Abstract：
BACKGROUND:Composition and diversity of intestinal microbial communities (microbiota) are generally accepted as a risk factor for poor outcomes; however, we cannot yet use this information to prevent adverse outcomes. METHODS:Stool was collected from 8 long-term acute care hospital patients experiencing diarrhea and 2 fecal microbiota transplant donors; 16S rDNA V1-V2 hypervariable regions were sequenced. Composition and diversity of each sample were described. Stool was also tested for Clostridium difficile, vancomycin-resistant enterococci (VRE), and carbapenem-resistant Enterobacteriaceae. Associations between microbiota diversity and demographic and clinical characteristics, including antibiotic use, were analyzed. RESULTS:Antibiotic exposure and Charlson Comorbidity Index were inversely correlated with diversity (Spearman = -0.7). Two patients were positive for VRE; both had microbiomes dominated by Enterococcus faecium, accounting for 67%-84% of their microbiome. CONCLUSIONS:Antibiotic exposure correlated with diversity; however, other environmental and host factors not easily obtainable in a clinical setting are also known to impact the microbiota. Therefore, direct measurement of microbiome disruption by sequencing, rather than reliance on surrogate markers, might be most predictive of adverse outcomes. If and when microbiome characterization becomes a standard diagnostic test, improving our understanding of microbiome dynamics will allow for interpretation of results to improve patient outcomes.
journal_name
Am J Infect Controljournal_title
American journal of infection controlauthors
Halpin AL,de Man TJ,Kraft CS,Perry KA,Chan AW,Lieu S,Mikell J,Limbago BM,McDonald LCdoi
10.1016/j.ajic.2016.01.003subject
Has Abstractpub_date
2016-07-01 00:00:00pages
830-6issue
7eissn
0196-6553issn
1527-3296pii
S0196-6553(16)00040-7journal_volume
44pub_type
杂志文章abstract：BACKGROUND:Removing unnecessary central lines is a critical step in reducing risk of infection and was 1 focus of a national quality improvement collaborative. We examined if participating adult intensive care units (ICUs) reduced central line days during the project period compared with the period before implementatio...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2014.06.003
更新日期：2014-10-01 00:00:00
abstract：:A 1-year prospective cohort study of health care-acquired infections was conducted at the neonatal intensive care unit of the University Clinical Centre Kragujevac, Serbia. The incidence rate of neonates with health care-acquired infections was 18.6%, and the incidence rate of the infections themselves was 19.4%. The ...
journal_title：American journal of infection control
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
abstract：:Microbial contamination of used, unprocessed internal components of dental handpieces (HPs) was assessed. HPs were dismantled aseptically, immersed in phosphate-buffered saline, ultrasonicated, and cultured. A median of 200 CFU per turbine (n = 40), 400 CFU per spray channel (n = 40), and 1000 CFU per item of surgical...
journal_title：American journal of infection control
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journal_title：American journal of infection control
pub_type： 杂志文章
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abstract：OBJECTIVE:To describe an outbreak of influenza A in an oncology unit, highlighting infection control methods implemented, and examining reasons health care workers (HCWs) present to work with influenza-like illness (ILI). METHODS:Confirmed cases were defined by the presence of ILI and a positive nasopharyngeal polymer...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2018.10.024
更新日期：2019-06-01 00:00:00
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journal_title：American journal of infection control
pub_type： 杂志文章
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更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:This study investigated the self-perceived infection control (IC) knowledge and practice levels of professional standards competency (PSC) among Korean infection control nurses (ICNs) to identify factors that may influence PSC. METHODS:Using a self-reporting questionnaire method, we collected data from a to...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2014.05.023
更新日期：2014-09-01 00:00:00
abstract：:Research has substantiated that animals improve human health, both psychologically and physiologically. Therefore, healthcare facilities have begun to implement programs, such as the "Furry Friends Foundation," that bring animals into the facility to improve the quality of life of patients. When implementing these pro...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2005.06.005
更新日期：2006-06-01 00:00:00
abstract：BACKGROUND:Skin prick tests are commonly used for human allergy testing and determination. Because solutions are kept at 4 degrees C and patient's skin is cleaned, the same solutions are used on many patients with the same applicators without sterilization. OBJECTIVES:Our objectives were to determine whether a model b...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2008.11.007
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journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/0196-6553(93)90007-q
更新日期：1993-06-01 00:00:00
abstract：BACKGROUND:Hospital rooms play an important role in the transmission of several health care-associated pathogens. During the last few years, a number of innovative cleaning-disinfecting products have been brought to market. In this study, commercially available products combining cleaning and disinfection were compared...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2017.04.290
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Environmental decontamination is one of the most effective methods to prevent transmission of infectious pathogens in child care centers (CCCs). Alongside state recommendations, national organizations-including the American Academy of Pediatrics (AAP)-offer best-practice policies. In Michigan, these sets of ...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2019.03.019
更新日期：2019-10-01 00:00:00
abstract：:Healthcare systems are expanding, no longer bound by county, state or country, thus necessitating the importance of consistent and standardized guidelines for the management and control of communicable diseases, including influenza. As a healthcare system consisting of diverse facilities with a focus not only on safe ...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2020.05.006
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:A cluster of seven cases of Acinetobacter caleoaceticus anitratus in a community teaching hospital intensive care unit was discovered (the seventh case was located in a step-down unit next to an infected patient recently transferred from the intensive care unit.) METHODS:An outbreak investigation, including...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/0196-6553(94)90020-5
更新日期：1994-10-01 00:00:00
abstract：BACKGROUND:Health care workers (HCWs) use their mobile phones during working hours or medical care. There is evidence that the instruments are colonized with pathogenic microorganisms. Here, we describe levels of Enterobacteriaceae contamination (EC) in cell phones and the risk factors associated with EC in Peruvian in...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2016.02.020
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVE:At present, the shortest recommended application time of alcoholic handrubs is an application interval of 30 seconds. However, application times shorter than 30 seconds are regularly practiced. Therefore, the aim of this study was to investigate whether a 15-second application time achieves a comparable wetta...
journal_title：American journal of infection control
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajic.2018.02.015
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Many studies have examined hand hygiene (HH) frequency and adherence in response to various interventions. This study used 2 methods to determine HH frequency and adherence to see how well the outcomes correlated. METHODS:HH frequency was measured over 4, 1-month periods (phases 1-4), using 2 methods: an au...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2005.07.006
更新日期：2006-04-01 00:00:00
abstract：:To assess the implementation of hepatitis B virus (HBV) vaccination programs for hospital workers, we mailed questionnaires to all 229 licensed Michigan hospitals. The response rate was 96% (221/229); of these, 68% (150/221) had vaccination programs. Although multiple hospital characteristics were associated with the ...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/0196-6553(88)90059-4
更新日期：1988-10-01 00:00:00
abstract：BACKGROUND:Urinary tract infections (UTIs) are the most common nosocomial infection experienced by patients in United States hospitals and are responsible for significant morbidity and excess hospital costs. The purpose of this study was to determine the efficacy of a silver alloy, hydrogel-coated, urinary catheter in ...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2004.05.002
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND:Point prevalence surveys (PPSs) in Japanese hospitals have not yet been reported. The purpose of this pilot PPS study was to evaluate the epidemiology of health care-associated infections (HAIs) and antimicrobial use in a Japanese tertiary university hospital. METHODS:A 1-day, cross-sectional PPS was perfor...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2016.03.045
更新日期：2016-07-01 00:00:00
abstract：:Health care workers (HCWs) are susceptible to hospital acquired varicella zoster virus (VZV). We evaluated seroprevalence and predictive value of a history of varicella disease (VD) with VZV serology in HCWs in northern Israel. A total of 200 HCWs were enrolled. A high rate of seropositivity for VZV-IgG was found: 98....
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2007.06.004
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:No information is available on the financial impact of nosocomial pneumonia in Argentina. To calculate the cost of nosocomial pneumonia in intensive care units, a 5-year, matched cohort study was undertaken at 3 hospitals in Argentina. SETTING:Six adult intensive care units (ICU). METHODS:Three hundred sev...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2004.08.008
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:Occupational risk for several bloodborne viruses is attributable to unsafe injection practices. To understand injection frequency and safety, we surveyed injection rates and factors influencing injection prescription in primary health care facilities and associated health clinics in Shiraz, Iran. METHODS:We...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2013.09.006
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:We were alerted to increased rates of Clostridium difficile-positive tests at all 3 hospitals in our health care system by MedMined Data Mining Surveillance Service, CareFusion (San Diego, CA). In response, an intervention of terminal room cleaning with dilute bleach was instituted to decrease the amount of ...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2009.11.003
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Ventilator-associated events are common in mechanically ventilated patients. They are associated with more days on mechanical ventilation, longer intensive care unit (ICU) stay, and increased risk of mortality. Theoretically, interventions that prevent ventilator-associated events should also reduce associat...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2018.06.022
更新日期：2019-01-01 00:00:00
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journal_title：American journal of infection control
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ajic.2020.06.008
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Infection control partially depends on hygiene and communication skills. Unfortunately, motivation for continuous training is lower than desired. Many health care providers (HCPs) do not recognize the need for training but express this need for others. This is attributable to heuristic errors, such as the ov...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2018.10.022
更新日期：2019-05-01 00:00:00
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journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2005.06.012
更新日期：2006-05-01 00:00:00
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journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2011.04.324
更新日期：2012-05-01 00:00:00
abstract：:Hand dermatitis as a result of frequent exposure to water and cleansing agents is a significant problem in the health care industry. In developing prevention efforts to address this problem, it is necessary to make appropriate recommendations for moisturizers that are compatible with latex gloves and/or handwashing ag...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1067/mic.2001.117298
更新日期：2001-12-01 00:00:00
