Abstract:
BACKGROUND/AIM:The present study aimed to identify hypoxia-regulated microRNAs (HRMs) in vitro and investigate the clinical role of candidate HRMs in patients with gastroesophageal cancer (GEC). MATERIALS AND METHODS:microRNA expression changes induced by hypoxia in human GEC cell lines were measured with microarrays and validated by quantitative real-time polymerase chain reaction. Candidate HRMs were measured in pre-therapeutic tumor samples from 195 patients with GEC. RESULTS:Expression of miR-210 was shown to be significantly induced in esophageal squamous cell carcinoma (9.26-fold, p<0.001) and adenocarcinoma cell lines (4.95-fold, p<0.001) and miR-27a-star was significantly up-regulated in adenocarcinoma cell lines (4.79-fold, p=0.04). A weak but significant correlation between miR-210 expression and a 15-gene hypoxia signature was observed (Pearson r correlation: r=0.38, p<0.001). No significant associations of HRMs and clinical outcome in patients with GEC were identified. CONCLUSION:This study supports the involvement of hypoxia on miRNAs in vitro and confirms the role of miR-210 as being a universal HRM.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Winther M,Alsner J,Sørensen BS,Wittrup CF,Tramm T,Baeksgaard L,Hofland K,Holtved E,Nordsmark Msubject
Has Abstractpub_date
2016-02-01 00:00:00pages
721-30issue
2eissn
0250-7005issn
1791-7530pii
36/2/721journal_volume
36pub_type
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journal_title:Anticancer research
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doi:
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