Abstract:
:Progress in finding a better alternative to alteplase has been slow. Tenecteplase and desmoteplase have better pharmacological profiles compared with alteplase, but definite clinical evidence of their superiority is lacking. The two major phase III studies that have tested the efficacy and safety of desmoteplase in ischemic stroke patients have shown neutral results and a promising safety profile, but the trials compared desmoteplase with placebo only in late admitted patients. Future trials should focus on testing novel thrombolytics in the early time window either as the sole acute recanalizing treatment or combined with thrombectomy.
journal_name
CNS Drugsjournal_title
CNS drugsauthors
Logallo N,Kvistad CE,Nacu A,Thomassen Ldoi
10.1007/s40263-015-0307-2subject
Has Abstractpub_date
2016-02-01 00:00:00pages
101-8issue
2eissn
1172-7047issn
1179-1934pii
10.1007/s40263-015-0307-2journal_volume
30pub_type
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