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K1K8: an Hp1404-derived antibacterial peptide.

Abstract：

:As an alternative class of antimicrobial agents used to overcome drug-resistant infections, antimicrobial peptides (AMPs) have recently gained significant attention. In this study, we designed an improved antimicrobial peptide, K1K8, based on the molecular template of Hp1404. Compared to the wild-type Hp1404, K1K8 showed an improved antibacterial spectrum in vitro, a lower hemolytic activity, and an enhanced serum stability. Importantly, K1K8 also decreased methicillin-resistant Staphylococcus aureus (MRSA) bacterial counts in the wounded region in a mouse skin infection model. Interestingly, K1K8 did not induce bacterial resistance or non-specific immune response reactions. Moreover, the peptide killed bacterial cells mainly by disrupting the bacterial membrane. In summary, K1K8 has the potential to be used as an improved anti-infection agent for topical use, which opens an avenue that potential anti-infection drugs may be designed and developed from the molecular templates of AMPs.

journal_name

Appl Microbiol Biotechnol

journal_title

Applied microbiology and biotechnology

authors

Li Z,Liu G,Meng L,Yu W,Xu X,Li W,Wu Y,Cao Z

doi

10.1007/s00253-016-7395-x

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

5069-77

issue

11

eissn

0175-7598

issn

1432-0614

pii

10.1007/s00253-016-7395-x

journal_volume

100

pub_type

杂志文章

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