Abstract:
:An induced pluripotent stem cell (iPSC) line was generated from a 36-year-old patient with sporadic Parkinson's disease (PD). Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated cell line (CSC-43) exhibits expression of common pluripotency markers, in vitro differentiation into three germ layers and normal karyotype. This iPSC line can be used to study the mechanisms underlying the development of PD.
journal_name
Stem Cell Resjournal_title
Stem cell researchauthors
Marote A,Pomeshchik Y,Goldwurm S,Collin A,Lamas NJ,Pinto L,Salgado AJ,Roybon Ldoi
10.1016/j.scr.2018.01.007subject
Has Abstractpub_date
2018-03-01 00:00:00pages
82-85eissn
1873-5061issn
1876-7753pii
S1873-5061(18)30007-2journal_volume
27pub_type
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