Abstract:
:Although macromolecular crystallography is a widely supported technique at synchrotron radiation facilities throughout the world, there are, in comparison, only very few beamlines dedicated to small-molecule crystallography. This limited provision is despite the increasing demand for beamtime from the chemical crystallography community and the ever greater overlap between systems that can be classed as either small macromolecules or large small molecules. In this article, a very brief overview of beamlines that support small-molecule single-crystal diffraction techniques will be given along with a more detailed description of beamline I19, a dedicated facility for small-molecule crystallography at Diamond Light Source.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Barnett SA,Nowell H,Warren MR,Wilcox A,Allan DRdoi
10.2174/0929866523666160115131217subject
Has Abstractpub_date
2016-01-01 00:00:00pages
211-6issue
3eissn
0929-8665issn
1875-5305pii
PPL-EPUB-73086journal_volume
23pub_type
杂志文章abstract:BACKGROUND:Microbe-Binding Peptides (MBPs) are currently being investigated to address the problem of antimicrobial resistance. Strategies enhancing their antimicrobial activity have been developed, including peptide dimerization. Here, we present an alternative approach based on peptide polymerization, yielding hapten...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200427212940
更新日期:2020-01-01 00:00:00
abstract::Porcine β defensin 2(pBD2)is a cationic 37-amino acid antimicrobial peptide with disulfide bonds. Synthetic pBD2 had broad antimicrobial activity against pathogenic bacteria, and thus pBD2 could be a good candidate as a bactericidal agent for pigs. This study reported the successful recombinant expression of pBD2 in E...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866511320060010
更新日期:2013-06-01 00:00:00
abstract::Marine species are comprising about a half of the whole global biodiversity; the sea offers an enormous resource for novel bioactive compounds. Several of the marine origin species show multifunctional bioactivities and characteristics that are useful for a discovery and/or reinvention of biologically active compounds...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866523666160802160222
更新日期:2017-01-01 00:00:00
abstract::In the last few decades, novel drug delivery strategies have been a big priority to the formulation scientists. Peptides and proteins have drawn a special attention for their wide scope in the area. Serum albumin, transferrin, recom- binant proteins, virus capsids etc. are used as carrier for drug and biomolecules. Co...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866521666140804160907
更新日期:2014-01-01 00:00:00
abstract::A Surface Plasmon Resonance Imaging (SPRI) sensor has been developed for highly selective determination of cathepsin D (Cat D) or/and E (Cat E). The sensor contains immobilised pepstatin A, which binds aspartyl proteases from solution. Pepstatin A activated with N-Hydroxysuccinimide (NHS) and N-Ethyl-N'-(3-dimethylami...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610791760450
更新日期:2010-09-01 00:00:00
abstract::DrTI was effective against trypsin-like enzymes from A. kuehniella and C. cephalonica, however an artificial diet was insufficient to affect the survival and body weight of either insect. The inhibitor stimulated chymotrypsin-like enzymes and probably induced the synthesis of enzymes insensitive to TLCK in neonate lar...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986609789839395
更新日期:2009-01-01 00:00:00
abstract::The small heat shock protein SsHSP14.1 from the hyper-thermophilic archeaon, Sulfolobus solfataricus (S. solfataricus) was able to protect proteins from thermal aggregation and prevent enzymes from heat induced inactivation. According to the 3D (dimensional) structural model of SsHSP14.1 developed by us before, the re...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611794578369
更新日期:2011-03-01 00:00:00
abstract::Plants reproductive phase, when grain yield and consequently farmers' investment is most in jeopardy, is considered as the most sensitive stage to drought stress. In this study, we aimed to explore the proteomic response of wheat anther at meiosis stage in a drought tolerant, Darab, and susceptible, Shiraz, wheat geno...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866523666161130143446
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Unstructured regions in proteins can vary from several amino acid residues to a completely disordered sequence. Since such regions play an important role in the protein functioning, much attention is being paid to their prediction. Special different programs are available for this purpose; however, predictio...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866525666180621143957
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Cysteine S-sulfenylation is a major type of dynamic post-translational modification of the protein that plays an important role in regulating many biological processes in both of prokaryotic and eukaryotic species. To understand the function of S-sulfenylated proteins, identification of S-sulfenylation sites...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866525666180905110619
更新日期:2018-01-01 00:00:00
abstract::Norepinephrine-stimulated skin secretions from the Sante Fe frog Leptodactylus laticeps contained high concentrations of a peptide, termed laticeptin, with the primary structure Gly-Val-Val-Asp-Ile-Leu-Lys-Gly-Ala-Ala-Lys-Asp-Leu-Ala-Gly-His-Leu-Ala-Thr-Lys-Val-Met-Asn-Lys-Leu.NH(2). Laticeptin inhibited the growth of...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606775974410
更新日期:2006-01-01 00:00:00
abstract::Galanin is a neuropeptide that is widely distributed in the central and peripheral nervous systems. Some small cell lung carcinoma (SCLC) cell lines such as SBC-3A release only the high-molecular-mass form, with lower molecular mass forms being undetectable. To investigate the mechanism of processing of progalanin to ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611796378693
更新日期:2011-10-01 00:00:00
abstract::Self-Interacting Proteins (SIPs), whose two or more copies can interact with each other, have significant roles in cellular functions and evolution of Protein Interaction Networks (PINs). Knowing whether a protein can act on itself is important to understand its functions. Previous studies on SIPs have focused on thei...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866527666191227141713
更新日期:2020-01-01 00:00:00
abstract::A series of 30 tripeptides were synthesized and tested as novel 5-HT4 receptor ligands. Receptor binding assays showed that a subset of compounds had reasonable potency relative to the agonists serotonin and 5-methoxytryptamine. Structure-activity analyses and molecular docking have highlighted avenues for further syn...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986609788681805
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:It is currently believed that protein folding rates are influenced by protein structure, environment and temperature, amino acid sequence and so on. We have been working for long to determine whether and in what ways mRNA affects the protein folding rate. A large number of palindromes aroused our attention i...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666191014144015
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:NMAAP1 plays a role in regulating macrophage differentiation to the M1 type and exerting antitumoral functions. It is not clear what role and mechanism NMAAP1 does play in the reversal of macrophages from M1 to M2. METHODS:We detected the typing of macrophages with high or low expression of NMAAP1 by QPCR a...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190503105343
更新日期:2019-01-01 00:00:00
abstract::Cinnamomin is a type II ribosome-inactivating protein (RIP) and its A-chain (CTA) is a RNA N-glycosidase. It is observed that modification of tyrosine residues by N-acetylimidazole (N-AI) causes almost complete loss of CTA activity. Adenine partially protects tyrosine residues from modification by N-AI. It is proposed...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866033478771
更新日期:2003-10-01 00:00:00
abstract::The description of protein backbone was recently improved with a group of structural fragments called Structural Alphabets instead of the regular three states (Helix, Sheet and Coil) secondary structure description. Protein Blocks is one of the Structural Alphabets used to describe each and every region of protein bac...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866511320030003
更新日期:2013-03-01 00:00:00
abstract::There is a growing body of evidence that the formation and accumulation of advanced glycation end products (AGE) have been known to progress under diabetic conditions, thereby being involved in diabetic vascular complications. Further, we, along with others, have recently found AGE could disturb insulin actions in cul...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610791760423
更新日期:2010-09-01 00:00:00
abstract::A thermostable uricase identified in Bacillus firmus DWD-33, which was isolated for the first time from soil, with an apparent molecular weight of 33.5 kDa was stable against oxidants and SDS. The highest expression yields were obtained in medium containing 0.8% maltose and 1.2% soybean powder as carbon and nitrogen s...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986652205150509213536
更新日期:2015-01-01 00:00:00
abstract::With a huge amount of protein sequence data, the computational method for protein-protein interaction (PPI) prediction using only the protein sequences information have drawn increasing interest. In this article, we propose a sequence-based method based on a novel representation of local protein sequence descriptors. ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610791760306
更新日期:2010-09-01 00:00:00
abstract::Hop is a tetratricopeptide repeat domain (TPR)-containing co-chaperone that is able to directly associate with both Hsp70 and Hsp90. Previous data showed that the TPR2A-domain is the primary site for dimerization and that the TPR2B-domain may also play a role in dimerization. We present Hop-D456G, a mutant within the ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610790963708
更新日期:2010-04-01 00:00:00
abstract::The stability of Merrifield linker in Fmoc deprotection process was quantitatively investigated by establishing working curve of two major decomposition components from two resin bound dipeptide models. By sampling reaction solution and analyzing with RP-HPLC, decomposition rate was determined. The results indicated t...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986613804725343
更新日期:2013-02-01 00:00:00
abstract::In 2008 cancer was identified by the World Health Organization (WHO) as one of four threats to human health and development. Since the early published reports of the first chemotherapeutic, mustine, in 1946, the anti-cancer drug and development industry has grown into a multi-billion dollar business enterprise. Worldw...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866521666140626102802
更新日期:2014-01-01 00:00:00
abstract::Numerous small molecules including cytokines primarily associated with immune response have been shown to play a role in normal mesenchymal stem cells (MSC) and tumour cells' communication. One characteristic that distinguishes MSC from fibroblast and other cells of mesenchymal origin is their pro-tumour migratory beh...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866522666150131123808
更新日期:2015-01-01 00:00:00
abstract::Michael Laskowski Jr. (1930-2004) was a pioneer in the field of Standard mechanism serine proteinase inhibitors. He made numerous important contributions in the field. This article highlights some of his most important contributions such as the discovery of the reactive site in serine proteinase inhibitors, the propos...
journal_title:Protein and peptide letters
pub_type: 传,历史文章,杂志文章
doi:10.2174/0929866054395347
更新日期:2005-07-01 00:00:00
abstract::Adenoregulin is a 33 amino acid antibiotic peptide who belongs to dermaseptin family which is the first vertebrate family to show lethal effects against filamentous fungi, as well as a broad spectrum of pathogenic microorganisms. Synthetic adenoregulin gene was cloned in 2, 4 and 6 tandem repeats and subcloned in pET3...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866053765671
更新日期:2005-05-01 00:00:00
abstract::Protein palmitoylation is an important and common post-translational lipid modification of proteins and plays a critical role in various cellular processes. Identification of Palmitoylation sites is fundamental to decipher the mechanisms of these biological processes. However, experimental determination of palmitoylat...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611794475084
更新日期:2011-02-01 00:00:00
abstract::Zwitterionic dipeptides have recently been shown to exist in water mainly as nine conformational forms with specific combinations of backbone Psi, omega and Phi torsions, which allows conformer-specific molecular recognition of peptide ligands by proteins. Here, we show that pairs of virtual backbone torsions can also...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866023408904
更新日期:2002-04-01 00:00:00
abstract::Polymyositis is an inflammatory myopathy characterized by muscle invasion of T-cells penetrating the basal lamina and displacing the plasma membrane of normal muscle fibers. In order to understand the different adhesive mechanisms at the T-cell surface, Schubert randomly selected 19 proteins expressed at the T-cell su...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986612801619534
更新日期:2012-08-01 00:00:00