Abstract:
:Cell adhesion molecule (CADM) genes encode immunoglobulin superfamily molecules, which are involved in cell-cell adhesion in a number of human epithelia. Through the maintenance of epithelia, CADM genes protect against malignant conversion and metastasis. Whilst numerous in vitro studies have investigated the molecular characteristics of CADM1 and CADM4 and in vivo studies have investigated CADM1 and CADM4 expression in a number of tumor types, the roles of CADM1 and CADM4 have yet to be elucidated. Therefore, in the present study, CADM1 and CADM4 expression levels were evaluated using immunohistochemistry staining in 208 patients with breast cancer and compared with clinicopathological factors. CADM1 and CADM4 expression levels were negative in 160 (76.9%) and 166 (79.8%) of the 208 cases, respectively. The lack of expression in these cases was associated with advanced tumor stage, suggesting that inactivation of CADM1 and CADM4 promotes breast cancer development. The prognostic role of CADM1 and CADM4 in breast cancer was also evaluated and the expression of CADM1 and CADM4 were not associated with cancer-specific survival or overall survival rate in the cohort of patients in the present study. Whilst these results suggested that CADM1 and CADM4 possess tumor suppressive roles, further functional experiments are required to address the important mechanisms involving CADM1 and CADM4.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Saito M,Goto A,Abe N,Saito K,Maeda D,Ohtake T,Murakami Y,Takenoshita Sdoi
10.3892/ol.2017.7536subject
Has Abstractpub_date
2018-02-01 00:00:00pages
2401-2406issue
2eissn
1792-1074issn
1792-1082pii
OL-0-0-7536journal_volume
15pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Pancreatic cancer remains among the most lethal cancers, despite ongoing advances in treatment for all stages of the disease. Disease prevention represents another opportunity to improve patient outcome, with metabolic syndrome and its components, such as diabetes, obesity and dyslipidemia, having been recognized as m...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5572
更新日期:2017-03-01 00:00:00
abstract::Multiple myeloma is defined as a malignant proliferation of a single clone of plasma cells resulting in monoclonal immunoglobulin production. Due to the number of plasma cell morphological variants, difficulty is often faced during morphological diagnosis. The current study describes the case of a 49-year-old woman pr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4197
更新日期:2016-03-01 00:00:00
abstract::Indocyanine green (ICG) fluorescence imaging represents a promising method for sentinel node (SN) biopsy in laparoscopic gastric surgery due to its signal stability. In the present study, the suitability and optimal settings of ICG fluorescence imaging for SN biopsy in early gastric cancer were determined. Patients wi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4492
更新日期:2016-06-01 00:00:00
abstract::The occurrence of primary carcinoma of the ureteral stump following radical nephrectomy for renal cell carcinoma is extremely rare; 7 patients with the disease have been reported previously. All these patients were males with transitional cell carcinoma. The current study reports the case of a 61-year-old woman, who p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4426
更新日期:2016-05-01 00:00:00
abstract::The present study aimed to identify polypeptides that specifically bond to breast cancer stem cells from a phage display random 12 peptide library, in addition to the affinity and specificity of polypeptides. A phage display random 12 peptide library was screened using breast cancer stem cells as targets isolated from...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5248
更新日期:2016-12-01 00:00:00
abstract::The present study aimed to investigate potential recurrence-risk biomarkers based on significant pathways for Luminal A breast cancer through gene expression profile analysis. Initially, the gene expression profiles of Luminal A breast cancer patients were downloaded from The Cancer Genome Atlas database. The differen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7940
更新日期:2018-04-01 00:00:00
abstract::Wilms tumor (WT) is the most common pediatric renal malignancy. A recent ontogenic model suggests that undifferentiated tumor state, and hence poor prognosis, in WT is determined by stabilization of β-catenin in the nucleus. Forkhead box M1 (FOXM1) is a downstream component of the Wnt pathway and promotes nuclear loca...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4958
更新日期:2016-10-01 00:00:00
abstract::Transcriptional co-activator with PDZ-binding motif (TAZ) is a transcriptional co-activator which binds to a variety of transcription factors. An increasing number of studies have provided evidence that TAZ may be a positive regulator of cell proliferation and tumorigenesis. To reveal the underlying mechanisms by whic...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6030
更新日期:2017-06-01 00:00:00
abstract::MicroRNA (miR)-125a-3p is derived from the 3'-end of pre-miR-125a, which is associated with several types of cancer, such as gastric and prostate cancer, and glioma. The aim of the present study was to identify the prognostic significance of miR-125a-3p expression levels in patients with NSCLC. The gene expression omn...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6809
更新日期:2017-10-01 00:00:00
abstract::The aim of the present study was to investigate the optimal strategy and dosimetric measurement of thoracic radiotherapy based on three-dimensional (3D) modeling of mediastinal lymph nodes (MLNs). A 3D model of MLNs was constructed from a Chinese Visible Human female dataset. Image registration and fusion between reco...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8084
更新日期:2018-04-01 00:00:00
abstract::Gastrointestinal stromal tumor (GIST) is the most common type of mesenchymal tumor in the gastrointestinal tract. A large tumor size often means a poor prognosis. This report presents a case of a large exophytic GIST with cyst change, for which the outcome of favourable prognosis was unexpected. A 78-year-old male pre...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1954
更新日期:2014-05-01 00:00:00
abstract::Expression of copper-transporting P-type adenosine triphosphatase A (ATP7A) is reportedly associated with platinum drug resistance in various types of solid tumors. However, the impact of ATP7A expression on platinum drug resistance in non-small cell lung cancer (NSCLC) has yet to be adequately elucidated. In vitro ci...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000147
更新日期:2010-09-01 00:00:00
abstract::The clinical decisions made when treating patients with metastatic cancer require knowledge of the current tumor extent and response to therapy. For the majority of solid tumors, a response assessment, which is based on imaging, is used to guide these decisions. However, measuring serum protein biomarkers (i.e. tumor ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11192
更新日期:2020-02-01 00:00:00
abstract::Little information from clinical trials is available regarding the efficacy of trastuzumab treatment in subcentimetric breast carcinomas (BCs). The aim of this study was to verify the existence of correlations between HER2 and hormone receptor status, Ki67 values, grade, histotype and node involvement in a cohort of p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.425
更新日期:2012-01-01 00:00:00
abstract::Inactivating mutations of the multiple endocrine neoplasia 1 (MEN1) gene cause MEN1 syndrome, characterized by primary hyperparathyroidism (pHPT), and parathyroid and gastro-entero-pancreatic pituitary tumors. At present, only 14 cases of malignant parathyroid tumor have been associated with the syndrome, with 6 cases...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6162
更新日期:2017-07-01 00:00:00
abstract::Serine/threonine kinase 39 (STK39) is associated with hypertension, autism, Parkinson's disease and various types of cancer in recent years. This study investigated STK39 expression and possible roles in osteosarcoma using qPCR and western blot analysis. Compared to normal bone tissues, the mRNA and protein expression...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6728
更新日期:2017-10-01 00:00:00
abstract::Peroxiredoxin 1 (Prx1) is important in the protection of cells from oxidative damage and the regulation of cell proliferation and apoptosis. Prx1 is overexpressed in oral precancerous lesions of oral leukoplakia (OLK) and oral cancer; however, the association between Prx1 expression and OLK pathogenesis remains unknow...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4659
更新日期:2016-07-01 00:00:00
abstract::Periosteal chondrosarcoma is an extremely rare low-grade malignant cartilaginous tumor arising from the external bone surface. Diagnosis of periosteal chondrosarcomas may be challenging, since this condition closely resembles periosteal chondromas. It has been reported that positron emission tomography (PET) is useful...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2010
更新日期:2014-06-01 00:00:00
abstract::Icotinib is an epidermal growth factor receptor tyrosine kinase inhibitor, which has been revealed to inhibit proliferation in tumor cells. However, the effect of icotinib on cancer cell metastasis remains to be explained. This study examines the effect of icotinib on the migration and invasion of squamous cells of to...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2311
更新日期:2014-09-01 00:00:00
abstract::Ameloblastoma is the most common and clinically relevant type of odontogenic tumor. Clear cell odontogenic carcinoma is histologically characterized by solid sheets and nests of clear cells, whereas clear cell ameloblastoma (CCAM) is histologically characterized by an ameloblastomatous component intermixed with an ext...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7116
更新日期:2017-12-01 00:00:00
abstract::Chylothorax is the accumulation of lymph fluid in the pleura. Gastric carcinoma with chylothorax and lymphedema as the initial manifestations has rarely been reported, with only 14 cases reported to date. The mechanisms of gastric carcinoma generating chylothorax have not yet been determined. The current study reports...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4285
更新日期:2016-04-01 00:00:00
abstract::Previous studies have demonstrated that nicotinamide N-methyltransferase (NNMT) is aberrantly expressed in a number of tumors. In the present study, it was demonstrated that the gene and protein levels of NNMT were significantly increased in gastric cancer cells. Furthermore, upregulation of NNMT significantly increas...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7885
更新日期:2018-04-01 00:00:00
abstract::Ubiquitin-like modifier-activating enzyme 7 (UBA7) is a specific E1-like ubiquitin-activating enzyme involved in interferon-stimulated gene 15 (ISG15) conjugation. UBA7 expression has been reported to be notably decreased in lung cancer. The present study aimed to investigate the changes in UBA7 expression in breast c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11406
更新日期:2020-04-01 00:00:00
abstract::Canonical WNT signaling promotes breast cancer progression. Although APC downregulated 1 (APCDD1) may inhibit canonical WNT signaling, its role in breast cancer remains to be fully understood. The present study demonstrated that APCDD1 suppressed in vitro breast cancer growth and metastasis by inhibiting canonical WNT...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6801
更新日期:2017-10-01 00:00:00
abstract::Factor that binds to the inducer of short transcripts of the human immunodeficiency virus-1 (FBI-1) represents as a crucial gene regulator in colorectal cancer; however, the correlation between FBI-1 and preoperative radiotherapy (RT) in rectal cancer (RC) has not yet been reported. The aim was to detect FBI-1 express...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10890
更新日期:2019-11-01 00:00:00
abstract::Nanoparticle albumin-bound (nab)-paclitaxel appears to exhibit better response rates in patients with metastatic urothelial cancer of the bladder whom are pretreated with nab-paclitaxel compared with conventional paclitaxel. Paclitaxel may induce multidrug resistance in patients with cancer, while the mechanisms of re...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5986
更新日期:2017-06-01 00:00:00
abstract::Histone methylation is closely associated with the occurrence of cancer. Histone H3 trimethylation at lysine 4 (H3K4me3) has been reported to modulate the expression of tumor-associated expression and be altered during the progression of several human cancers. WD Repeat Domain 82 (Wdr82), a key epigenetics-associated ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8902
更新日期:2018-08-01 00:00:00
abstract::While erlotinib is primarily administered to patients with non-small cell lung cancer with sensitizing epidermal growth factor receptor (EGFR) mutations, it is also prescribed to patients with wild type (wt) EGFR in higher lines of treatment. However, there is no predictive marker for erlotinib efficacy in patients wi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11663
更新日期:2020-08-01 00:00:00
abstract::The present study was conducted to evaluate the methanolic extract of Piper betle leaves (MPBL) and its organic fractions with regard to antitumor activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice and to confirm their antioxidant activities. At 24 h post-intraperitoneal inoculation of tumor cells i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2738
更新日期:2015-02-01 00:00:00
abstract::Primary penile lymphoma presenting with priapism as the initial symptom is extremely rare. In total, <10 cases have been previously reported. The diagnosis can be difficult and patients often develop metastasis. The current study reports the case of a 48-year-old male, who presented with a one-month history of painles...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2488
更新日期:2014-11-01 00:00:00