Feasibility, Process, and Outcomes of Cardiovascular Clinical Trial Data Sharing: A Reproduction Analysis of the SMART-AF Trial.

abstract：Importance:Persons with human immunodeficiency virus (HIV) that is treated with antiretroviral therapy have improved longevity but face an elevated risk of myocardial infarction (MI) due to common MI risk factors and HIV-specific factors. Despite these elevated MI rates, optimal methods to predict MI risks for HIV-infe...

journal_title：JAMA cardiology

authors： Feinstein MJ,Nance RM,Drozd DR,Ning H,Delaney JA,Heckbert SR,Budoff MJ,Mathews WC,Kitahata MM,Saag MS,Eron JJ,Moore RD,Achenbach CJ,Lloyd-Jones DM,Crane HM

更新日期：2017-02-01 00:00:00

abstract：Importance:There are major gaps in use of guideline-directed medical therapy (GDMT) for patients with heart failure (HF). Patient-reported data outlining patient goals and preferences associated with GDMT are not available. Objective:To survey patients with chronic HF to better understand their experiences and percept...

journal_title：JAMA cardiology

authors： Samsky MD,Lin L,Greene SJ,Lippmann SJ,Peterson PN,Heidenreich PA,Laskey WK,Yancy CW,Greiner MA,Hardy NC,Kavati A,Park S,Mentz RJ,Fonarow GC,O'Brien EC

更新日期：2020-03-01 00:00:00

abstract：Importance:After a period of rapid growth, use of cardiac stress testing has recently decreased among Medicare beneficiaries and in a large integrated health system. However, it is not known whether declines in cardiac stress testing are universal or are confined to certain populations. Objective:To determine trends i...

journal_title：JAMA cardiology

authors： Kini V,McCarthy FH,Dayoub E,Bradley SM,Masoudi FA,Ho PM,Groeneveld PW

更新日期：2016-12-01 00:00:00

abstract：Importance:The Department of Veterans Affairs (VA) operates a nationwide system of hospitals and hospital-affiliated clinics, providing health care to more than 2 million veterans with cardiovascular disease. While data permitting hospital comparisons of the outcomes of acute cardiovascular care (eg, myocardial infarct...

journal_title：JAMA cardiology

authors： Groeneveld PW,Medvedeva EL,Walker L,Segal AG,Richardson DM,Epstein AJ

更新日期：2018-07-01 00:00:00

abstract：Importance:Improvements in symptoms, functional capacity, and quality of life are among the key goals of edge-to-edge transcatheter mitral valve repair (TMVR) for mitral regurgitation. Objective:To examine health status outcomes among patients undergoing TMVR in clinical practice and the factors associated with improv...

journal_title：JAMA cardiology

authors： Arnold SV,Li Z,Vemulapalli S,Baron SJ,Mack MJ,Kosinski AS,Reynolds MR,Hermiller JB,Rumsfeld JS,Cohen DJ

更新日期：2018-12-01 00:00:00

abstract：Importance:Strategies for reliable selection of high-risk patients with hypertrophic cardiomyopathy (HCM) for prevention of sudden cardiac death (SCD) with implantable cardioverter/defibrillators (ICDs) are incompletely resolved. Objective:To assess the reliability of SCD prediction methods leading to prophylactic ICD...

journal_title：JAMA cardiology

authors： Maron MS,Rowin EJ,Wessler BS,Mooney PJ,Fatima A,Patel P,Koethe BC,Romashko M,Link MS,Maron BJ

更新日期：2019-07-01 00:00:00

abstract：Importance:Low-density lipoprotein cholesterol (LDL-C) is an important modifiable risk factor for atherosclerotic cardiovascular disease. It is unclear whether the percentage LDL-C lowering with pharmacotherapies differs on the basis of baseline LDL-C levels. Objective:To evaluate the association between baseline LDL-...

journal_title：JAMA cardiology

authors： Marcusa DP,Giugliano RP,Park JG,de Lemos JA,Cannon CP,Sabatine MS

更新日期：2020-11-13 00:00:00

abstract：:P values and hypothesis testing methods are frequently misused in clinical research. Much of this misuse appears to be owing to the widespread, mistaken belief that they provide simple, reliable, and objective triage tools for separating the true and important from the untrue or unimportant. The primary focus in inter...

journal_title：JAMA cardiology

authors： Mark DB,Lee KL,Harrell FE Jr

更新日期：2016-12-01 00:00:00

abstract：Importance:Use of transcatheter aortic valve replacement (TAVR) for severe aortic stenosis is growing rapidly. However, to our knowledge, the durability of these prostheses is incompletely defined. Objective:To determine the midterm hemodynamic performance of balloon-expandable transcatheter heart valves. Design, Set...

journal_title：JAMA cardiology

authors： Douglas PS,Leon MB,Mack MJ,Svensson LG,Webb JG,Hahn RT,Pibarot P,Weissman NJ,Miller DC,Kapadia S,Herrmann HC,Kodali SK,Makkar RR,Thourani VH,Lerakis S,Lowry AM,Rajeswaran J,Finn MT,Alu MC,Smith CR,Blackstone EH,

更新日期：2017-11-01 00:00:00

abstract：Importance:Only 1 class of glucose-lowering agents-sodium-glucose cotransporter 2 (SGLT2) inhibitors-has been reported to decrease the risk of cardiovascular events primarily by reducing the risk of the development or progression of heart failure. In a landmark trial called Empagliflozin, Cardiovascular Outcomes, and M...

journal_title：JAMA cardiology

authors： Packer M,Anker SD,Butler J,Filippatos G,Zannad F

更新日期：2017-09-01 00:00:00

abstract：Importance:Physicians have been criticized for having an overly enthusiastic response to new device approvals, especially for novel technologies. However, to our knowledge, the rates of new product adoption and patterns of new device usage in clinical practice have not been well described. Objective:To characterize th...

journal_title：JAMA cardiology

authors： Chau KH,Kennedy KF,Messenger JC,Garratt KN,Maddox TM,Yeh RW,Kirtane AJ

更新日期：2019-06-01 00:00:00

abstract：Importance:The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated the benefit of lowering systolic blood pressure (SBP) to 120 mm Hg, yet other trials, such as Heart Outcomes Prevention Evaluation-3 (HOPE-3), did not find consistent benefit. How to incorporate these results into the treatment of those wit...

journal_title：JAMA cardiology

authors： Navar AM,Pencina MJ,Peterson ED

更新日期：2016-11-01 00:00:00

abstract：Importance:Limited evidence is available regarding the benefit and hazard of higher-intensity treatment to lower lipid levels among patients 75 years or older. As a result, guideline recommendations differ for this age group compared with younger patients. Objective:To determine the effect on outcomes and risks of com...

journal_title：JAMA cardiology

authors： Bach RG,Cannon CP,Giugliano RP,White JA,Lokhnygina Y,Bohula EA,Califf RM,Braunwald E,Blazing MA

更新日期：2019-09-01 00:00:00

abstract：IMPORTANCE:Reduced rates of cardiac catheterization, percutaneous coronary intervention (PCI), and coronary artery bypass graft (CABG) are an unintended consequence of public reporting of cardiogenic shock outcomes in New York. OBJECTIVES:To evaluate whether the referral rates for cardiac catheterization, PCI, or CABG...

journal_title：JAMA cardiology

authors： Bangalore S,Guo Y,Xu J,Blecker S,Gupta N,Feit F,Hochman JS

更新日期：2016-09-01 00:00:00

abstract：Importance:Medicare Advantage (MA), a private insurance plan option, now covers one-third of all Medicare beneficiaries. Although patients with cardiovascular disease enrolled in MA have been reported to receive higher quality of care in the ambulatory setting than patients enrolled in fee-for-service (FFS) Medicare, i...

journal_title：JAMA cardiology

authors： Figueroa JF,Wadhera RK,Frakt AB,Fonarow GC,Heidenreich PA,Xu H,Lytle B,DeVore AD,Matsouaka R,Yancy CW,Bhatt DL,Joynt Maddox KE

更新日期：2020-09-02 00:00:00

abstract：Importance:Hospitalizations for worsening heart failure (WHF) represent an enormous public health and financial burden, with physicians, health systems, and payers placing increasing emphasis on hospitalization prevention. In addition, maximizing time out of the hospital is an important patient-centered outcome. In thi...

journal_title：JAMA cardiology

authors： Greene SJ,Mentz RJ,Felker GM

更新日期：2018-03-01 00:00:00

abstract：Importance:Cohort studies have reported increased incidence of cardiovascular disease (CVD) among individuals with low vitamin D status. To date, randomized clinical trials of vitamin D supplementation have not found an effect, possibly because of using too low a dose of vitamin D. Objective:To examine whether monthly...

journal_title：JAMA cardiology

authors： Scragg R,Stewart AW,Waayer D,Lawes CMM,Toop L,Sluyter J,Murphy J,Khaw KT,Camargo CA Jr

更新日期：2017-06-01 00:00:00

abstract：IMPORTANCE:Dyslipidemia in young adults in the United States during their childbearing years is common, and the consequences for the next generation are poorly understood. Further understanding of the harmful consequences of elevated low-density lipoprotein cholesterol (LDL-C) levels in young adults may help to inform ...

journal_title：JAMA cardiology

authors： Mendelson MM,Lyass A,O'Donnell CJ,D'Agostino RB Sr,Levy D

更新日期：2016-04-01 00:00:00

abstract：Importance:Computed tomography-derived fractional flow reserve (FFR-CT) is a novel, noninvasive test for myocardial ischemia. Clinicians using FFR-CT must be able to interpret individual FFR-CT results to determine subsequent patient care. Objective:To provide clinicians a means of interpreting individual FFR-CT resul...

journal_title：JAMA cardiology

authors： Cook CM,Petraco R,Shun-Shin MJ,Ahmad Y,Nijjer S,Al-Lamee R,Kikuta Y,Shiono Y,Mayet J,Francis DP,Sen S,Davies JE

更新日期：2017-07-01 00:00:00

abstract：Importance:The Open-Label Study of Long-term Evaluation Against LDL-C (OSLER-1) evaluated the durability of long-term efficacy and safety during long-term therapy with evolocumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9 (PCSK9). Objective:To determine whether LDL-C level reductions ...

journal_title：JAMA cardiology

authors： Koren MJ,Sabatine MS,Giugliano RP,Langslet G,Wiviott SD,Kassahun H,Ruzza A,Ma Y,Somaratne R,Raal FJ

更新日期：2017-06-01 00:00:00

abstract：IMPORTANCE:Although survival of patients with in-hospital cardiac arrest varies markedly among hospitals, specific resuscitation practices that distinguish sites with higher cardiac arrest survival rates remain unknown. OBJECTIVE:To identify resuscitation practices associated with higher rates of in-hospital cardiac a...

journal_title：JAMA cardiology

authors： Chan PS,Krein SL,Tang F,Iwashyna TJ,Harrod M,Kennedy M,Lehrich J,Kronick S,Nallamothu BK,American Heart Association's Get With the Guidelines–Resuscitation Investigators.

更新日期：2016-05-01 00:00:00

abstract：Importance:Many of the quality measures used to assess accountable care organization (ACO) performance in the Medicare Shared Savings Program (MSSP) focus on disease control and medication use among patients with cardiovascular disease and diabetes. To date, the association between participation in the MSSP by provider...

journal_title：JAMA cardiology

authors： McWilliams JM,Najafzadeh M,Shrank WH,Polinski JM

更新日期：2017-09-01 00:00:00

abstract：Importance:Observational studies have reported an association between low serum vitamin D levels and elevated risk of cardiovascular disease (CVD) events, but such studies cannot prove causation because of possible unmeasured confounding. Objective:We conducted a meta-analysis of randomized clinical trials that tested...

journal_title：JAMA cardiology

authors： Barbarawi M,Kheiri B,Zayed Y,Barbarawi O,Dhillon H,Swaid B,Yelangi A,Sundus S,Bachuwa G,Alkotob ML,Manson JE

更新日期：2019-08-01 00:00:00

abstract：Importance:Electronic health record (EHR) biobanks containing clinical and genomic data on large numbers of individuals have great potential to inform drug discovery. Individuals with interleukin 6 receptor (IL6R) single-nucleotide polymorphisms (SNPs) who are not receiving IL6R blocking therapy have biomarker profiles...

journal_title：JAMA cardiology

authors： Cai T,Zhang Y,Ho YL,Link N,Sun J,Huang J,Cai TA,Damrauer S,Ahuja Y,Honerlaw J,Huang J,Costa L,Schubert P,Hong C,Gagnon D,Sun YV,Gaziano JM,Wilson P,Cho K,Tsao P,O'Donnell CJ,Liao KP,VA Million Veteran Program.

更新日期：2018-09-01 00:00:00

abstract：Importance:Quality of percutaneous coronary intervention (PCI) is commonly assessed by risk-adjusted mortality. However, this metric may result in procedural risk aversion, especially for high-risk patients. Objective:To determine correlation and reclassification between hospital-level disease-specific mortality and P...

journal_title：JAMA cardiology

authors： Nathan AS,Xiang Q,Wojdyla D,Khatana SAM,Dayoub EJ,Wadhera RK,Bhatt DL,Kolansky DM,Kirtane AJ,Rao SV,Yeh RW,Groeneveld PW,Wang TY,Giri J

更新日期：2020-07-01 00:00:00

abstract：Importance:The period following heart failure hospitalization (HFH) is a vulnerable time with high rates of death or recurrent HFH. Objective:To evaluate clinical characteristics, outcomes, and treatment response to vericiguat according to prespecified index event subgroups and time from index HFH in the Vericiguat Gl...

journal_title：JAMA cardiology

authors： Lam CSP,Giczewska A,Sliwa K,Edelmann F,Refsgaard J,Bocchi E,Ezekowitz JA,Hernandez AF,O'Connor CM,Roessig L,Patel MJ,Pieske B,Anstrom KJ,Armstrong PW,VICTORIA Study Group.

更新日期：2020-11-13 00:00:00

abstract：Importance:Long-term blood pressure (BP) variability has emerged as a reproducible measure that is associated with heart failure independent of systemic BP. Visit-to-visit BP variability may be associated with the risk of heart failure early in the life course and thus may be reflected in subclinical alterations in car...

journal_title：JAMA cardiology

authors： Nwabuo CC,Yano Y,Moreira HT,Appiah D,Vasconcellos HD,Aghaji QN,Viera A,Rana JS,Shah RV,Murthy VL,Allen NB,Schreiner PJ,Lloyd-Jones DM,Lima JAC

更新日期：2020-07-01 00:00:00

abstract：Importance:It is unknown whether coronary revascularization, when added to optimal medical therapy, improves prognosis in patients with stable ischemic heart disease (SIHD) at increased risk of cardiovascular events owing to moderate or severe ischemia. Objective:To describe baseline characteristics of participants en...

journal_title：JAMA cardiology

authors： Hochman JS,Reynolds HR,Bangalore S,O'Brien SM,Alexander KP,Senior R,Boden WE,Stone GW,Goodman SG,Lopes RD,Lopez-Sendon J,White HD,Maggioni AP,Shaw LJ,Min JK,Picard MH,Berman DS,Chaitman BR,Mark DB,Spertus JA,Cyr D

更新日期：2019-03-01 00:00:00

abstract：Importance:With improved survival, heart failure (HF) has become a major complication for individuals with human immunodeficiency virus (HIV) infection. It is unclear if this risk extends to different types of HF in the antiretroviral therapy (ART) era. Determining whether HIV infection is associated with HF with reduc...

journal_title：JAMA cardiology

authors： Freiberg MS,Chang CH,Skanderson M,Patterson OV,DuVall SL,Brandt CA,So-Armah KA,Vasan RS,Oursler KA,Gottdiener J,Gottlieb S,Leaf D,Rodriguez-Barradas M,Tracy RP,Gibert CL,Rimland D,Bedimo RJ,Brown ST,Goetz MB,Warner

更新日期：2017-05-01 00:00:00

abstract：Importance:Bioresorbable scaffolds were designed to provide clinical benefits after their complete bioresorption. Prior studies demonstrated early risks with the Absorb polymeric bioresorbable vascular scaffold (BVS). Whether this risk profile changes over time during the course of its bioresorption is unknown. Object...

journal_title：JAMA cardiology

authors： Stone GW,Kimura T,Gao R,Kereiakes DJ,Ellis SG,Onuma Y,Chevalier B,Simonton C,Dressler O,Crowley A,Ali ZA,Serruys PW

更新日期：2019-12-01 00:00:00