Kinetic analysis of RNA editing of Newcastle disease virus P gene in the early period of infection.

Abstract:

UNLABELLED:As a paramyxovirus, Newcastle disease virus (NDV) has the ability to edit its P (phosphoprotein) gene to synthesize three kinds of viral protein (P, V and W). It is technically very difficult to differentiate P, V and W mRNAs, and little was known about NDV regulation of RNA-editing frequency. To investigate the rules of NDV RNA editing, the ratio of the P gene-derived transcripts (P, V and W) was determined by sequencing at different time points post-infection. The results showed unstable ratio of V and W mRNA at different time points, and the frequency of NDV editing was significantly increased at the early period of infection (P  KEYWORDS:Newcastle disease virus; phosphoprotein; RNA editing; G insertion.

journal_name

Acta Virol

journal_title

Acta virologica

authors

Qiu X,Fu Q,Meng C,Yu S,Zhan Y,Dong L,Ren T,Sun Y,Tan L,Song C,Han X,Ding C

doi

10.4149/av_2016_01_71

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

71-7

issue

1

eissn

0001-723X

issn

1336-2305

journal_volume

60

pub_type

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