Abstract:
Background & Objective:Catalase (CAT) is an important endogenous antioxidant enzyme that detoxifies H2O2 into water and oxygen, consequently limiting the deleterious effects of reactive oxygen species. It has suggested that CAT-21A/T (rs7943316) OMIM: 115500 gene promoter polymorphism is predominantly associated with different human disorders such as hypertension, cancers, diabetes, nephropathy, and other diseases accompanied by oxidative stress. This study was designed to investigate the prevalence of mutant T allele frequency in healthy individuals. Methods:The study group consisted of 110 healthy individuals were enrolled from Baqai Institute of Diabetology and Endocrinology (BIDE), Karachi, Pakistan, during the period of April 2010 to May 2013. DNA was isolated from leukocytes. Genotyping of CAT-21A/T (rs7943316) gene promoter polymorphism was carried out using thermal cycler followed by RFLP. Blast N analysis was performed for the confirmation of gene sequences. Results:In CAT-21A/T (rs7943316) gene promoter polymorphism, wild type genotype (AA) was observed in 18.26% and alterered genotype (AT/TT) found in 81.74% cases. Conclusions:Data demonstrates that frequency and distribution of mutant T allele was more prevalent as compared to wild type A allele in the study group.
journal_name
Pak J Med Scijournal_title
Pakistan journal of medical sciencesauthors
Nawab SN,Zehra S,Fawwad A,Azhar Adoi
10.12669/pjms.336.13188subject
Has Abstractpub_date
2017-11-01 00:00:00pages
1521-1524issue
6eissn
1682-024Xissn
1681-715Xpii
PJMS-33-1521journal_volume
33pub_type
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