Genotyping of clinical and environmental Aspergillus flavus isolates from Iran using microsatellites.

Abstract:

:Aspergillus flavus is the second most important Aspergillus species causing human infections in tropical countries. Despite an increasing number of infections of A. flavus in Iran, the molecular epidemiology of clinical and environmental strains has not been well studied. We used a panel of nine microsatellite markers to analyse the genetic relatedness of A. flavus. Microsatellite typing of 143 (n = 119 clinical and n = 24 environmental) isolates demonstrated 118 different genotypes. A possible outbreak at a pulmonary ward was discovered. The discriminatory power for the individual markers ranged from 0.4812 to 0.9457 and the panel of all nine markers combined yielded a diversity index of 0.9948. This high-resolution typing method assists in better understanding of the molecular epidemiology of A. flavus.

journal_name

Mycoses

journal_title

Mycoses

authors

Khodavaisy S,Badali H,Rezaie S,Nabili M,Moghadam KG,Afhami S,Hagen F,Aala F,Hashemi SJ,Meis JF

doi

10.1111/myc.12451

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

220-225

issue

4

eissn

0933-7407

issn

1439-0507

journal_volume

59

pub_type

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