Abstract：
:As an antibiotic that prevents and treats infections caused by Gram-positive bacteria such as Staphylococcus aureus, vancomycin incorporated in a biodegradable polymer poly(lactide-co-glycolide) provides opportunities to construct controlled-release drug delivery systems. Developments associated with this promising system have been largely concentrated on areas of drug delivery kinetics and biodegradability. In order to provide surface analytical approaches to this important system, the authors demonstrate applicability of time-of-flight secondary ion mass spectrometry (TOF-SIMS) in three-dimensional molecular imaging for a model system consisting of alternating layers of ploy(lactide-co-glycolide) and vancomycin. TOF-SIMS imaging clarified that the two chemicals can undergo phase separation when dimethyl sulfoxide is used as the solvent. The authors identified two diagnostic ions that are abundant and structural moieties of vancomycin. The results on TOF-SIMS imaging and depth profiling vancomycin provide useful information for further applications of TOF-SIMS in the development of antibiotic drug delivery systems involving the use of vancomycin.
journal_name
Biointerphasesjournal_title
Biointerphasesauthors
Du L,Yang X,Li W,Li H,Feng S,Zeng R,Yu B,Xiao L,Liu Y,Tu M,Nie HYdoi
10.1116/1.5016186subject
Has Abstractpub_date
2018-01-10 00:00:00pages
03B401issue
3eissn
1934-8630issn
1559-4106journal_volume
13pub_type
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