Abstract:
:The tumour subtype, TNM classification, and histopathological data are sometimes not sufficient for understanding and assessing the behaviour of oral cancers. In an attempt to find additional markers of tumour biology and behaviour, this study sought to determine the incidence and consequently the relevance of c-erb-B2, c-Myc, and H-ras gene alterations in tumour-free margins of oral squamous cell carcinoma (OSCC). Fifty samples of OSCC were analyzed for c-erb-B2 and c-Myc amplification by real-time polymerase chain reaction and for H-ras point mutations by sequencing. A relatively high incidence of genetic lesions was detected: 22% of cases had c-erb-B2 and 30% had c-Myc amplification, whilst only 12% harboured H-ras mutations. Kaplan-Meier analysis and the log-rank test showed statistically significant differences in 5-year survival rates and relapse between patients with tumour margins positive for c-erb-B2 amplification and those with margins that were negative (P=0.002). H-ras and c-Myc alterations could not be associated with tumour behaviour. Molecular analysis of margins, targeting cancer genes, could identify additional, independent predictors of risk and outcome in OSCC.
journal_name
Int J Oral Maxillofac Surgjournal_title
International journal of oral and maxillofacial surgeryauthors
Jelovac DB,Tepavčević Z,Nikolić N,Ilić B,Eljabo N,Popović B,Čarkić J,Konstantinović V,Vukadinović M,Miličić B,Milašin Jdoi
10.1016/j.ijom.2015.11.014subject
Has Abstractpub_date
2016-06-01 00:00:00pages
700-5issue
6eissn
0901-5027issn
1399-0020pii
S0901-5027(15)01427-7journal_volume
45pub_type
杂志文章abstract::The development of three-dimensional (3D) cephalometric analysis is essential for the computer-assisted planning of orthognathic surgery. The aim of this study was to transform and adapt Delaire's two-dimensional cephalometric analysis into the third dimension; this transposition was then validated. The comparative ad...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2007.05.022
更新日期:2007-09-01 00:00:00
abstract::The maxilla may be affected by squamous cell carcinoma (SCC) from both oral and sinus sites. We sought to determine whether the site of origin of the maxillary tumour, oral as compared to sinus, influences survival. Univariate Kaplan-Meier and multivariate Cox proportional hazard models analysis of 58 patients with SC...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2013.09.008
更新日期:2014-02-01 00:00:00
abstract::Microvascular free tissue transfer is a routine procedure with high predictability and a low complication rate. However, compromised flap perfusion remains a challenge and there is no consensus regarding the appropriate flap salvage protocol. The purpose of this study was to identify techniques with implications for f...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章,评审
doi:10.1016/j.ijom.2016.06.020
更新日期:2016-11-01 00:00:00
abstract::The aim of this study was to compare the satisfaction of skeletal class III patients following treatment with three different methods of orthognathic surgery. Eighty-two patients were divided into three groups according to the surgical procedure performed to correct their class III dentofacial deformity, and answered ...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2014.09.015
更新日期:2015-02-01 00:00:00
abstract::A postal survey of the views of 100 international experts in temporomandibular joint surgery was performed. Generally, there was a considerable degree of consensus on definitions, diagnosis, and broad treatment principles. However, specific surgical techniques for particular stages of internal derangement and osteoart...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/s0901-5027(05)80804-5
更新日期:1993-04-01 00:00:00
abstract::The use of ultrasound to cut bone in oral and craniofacial surgery has increased. There is concern that the application of ultrasound to the craniofacial skeleton might represent a potential hazard to the inner ear because of sound transmission by bone conduction resulting in hearing trauma. Conventional and ultrasoun...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2015.03.004
更新日期:2015-11-01 00:00:00
abstract::A new therapy for the treatment of oral leukoplakia by 5-aminolevulinic acid (ALA) and photodynamic therapy (PDT) is presented. ALA, a precursor in the biosynthesis of haeme, induces the production of the endogenous photosensitizer protoporphyrin IX which can be used for PDT. Twelve patients, who had been suffering fr...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 临床试验,杂志文章
doi:10.1016/s0901-5027(98)80040-4
更新日期:1998-12-01 00:00:00
abstract::The oral function of 81 consecutive patients with intraoral squamous cell carcinoma was assessed at diagnosis and during the follow-up 1-2 years after diagnosis. Patients received either radiotherapy, surgery, or radiotherapy and surgery. Speech function and tongue mobility were better among patients who received radi...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/s0901-5027(05)80352-2
更新日期:1993-02-01 00:00:00
abstract::This retrospective study evaluated the presence, location, and diameter of the mandibular lingual canals in a Taiwanese population using cone beam computed tomography (CBCT), to help improve the safety of mandibular surgical procedures. A total of 101 patients (46 men and 55 women), with a mean age of 55 years, were e...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2015.03.014
更新日期:2015-09-01 00:00:00
abstract::A case is described of a patient with progressive HA who presented because of left TMJ pain, jaw locking and ipsilateral masticatory muscle spasm. Several reports exist in the literature of masticatory muscle spasm associated with HA. A diagnosis of TMJPDS was made and an occlusal splint was provided which produced re...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/s0901-5027(88)80044-4
更新日期:1988-08-01 00:00:00
abstract::A case of intraductal carcinoma arising from a minor salivary gland of the tongue is reported. The relevant literature is discussed. ...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章,评审
doi:10.1016/s0901-5027(05)80011-6
更新日期:1991-06-01 00:00:00
abstract::Two examples are presented of osteotomies performed simultaneously with surgical recontouring in cases of fibrous dysplasia of the jaws. Osteotomies are necessary when a coexistent discrepancy in jaw relationship is present. This provides a functional as well as aesthetic result. Rigid miniplate fixation was utilised,...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/s0901-5027(05)80264-4
更新日期:1991-12-01 00:00:00
abstract::The transverse inclination, height and width of 20 lingually placed hydroxylapatite (HA) implants, to augment the atrophic mandibular ridge, were examined using computed tomography of cross sections through the first molar region. Favourable prosthetic conditions are achieved if the HA-implants are placed in a lingual...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/s0901-5027(05)80154-7
更新日期:1991-10-01 00:00:00
abstract::This study aimed to determine the effect of the co-administration of dexamethasone 8mg and nimesulide 100mg given 1h before mandibular third molar surgery. A prospective, randomized, triple-blind, split-mouth clinical trial was developed at the study institution in Pernambuco, Brazil. A pilot study was first performed...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijom.2016.10.011
更新日期:2017-02-01 00:00:00
abstract::A retrospective study of 64 patients with orofacial dysaesthesia is presented. Special emphasis is placed on the patients' symptoms and on the manipulative treatments they received before they were referred for psychiatric consultation. The patients had suffered from chronic orofacial pain or feelings of discomfort fo...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/s0901-5027(87)80074-7
更新日期:1987-08-01 00:00:00
abstract::This study investigated the development of temporomandibular joint (TMJ) ankylosis after condylar fracture and the functional results of surgery that included repositioning of the articular discs. In a total of 18 patients, there were 13 cases of fibrous ankylosis (type I) and 11 of partial bony ankylosis (type II). C...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2006.09.003
更新日期:2006-12-01 00:00:00
abstract::Seventeen patients, who presented mandibular fractures following third molar removal, were treated in the Department of Oral and Maxillofacial Surgery at the University Hospital Freiburg between 2000 and 2004. Clinical and radiological data were analysed to evaluate the possible risk of fracture following third molar ...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2005.03.003
更新日期:2005-10-01 00:00:00
abstract::The objective of this study is to retrospectively assess the clinical relevance, i.c. the event of a local recurrence, in patients surgically treated for tongue and floor of mouth squamous cell carcinoma when tumour cell are observed histopathologically at a distance of less than 0.5 cm. Furthermore, the pattern of in...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1054/ijom.2002.0469
更新日期:2004-03-01 00:00:00
abstract::The selection of the superficial or deep drainage system for use with the radial forearm free flap (RFFF) remains controversial. The aim of this study was to identify the optimal drainage system for single venous anastomosis. A systematic review and cumulative meta-analysis was performed to assess superficial and deep...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2020.11.007
更新日期:2020-12-05 00:00:00
abstract::In magnetic resonance imaging (MRI) of the oral and maxillofacial region, where large amounts of fat are normally present, the high signal intensity of fat on T1-weighted images (T1WI) and the chemical-shift artifact have limited the utility of paramagnetic contrast agents. Eliminating fat signal by fat-suppression te...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/s0901-5027(96)80084-1
更新日期:1996-12-01 00:00:00
abstract::A case of osteomyelitis in a 71-year-old woman with paroxysmal nocturnal hemoglobinuria (PNH) is reported. Osteomyelitis of the jaw is a well known condition of the oral and maxillofacial region that may cause severe morbidity. It is well documented that vaso-occlusive crises in sickle cell anaemia, a hemolytic blood ...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2011.06.016
更新日期:2011-12-01 00:00:00
abstract::The purpose of this study was to examine the changes in lip pressure before and after orthognathic surgery for skeletal class III patients. The subject groups were 32 female and 31 male patients diagnosed with mandibular prognathism and/or maxillary retrognathism who underwent orthognathic surgery. Control groups cons...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2012.02.007
更新日期:2012-07-01 00:00:00
abstract::The knotting of an intragastric tube is a rare complication, and knotting of a feeding jejunostomy tube is rarer, and the removal or replacement of the tube is difficult. There are many reports on the removal of intragastric knotted tubes, but these methods cannot be applied for the removal of knotted feeding jejunost...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2010.04.043
更新日期:2010-09-01 00:00:00
abstract::A case of complete median cleft of the lower lip and mandible and bifid tongue with ankyloglossia is presented. Unlike other reported cases of similar disorders, no other abnormalities were present. A satisfactory result was achieved with early surgical correction of both hard- and soft-tissue defects. ...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/s0901-5027(06)80054-8
更新日期:1996-08-01 00:00:00
abstract::The results of endoscope-assisted parotid surgery are presented as a minimally invasive alternative to parotidectomy for large parotid stones. From 1999 to 2007, 70 patients with parotid sialoliths were treated by minimally invasive surgical techniques in three specialist centres. At surgery a combination of sialoendo...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.ijom.2009.06.030
更新日期:2010-01-01 00:00:00
abstract::Arthroscopy of the temporomandibular joint (TMJ) has become a clinically important and increasingly accepted method for diagnosis and treatment of TMJ alteration. This minimally invasive method is clearly limited by the anatomic dimensions of the TMJ. The 308-nm excimer laser has already found clinical applications in...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/s0901-5027(05)80037-2
更新日期:1994-12-01 00:00:00
abstract::The effect of platelet-rich fibrin (PRF) in enhancing the healing after oral surgical interventions is still a matter of debate. The purpose of this study was to identify instances where PRF has been shown to be effective in oral surgical procedures. A comprehensive literature search was performed up to 2017 on PubMed...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章,meta分析
doi:10.1016/j.ijom.2018.07.007
更新日期:2019-03-01 00:00:00
abstract::The aim of this systematic review was to investigate the influence of the presence and position of mandibular third molars in mandibular condyle fractures. An electronic search was conducted in PubMed, Scopus, Web of Science, Cochrane Library, and VHL, through January 2016. The eligibility criteria included observatio...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ijom.2017.02.1265
更新日期:2017-06-01 00:00:00
abstract::Teratomas are tumors that are derived from two or three of the primordial germ layers: ectoderm, mesoderm and endoderm. They arise most commonly in a midline or paraxial location from the brain to the sacral area and are most often located in the sacrococcygeal region. Head and neck teratomas are rare neoplasms and th...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章,评审
doi:10.1016/j.ijom.2009.06.018
更新日期:2009-12-01 00:00:00
abstract::The aim of this study was to establish whether the pre-emptive use of lornoxicam (16mg) in third molar surgery ensures successful postoperative analgesia and reduces rescue analgesic intake when compared to postoperative application, and in comparison with placebo. Ninety patients were split randomly into three groups...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijom.2016.11.008
更新日期:2017-05-01 00:00:00