract:BACKGROUND AND OBJECTIVES:The aims of this study were to establish a reliable model of chronic mitral regurgitation (MR) in rats and verify the pathophysiological features of this model by evaluating cardiac function using serial echocardiography and a pressure-volume analysis. MATERIALS AND METHODS:MR was created in ...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2011.41.10.603

    authors: Kim KH,Kim YJ,Lee SP,Kim HK,Seo JW,Sohn DW,Oh BH,Park YB

    更新日期:2011-10-01 00:00:00

  • Ventricular tachyarrhythmias in a patient with Andersen-Tawil syndrome.

    abstract::Andersen-Tawill syndrome (ATS), a rare autosomal dominant disorder, is characterized by periodic paralysis, dysmorphic features and cardiac arrhythmias. This syndrome is caused by mutations of KCNJ2 gene, which encodes inward rectifying potassium channel. Here, we report an 18-year-old girl who was presented with life...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2013.43.1.62

    authors: Pyo JY,Joh DH,Park JS,Lee SJ,Lee H,Kim W,Joung B

    更新日期:2013-01-01 00:00:00

  • Clopidogrel versus Aspirin after Dual Antiplatelet Therapy in Acute Myocardial Infarction Patients Undergoing Drug-Eluting Stenting.

    abstract:BACKGROUND AND OBJECTIVES:There is a paucity of data regarding the benefit of clopidogrel monotherapy after dual antiplatelet therapy (DAPT) in patients treated with drug-eluting stents (DES). This study compared outcome between clopidogrel versus aspirin as monotherapy after DES for acute myocardial infarction (MI). ...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2019.0166

    authors: Sim DS,Jeong MH,Kim HS,Gwon HC,Seung KB,Rha SW,Chae SC,Kim CJ,Cha KS,Park JS,Yoon JH,Chae JK,Joo SJ,Choi DJ,Hur SH,Seong IW,Cho MC,Kim DI,Oh SK,Ahn TH,Hwang JY,KAMIR-NIH registry investigators.

    更新日期:2020-02-01 00:00:00

  • Dyslipidemia, low left ventricular ejection fraction and high wall motion score index are predictors of progressive left ventricular dilatation after acute myocardial infarction.

    abstract:BACKGROUND AND OBJECTIVES:Left ventricular (LV) remodeling is a heterogeneous process, involving both infarcted and non-infarcted zones, which affects wall thickness and chamber size, shape and function. SUBJECTS AND METHODS:A total of 758 consecutive patients (62.8±12.0 years, 539 males) with acute myocardial infarct...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2011.41.3.124

    authors: Yoon HJ,Jeong MH,Bae JH,Kim KH,Ahn Y,Cho JG,Park JC,Kang JC

    更新日期:2011-03-01 00:00:00

  • Recurrent very late stent thrombosis in a systemic lupus erythematous patient.

    abstract::Coronary artery disease is the most important cause of mortality in patients with systemic lupus erythematous (SLE). After stenting for coronary artery disease in SLE patients similar to non-SLE patients, the risk of stent thrombosis is always present. Although there are reports of stent thrombosis in SLE patients, ve...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2012.42.2.118

    authors: Lee DY,Park JP,Ko SJ,Lee SE,Jhon SH,Lim JH,Rhew JY

    更新日期:2012-02-01 00:00:00

  • Does a negative ergonovine provocation test truly predict freedom from variant angina?

    abstract::Ergonovine provocation test is known to be very sensitive for diagnosing variant angina. The patient described in this study initially presented with atypical chest pain and underwent coronary angiography and ergonovine provocation tests, which were negative. The patient was subsequently prescribed a proton pump inhib...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2013.43.3.199

    authors: Kim YG,Kim HJ,Choi WS,Im MS,Yoon CH,Suh JW,Choi DJ

    更新日期:2013-03-01 00:00:00

  • Effects of Long-term Thrombin Inhibition (Dabigatran Etexilate) on Spontaneous Thrombolytic Activity during the Progression of Atherosclerosis in ApoE-/--LDLR-/- Double-Knockout Mice.

    abstract:BACKGROUND AND OBJECTIVES:Atherosclerosis is characterized by a hypercoagulable state, during which coagulation and fibrinolytic factors are activated simultaneously. However, details regarding the thrombolytic pathway in this context remain unknown. Here we investigated how direct long-term inhibition of thrombin infl...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2020.0055

    authors: Sanda T,Yoshimura M,Hyodo K,Ishii H,Yamashita T

    更新日期:2020-09-01 00:00:00

  • Temporal Trends of Cardiac Implantable Electronic Device Implantations: a Nationwide Population-based Study.

    abstract:BACKGROUND AND OBJECTIVES:Implantation of cardiac implantable electronic devices (CIED), including permanent pacemakers (PM), implantable cardioverter-defibrillators (ICD), and cardiac resynchronization therapy (CRT) devices, has increased significantly over the past several years. However, limited data exists regardin...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2018.0444

    authors: Lee JH,Lee SR,Choi EK,Jeong J,Park HD,You SJ,Lee SS,Oh S

    更新日期:2019-09-01 00:00:00

  • Percutaneous closure of an iatrogenic ventricular septal defect following concomitant septal myectomy at the time of aortic valve replacement.

    abstract::A 77-year-old female patient underwent aortic valve replacement (AVR) with concomitant septal myectomy and tricuspid annuloplasty. Her symptoms did not improve after a successful operation. Echocardiogram demonstrated the presence of an iatrogenic ventricular septal defect (VSD). It was muscular in location and not th...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2014.44.1.45

    authors: Ryu IH,Kim WH,Ryu AJ,Kim MG,Jeon JW,Kim JS,Lee JJ,Choi JH

    更新日期:2014-01-01 00:00:00

  • Remote Ischemic Conditioning by Effluent Collected from a Novel Isolated Hindlimb Model Reduces Infarct Size in an Isolated Heart Model.

    abstract:BACKGROUND AND OBJECTIVES:Experimental protocols for remote ischemic conditioning (RIC) utilize models in which a tourniquet is placed around the hindlimb or effluent is collected from an isolated heart. In analyzing the humoral factors that act as signal transducers in these models, sampled blood can be influenced by ...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2017.0092

    authors: Youn YJ,Yoo BS,Son JW,Lee JW,Ahn MS,Ahn SG,Kim JY,Lee SH,Yoon J,Eom YW,Oh JE,Choi SK

    更新日期:2017-09-01 00:00:00

  • Clinical characteristics and prognostic factors of stress-induced cardiomyopathy.

    abstract:BACKGROUND AND OBJECTIVES:Stress-induced cardiomyopathy (SCM) is characterized by a transient left ventricular (LV) dysfunction due to emotional and physical stress. There are limited data about the clinical characteristics in Korean patients. We sought to clarify the clinical features and prognosis in patients with SC...

    journal_title:Korean circulation journal

    pub_type: 杂志文章

    doi:10.4070/kcj.2010.40.6.277

    authors: Lee JW,Kim JY,Youn YJ,Sung JK,Lee NS,Lee KH,Yoo BS,Lee SH,Yoon J,Choe KH

    更新日期:2010-06-01 00:00:00