Covalent Modification of CDK2 by 4-Hydroxynonenal as a Mechanism of Inhibition of Cell Cycle Progression.

abstract：:Catalase is an important antioxidant enzyme, which has been shown to provide cardiac protection from acute toxicity induced by doxorubicin, a most effective anticancer agent. Because cumulative dose-dependent chronic cardiomyopathy due to a long-term administration of doxorubicin is a significant clinical problem, the...

journal_title：Chemical research in toxicology

authors： Kang YJ,Sun X,Chen Y,Zhou Z

更新日期：2002-01-01 00:00:00

abstract：:Proton pump inhibitors (PPIs) are extensively used for the treatment of gastric acid-related disorders. PPIs appear to be well tolerated and almost have no short-term side effects. However, the clinical adverse reactions of long-term PPI usage are increasingly reported in recent years. So far, there is no study that e...

journal_title：Chemical research in toxicology

authors： Wu D,Qiu T,Zhang Q,Kang H,Yuan S,Zhu L,Zhu R

更新日期：2015-03-16 00:00:00

abstract：:It has previously been shown that malonaldehyde forms conjugates with acetaldehyde and that these conjugates react with nucleobases forming so-called conjugate adducts. In the current study, it is shown that conjugate adducts are also formed in calf thymus DNA when incubated simultaneously with malonaldehyde and aceta...

journal_title：Chemical research in toxicology

authors： Pluskota-Karwatka D,Pawłowicz AJ,Kronberg L

更新日期：2006-07-01 00:00:00

abstract：:The increasing use of fullerene nanomaterials has prompted widespread concern over their biological effects. Herein, we have studied the phototoxicity of gamma-cyclodextrin bicapped pristine C 60 [(gamma-CyD) 2/C 60] and its water-soluble derivative C 60(OH) 24 toward human keratinocytes. Our results demonstrated that...

journal_title：Chemical research in toxicology

authors： Zhao B,He YY,Bilski PJ,Chignell CF

更新日期：2008-05-01 00:00:00

abstract：:DNA oxidation damage has been regarded as one of the possible mechanisms for the hepatic carcinogenesis of dioxin-like compounds (DLCs). In this study, we evaluated the toxic equivalency factor (TEF) from the standpoint of induced DNA oxidation products and their relationship to toxicity and carcinogenicity. Nine DNA ...

journal_title：Chemical research in toxicology

authors： Gao L,Mutlu E,Collins LB,Walker NJ,Hartwell HJ,Olson JR,Sun W,Gold A,Ball LM,Swenberg JA

更新日期：2017-03-20 00:00:00

abstract：:Human exposure to engineered nanomaterials (ENMs) is inevitable due to the plethora of applications for which they are being manufactured and integrated within. ENMs demonstrate plentiful advantages in terms of industrial approaches as well as from a consumer perspective. However, despite such positives, doubts remain...

journal_title：Chemical research in toxicology

authors： Cronin JG,Jones N,Thornton CA,Jenkins GJS,Doak SH,Clift MJD

更新日期：2020-05-18 00:00:00

abstract：:Thiacetazone (TAZ) and ethionamide (ETA) are, respectively, thiourea- and thioamide-containing second line antitubercular prodrugs for which there is an extensive clinical history of cross-resistance in Mycobacterium tuberculosis. EtaA, a recently identified flavin-containing monooxygenase (FMO), is responsible for th...

journal_title：Chemical research in toxicology

authors： Qian L,Ortiz de Montellano PR

更新日期：2006-03-01 00:00:00

abstract：:The metabolic pathways of dietary flavonoids are still largely unknown. In the present work, mass spectrometry and UV-vis spectroscopy studies were used to show that the naturally occurring flavonoid catechin underwent enzymatic oxidation by tyrosinase in the presence of glutathione (GSH) to form mono-, bi-, and tri-g...

journal_title：Chemical research in toxicology

authors： Moridani MY,Scobie H,Salehi P,O'Brien PJ

更新日期：2001-07-01 00:00:00

abstract：:Diabetes mellitus is a metabolic disorder constituting a major health problem whose prevalence has gradually increased worldwide over the past few decades. Type 2 diabetes mellitus (T2DM) remains more complex and heterogeneous and arises as a combination of insulin resistance and inadequate functional β-cell mass and ...

journal_title：Chemical research in toxicology

authors： Dornadula S,Elango B,Balashanmugam P,Palanisamy R,Kunka Mohanram R

更新日期：2015-09-21 00:00:00

abstract：:The crystal structure of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) has been determined by single-crystal X-ray crystallography. Crystals grown by evaporation of an aqueous solution form in the monoclinic space group P2(1)/n with two molecules of PhIP per asymmetric unit, along with six w...

journal_title：Chemical research in toxicology

authors： Parkin S,Marsch GA,Hope H,Whitney E,Winter NW,Colvin ME,Felton JS,Turteltaub KW

更新日期：1996-04-01 00:00:00

abstract：:Tocopherols (alpha-, beta-, gamma-, and delta-Toc) and tocopheryl quinones (alpha-, beta-, gamma-, and delta-TQ) were recently suggested to modulate mitochondrial electron transfer in mammals. Intriguingly, Tocs and stigmatellin, a potent inhibitor of the mitochondrial cytochrome (cyt) bc(1) complex, possess a common ...

journal_title：Chemical research in toxicology

authors： Müllebner A,Patel A,Stamberg W,Staniek K,Rosenau T,Netscher T,Gille L

更新日期：2010-01-01 00:00:00

abstract：:This study was conducted to investigate the protein adducts with pesticides in a cohort of 172 factory workers that were exposed to a mixture of pesticides. The 35 samples showing considerable variation in biochemical parameters, i.e., butyrylcholinestrase (BChE), serum glutamic pyruvic transaminase (SGPT), serum glut...

journal_title：Chemical research in toxicology

authors： Rehman T,Khan MM,Shad MA,Hussain M,Oyler BL,Goo YA,Goodlett DR

更新日期：2016-10-17 00:00:00

abstract：:2,4-Dichlorophenol (2,4-DCP), an environmental pollutant, was reported to cause hepatotoxicity. The biochemical mechanisms of 2,4-DCP induced liver injury remain unknown. The present study showed that 2,4-DCP is chemically reactive and spontaneously reacts with GSH and bovine serum albumin to form GSH conjugates and B...

journal_title：Chemical research in toxicology

authors： Li Q,Li W,Zhao J,Guo X,Zou Q,Yang Z,Tian R,Peng Y,Zheng J

更新日期：2020-09-21 00:00:00

abstract：:The effect of adduct stereochemistry on the susceptibility to hydrolysis by snake venom (VPD) and bovine spleen (SPD) phosphodiesterases was investigated with short deoxyoligonucleotides containing defined adducts derived from alkylation of the exocyclic 6-amino group of dA by polycyclic aromatic hydrocarbon diol epox...

journal_title：Chemical research in toxicology

authors： Ilankumaran P,Pannell LK,Gebreselassie P,Pilcher AS,Yagi H,Sayer JM,Jerina DM

更新日期：2001-09-01 00:00:00

abstract：:The present study describes a novel integrated approach for rapid analysis of reactive metabolites with a linear ion trap mass spectrometer (LTQ). In this approach, an isotope pattern-dependent scanning method was applied to the data acquisition of glutathione (GSH)-trapped reactive metabolites. Recorded full-scan MS ...

journal_title：Chemical research in toxicology

authors： Ma L,Wen B,Ruan Q,Zhu M

更新日期：2008-07-01 00:00:00

abstract：:The Adverse Outcome Pathway (AOP) paradigm details the existing knowledge that links the initial interaction between a chemical and a biological system, termed the molecular initiating event (MIE), through a series of intermediate events, to an adverse effect. An important example of a well-defined MIE is the formatio...

journal_title：Chemical research in toxicology

authors： Ebbrell DJ,Madden JC,Cronin MT,Schultz TW,Enoch SJ

更新日期：2016-06-20 00:00:00

abstract：:The toxic alpha,beta-unsaturated aldehyde acrolein readily attacks proteins, generating adducts at cysteine, histidine, and lysine residues. In this study, rabbit antiserum was raised against acrolein-modified keyhole limpet hemocyanin in the expectation that it would allow immunodetection of adducted proteins in biol...

journal_title：Chemical research in toxicology

authors： Burcham PC,Fontaine FR,Petersen DR,Pyke SM

更新日期：2003-10-01 00:00:00

abstract：:The genotoxicity of the dihydrofurans aflatoxin B1 (AFB1), aflatoxin G1 (AFG1), and sterigmatocystin (STG) was examined in a bacterial system in which the induction of SOS repair is monitored with the umuC gene linked to a lacZ reporter gene in plasmid pSK1002. Human liver microsomal cytochrome P-450NF oxidized the di...

journal_title：Chemical research in toxicology

authors： Baertschi SW,Raney KD,Shimada T,Harris TM,Guengerich FP

更新日期：1989-03-01 00:00:00

abstract：:The toxicity of paraquat (PQ2+) is attributed to intracellularly formed PQ*+, O(2)*-, H(2)O(2), and secondary.OH radicals generated through Fenton-like reactions. Yet, no antidote for PQ2+ toxicity in human has been found also due to poor cell permeability of many common antioxidants that remove toxic species predomin...

journal_title：Chemical research in toxicology

authors： Goldstein S,Samuni A,Aronovitch Y,Godinger D,Russo A,Mitchell JB

更新日期：2002-05-01 00:00:00

abstract：:Studies on the metabolic bioactivation of the psychotomimetic amine phencyclidine have been pursued through the characterization of a new metabolite which is formed via initial cytochrome P-450 catalyzed oxidation of the parent drug to the corresponding iminium species. CI mass spectrometric and diode array UV and 1H ...

journal_title：Chemical research in toxicology

authors： Hoag MK,Schmidt-Peetz M,Lampen P,Trevor A,Castagnoli N Jr

更新日期：1988-03-01 00:00:00

abstract：:Exposures to sulfur mustard (HD; bis(2-chloroethyll) sulfide) are well-known to result in the formation of adducts with free aspartate and glutamate residues of plasma proteins (Lawrence, R. J., Smith, J. R., and Capacio, B. R. 2008 32, (1), 31-36). A modified version of the analytical method reported previously for t...

journal_title：Chemical research in toxicology

authors： Young SA,Capacio BR

更新日期：2020-07-20 00:00:00

abstract：:Previous studies have demonstrated that reactive dicarbonyl compounds [e.g., methylglyoxal (MGO) and glyoxal (GO)] irreversibly and progressively modify proteins over time and yield advanced glycation end products (AGEs), which are thought to contribute to the development of diabetes mellitus and its subsequent compli...

journal_title：Chemical research in toxicology

authors： Sang S,Shao X,Bai N,Lo CY,Yang CS,Ho CT

更新日期：2007-12-01 00:00:00

abstract：:This paper reports on the analysis of the toxin content from Palythoa tuberculosa and Palythoa toxica samples collected off of the Hawaiian coast. Our work, based on in-depth high-resolution liquid chromatography-mass spectrometry analysis along with extensive NMR study, led us to structurally characterize 42-hydroxy-...

journal_title：Chemical research in toxicology

authors： Ciminiello P,Dell'aversano C,Dello Iacovo E,Fattorusso E,Forino M,Grauso L,Tartaglione L,Florio C,Lorenzon P,De Bortoli M,Tubaro A,Poli M,Bignami G

更新日期：2009-11-01 00:00:00

abstract：:The perfluorinated carboxylic acid, perfluoro-n-decanoic acid (PFDA), is a known peroxisome proliferator which displays toxicity in rodents. Using a paired-tracer first-pass extraction technique, the effect of PFDA on hepatic glucose transport was determined in the isolated perfused rat liver. In brief, livers isolate...

journal_title：Chemical research in toxicology

authors： Goecke-Flora CM,Wyman JF,Jarnot BM,Reo NV

更新日期：1995-01-01 00:00:00

abstract：:This study was designed to distinguish and evaluate the contribution of reactive metabolite and reactive oxygen species as the mechanism of metabolism-dependent valproic acid-induced in vitro cytotoxicity. The involvement of reactive oxygen species in the mechanism of in vitro cytotoxicity was examined by the addition...

journal_title：Chemical research in toxicology

authors： Tabatabaei AR,Thies RL,Abbott FS

更新日期：1999-04-01 00:00:00

abstract：:Sulfamethoxazole (SMX) is an important antibiotic in the management of patients with cystic fibrosis, but allergic reactions may develop thus restricting therapy. The aim of this study was to utilize drug (metabolite) antigens to diagnose SMX-mediated allergic reactions in patients with cystic fibrosis. Lymphocytes fr...

journal_title：Chemical research in toxicology

authors： Lavergne SN,Whitaker P,Peckham D,Conway S,Park BK,Naisbitt DJ

更新日期：2010-06-21 00:00:00

abstract：:2,5-Hexanedione (2,5-HD) is the neurotoxic gamma-diketone metabolite of the industrial solvent n-hexane. Substantial evidence indicates that 2,5-HD reacts with neurofilament protein lysine epsilon-amines to yield 2,5-dimethylpyrrole adducts and that this reaction is critical to the mechanism of toxicity. Alkylpyrroles...

journal_title：Chemical research in toxicology

authors： Zhu M,Spink DC,Yan B,Bank S,DeCaprio AP

更新日期：1994-07-01 00:00:00

abstract：:Trans-Resveratrol (tRes) has been shown to have powerful antioxidant, anti-inflammatory, anticarcinogenic, and antiaging properties; however, its use as a therapeutic agent is limited by its rapid metabolism into its conjugated forms by UDP-glucuronosyltransferases (UGTs). The aim of the current study was to test the ...

journal_title：Chemical research in toxicology

authors： Greer AK,Madadi NR,Bratton SM,Eddy SD,Mazerska Z,Hendrickson HP,Crooks PA,Radominska-Pandya A

更新日期：2014-04-21 00:00:00

abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly population, above 65 years of age. Multiple lines of evidence confirm the central role of 40-42 residue Abeta peptides in the pathogenesis of AD, but exact mechanisms of Abeta toxicity remain unclear. Recently, evidence has accumulat...

journal_title：Chemical research in toxicology

authors： Rózga M,Bal W

更新日期：2010-02-15 00:00:00

abstract：:Arylamines (AAs) and heterocyclic aromatic amines (HAAs) are structurally related carcinogens formed during the combustion of tobacco or cooking of meat. They undergo cytochrome P450 mediated N-hydroxylation to form metabolites which bind to DNA and lead to mutations. The N-hydroxylated metabolites of many AAs also ca...

journal_title：Chemical research in toxicology

authors： Pathak KV,Chiu TL,Amin EA,Turesky RJ

更新日期：2016-03-21 00:00:00