Abstract:
:Mouse mammary tumor virus (MMTV) induces breast cancer in mice in the absence of known virally-encoded oncogenes. Tumorigenesis by MMTV is thought to occur primarily through insertional mutagenesis, leading to the activation of cellular proto-oncogenes and outgrowth of selected cells. Here we investigated whether MMTV encodes microRNAs (miRNAs) and/or modulates host miRNAs that could contribute to tumorigenesis. High throughput small RNA sequencing analysis of MMTV-infected cells and MMTV-induced mammary tumors demonstrates that MMTV does not encode miRNAs. However, infected tissues have altered levels of several host miRNAs, including increased expression of members of the oncogenic miRNA cluster, miR-17-92. Notably, similar changes in miRNA levels have been previously reported in human breast cancers. Combined, our results demonstrate that virally encoded miRNAs do not contribute to MMTV-mediated tumorigenesis, but that changes in specific host miRNAs in infected cells may contribute to virus replication and tumor biology.
journal_name
Virologyjournal_title
Virologyauthors
Kincaid RP,Panicker NG,Lozano MM,Sullivan CS,Dudley JP,Mustafa Fdoi
10.1016/j.virol.2017.09.030subject
Has Abstractpub_date
2018-01-01 00:00:00pages
180-187eissn
0042-6822issn
1096-0341pii
S0042-6822(17)30342-2journal_volume
513pub_type
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