Childhood to adult transition and long-term follow-up after blood and marrow transplantation.

abstract：:Fifteen patients with stage II-III multiple myeloma were intended to undergo two sequential cycles of myeloablative chemoradiotherapy with autologous bone marrow or blood stem cell transplantation after response to primary induction chemotherapy. BM grafts were used in 13 of the 15 first transplants whereas PBSC were ...

journal_title：Bone marrow transplantation

authors： Björkstrand B,Ljungman P,Bird JM,Samson D,Gahrton G

更新日期：1995-03-01 00:00:00

abstract：:Repeated high-dose (HD) chemotherapy with peripheral blood stem cell (PBSC) transplantation is a new modality aimed at increasing both the dose and its intensity in the treatment of chemosensitive tumours. The aim of this study was to evaluate the tolerance, pharmacokinetics (PK) and pharmacodynamics (PD) of HD single...

journal_title：Bone marrow transplantation

authors： Vassal G,Tranchand B,Valteau-Couanet D,Mahé C,Couanet D,Schoeppfer C,Grill J,Kalifa C,Hill C,Ardiet C,Hartmann O

更新日期：2001-03-01 00:00:00

abstract：:While prospects for long-term survival following bone marrow transplantation (BMT) have increased, little is known about the quality of that survival. The present study was intended to document the physical and psychosocial functioning of survivors of allogeneic BMT as well as identify factors associated with variabil...

journal_title：Bone marrow transplantation

authors： Andrykowski MA,Henslee PJ,Farrall MG

更新日期：1989-01-01 00:00:00

abstract：:Current graft-versus-host disease (GVHD) prophylaxis is not uniformly successful. Since the development of GVHD has a profound impact on transplant success, treatment is required. The mainstay of therapy has been glucocorticoids (steroids), along with anti-thymocyte globulin, cyclosporine, monoclonal antibodies, and a...

journal_title：Bone marrow transplantation

authors： Deeg HJ,Henslee-Downey PJ

更新日期：1990-07-01 00:00:00

abstract：SUMMARY:Encephalopathy is a poorly characterized complication of hematopoietic stem cell transplantation (HSCT). No comprehensive report of encephalopathy exists for children, and the literature contains only a few for adults. We analyzed a large cohort of 405 pediatric patients who underwent allogeneic HSCT during a 1...

journal_title：Bone marrow transplantation

authors： Woodard P,Helton K,McDaniel H,Khan RB,Thompson S,Hale G,Benaim E,Kasow K,Leung W,Horwitz E,Srivastava DK,Tong X,Yusuf U,Cunningham JM,Handgretinger R

更新日期：2004-06-01 00:00:00

abstract：:Between February 1998 and October 1999, 24 patients with advanced leukemia, lymphoma or solid tumors received G-CSF mobilized peripheral blood stem cells (PBSC) from HLA-matched sibling donors after dose-reduced conditioning therapy. Only patients with reduced performance status or major infectious complications, not ...

journal_title：Bone marrow transplantation

authors： Bornhäuser M,Thiede C,Schuler U,Platzbecker U,Freiberg-Richter J,Helwig A,Plettig R,Röllig C,Naumann R,Kroschinsky F,Neubauer A,Ehninger G

更新日期：2000-07-01 00:00:00

abstract：:Retrospective analysis of 206 patients undergoing 215 consecutive bone marrow transplants (BMT) at St Jude Children's Research Hospital between November 1990 and December 1994 identified 6% (seven male, six female) with adenovirus infection. The affected patients had a median age of 7.9 years (range 3-24 years) at tim...

journal_title：Bone marrow transplantation

authors： Hale GA,Heslop HE,Krance RA,Brenner MA,Jayawardene D,Srivastava DK,Patrick CC

更新日期：1999-02-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Bone marrow transplantation

authors： Moffet JR,Mahadeo KM,McArthur J,Hsing DD,Gertz SJ,Smith LS,Loomis A,Fitzgerald JC,Nitu ME,Duncan CN,Hall MW,Pinos EL,Tamburro RF,Simmons RA,Troy J,Cheifetz IM,Rowan CM,Investigators of the Pediatric Acute Lung Injury an

更新日期：2020-02-01 00:00:00

abstract：:Between December 1983 and November 1985 we treated 39 patients with chronic myeloid leukaemia by chemoradiotherapy and transplantation from HLA-identical sibling donors using bone marrow that had been depleted of T cells ex vivo with the rat monoclonal antibody Campath-1. Twenty-eight of the patients were in the chron...

journal_title：Bone marrow transplantation

authors： Apperley JF,Jones L,Hale G,Waldmann H,Hows J,Rombos Y,Tsatalas C,Marcus RE,Goolden AW,Gordon-Smith EC

更新日期：1986-05-01 00:00:00

abstract：:We initiated a randomized study of amifostine (the organic thiophosphate formerly known as WR-2721) given to patients during myeloablative conditioning therapy for allogeneic bone marrow transplantation. Amifostine was given at a dose of 1000 mg/day of conditioning and was well tolerated if attention was given to seru...

journal_title：Bone marrow transplantation

authors： Hwang WY,Koh LP,Ng HJ,Tan PH,Chuah CT,Fook SC,Chow H,Tan KW,Wong C,Tan CH,Goh YT

更新日期：2004-07-01 00:00:00

abstract：:We report long-term results of high-dose cyclophosphamide, etoposide and carboplatin with ABMT in 20 patients with metastatic breast cancer. Median age of the group was 41 years, ECOG performance status = 0 in 18 patients and 1 in two patients. Twelve patients had received adjuvant chemotherapy. Predominant sites of m...

journal_title：Bone marrow transplantation

authors： Baker WJ,Vukelja SJ,Burrell LM,Lee N,Perry JJ

更新日期：1998-04-01 00:00:00

abstract：:The bare lymphocyte syndrome is a combined immunodeficiency resulting from the lack of expression of either class I or class II HLA antigens at the cell surface. The main clinical manifestations are infections of the respiratory or the digestive tract. The immunodeficiency involves the absence of antibody formation an...

journal_title：Bone marrow transplantation

authors： Touraine JL,Marseglia GL,Betuel H,Souillet G,Gebuhrer L

更新日期：1992-01-01 00:00:00

abstract：:One or two cycles of high-dose chemotherapy with autologous hematopoietic stem cell transplantation have been shown to improve response rates and survival in myeloma. While this observation has largely been made in patients under the age of 65 years, there is evidence to suggest that the conclusions can be extrapolate...

journal_title：Bone marrow transplantation

authors： Mehta J,Singhal S

更新日期：2007-12-01 00:00:00

abstract：:In order to identify cytomegalovirus (CMV)-seropositive patients who are at risk of developing CMV infection following first allogeneic hematopoietic cell transplantation (allo-HCT), we built up a scoring system based on patient/donor characteristics and transplantation modalities. To this end, 3690 consecutive patien...

journal_title：Bone marrow transplantation

authors： Beauvais D,Drumez E,Blaise D,Peffault de Latour R,Forcade E,Ceballos P,Uyttebroeck A,Labussière H,Nguyen S,Bourhis JH,Chevallier P,Thiebaut A,Poiré X,Maury S,Deconinck E,Cluzeau T,Brissot E,Huynh A,Rubio MT,Duhamel

更新日期：2020-12-18 00:00:00

abstract：:A 6-year-old boy with the severe form of the leukocyte adhesion deficiency syndrome (LAD) received a transplant of cord blood (CBT) from his HLA-identical brother. The donor was proved healthy by successful prenatal diagnosis. CBT was performed after conditioning with etoposide, busulfan and cyclophosphamide. After he...

journal_title：Bone marrow transplantation

authors： Starý J,Bartůnková J,Kobylka P,Vávra V,Hrusák O,Calda P,Král V,Svorc K

更新日期：1996-07-01 00:00:00

abstract：:Knowledge of the vital role of adenosine deaminase in lymphatic tissues has led to the development of enzyme inhibitors for treatment of lymphoid neoplasms. Deoxycoformycin is a potent ADA inhibitor and has been shown to be active in acute lymphoblastic leukemia at high doses but associated with unpredictable toxicity...

journal_title：Bone marrow transplantation

authors： Ho AD,Thaler J,Willemze R,Lauria F,Derossi G,Kuse R,Stryckmans P,Blanc CM,Cataldo F,McVie G

更新日期：1989-01-01 00:00:00

abstract：:Detectable measurable residual disease (MRD) is a key prognostic factor in both acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) patients. Thus, we conducted a survey in EBMT transplant centers focusing on pre- and post-allo-HCT MRD. One hundred and six centers from 29 countries responded. One hundr...

journal_title：Bone marrow transplantation

authors： Nagler A,Baron F,Labopin M,Polge E,Esteve J,Bazarbachi A,Brissot E,Bug G,Ciceri F,Giebel S,Gilleece MH,Gorin NC,Lanza F,Peric Z,Ruggeri A,Sanz J,Savani BN,Schmid C,Shouval R,Spyridonidis A,Versluis J,Mohty M

更新日期：2021-01-01 00:00:00

abstract：:Oral mucositis is a major dose-limiting toxic effect of intensive cancer chemotherapy. Oral complications may lead to dose reduction or delay in further cancer treatment. Mucositis can be caused directly by cytotoxic effects and indirectly by sustained neutropenia after cytostatic therapy. An impaired mucosal barrier ...

journal_title：Bone marrow transplantation

authors： Karthaus M,Rosenthal C,Ganser A

更新日期：1999-11-01 00:00:00

abstract：:A potential problem of autologous transplantation in the treatment of multiple myeloma (MM) is the infusion of tumor cells. CD34+ selection has been used to purge autografts in MM and it is also possible to reduce tumour cell contamination of autografts by cytotoxic drug therapy prior to peripheral blood stem cell (PB...

journal_title：Bone marrow transplantation

authors： Dyson PG,Horvath N,Joshua D,Barrow L,Van Holst NG,Brown R,Gibson J,To LB

更新日期：2000-06-01 00:00:00

abstract：:Measles vaccination has been recommended after the second year following bone marrow transplant (BMT) in patients not receiving immunosuppressive drugs. During a measles outbreak, we vaccinated all patients after the first year of transplant, and conducted a prospective trial to evaluate safety, effectiveness and sust...

journal_title：Bone marrow transplantation

authors： Machado CM,de Souza VA,Sumita LM,da Rocha IF,Dulley FL,Pannuti CS

更新日期：2005-04-01 00:00:00

abstract：:We report the cases of two severe aplastic anemia (SAA) patients who were successfully treated with syngeneic peripheral blood stem cell transplantation (PBSCT) using immunosuppression without high-dose chemotherapy or irradiation for conditioning. A 21-year-old woman with SAA of 6 years duration had been transfused h...

journal_title：Bone marrow transplantation

authors： Hwang WL,Yang Y,Chen GR,Tsai CS,Jour JH

更新日期：2000-02-01 00:00:00

abstract：:Thirty-five patients with myelodysplastic syndromes (MDS) were treated with BMT between 1986 and 1994. Their median age was 41 years (range 23-60). Thirteen patients had transfusion-dependent refractory anaemia (RA). Twenty-two patients suffered from more advanced stages of MDS, 15 being in complete remission (CR) aft...

journal_title：Bone marrow transplantation

authors： Mattijssen V,Schattenberg A,Schaap N,Preijers F,De Witte T

更新日期：1997-04-01 00:00:00

abstract：:As a consequence of the significantly larger inoculum of lymphoid cells present in peripheral blood stem cell (PBSC) harvests compared to bone marrow (BM), it is possible that autoPBSCT recipients may have an earlier and*or enhanced response to vaccines. Until data to confirm this become available, the European Blood ...

journal_title：Bone marrow transplantation

authors： Gandhi MK,Egner W,Sizer L,Inman I,Zambon M,Craig JI,Marcus RE

更新日期：2001-10-01 00:00:00

abstract：:The incidence of bacteremia following hemopoietic SCT (HSCT) changes over time from the procedure. The first 30 days have the highest incidence, both in autologous and allogeneic HSCT recipients. In the following periods, bacteremia is a frequent complication in allogeneic HSCT, especially from alternative donors. Gra...

journal_title：Bone marrow transplantation

authors： Castagnola E,Faraci M,Moroni C,Bandettini R,Caruso S,Bagnasco F,Caviglia I,Natalizia AR,de Fazio V,Morreale G,Lanino E,Dini G,Haupt R

更新日期：2008-06-01 00:00:00

abstract：:Twenty successive adult patients with lymphoblastic lymphoma entered a study of sequential chemotherapy consisting of an intensive LSA2-L2-type protocol to induce first complete remission. Twelve patients in first CR (median age 22 years, range 15-43), after receiving a conditioning regimen consisting of cyclophospham...

journal_title：Bone marrow transplantation

authors： Santini G,Coser P,Chisesi T,Porcellini A,Sertoli R,Contu A,Congiu AM,Manna A,Rossi E,Scarpati D

更新日期：1989-07-01 00:00:00

abstract：:Pretransplant conditioning regimens designed to decrease leukemia relapse and increase leukemia-free survival in allotransplants in acute myelogenous leukemia (AML) were developed recently. We review studies of new regimens containing drugs like busulfan, cytarabine, melphalan or etoposide as well as novel radiation s...

journal_title：Bone marrow transplantation

authors： Aurer I,Gale RP

更新日期：1991-04-01 00:00:00

abstract：:Extracorporeal photopheresis (ECP) is beneficial in patients with T-cell-mediated disorders, including GvHD, but the underlying immunological mechanisms are incompletely understood. Myeloid-derived suppressor cells (MDSCs) are innate immune cells characterized by their capacity to suppress T-cell proliferation. We qua...

journal_title：Bone marrow transplantation

authors： Rieber N,Wecker I,Neri D,Fuchs K,Schäfer I,Brand A,Pfeiffer M,Lang P,Bethge W,Amon O,Handgretinger R,Hartl D

更新日期：2014-04-01 00:00:00

abstract：:A 12-year-old girl with Fanconi anaemia (FA) received a bone marrow transplant from her HLA-identical brother following conditioning with cyclophosphamide (20 mg/kg), thoraco-abdominal radiation (TAI) (4 Gy) and equine anti-thymocyte globulin (ATG) (90 mg/kg). Engraftment was delayed and initially tenuous, and was fol...

journal_title：Bone marrow transplantation

authors： Mital MK,Curtis A,Spencer V,Barge D,Skinner R

更新日期：1999-07-01 00:00:00

abstract：:The severe phenotype of leukocyte adhesion deficiency is a rare, congenital disorder of leukocyte function that is usually fatal in the first few years of life. Allogeneic hematopoietic stem cell transplantation currently offers the only curative approach for this disease. We describe the first successful matched unre...

journal_title：Bone marrow transplantation

authors： Mancias C,Infante AJ,Kamani NR

更新日期：1999-12-01 00:00:00

abstract：:HLA-DP typing is not routinely performed before allogeneic BMT. This highly polymorphic class II locus is implicated in immune response and DP molecules may act as transplantation antigens. HLA-DP incompatibilities contribute to MCL. In BMT performed between siblings, HLA-DP mismatches are rare and the role of such in...

journal_title：Bone marrow transplantation

authors： Moreau P,Cesbron A

更新日期：1994-06-01 00:00:00