Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer.

Abstract:

:Cell adhesion molecule (CADM) genes encode immunoglobulin superfamily molecules, which are involved in cell-cell adhesion in a number of human epithelia. Through the maintenance of epithelia, CADM genes protect against malignant conversion and metastasis. Whilst numerous in vitro studies have investigated the molecular characteristics of CADM1 and CADM4 and in vivo studies have investigated CADM1 and CADM4 expression in a number of tumor types, the roles of CADM1 and CADM4 have yet to be elucidated. Therefore, in the present study, CADM1 and CADM4 expression levels were evaluated using immunohistochemistry staining in 208 patients with breast cancer and compared with clinicopathological factors. CADM1 and CADM4 expression levels were negative in 160 (76.9%) and 166 (79.8%) of the 208 cases, respectively. The lack of expression in these cases was associated with advanced tumor stage, suggesting that inactivation of CADM1 and CADM4 promotes breast cancer development. The prognostic role of CADM1 and CADM4 in breast cancer was also evaluated and the expression of CADM1 and CADM4 were not associated with cancer-specific survival or overall survival rate in the cohort of patients in the present study. Whilst these results suggested that CADM1 and CADM4 possess tumor suppressive roles, further functional experiments are required to address the important mechanisms involving CADM1 and CADM4.

journal_name

Oncol Lett

journal_title

Oncology letters

authors

Saito M,Goto A,Abe N,Saito K,Maeda D,Ohtake T,Murakami Y,Takenoshita S

doi

10.3892/ol.2017.7536

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

2401-2406

issue

2

eissn

1792-1074

issn

1792-1082

pii

OL-0-0-7536

journal_volume

15

pub_type

杂志文章
  • Statins and pancreatic cancer.

    abstract::Pancreatic cancer remains among the most lethal cancers, despite ongoing advances in treatment for all stages of the disease. Disease prevention represents another opportunity to improve patient outcome, with metabolic syndrome and its components, such as diabetes, obesity and dyslipidemia, having been recognized as m...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.5572

    authors: Gong J,Sachdev E,Robbins LA,Lin E,Hendifar AE,Mita MM

    更新日期:2017-03-01 00:00:00

  • Small-lymphoid cells and myeloid antigen expression in a patient with IgG myeloma: A case report.

    abstract::Multiple myeloma is defined as a malignant proliferation of a single clone of plasma cells resulting in monoclonal immunoglobulin production. Due to the number of plasma cell morphological variants, difficulty is often faced during morphological diagnosis. The current study describes the case of a 49-year-old woman pr...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4197

    authors: Jiang P,Xia W,Sun X,Dai X,Li L

    更新日期:2016-03-01 00:00:00

  • Optimal settings and accuracy of indocyanine green fluorescence imaging for sentinel node biopsy in early gastric cancer.

    abstract::Indocyanine green (ICG) fluorescence imaging represents a promising method for sentinel node (SN) biopsy in laparoscopic gastric surgery due to its signal stability. In the present study, the suitability and optimal settings of ICG fluorescence imaging for SN biopsy in early gastric cancer were determined. Patients wi...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4492

    authors: Kinami S,Oonishi T,Fujita J,Tomita Y,Funaki H,Fujita H,Nakano Y,Ueda N,Kosaka T

    更新日期:2016-06-01 00:00:00

  • Primary carcinoma of the ureteral stump following radical nephrectomy for renal cell carcinoma: A case report and literature review.

    abstract::The occurrence of primary carcinoma of the ureteral stump following radical nephrectomy for renal cell carcinoma is extremely rare; 7 patients with the disease have been reported previously. All these patients were males with transitional cell carcinoma. The current study reports the case of a 61-year-old woman, who p...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4426

    authors: Jin S,Wang G,Yu C,Li N

    更新日期:2016-05-01 00:00:00

  • Screening specific polypeptides of breast cancer stem cells from a phage display random peptide library.

    abstract::The present study aimed to identify polypeptides that specifically bond to breast cancer stem cells from a phage display random 12 peptide library, in addition to the affinity and specificity of polypeptides. A phage display random 12 peptide library was screened using breast cancer stem cells as targets isolated from...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.5248

    authors: Liu F,Qi CL,Kong M,Liu TT,Li L,Li BJ

    更新日期:2016-12-01 00:00:00

  • Investigating a multigene prognostic assay based on significant pathways for Luminal A breast cancer through gene expression profile analysis.

    abstract::The present study aimed to investigate potential recurrence-risk biomarkers based on significant pathways for Luminal A breast cancer through gene expression profile analysis. Initially, the gene expression profiles of Luminal A breast cancer patients were downloaded from The Cancer Genome Atlas database. The differen...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.7940

    authors: Gao H,Yang M,Zhang X

    更新日期:2018-04-01 00:00:00

  • Association of FOXM1 expression with tumor histology and prognosis in Wilms tumor: Potential for a new prognostic marker.

    abstract::Wilms tumor (WT) is the most common pediatric renal malignancy. A recent ontogenic model suggests that undifferentiated tumor state, and hence poor prognosis, in WT is determined by stabilization of β-catenin in the nucleus. Forkhead box M1 (FOXM1) is a downstream component of the Wnt pathway and promotes nuclear loca...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4958

    authors: Apelt N,Hubertus J,Mayr D,Graf N,Furtwängler R,Von Schweinitz D,Kappler R

    更新日期:2016-10-01 00:00:00

  • Transcriptional co-activator with PDZ-binding motif overexpression promotes cell proliferation and transcriptional co-activator with PDZ-binding motif deficiency induces cell cycle arrest in neuroblastoma.

    abstract::Transcriptional co-activator with PDZ-binding motif (TAZ) is a transcriptional co-activator which binds to a variety of transcription factors. An increasing number of studies have provided evidence that TAZ may be a positive regulator of cell proliferation and tumorigenesis. To reveal the underlying mechanisms by whic...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6030

    authors: Yang L,Huang M,Tan J,Hou J,He J,Wang F,Cui H,Yi L

    更新日期:2017-06-01 00:00:00

  • MicroRNA-125a-3p downregulation correlates with tumorigenesis and poor prognosis in patients with non-small cell lung cancer.

    abstract::MicroRNA (miR)-125a-3p is derived from the 3'-end of pre-miR-125a, which is associated with several types of cancer, such as gastric and prostate cancer, and glioma. The aim of the present study was to identify the prognostic significance of miR-125a-3p expression levels in patients with NSCLC. The gene expression omn...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6809

    authors: Hou L,Luo P,Ma Y,Jia C,Yu F,Lv Z,Wu C,Fu D

    更新日期:2017-10-01 00:00:00

  • A dosimetric phantom study of thoracic radiotherapy based on three-dimensional modeling of mediastinal lymph nodes.

    abstract::The aim of the present study was to investigate the optimal strategy and dosimetric measurement of thoracic radiotherapy based on three-dimensional (3D) modeling of mediastinal lymph nodes (MLNs). A 3D model of MLNs was constructed from a Chinese Visible Human female dataset. Image registration and fusion between reco...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8084

    authors: Zhang JB,Zhao LR,Cui TX,Chen XW,Yang Q,Zhou YB,Chen ZT,Zhang SX,Sun JG

    更新日期:2018-04-01 00:00:00

  • Exophytic gastrointestinal stromal tumor with cystic changes: A case report.

    abstract::Gastrointestinal stromal tumor (GIST) is the most common type of mesenchymal tumor in the gastrointestinal tract. A large tumor size often means a poor prognosis. This report presents a case of a large exophytic GIST with cyst change, for which the outcome of favourable prognosis was unexpected. A 78-year-old male pre...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.1954

    authors: Zhu CC,Liu Y,Zhao G

    更新日期:2014-05-01 00:00:00

  • Association of ATP7A expression and in vitro sensitivity to cisplatin in non-small cell lung cancer.

    abstract::Expression of copper-transporting P-type adenosine triphosphatase A (ATP7A) is reportedly associated with platinum drug resistance in various types of solid tumors. However, the impact of ATP7A expression on platinum drug resistance in non-small cell lung cancer (NSCLC) has yet to be adequately elucidated. In vitro ci...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol_00000147

    authors: Inoue Y,Matsumoto H,Yamada S,Kawai K,Suemizu H,Gika M,Takanami I,Iwazaki M,Nakamura M

    更新日期:2010-09-01 00:00:00

  • Evaluation of circulating cell-free DNA as a molecular monitoring tool in patients with metastatic cancer.

    abstract::The clinical decisions made when treating patients with metastatic cancer require knowledge of the current tumor extent and response to therapy. For the majority of solid tumors, a response assessment, which is based on imaging, is used to guide these decisions. However, measuring serum protein biomarkers (i.e. tumor ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.11192

    authors: Hufnagl C,Leisch M,Weiss L,Melchardt T,Moik M,Asslaber D,Roland G,Steininger P,Meissnitzer T,Neureiter D,Greil R,Egle A

    更新日期:2020-02-01 00:00:00

  • Morphological and biomolecular characteristics of subcentimetric invasive breast carcinomas in Sicily: A multicentre retrospective study in relation to trastuzumab treatment.

    abstract::Little information from clinical trials is available regarding the efficacy of trastuzumab treatment in subcentimetric breast carcinomas (BCs). The aim of this study was to verify the existence of correlations between HER2 and hormone receptor status, Ki67 values, grade, histotype and node involvement in a cohort of p...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2011.425

    authors: Ieni A,Giuffrè G,Lanzafame S,Nuciforo G,Curduman M,Villari L,Roz E,Certo G,Cabibi D,Salomone E,Labate A,Messina D,Franco V,Adamo V,Tuccari G

    更新日期:2012-01-01 00:00:00

  • Novel association of MEN1 gene mutations with parathyroid carcinoma.

    abstract::Inactivating mutations of the multiple endocrine neoplasia 1 (MEN1) gene cause MEN1 syndrome, characterized by primary hyperparathyroidism (pHPT), and parathyroid and gastro-entero-pancreatic pituitary tumors. At present, only 14 cases of malignant parathyroid tumor have been associated with the syndrome, with 6 cases...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6162

    authors: Cinque L,Sparaneo A,Cetani F,Coco M,Clemente C,Chetta M,Balsamo T,Battista C,Sanpaolo E,Pardi E,D'Agruma L,Marcocci C,Maiello E,Hendy GN,Cole DEC,Scillitani A,Guarnieri V

    更新日期:2017-07-01 00:00:00

  • STK39, overexpressed in osteosarcoma, regulates osteosarcoma cell invasion and proliferation.

    abstract::Serine/threonine kinase 39 (STK39) is associated with hypertension, autism, Parkinson's disease and various types of cancer in recent years. This study investigated STK39 expression and possible roles in osteosarcoma using qPCR and western blot analysis. Compared to normal bone tissues, the mRNA and protein expression...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6728

    authors: Huang T,Zhou Y,Cao Y,Tao J,Zhou ZH,Hang DH

    更新日期:2017-10-01 00:00:00

  • Peroxiredoxin 1 has an anti-apoptotic role via apoptosis signal-regulating kinase 1 and p38 activation in mouse models with oral precancerous lesions.

    abstract::Peroxiredoxin 1 (Prx1) is important in the protection of cells from oxidative damage and the regulation of cell proliferation and apoptosis. Prx1 is overexpressed in oral precancerous lesions of oral leukoplakia (OLK) and oral cancer; however, the association between Prx1 expression and OLK pathogenesis remains unknow...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4659

    authors: Zhang J,Jing X,Niu W,Zhang M,Ge L,Miao C,Tang X

    更新日期:2016-07-01 00:00:00

  • Usefulness of PET/CT for diagnosis of periosteal chondrosarcoma of the femur: A case report.

    abstract::Periosteal chondrosarcoma is an extremely rare low-grade malignant cartilaginous tumor arising from the external bone surface. Diagnosis of periosteal chondrosarcomas may be challenging, since this condition closely resembles periosteal chondromas. It has been reported that positron emission tomography (PET) is useful...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2010

    authors: Morimoto S,Futani H,Tsuchiyama K,Fukunaga S,Tsukamoto Y,Yoshiya S

    更新日期:2014-06-01 00:00:00

  • Icotinib inhibits the invasion of Tca8113 cells via downregulation of nuclear factor κB-mediated matrix metalloproteinase expression.

    abstract::Icotinib is an epidermal growth factor receptor tyrosine kinase inhibitor, which has been revealed to inhibit proliferation in tumor cells. However, the effect of icotinib on cancer cell metastasis remains to be explained. This study examines the effect of icotinib on the migration and invasion of squamous cells of to...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2311

    authors: Yang C,Yan J,Yuan G,Zhang Y,Lu D,Ren M,Cui W

    更新日期:2014-09-01 00:00:00

  • The role of computed tomography and magnetic resonance imaging in diagnosing clear cell ameloblastoma: A case report.

    abstract::Ameloblastoma is the most common and clinically relevant type of odontogenic tumor. Clear cell odontogenic carcinoma is histologically characterized by solid sheets and nests of clear cells, whereas clear cell ameloblastoma (CCAM) is histologically characterized by an ameloblastomatous component intermixed with an ext...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.7116

    authors: Gamoh S,Wato M,Akiyama H,Tsuji K,Ishikawa H,Naruse K,Yoshida H,Morita S,Tanaka A,Shimizutani K

    更新日期:2017-12-01 00:00:00

  • Chylothorax and lymphedema as the initial manifestations of gastric carcinoma: A case report and review of the literature.

    abstract::Chylothorax is the accumulation of lymph fluid in the pleura. Gastric carcinoma with chylothorax and lymphedema as the initial manifestations has rarely been reported, with only 14 cases reported to date. The mechanisms of gastric carcinoma generating chylothorax have not yet been determined. The current study reports...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4285

    authors: Wu J,Lv L,Zhou K,Huo J

    更新日期:2016-04-01 00:00:00

  • Nicotinamide N-methyltransferase promotes epithelial-mesenchymal transition in gastric cancer cells by activating transforming growth factor-β1 expression.

    abstract::Previous studies have demonstrated that nicotinamide N-methyltransferase (NNMT) is aberrantly expressed in a number of tumors. In the present study, it was demonstrated that the gene and protein levels of NNMT were significantly increased in gastric cancer cells. Furthermore, upregulation of NNMT significantly increas...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.7885

    authors: Liang L,Zeng M,Pan H,Liu H,He Y

    更新日期:2018-04-01 00:00:00

  • Ubiquitin-like modifier-activating enzyme 7 as a marker for the diagnosis and prognosis of breast cancer.

    abstract::Ubiquitin-like modifier-activating enzyme 7 (UBA7) is a specific E1-like ubiquitin-activating enzyme involved in interferon-stimulated gene 15 (ISG15) conjugation. UBA7 expression has been reported to be notably decreased in lung cancer. The present study aimed to investigate the changes in UBA7 expression in breast c...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11406

    authors: Lin M,Li Y,Qin S,Jiao Y,Hua F

    更新日期:2020-04-01 00:00:00

  • APC downregulated 1 inhibits breast cancer cell invasion by inhibiting the canonical WNT signaling pathway.

    abstract::Canonical WNT signaling promotes breast cancer progression. Although APC downregulated 1 (APCDD1) may inhibit canonical WNT signaling, its role in breast cancer remains to be fully understood. The present study demonstrated that APCDD1 suppressed in vitro breast cancer growth and metastasis by inhibiting canonical WNT...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6801

    authors: Cho SG

    更新日期:2017-10-01 00:00:00

  • Prognostic value of nuclear FBI-1 in patients with rectal cancer with or without preoperative radiotherapy.

    abstract::Factor that binds to the inducer of short transcripts of the human immunodeficiency virus-1 (FBI-1) represents as a crucial gene regulator in colorectal cancer; however, the correlation between FBI-1 and preoperative radiotherapy (RT) in rectal cancer (RC) has not yet been reported. The aim was to detect FBI-1 express...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10890

    authors: Wang CJ,Chao CR,Liu HM,Zhu YY,Adell G,Jarlsfelt I,Zhang H,Sun XF

    更新日期:2019-11-01 00:00:00

  • Resistance to nanoparticle albumin-bound paclitaxel is mediated by ABCB1 in urothelial cancer cells.

    abstract::Nanoparticle albumin-bound (nab)-paclitaxel appears to exhibit better response rates in patients with metastatic urothelial cancer of the bladder whom are pretreated with nab-paclitaxel compared with conventional paclitaxel. Paclitaxel may induce multidrug resistance in patients with cancer, while the mechanisms of re...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.5986

    authors: Vallo S,Köpp R,Michaelis M,Rothweiler F,Bartsch G,Brandt MP,Gust KM,Wezel F,Blaheta RA,Haferkamp A,Cinatl J Jr

    更新日期:2017-06-01 00:00:00

  • H3K4me3 and Wdr82 are associated with tumor progression and a favorable prognosis in human colorectal cancer.

    abstract::Histone methylation is closely associated with the occurrence of cancer. Histone H3 trimethylation at lysine 4 (H3K4me3) has been reported to modulate the expression of tumor-associated expression and be altered during the progression of several human cancers. WD Repeat Domain 82 (Wdr82), a key epigenetics-associated ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8902

    authors: Liu H,Li Y,Li J,Liu Y,Cui B

    更新日期:2018-08-01 00:00:00

  • Thyroid transcription factor 1 and p63 expression is associated with survival outcome in patients with non-small cell lung cancer treated with erlotinib.

    abstract::While erlotinib is primarily administered to patients with non-small cell lung cancer with sensitizing epidermal growth factor receptor (EGFR) mutations, it is also prescribed to patients with wild type (wt) EGFR in higher lines of treatment. However, there is no predictive marker for erlotinib efficacy in patients wi...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11663

    authors: Svaton M,Fiala O,Krakorova G,Blazek J,Hurdalkova K,Barinova M,Mukensnabl P,Pesek M

    更新日期:2020-08-01 00:00:00

  • Piper betle extracts exhibit antitumor activity by augmenting antioxidant potential.

    abstract::The present study was conducted to evaluate the methanolic extract of Piper betle leaves (MPBL) and its organic fractions with regard to antitumor activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice and to confirm their antioxidant activities. At 24 h post-intraperitoneal inoculation of tumor cells i...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2738

    authors: Alam B,Majumder R,Akter S,Lee SH

    更新日期:2015-02-01 00:00:00

  • Priapism as the initial symptom of primary penile lymphoma: A case report.

    abstract::Primary penile lymphoma presenting with priapism as the initial symptom is extremely rare. In total, <10 cases have been previously reported. The diagnosis can be difficult and patients often develop metastasis. The current study reports the case of a 48-year-old male, who presented with a one-month history of painles...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2488

    authors: Gong Z,Zhang Y,Chu H,Lian P,Zhang L,Sun P,Chen J

    更新日期:2014-11-01 00:00:00