Complete genome sequence of Streptomyces globisporus C-1027, the producer of an enediyne antibiotic lidamycin.

Abstract:

:Streptomyces globisporus C-1027 produces a nine-membered enediyne antitumor antibiotic lidamycin. Here we report the complete genome sequence of S. globisporus C-1027, which consists of a 7,608,611 bp linear chromosome, a 167,754 bp linear plasmid SGLP1 and a 7,234 bp circular plasmid pSGL1. The biosynthetic gene cluster for lidamycin was located in the linear plasmid SGLP1. Genome analysis also revealed a number of genes related to biosynthesis of diverse secondary metabolites. The genome sequence of C-1027 will enable us to disclose biosynthetic pathways of these secondary metabolites and discover new natural products with potential applications notably in human health.

journal_name

J Biotechnol

journal_title

Journal of biotechnology

authors

Li X,Lei X,Zhang C,Jiang Z,Shi Y,Wang S,Wang L,Hong B

doi

10.1016/j.jbiotec.2016.02.004

subject

Has Abstract

pub_date

2016-03-20 00:00:00

pages

9-10

eissn

0168-1656

issn

1873-4863

pii

S0168-1656(16)30049-9

journal_volume

222

pub_type

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