Abstract:
:Streptomyces globisporus C-1027 produces a nine-membered enediyne antitumor antibiotic lidamycin. Here we report the complete genome sequence of S. globisporus C-1027, which consists of a 7,608,611 bp linear chromosome, a 167,754 bp linear plasmid SGLP1 and a 7,234 bp circular plasmid pSGL1. The biosynthetic gene cluster for lidamycin was located in the linear plasmid SGLP1. Genome analysis also revealed a number of genes related to biosynthesis of diverse secondary metabolites. The genome sequence of C-1027 will enable us to disclose biosynthetic pathways of these secondary metabolites and discover new natural products with potential applications notably in human health.
journal_name
J Biotechnoljournal_title
Journal of biotechnologyauthors
Li X,Lei X,Zhang C,Jiang Z,Shi Y,Wang S,Wang L,Hong Bdoi
10.1016/j.jbiotec.2016.02.004subject
Has Abstractpub_date
2016-03-20 00:00:00pages
9-10eissn
0168-1656issn
1873-4863pii
S0168-1656(16)30049-9journal_volume
222pub_type
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