Nitric oxide mediated effects of nebivolol in myocardial infarction: the source of nitric oxide.

Abstract:

OBJECTIVE:After MI pathological LV remodeling is one of the major causes of death. We previously showed the NO mediated beneficial effects of nebivolol in rat MI model, in this study we aimed to evaluate the NOS related mechanisms in this phenomenon. MATERIALS AND METHODS:Rats were divided into four groups: sham operated (sham-control), MI-induced (MI-control), immediate nebivolol loaded (MI-neb1), orally nebivolol treated (MI-neb2). MI was induced by the ligation of the LAD. Loading dose of nebivolol (0.1 mg/kg) was administrated i.v. during reperfusion and continuation dose was administrated orally (2 mg/kg) by gastric gavages once daily. NOS related mechanisms were assessed either in acute (2nd day) and sub-acute (28th day) period of MI by histologic, hemodynamic and biologic studies. RESULTS:Compared to MI-control rats, physiological functions of LV (LVEDP, Δ±dp/dt) were prevented in both nebivolol treated groups. Improvements in anatomical parameters (LEV, HW, LVW/HW) were consistent with functional improvement too. Moreover, oxidative (characterized by decreased MDA and increased SOD levels) and nitrosative (characterized by decreased ONOO- levels) damage were limited in these groups. Compared to MI-control rats, most marked change was seen in the nNOS labelling in the nebivolol treated groups. The decrease in iNOS labelling was also prominent in these groups too. CONCLUSIONS:NOS mediated mechanisms of nebivolol can be summarized as: 1) diminishing iNOS expression together with restoration of MI induced eNOS activation both in vascular bed and myocytes at the acute period of MI, and 2) prevention of deterioration in nNOS expression in myocardial cells at the sub-acute period of MI.

authors

Mercanoglu G,Safran N,Ahishali B B,Uzun H,Yalcin A,Mercanoglu F

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

4872-89

issue

24

eissn

1128-3602

issn

2284-0729

journal_volume

19

pub_type

杂志文章
  • Migraine: diagnosis and pharmacologic treatment in emergency department.

    abstract::Acute headache is a common chief complaint in the Emergency Department (ED), accounting for up to 4% of all ED visits. Migraine is a common, chronic, at times incapacitating disorder, characterized by attacks of severe headache, autonomic nervous system dysfunction, and in some patients, an aura characterized by vario...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Bounes V,Edlow JA

    更新日期:2011-02-01 00:00:00

  • Expression level of lncRNA PVT1 in serum of patients with coronary atherosclerosis disease and its clinical significance.

    abstract:OBJECTIVE:The purpose of this study was to detect the expression level of PVT1 in the serum of coronary artery disease (CAD) patients, and to explore the clinical significance of PVT1 in CAD. PATIENTS AND METHODS:A total of 200 CAD patients and 200 healthy controls in the same period were included. The serum level of ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202006_21531

    authors: Quan W,Hu PF,Zhao X,Lianhua CG,Batu BR

    更新日期:2020-06-01 00:00:00

  • Role of three commonly used scoring systems in prediction of pulmonary thromboembolism in Xining area.

    abstract:OBJECTIVE:To analyze the clinical values of three commonly used scoring systems including Wells score, revised Geneva score and Pisa score in predicting pulmonary thromboembolism (PTE) in Xining area. PATIENTS AND METHODS:A total of 67 patients who had received CT pulmonary angiography (CTPA) in Qinghai Provincial Peo...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Gu YH,Zhao Z

    更新日期:2014-11-01 00:00:00

  • Diagnostic value of miRNA-122 in Kawasaki disease.

    abstract:OBJECTIVE:To explore the expression pattern and diagnostic value of microRNA-122 (miRNA-122) in childhood Kawasaki disease (KD). PATIENTS AND METHODS:A total of 150 children with KD were included in the KD group. During the same period, 150 children with respiratory infection complicated with fever and without myocard...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202011_23610

    authors: Lv HF,Sun XQ,Zhou HX,Qin Z,Shi YY,Wang Q,Li F

    更新日期:2020-11-01 00:00:00

  • Correlation between microRNA-766 expression in patients with advanced gastric cancer and the efficacy of platinum-containing chemotherapy.

    abstract:OBJECTIVE:We aimed at observing the correlation between microRNA-766 expression and the efficacy of platinum-containing chemotherapy in patients with stage IV gastric cancer (GCa). PATIENTS AND METHODS:Tissue specimens were obtained from 100 patients with stage IV GCa who received platinum-based chemotherapy, and micr...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202009_22821

    authors: Xue YF,Xue D,Yao B,Hu CG,Liu J

    更新日期:2020-09-01 00:00:00

  • Alterations of the vaginal microbiota in the third trimester of pregnancy and pPROM.

    abstract:OBJECTIVE:Preterm premature rupture of membranes (pPROM) is a significant issue in obstetric practice. One of the risk factors for pPROM are vaginal infections in the third trimester of pregnancy. PATIENTS AND METHODS:We performed an observational study on 600 pregnant women, analyzing the lactobacillary grade (LBG) a...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Genovese C,Corsello S,Nicolosi D,Aidala V,Falcidia E,Tempera G

    更新日期:2016-08-01 00:00:00

  • β4GalT1 promotes inflammation in human osteoarthritic fibroblast-like synoviocytes by enhancing autocrine TNF-α activity.

    abstract:OBJECTIVE:Synovial inflammation plays an important role in the pathogenesis of osteoarthritis (OA), and β4GalT1 has been reported to be involved in the inflammatory process. The aim of our study was to investigate the role of β4GalT1 in the progression of inflammation and analyze the association between β4GalT1 and tum...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201906_18028

    authors: Xu DW,Zhu XH,He MQ,Yuan Q,Dong QR

    更新日期:2019-06-01 00:00:00

  • GACAT3 promoted proliferation of osteoarthritis synoviocytes by IL-6/STAT3 signaling pathway.

    abstract:OBJECTIVE:Osteoarthritis (OA) is one of the most common chronic joint diseases, caused by lesions in articular cartilage and synovial membranes. Synovitis is a major characteristic of OA, due to the proliferation of synoviocytes. Long noncoding RNAs (lncRNAs) have implicated to play an important role in many different ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201808_15705

    authors: Li X,Ren W,Xiao ZY,Wu LF,Wang H,Guo PY

    更新日期:2018-08-01 00:00:00

  • Human parvovirus B 19 and Epstein-Barr virus co-infection in a child with hereditary spherocytosis.

    abstract:BACKGROUND:In patients with chronic congenital haemolytic disorders, human Parvovirus B19 (HPV B19) is frequently involved in pure red-cell aplastic crises. Furthermore, it may inhibit three-lineage haematopoiesis in the bone marrow, causing severe pancytopenia. In such patients, Epstein Barr virus (EBV) infection also...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Cefalo MG,Arlotta A,Maurizi P,Russo I,Sani I,Battista A,Mastrangelo S,Ruggiero A,Riccardi R

    更新日期:2012-02-01 00:00:00

  • Long non-coding RNA 00152 promotes cell proliferation in cervical cancer via regulating miR-216b-5p/HOXA1 axis.

    abstract:OBJECTIVE:Several studies demonstrated that aberrant lncRNA expression contributes to cervical cancer (CC) development and progression. LINC00152, a novel lncRNA, has been identified as an oncogene involved in various cancers. In the present study, we aim to investigate the expression pattern, clinical significance, po...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201905_17789

    authors: Zheng JJ,Du XJ,Wang HP,Zhou LY,Wang YJ,Zhang L,Xu H,Zhang J,Hu ZF

    更新日期:2019-05-01 00:00:00

  • Autonomic impairment in patients with migraine.

    abstract:OBJECTIVE:Heart rate variability analysis of electrocardiogram is becoming an increasingly common method to non-invasively evaluate autonomic nervous function. The aim of the study was to investigate cardiac autonomic function in subjects with and without migraine by using 24-hour ambulatory electrocardiographic record...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Matei D,Constantinescu V,Corciova C,Ignat B,Matei R,Popescu CD

    更新日期:2015-10-01 00:00:00

  • The potential role of trans-resveratrol/carboxymethylated (1.3/1.6)-β-d-glucan minimizing symptoms and improve healing after functional endoscopic sinus surgery.

    abstract:OBJECTIVE:This study aims to evaluate the effect of trans-resveratrol/carboxymethylated (1.3/1.6)-β-d-glucan administered via nasal, after FESS, assessing nasal respiratory distress and nasal mucosa healing. PATIENTS AND METHODS:We enrolled 70 patients, from March 2019 to February 2020, with chronic nasal obstruction ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202012_24034

    authors: Frari V,Capuano F,Micera A,Greco F,Salvinelli F

    更新日期:2020-12-01 00:00:00

  • Long non-coding RNA OR3A4 facilitates cell proliferation and migration in colorectal cancer through the Wnt/β-catenin signaling pathway.

    abstract:OBJECTIVE:Colorectal cancer (CRC) remains one of the most ordinary cancers worldwide. Recently, researches have suggested the important role of long noncoding RNAs (lncRNAs) in the progression of tumorigenesis. This study aims to identify how lncRNA OR3A4 functions in the development of CRC. PATIENTS AND METHODS:OR3A4...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202005_21319

    authors: Sun W,Chen GR,Wang J,Yu XY,Hao XF,Hu MY

    更新日期:2020-05-01 00:00:00

  • Circular RNA circ_0079593 promotes glioma development through regulating KPNA2 expression by sponging miR-499a-5p.

    abstract:OBJECTIVE:Glioma is a common aggressive cancer and a major public health problem worldwide, with high incidence, recurrence, and mortality. Circular RNA (circRNA) has been reported to be involved in glioma, but the role of circ_0079593 in glioma is still unclear. MATERIALS AND METHODS:The real-time quantitative polyme...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202001_20186

    authors: Yang Z,Li C,Fan XY,Liu LJ

    更新日期:2020-01-01 00:00:00

  • Prognostic and diagnostic significance of long non-coding RNA AGAP2-AS1 levels in patients with non-small cell lung cancer.

    abstract:OBJECTIVE:The purpose of this study was to explore whether long non-coding RNA AGAP2-AS1 (AGAP2-AS1) could serve as a novel biomarker for non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS:Cancer and matched normal lung tissues were collected from 198 patients. AGAP2-AS1 levels were examined by RT-PCR, and the a...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Fan KJ,Liu Y,Yang B,Tian XD,Li CR,Wang B

    更新日期:2017-05-01 00:00:00

  • Butorphanol protects on myocardial ischemia/reperfusion injury in rats through MAPK signaling pathway.

    abstract:OBJECTIVE:To explore the influence of butorphanol on myocardial ischemia/reperfusion (I/R) injury in rats through the mitogen-activated protein kinase (MAPK) signaling pathway. MATERIALS AND METHODS:The I/R model in Sprague-Dawley rats was established. The rats were randomly divided into normal group (n=20), myocardia...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201912_19695

    authors: Wang H,Wang JL,Ren HW,He WF,Sun M

    更新日期:2019-12-01 00:00:00

  • Chemotherapy for locally advanced and metastatic gastric cancer: state of the art and future perspectives.

    abstract::Despite a decline in the incidence in Western countries, gastric cancer is still the second most common cause of cancer-related death worldwide. Many advances have been made in diagnosis and treatment of gastric cancer in the last decades but the prognosis for gastric cancer patients remains disappointing, especially ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Bittoni A,Maccaroni E,Scartozzi M,Berardi R,Cascinu S

    更新日期:2010-04-01 00:00:00

  • Relationship between deficiency of vitamin D and exponents of metabolic syndrome.

    abstract:OBJECTIVE:Widespread hypovitaminosis D and an increased incidence of metabolic syndrome (MetS) represent significant problems of contemporary medicine but link between them remain unresolved. We aimed to define relationship between vitamin D serum concentration and exponents of MetS. PATIENTS AND METHODS:The studies w...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Kramkowska M,Grzelak T,Walczak M,Bogdanski P,Pupek-Musialik D,Czyzewska K

    更新日期:2015-06-01 00:00:00

  • MiR-203 regulates DJ-1 expression and affects proliferation, apoptosis and DDP resistance of pancreatic cancer cells.

    abstract:OBJECTIVE:DJ-1 is a negative regulator of PTEN and plays a role in tumorigenesis. Abnormal miR-203 expression is associated with pancreatic cancer. Bioinformatics analysis showed a targeted relationship between miR-203 and DJ-1 3'-UTR. This study investigated whether miR-203 regulates DJ-1 expression and its role in pa...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201910_19278

    authors: Du SL,Xu LY,Gao P,Liu QS,Lu FF,Mo ZH,Fan ZZ,Cheng XL,Dong ZH

    更新日期:2019-10-01 00:00:00

  • Circ-0003998 promotes cell proliferative ability and invasiveness by binding to miR-197-3p in osteosarcoma.

    abstract:OBJECTIVE:The aim of this study was to investigate the level of circ-0003998 in osteosarcoma tissues and cell lines, and to analyze its relation with prognosis of patients, as well as its effect on biological behaviors of osteosarcoma cells. In addition, the potential mechanism of circ-0003998 in promoting osteosarcoma...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201912_19761

    authors: Wang L,Du ZG,Huang H,Li FS,Li GS,Xu SN

    更新日期:2019-12-01 00:00:00

  • The effect of miR-224 down-regulation on SW80 cell proliferation and apoptosis and weakening of ADM drug resistance.

    abstract::Since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, "The effect of miR-224 down-regulation on SW80 cell proliferation and apoptosis and weakening of ADM drug resistance, by C.-Q. Liang, Y.-M. Fu, Z.-Y. Liu, ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202007_22247

    authors: Liang CQ,Fu YM,Liu ZY,Xing BR,Jin Y,Huang JL

    更新日期:2020-07-01 00:00:00

  • MiR-638 inhibits cervical cancer metastasis through Wnt/β-catenin signaling pathway and correlates with prognosis of cervical cancer patients.

    abstract:OBJECTIVE:MiR‑638 has been demonstrated to be correlated with several tumor progressions. However, the exact role of miRNA-638 in cervical cancer (CC) has not been investigated. The aim of present study was to explore the prognostic value of miR-638 in patients with CC and analyze molecular mechanisms of miR-638 in CC ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201712_13999

    authors: Wei H,Zhang JJ,Tang QL

    更新日期:2017-12-01 00:00:00

  • Putative role of Brugada syndrome genes in familial atrial fibrillation.

    abstract:OBJECTIVE:Familial atrial fibrillation (FAF), a not uncommon arrhythmia of the atrium, is characterized by heritability, early onset and absence of other heart defects. The molecular and genetic basis is still not completely clear and genetic diagnosis cannot be achieved in about 90% of patients. In this study, we pres...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201909_18880

    authors: Maltese PE,Aldanova E,Kriuchkova N,Averianov A,Manara E,Paolacci S,Bruson A,Miotto R,Sartori M,Guerri G,Zuntini M,Marceddu G,Tezzele S,Tadtaeva K,Chernova A,Aksyutina N,Nikulina S,Nodari S,Bertelli M

    更新日期:2019-09-01 00:00:00

  • On a case of "Macrodystrophia lipomatosa".

    abstract::Macrodistrophia Lipomatosa is a congenital malformation of rare finding and unknown pathogenic mechanism. The pathology is mainly characterized by the interest of lower extremities and peculiar macroscopic feature is the presence of hyperthrophic fibro-adipose tissue. In our experience the localization to the upper ex...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Di Ianni F,Di Ianni G,Isidoro C,Migliorato L,Piersante S

    更新日期:1997-09-01 00:00:00

  • Liver resections for hilar cholangiocarcinoma.

    abstract::Hilar cholangiocarcinoma (HC) is a rare tumor which has to be distinguished by intrahepatic cholagiocarcinoma invading hepatic hilum because the former has better prognosis then the latter. Patients with HC are difficult to manage because many challenging issues remain in the treatment of this tumour regarding correct...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Giuliante F,Ardito F,Vellone M,Nuzzo G

    更新日期:2010-04-01 00:00:00

  • miR-497 promotes the progression of cutaneous squamous cell carcinoma through FAM114A2.

    abstract:OBJECTIVE:To explore the possible role and mechanism of miR-497 in cutaneous squamous cell carcinoma. PATIENTS AND METHODS:Quantitative Real-time polymerase chain reaction (qRT-PCR) was used to detect miR-497 and FAM114A2 expression level in 38 cases of cutaneous squamous cell carcinoma (CSCC) and 22 normal skin tissu...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201811_16272

    authors: Wei XH,Gu XL,Zhou XT,Ma M,Lou CX

    更新日期:2018-11-01 00:00:00

  • Circular RNA circDENND4C facilitates proliferation, migration and glycolysis of colorectal cancer cells through miR-760/GLUT1 axis.

    abstract:OBJECTIVE:Colorectal cancer is a common malignant tumor of the digestive tract, and its incidence is closely related to lifestyle inheritance and colorectal adenoma. Circular RNA (circRNA) has been proved to participate in the progression of colorectal cancer cells. Our study aimed to investigate the function and the u...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202003_20506

    authors: Zhang ZJ,Zhang YH,Qin XJ,Wang YX,Fu J

    更新日期:2020-03-01 00:00:00

  • The role of PTEN up-regulation in suppressing glomerular mesangial cells proliferation and nephritis pathogenesis.

    abstract:OBJECTIVE:Over-proliferation of mesangial cells is the major pathological change of mesangial proliferative glomerulonephritis (MPGN). PTEN-PI3K/AKT pathway plays a role in regulating proliferation of mesangial cells. Anti-thymocyte serum nephritis (ATSN) is a widely used animal model for studying MPGN. This study esta...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Gao HY,Han CX

    更新日期:2017-08-01 00:00:00

  • MiR-140-5p targets BCL2L1 to promote cardiomyocyte apoptosis.

    abstract::The article "MiR-140-5p targets BCL2L1 to promote cardiomyocyte apoptosis, by M.-Y. Sun, L.-P. Li, published in Eur Rev Med Pharmacol Sci 2020; 24 (11): 6311-6322-DOI: 10.26355/eurrev_202006_21529-PMID: 32572928" has been withdrawn from the authors. They stated that "they are still working on this study" and that "the...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202101_24298

    authors: Sun MY,Li LP

    更新日期:2021-01-01 00:00:00

  • Risk factors for mortality in severe multiply injury patients with acute hypoxemic respiratory failure.

    abstract:OBJECTIVE:To investigate the risk factors related to mortality in severe polytrauma patients with acute hypoxemic respiratory failure (AHRF). PATIENTS AND METHODS:From December 2011 to December 2014, we identified and intubated 524 traumatic AHRF patients in a level 1 trauma centers. Amongst those, we enrolled seventy...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Chen YD,Feng XL,Deng L,Zhou P,Wang JD,Cai B,Jiang H,Dong Y,Zhang XH

    更新日期:2015-10-01 00:00:00