Increased copy number of mitochondrial DNA predicts poor prognosis of esophageal squamous cell carcinoma.

abstract：:The present study aimed to investigate the effects of Na+/H+ exchanger regulatory factor 1 (NHERF1) gene knockdown, using short-hairpin RNA (shRNA), on the malignant behaviors of prostate cancer cells. A pSuper.puro NHERF1 shRNA vector was transfected into PC-3M prostate cancer cells using Lipofectamine 2000. Stable c...

journal_title：Oncology letters

authors： Ma Q,Jiao Y,Hao Y,Yan S,Lyu N,Gao H,Li D,Liu Q,Zheng J,Song N

更新日期：2016-02-01 00:00:00

abstract：:A 20-year-old male presented to hospital with blood in the mucus, which had occurred for 6 months, and was diagnosed with nasopharyngeal carcinoma (NPC). Due to passive smoking, the patient developed a constant and violent cough, pain behind the right ear and swelling of the retropharynx. The results of a computed tom...

journal_title：Oncology letters

authors： Liu LH,Yang XF

更新日期：2016-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 base pairs that regulate the expression of genes by targeting messenger RNA with complementarity with the miRNA base sequence. Regulation of gene expression by miRNAs is crucial in cellular development and differentiation, and recent studies suggest a re...

journal_title：Oncology letters

authors： Yanokura M,Banno K,Kobayashi Y,Kisu I,Ueki A,Ono A,Masuda K,Nomura H,Hirasawa A,Susumu N,Aoki D

更新日期：2010-11-01 00:00:00

abstract：:Aberrant expression of microRNAs (miRNAs) contributes to the progression and outcomes of several types of tumor, while circulating miRNAs have been reported to act as biomarkers for several types of cancer. To identify specific circulating miRNAs associated with multiple myeloma (MM), a miRNA microarray analysis was u...

journal_title：Oncology letters

authors： Jiang Y,Luan Y,Chang H,Chen G

更新日期：2018-09-01 00:00:00

abstract：:Carbohydrate sulfotransferase 15 (CHST15) synthesizes matrix proteoglycan that regulates various pathogenic mediators and contributes to tissue remodeling and fibrosis during injury. CHST15 has been reported to promote tumor growth and invasion in various types of cancer. Our previous study reported the safety and eff...

journal_title：Oncology letters

authors： Matsuda Y,Fujii Y,Matsukawa M,Ishiwata T,Nishimura M,Arai T

更新日期：2019-10-01 00:00:00

abstract：:Oncostatin M (OSM) induces the differentiation of liver cancer stem cells (LCSCs) and increases sensitivity to the chemotherapeutic agent 5-fluorouracil, whereas salinomycin (Sal) induces apoptosis in cancer stem cells and inhibits the proliferation of liver cancer cells. However, there have been no studies investigat...

journal_title：Oncology letters

authors： Fu C,Wang L,Tian G,Zhang C,Zhao Y,Xu H,Su M,Wang Y

更新日期：2019-02-01 00:00:00

abstract：:The aberrant expression of microRNAs (miRs) has a significant impact on the biological characteristics of lymphocytes, and is important in the pathogenesis of diffuse large B-cell lymphoma (DLBCL). It has been demonstrated, using miR profiling and detecting distinct miR signatures, that certain miRs may accurately dis...

journal_title：Oncology letters

authors： Ni H,Tong R,Zou L,Song G,Cho WC

更新日期：2016-02-01 00:00:00

abstract：:In order to estimate the effects of small interfering RNA (siRNA) targeting retinoblastoma binding protein 2 (RBP2) on the proliferation, expression, invasion, migration and tumorigenicity abilities of papillary thyroid carcinoma K1 cells, siRNA targeting RBP2 (RBP2-siRNA) and negative control siRNA were transfected i...

journal_title：Oncology letters

authors： Kong LL,Man DM,Wang T,Zhang GA,Cui W

更新日期：2015-12-01 00:00:00

abstract：:The incidence of synchronous multiple primary lung cancer (MPLC) is increasing. However, present diagnostic methods are unable to satisfy the individualized treatment requirements of patients with MPLC. The present study aimed to establish a quantitative mathematical model and analyze its diagnostic value for distingu...

journal_title：Oncology letters

authors： Chen D,Mei L,Zhou Y,Shen C,Xu H,Niu Z,Che G

更新日期：2015-03-01 00:00:00

abstract：:K-ras is involved in the EGFR pathway that regulates cell survival, motility and proliferation, as well as angiogenesis and metastasis. It is also essential for carcinogenesis. The K-ras mutation status can be used to predict the therapeutic efficacy of targeted drugs such as cetuximab. The aim of this study was to co...

journal_title：Oncology letters

authors： Peng N,Zhao X

更新日期：2014-08-01 00:00:00

abstract：:The S100 protein family is widely involved in the pathological process of various types of cancer. However, the prognostic value of the S100 protein family member S100A12 in hepatocellular carcinoma (HCC) remains unknown. A total of 139 patients undergoing curative surgical resection for HCC from December 2005 to June...

journal_title：Oncology letters

authors： Cai H,Ye BG,Ao JY,Zhu XD,Zhang YY,Chai ZT,Wang CH,Sun HC

更新日期：2018-10-01 00:00:00

abstract：:Carcinogenesis is characterized by an abnormal regulation of the cell cycle. Regulators of the cell cycle such as cyclin E play an important role in neoplasia and may be correlated with prognosis. The clinical significance of the expression of cyclin E in stage III colorectal carcinoma has not yet been investigated. T...

journal_title：Oncology letters

authors： Rath-Wolfson L,Bergman M,Ori Y,Goldman A,Ram E,Koren R,Salman H

更新日期：2013-01-01 00:00:00

abstract：:Radical cystectomy, as the most common surgical treatment for patients with invasive bladder cancer (IBC) complicated by peritoneal metastasis, is usually accompanied by a urinary diversion procedure. In this study, we evaluated the improved tubeless cutaneous ureterostomy technique by comparing the resulting clinical...

journal_title：Oncology letters

authors： Liu Z,Tian Q,Xia S,Yin H,Yao D,Xiu Y

更新日期：2016-02-01 00:00:00

abstract：:The aim of this study was to investigate the effect of dexmedetomidine (Dex) on the respiratory function during anesthesia induction in pediatric patients undergoing retinoblastoma (RB) resection. A total of 87 pediatric patients who underwent RB resection in Yidu Central Hospital of Weifang were recruited into this s...

journal_title：Oncology letters

authors： Rong X,Sun C,Zhang F,Zheng J

更新日期：2019-03-01 00:00:00

abstract：:The long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been identified as an oncogene in numerous diseases, and aberrant lncRNA PVT1 expression has been associated with the development of cancer. However, the underlying mechanism by which lncRNA PVT1 affects cell invasion in esophageal cancer...

journal_title：Oncology letters

authors： Zheng X,Hu H,Li S

更新日期：2016-10-01 00:00:00

abstract：:Fibroadenoma (FA) is the most common type of breast lesion in young female individuals. Although malignant transformation in FA is rare, there is evidence of an association with breast carcinoma, particularly in middle-aged females with associated risk factors, such as a strong family history and/or BRCA-1/2 mutations...

journal_title：Oncology letters

authors： Hua B,Xu JY,Jiang L,Wang Z

更新日期：2015-09-01 00:00:00

abstract：:Angiomatoid fibrous histiocytoma (AFH) is a rare, low-grade malignant potential soft tissue tumor which occurs most commonly in children and young adults. Only a few case reports have been described that typically occur in the extremities of the deep dermis and subcutaneous tissue, followed by the trunk, as well as th...

journal_title：Oncology letters

authors： Xiang L,Zhou J,Gu W,Yang B

更新日期：2013-06-01 00:00:00

abstract：:Choristoma is a mass of tissue that is histologically normal for the organ or part of the body from which it originates, but is located at an abnormal site. Choristoma of the nervous system involves the occurrence of residual dysplastic tissues outside the nervous system and exhibits a low incidence. Thus far, there h...

journal_title：Oncology letters

authors： Chang PF,Qu LM,Li M,Qi B

更新日期：2017-08-01 00:00:00

abstract：:Activation of the hepatocyte growth factor (HGF)/c-Met signaling pathway was identified to be associated with malignant tumors. The present study aimed at determining the expression of HGF and c-Met in gastric carcinogenesis and its association with Helicobacter pylori infection. Gastric biopsies were obtained from 16...

journal_title：Oncology letters

authors： Xie C,Yang Z,Hu Y,Cao X,Chen J,Zhu Y,Lu N

更新日期：2017-11-01 00:00:00

abstract：:The present study aimed to identify polypeptides that specifically bond to breast cancer stem cells from a phage display random 12 peptide library, in addition to the affinity and specificity of polypeptides. A phage display random 12 peptide library was screened using breast cancer stem cells as targets isolated from...

journal_title：Oncology letters

authors： Liu F,Qi CL,Kong M,Liu TT,Li L,Li BJ

更新日期：2016-12-01 00:00:00

abstract：:Corosolic acid (CRA), a pentacyclic triterpene isolated from medicinal herbs, has been reported to exhibit anticancer properties in several cancers. However, the anticancer activity of CRA in osteosarcoma cells is still unclear. In the present study, the inhibitory effect of CRA in osteosarcoma MG-63 cells was investi...

journal_title：Oncology letters

authors： Jia Y,Yuan H,Shan S,Xu G,Yu J,Zhao C,Mou X

更新日期：2016-11-01 00:00:00

abstract：:Malignant gastrointestinal neuroectodermal tumors (GNETs) are rare aggressive malignant neoplasms that exclusively occur within the wall of the gastrointestinal tract. The GNET was first described as an 'osteoclast-rich tumor of the gastrointestinal tract with features resembling clear cell sarcoma (CCS) of soft parts...

journal_title：Oncology letters

authors： Huang GX,Chen QY,Zhong LL,Chen H,Zhang HP,Liu XF,Tang F

更新日期：2019-04-01 00:00:00

abstract：:This study aims to comparatively analyze the impact of laparoscopic myomectomy (LM) and transcervical resection of myoma (TCRM) on ovarian function, immune function and quality of sexual life of patients with hysteromyoma. Two hundred and forty patients with hysteromyoma admitted into the Second Affiliated Hospital of...

journal_title：Oncology letters

authors： Zhang Y,Gu X,Meng Y,Guo H,Du J,Xing W

更新日期：2018-03-01 00:00:00

abstract：:Previous studies have reported that alcohol dehydrogenase (ADH) isoenzymes possess diagnostic value in gastric cancer (GC). However, the prognostic value of ADH isoenzymes in GC remains unclear. The aim of the present study was to identify the prognostic value of ADH genes in patients with GC. The prognostic value of ...

journal_title：Oncology letters

authors： Guo E,Wei H,Liao X,Xu Y,Li S,Zeng X

更新日期：2018-04-01 00:00:00

abstract：:The novel synthesis of dibenzofluorene has been achieved by a cyclodehydration method. Several derivatives have also been prepared using this hydrocarbon. These compounds have been tested against a number of cancer cell lines in vitro, and useful selectivity has been observed. ...

journal_title：Oncology letters

authors： Banik BK,Mukhopadhyay C,Becker FF

更新日期：2010-03-01 00:00:00

abstract：:Partial hydatidiform mole and coexisting fetus (PHMCF) is a rare condition that presents a dilemma for physicians and the parents of the fetus, particularly when PHMCF is detected during the second trimester of pregnancy. The present study reports a case of PHMCF terminated by induction of labor via administration of ...

journal_title：Oncology letters

authors： Wang Y,Qian H,Wang J

更新日期：2015-12-01 00:00:00

abstract：:An alteration in the mitochondrial DNA (mtDNA) copy number has been detected in numerous human cancers. However, certain changes in the mtDNA copy number that occur during the initiation and progression of gastric cancer remain undetected. In the present study, using quantitative PCR analysis, the quantitative changes...

journal_title：Oncology letters

authors： Wen SL,Zhang F,Feng S

更新日期：2013-10-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide and remains the third leading cause of cancer-associated mortality. The present study aimed to fully elucidate the pathogenesis of CRC and identify associated genes in tumor development. Microarray GSE44076, GSE41328 and GSE44861 datasets were...

journal_title：Oncology letters

authors： Shen X,Yue M,Meng F,Zhu J,Zhu X,Jiang Y

更新日期：2016-11-01 00:00:00

abstract：:Hedgehog (HH) and Wnt pathway activation have been implicated in poor prognosis of breast cancer. Crosstalk between these two pathways has been demonstrated to be important in breast cancer progression, however the association between these two pathways and breast cancer survival rate is unknown. The present study com...

journal_title：Oncology letters

authors： Arnold KM,Pohlig RT,Sims-Mourtada J

更新日期：2017-11-01 00:00:00

abstract：:KG-1 and its less differentiated subline KG-1a are leukemia cell lines used in research in a number of laboratories. The karyotypes of the two lines were initially identical. In the following years, further analysis revealed that the cell lines had acquired additional karyotypical abnormalities and differed in the pre...

journal_title：Oncology letters

authors： Pelliccia F,Ubertini V,Bosco N

更新日期：2012-08-01 00:00:00