Abstract:
PURPOSE:Disturbed peripapillary microcirculation may have a role in the development of glaucoma. Recently, using noninvasive optical coherence tomography (OCT) angiography with the AngioVue OCT (Optovue Inc., -Fremont, CA, USA), reduced peripapillary vessel density was found in glaucoma. In this case series, we investigate the relationship between retinal nerve fiber layer (RNFL) damage and peripapillary angioflow density (PAFD, % of the analyzed retinal area) in the superotemporal (ST), inferotemporal (IT), and temporal (T) peripapillary sectors in normal, ocular hypertensive (OHT), and primary open-angle glaucoma eyes. CASE REPORT:The AngioVue OCT and the 2015.100.0.33 software version was used for PAFD measurements. The PAFD in the radial peripapillary capillary layer was similar (approximately 60%) in all 3 sectors in healthy eyes. In glaucoma with severe ST and/or IT RNFL defect, PAFD declined to 32%-45% in the damaged sectors but remained above 55% in the T sector. In the OHT eyes with no visual field defect and no RNFL sector outside the normal limits but with mild ST or IT RNFL damage, PAFD declined to 54% in the involved sector in all cases, while it remained around 60% in the other sectors. CONCLUSIONS:Our cases suggest that PADF measurements can identify decreased peripapillary perfusion early in the glaucomatous RNFL thinning process, prior to the development of clinically significant RNFL damage and visual field deterioration. Decreased PAFD corresponds spatially with the damaged RNFL bundles. The results suggest that prospective studies using PAFD may help to understand the role of vascular dysfunction in glaucoma.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Holló Gdoi
10.5301/ejo.5000717subject
Has Abstractpub_date
2016-04-12 00:00:00pages
e42-5issue
3eissn
1120-6721issn
1724-6016pii
36B44AE1-97B4-4FCB-838A-47C9E1464C40journal_volume
26pub_type
杂志文章abstract:PURPOSE:Several types of inborn errors of the O-glycan biosynthesis are known, leading to clinically very distinct phenotypes. Children with O-mannosyl glycan biosynthesis defects commonly present as a severe form of congenital muscular dystrophy with decreased alpha-dystroglycan staining, congenital eye anomalies, and...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210601600134
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To evaluate the safety and efficacy of sealed implantation, a simple technique for implanting foldable intraocular lenses (IOLs). METHODS:This was a retrospective study including consecutive patients who underwent phacoemulsification cataract using the sealed implantation technique. Sealed implantation is a te...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000997
更新日期:2017-08-30 00:00:00
abstract:PURPOSE:To evaluate rotational stability, astigmatism correction, visual outcomes, and patient satisfaction after implantation of the toric intraocular lens (IOL) Torica-aA following cataract extraction over a 6-month follow-up period. METHODS:This prospective observational study enrolled 40 eyes of 26 patients presen...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000696
更新日期:2016-06-10 00:00:00
abstract:PURPOSE:To compare rod function among diabetic patients without and with mild nonproliferative diabetic retinopathy (DR) and healthy controls by means of scotopic microperimetry and dark-adapted electroretinography. METHODS:Sixty-one diabetic patients and 30 age-matched controls (control group) underwent complete opht...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000800
更新日期:2016-08-04 00:00:00
abstract:PURPOSE:To compare lateral rectus recession (LRc) and medial rectus advancement (MRadv) for correction of consecutive exotropia (CXT). METHODS:Of the 43 exotropic patients 20 of them underwent LRc (group 1) and 23 of them underwent MRadv (group 2). Postoperative exodrift, strabismic angle, dose effect relationship wer...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120983199
更新日期:2021-01-09 00:00:00
abstract:PURPOSE:We evaluate the functional and anatomic outcome after intravitreal ranibizumab treatment in patients with choroidal neovascularization (CNV) related to chronic central serous chorioretinopathy (CSC). METHODS:This is a small case series of 5 eyes with CNV associated with chronic CSC treated with intravitreal in...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000524
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:To examine the nature and frequency of ocular side effects due to systemic target therapy with BRAF and MEK inhibitors as well as immunotherapy with cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death 1 (PD-1) monoclonal antibodies used in the treatment of cutaneous malignant melanoma (CMM). DE...
journal_title:European journal of ophthalmology
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abstract:PURPOSE:To report the visual and refractive outcomes of sequential intracorneal ring segment (ICRS) and toric phakic intraocular lens (IOL) insertion for visual rehabilitation in keratoconus. METHODS:A retrospective interventional cohort study was performed through the Corneoplastics unit and Eye Bank, Queen Victoria ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120969600
更新日期:2020-11-02 00:00:00
abstract:PURPOSE:The aim of this study was to assess structural and histological changes associated with pre-Descemet corneal dystrophy with multimodal in vivo imaging. METHODS:Retrospective case series including eight corneas from four unrelated male patients with pre-Descemet corneal dystrophy characterized by the presence o...
journal_title:European journal of ophthalmology
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doi:10.1177/1120672119862505
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:To compare the results of viscocanalostomy with and without mitomycin-C (MMC). METHODS:Retrospective results of 15 standard viscocanalostomy (VCO) operations (Group 1) were compared with the prospective results of 15 VCO operations performed with intraoperative adjunctive MMC (Group 2). MMC (0.2 mg/mL) was app...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1177/112067210501500204
更新日期:2005-03-01 00:00:00
abstract:PURPOSE::To describe the patterns of regression of choroidal melanoma after treatment with plaque brachytherapy. METHODS::Retrospective interventional case series including 170 consecutive patients treated with 103Pd eye plaque radiation for choroidal melanoma. Outcome measures were changes in tumor thickness, surface...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118776146
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:The study was conducted to assess the central corneal thickness (CCT) of the healthy cornea with a recently developed noncontact specular microscope (EM-3000; Tomey) and compare the results with those measured with a contact specular microscope and an ultrasound pachymeter. Agreement between measurements taken ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000504
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:To asses visual quality after bilateral implantation of the Acri.LISA 366D intraocular lens (IOL) (Carl Zeiss Meditec) in patients with high and low-moderate myopia. METHODS:A total of 304 eyes of 152 patients had bilateral implantation of the Acri.LISA 366D IOL. The patients were divided into 2 groups: low-mo...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000111
更新日期:2010-01-01 00:00:00
abstract::Purpose. To record the information used in order to make a retreatment decision in patients with exudative age-related macular degeneration (AMD) and to assess if an optical coherence tomography (OCT)-only follow-up clinic would suffice. Methods. Two hundred patients under treatment with intravitreal anti-vascular end...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000190
更新日期:2012-08-06 00:00:00
abstract:PURPOSE:To determine the relationship between movements of the posterior and anterior eye segments during arbitrary gaze shifts and to obtain information for monitoring fixation during radiotherapy for ocular diseases. METHODS:We examined eye movements of ten emmetropic volunteers in a 1.5 T magnetic resonance system....
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210301300212
更新日期:2003-03-01 00:00:00
abstract::Non-arteritic anterior ischemic optic neuropathy (NAION) is characterized by the progressive and irreversible death of retinal ganglion cells (RGCs) which is caused by the insufficient blood supply to the optic nerve (ON) head. At present, hormone therapy is used to reduce optic edema, followed by nerve nutrition ther...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120974283
更新日期:2020-11-21 00:00:00
abstract:PURPOSE:We report spectral domain optical coherence tomography findings of the peripheral retina in a patient with senile (acquired) retinoschisis. METHODS:This is an observational case report. Spectral domain optical coherence tomography was performed to image the peripheral retina at the area of retinoschisis in a 7...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000610
更新日期:2010-11-01 00:00:00
abstract:PURPOSE:The aim of this study is to evaluate the incidence, natural course, and distribution pattern of superficial punctate keratopathy and describe the changes in signs and symptoms of dry eye after cataract surgery. SETTING:The setting of this study is University Hospital Rio Hortega and Instituto Universitario de ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119896427
更新日期:2020-11-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to evaluate repeatability and reproducibility of newly calculated biomechanical parameters of the cornea, developed by our research group. METHODS:One eye from each of the 23 healthy subjects was measured three times consecutively, three times at different daytimes and on three d...
journal_title:European journal of ophthalmology
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doi:10.1177/1120672119864554
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abstract:PURPOSE:To evaluate the efficacy, safety, and tolerability of Timogel® preservative-free once daily compared to timolol 0.5% ophthalmic solution bid in patients with ocular hypertension (OHT) and patients with primary open-angle glaucoma (POAG). METHODS:A total of 75 patients with OHT and patients with POAG treated wi...
journal_title:European journal of ophthalmology
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更新日期:2012-01-01 00:00:00
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journal_title:European journal of ophthalmology
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doi:10.1177/112067210801800618
更新日期:2008-11-01 00:00:00
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journal_title:European journal of ophthalmology
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doi:10.5301/ejo.5000890
更新日期:2017-05-11 00:00:00
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journal_title:European journal of ophthalmology
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更新日期:2012-03-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210201200418
更新日期:2002-07-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000272
更新日期:2013-07-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210701700510
更新日期:2007-09-01 00:00:00
abstract::Peripheral choroidal neovascularization can result in an elevated subretinal lesion which can simulate a choroidal tumor. We reviewed 8 eyes with 11 peripheral areas of subretinal fluid and exudate which were subsequently determined to be secondary to peripheral choroidal neovascularization. Previous reports of periph...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
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更新日期:2020-11-24 00:00:00
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journal_title:European journal of ophthalmology
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doi:
更新日期:2004-11-01 00:00:00