Abstract:
:Human life expectancy is rapidly increasing with an associated increasing burden of chronic diseases, such as neurodegenerative diseases and cancer. However, there is limited progress in finding effective treatment for these conditions. For this reason, members of the genus Streptomyces have been explored extensively over the past decades as these filamentous bacteria are highly efficient in producing bioactive compounds with human health benefits. Being ubiquitous in nature, streptomycetes can be found in both terrestrial and marine environments. Previously, two Streptomyces strains (MUSC 137T and MUM 256) isolated from mangrove sediments in Peninsular Malaysia demonstrated potent antioxidant and cytotoxic activities against several human cancer cell lines on bioactivity screening. These results illustrate the importance of streptomycetes from underexplored regions aside from the terrestrial ecosystem. Here we provide the insights and significance of Streptomyces species in the search of anticancer and/or chemopreventive agents and highlight the impact of next generation sequencing on drug discovery from the Streptomyces arsenal.
journal_name
Front Microbioljournal_title
Frontiers in microbiologyauthors
Ser HL,Tan LT,Law JW,Chan KG,Duangjai A,Saokaew S,Pusparajah P,Ab Mutalib NS,Khan TM,Goh BH,Lee LHdoi
10.3389/fmicb.2017.02065subject
Has Abstractpub_date
2017-11-01 00:00:00pages
2065issn
1664-302Xjournal_volume
8pub_type
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