Abstract:
:Lymphatic malformations (LMs) occur in 2.8 to 5 per 100,000 live births. Most involve the head and neck and they are equally common in men and women. They are developmental anomalies of unknown cause, although recent evidence suggests that an upregulation of the mammalian target of rapamycin (mTOR) pathway may be a causal factor leading to the overproduction of abnormal lymph vessels. These vessels are likely dilated lymphatic sacs sequestered from the lymphatic and venous systems. This overproduction results in the accumulation of lymph in dilated cystic spaces, which in turn results in the clinical features of an LM.
journal_name
Otolaryngol Clin North Amjournal_title
Otolaryngologic clinics of North Americaauthors
Waner M,O TMdoi
10.1016/j.otc.2017.09.012subject
Has Abstractpub_date
2018-02-01 00:00:00pages
159-172issue
1eissn
0030-6665issn
1557-8259pii
S0030-6665(17)30172-Xjournal_volume
51pub_type
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journal_title:Otolaryngologic clinics of North America
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