Abstract:
:Optical coherence tomography (OCT) enables noninvasive high-resolution 3D imaging of the human retina, and thus plays a fundamental role in ophthalmology. Via OCT examination, even subtle retinal changes can be captured, which occur in very early stages of different diseases (e.g., glaucoma, diabetes mellitus, or age-related macular degeneration). Yet, analyzing the resulting data is challenging. Conventionally, OCT data are strongly aggregated via automated methods. While this reduces the amount of information to be analyzed, it also makes it difficult, if not impossible, to identify small and localized retinal changes. This might lead to wrong diagnoses, since these methods do not account for patient-specific characteristics. We address this problem by providing new and efficient visual-interactive methods. Particularly, we introduce dedicated visualizations that show different aspects of the data. In addition, we support patient-specific selections of relevant data regions. Selected regions are emphasized, or separately visualized to inspect retinal substructures in detail. By visually comparing the regions to reference data, even very small retinal changes can be detected. We demonstrate the utility of our approach by applying it to data of a study with pediatric patients suffering from diabetes mellitus type 1. Our results show that visual-interactive methods indeed help to analyze subtle retinal changes and, thus, support the diagnosis of diseases in an early stage. :Die optische Kohärenztomografie (OCT) als bildgebendes In-vivo-Verfahren eröffnet völlig neue Möglichkeiten bei der Diagnose von Netzhaut- und Sehnervenerkrankungen. Im Rahmen einer Patientenuntersuchung entstehen hochaufgelöste Volumendatensätze, die kleinste Veränderungen der Netzhaut, wie sie in einem sehr frühen Krankheitsstadium auftreten, erfassen können. Allerdings erschwert die Komplexität des Datenmaterials auch die Auswertung. Deshalb werden die Daten üblicherweise zunächst auf ein handhabbares Maß reduziert, wobei meist automatische, stark vereinfachende Methoden eingesetzt werden. Dies macht es schwer, wenn nicht sogar unmöglich, minimale strukturelle, gegebenenfalls auch lokale Veränderungen der Netzhaut zu extrahieren, um eine entsprechende Diagnose zu stellen. Unser Ziel ist es, die bisherigen etablierten Verfahren um visuell-interaktive Analysemethoden zu ergänzen. Damit soll sowohl eine patientenspezifische Selektion relevanter Daten als auch die Erkennung minimaler Netzhautveränderungen unterstützt werden. Je nach Fragestellung visualisieren wir die OCT-Daten aus unterschiedlichen Perspektiven. Anhand dieser Bilder kann gezielt eine individualisierte Datenselektion durchgeführt werden. Die relevanten Datenbereiche lassen sich dann im Kontext der gesamten Datenmenge hervorheben oder in separaten sogenannten Views anzeigen. So wird es möglich, relevante Substrukturen im Detail zu analysieren und mit Vergleichsdaten zu korrelieren. Insbesondere für Kohortenvergleiche und Vergleiche zwischen Individuen und einer Kontrollgruppe ergeben sich dadurch neue klinische und experimentelle Möglichkeiten. Wir belegen dies beispielhaft anhand einer Studie mit pädiatrischen Patienten mit Diabetes mellitus Typ 1 (T1DM). Unsere Ergebnisse zeigen, dass durch die Einbindung von visuell-interaktiven Analysemethoden entscheidende Fortschritte hinsichtlich einer patientenspezifischen Diagnostik sowie zur Beurteilung von klinischen Studien möglich werden.
journal_name
Klin Monbl Augenheilkdjournal_title
Klinische Monatsblatter fur Augenheilkundeauthors
Röhlig M,Jünemann A,Fischer DC,Prakasam RK,Stachs O,Schumann Hdoi
10.1055/s-0043-121705subject
Has Abstractpub_date
2017-12-01 00:00:00pages
1463-1471issue
12eissn
0023-2165issn
1439-3999journal_volume
234pub_type
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journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1045984
更新日期:1991-05-01 00:00:00
abstract:PURPOSE:The aim of this communication is to report a case of epiretinal membrane removal with intra-operative unexpected subretinal extension of the membrane. METHODS:This is an observational case report. An 83-year-old female patient with bilateral pigmented secondary macular pucker after laser coagulation for diabet...
journal_title:Klinische Monatsblatter fur Augenheilkunde
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journal_title:Klinische Monatsblatter fur Augenheilkunde
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journal_title:Klinische Monatsblatter fur Augenheilkunde
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更新日期:2007-03-01 00:00:00
abstract::We document a case of unilateral hemiarcus lipoides, which developed de novo 10 months after trabeculectomy in the left eye of a 54-year-old woman. The involved eye showed heterochromia complicata Fuchs and had undergone intracapsular cataract extraction 11 years and trabeculectomy one year earlier. Except for intermi...
journal_title:Klinische Monatsblatter fur Augenheilkunde
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abstract::Epibulbar osteomas are benign tumors which are usually present at birth. Up to now 39 cases have been described in the literature. In the last three years 4 further cases have been found in the Freiburg, Hamburg, Marburg, and Munich University Eye Clinics. Epibulbar osteomas probably occur more often than is generally...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
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journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2001-18386
更新日期:2001-10-01 00:00:00
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journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0034-1368376
更新日期:2014-09-01 00:00:00
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journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
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更新日期:2006-06-01 00:00:00
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journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050918
更新日期:1985-04-01 00:00:00
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journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
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更新日期:2017-09-01 00:00:00
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journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
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更新日期:2005-02-01 00:00:00
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journal_title:Klinische Monatsblatter fur Augenheilkunde
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更新日期:1992-05-01 00:00:00
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journal_title:Klinische Monatsblatter fur Augenheilkunde
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更新日期:1997-02-01 00:00:00
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journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
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更新日期:2004-09-01 00:00:00
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journal_title:Klinische Monatsblatter fur Augenheilkunde
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doi:
更新日期:1977-02-01 00:00:00
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journal_title:Klinische Monatsblatter fur Augenheilkunde
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更新日期:1981-07-01 00:00:00
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journal_title:Klinische Monatsblatter fur Augenheilkunde
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journal_title:Klinische Monatsblatter fur Augenheilkunde
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journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
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更新日期:2016-03-01 00:00:00
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journal_title:Klinische Monatsblatter fur Augenheilkunde
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doi:
更新日期:1996-05-01 00:00:00
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更新日期:2010-08-01 00:00:00
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journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1057700
更新日期:1980-11-01 00:00:00
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journal_title:Klinische Monatsblatter fur Augenheilkunde
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journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-02-01 00:00:00
abstract:BACKGROUND:Infections with varicella zoster virus may involve the optic nerve and the retina. Different pathomechanisms have been discussed. We present a case with an autoimmune inflammatory reaction according to the clinical course. PATIENT:A 69-year-old female was referred to our clinic because of suspected bilatera...
journal_title:Klinische Monatsblatter fur Augenheilkunde
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更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:Xerophthalmia, the eye manifestation of vitamin A deficiency, is one of the main reasons of blindness in developing countries but is rare in industrial countries. PATIENTS:We report on 2 cases of night blindness and conjunctival and corneal xerosis because of hypovitaminosis A. One patient developed vitamin...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2000-10386
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Lid tumors show a heterogenous clinical spectrum. Tumors which display some criteria of malignancy may histologically be diagnosed as inflammatory lesions without any neoplastic component. In contrast, malignant tumors can induce changes on the lid margin mimicking inflammatory changes. MATERIAL AND METHODS...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
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更新日期:2018-07-01 00:00:00