Abstract：
:In this study we longitudinally investigated the rate of microstructural alterations in the occipital cortex in different stages of Huntington's disease (HD) by applying an automated atlas-based approach to diffusion MRI data. Twenty-two premanifest (preHD), 10 early manifest HD (early HD) and 24 healthy control subjects completed baseline and two year follow-up scans. The preHD group was stratified based on the predicted years to disease onset into a far (preHD-A) and near (preHD-B) to disease onset group. Clinical and behavioral measures were collected per assessment time point. An automated atlas-based DTI analysis approach was used to obtain the mean, axial and radial diffusivities of the occipital cortex. We found that the longitudinal rate of diffusivity change in the superior occipital gyrus (SOG), middle occipital gyrus (MOG), and inferior occipital gyrus (IOG) was significantly higher in early HD compared to both preHD and controls (all p's ≤ 0.005), which can be interpreted as an increased rate of microstructural degeneration. Furthermore, the change rate in the diffusivity of the MOG could significantly discriminate between preHD-B compared to preHD-A and the other groups (all p's ≤ 0.04). Finally, we found an inverse correlation between the Stroop Word Reading task and diffusivities in the SOG and MOG (all p's ≤ 0.01). These findings suggest that measures obtained from the occipital cortex can serve as sensitive longitudinal biomarkers for disease progression in preHD-B and early HD. These could in turn be used to assess potential effects of proposed disease modifying therapies.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Odish OFF,Reijntjes RHAM,van den Bogaard SJA,Roos RAC,Leemans Adoi
10.1007/s11682-018-9849-5subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1786-1794issue
6eissn
1931-7557issn
1931-7565pii
10.1007/s11682-018-9849-5journal_volume
12pub_type
杂志文章abstract：:The neuroimaging literature in moral cognition has rapidly developed in the last decade with more than 200 publications on the topic. Neuroimaging based models generally agree that limbic regions work with medial prefrontal and temporal regions during moral processing to integrate emotional, social, and cognitive elem...
journal_title：Brain imaging and behavior
pub_type： 杂志文章,meta分析
doi：10.1007/s11682-019-00035-5
更新日期：2020-04-01 00:00:00
abstract：:Working memory (WM) training improves WM ability in Attention-Deficit/Hyperactivity Disorder (ADHD), but its efficacy for non-cognitive ADHD impairments ADHD has been sharply debated. The purpose of this preliminary study was to characterize WM training-related changes in ADHD brain function and see if they were linke...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-015-9416-2
更新日期：2016-06-01 00:00:00
abstract：:We examined whether abnormal volumes of several brain regions as well as their mutual associations that have been observed in patients with schizophrenia, are also present in individuals at clinical high-risk (CHR) for developing psychosis. 3T magnetic resonance imaging was acquired in 19 CHR and 20 age- and handednes...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-017-9758-z
更新日期：2018-08-01 00:00:00
abstract：:Although an increasing number of studies has explored the neural mechanisms of auditory verbal hallucination (AVH) using many modalities, including neuroimaging, neurotransmitters, and electroencephalography, the etiology of AVH remains unclear. In this study, we investigated the neuroimaging characteristics of AVH in...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-019-00222-4
更新日期：2020-12-01 00:00:00
abstract：:Several behavioral and neuroimaging markers could be used to predict eventual antidepressant medication (ADM) outcomes in patients with major depressive disorder (MDD). However, these predictors are either subjective or complex, which has limited their clinical use. Thus, we aimed to identify an objective and easy-to-...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-018-9845-9
更新日期：2018-12-01 00:00:00
abstract：:Prenatal alcohol exposure leads to alterations in cognition, behavior and underlying brain architecture. However, prior studies have not integrated structural and functional imaging data in children with prenatal alcohol exposure. The aim of this study was to characterize disruptions in both structural and functional ...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-020-00277-8
更新日期：2020-04-18 00:00:00
abstract：:The cerebellum is known to influence cerebral cortical activity via cerebello-thalamo-cortical (CTC) circuits and thereby may be implicated in the pathophysiology of multiple system atrophy (MSA). As the aim of this study, we investigated the abnormalities of corticocerebellar functional connectivity (FC) in patients ...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-019-00097-5
更新日期：2019-12-01 00:00:00
abstract：:Clinical neuropsychology lacks tests of basic visuoperceptual and spatial skills that have well-controlled administration and sophisticated measurement methods. Items from the Visual Assessment Battery (VAB), a simultaneous match-to-sample task, assessed visual discrimination in 40 healthy adults aged 51-91 during fMR...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-020-00301-x
更新日期：2020-07-25 00:00:00
abstract：:Cumulative evidence suggests the existence of common processes underlying subjective experience of cognitive and physical fatigue. However, mechanistic understanding of the brain structural connections underlying the experience of fatigue in general, without the influence of clinical conditions, is limited. The purpos...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-019-00201-9
更新日期：2020-12-01 00:00:00
abstract：:Levodopa therapy is widely recognized as an effective treatment for PD patients, however, it is rare of the study looking at effects of levodopa therapy on the whole-brain network. This study was to evaluate the effects of levodopa on whole-brain degree centrality (DC) and seed-based functional connectivity (FC) in PD...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-018-9936-7
更新日期：2019-10-01 00:00:00
abstract：:Reading disorder (RD) is characterized by deficient phonological processing, but children with RD also have cognitive control deficits, the neural correlates of which are not fully understood. We used fMRI to assess neural activity during the resolution of cognitive conflict on the Simon Spatial Incompatibility task a...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-019-00083-x
更新日期：2020-10-01 00:00:00
abstract：:Abnormalities in brain white matter (WM) structure have been reported in youths having a family history of substance use disorders (SUDs). It was hypothesized that these abnormalities constitute features of the liability for SUDs transmitted across generations. The association between severity of intergenerational ris...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-017-9679-x
更新日期：2018-02-01 00:00:00
abstract：:The ability to suppress responses that are inappropriate, as well as the mechanisms monitoring the accuracy of actions in order to compensate for errors, is central to human behavior. Neural alterations that prevent stopping an inaccurate response, combined with a decreased ability of error monitoring, are considered ...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-016-9654-y
更新日期：2017-12-01 00:00:00
abstract：:Three to 6 months after an acute coronary syndrome (ACS), cognitive impairment is observed in more than 30 % of the patients, mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of executive dysfunction. Thirty-three patients were recr...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-015-9483-4
更新日期：2016-09-01 00:00:00
abstract：:Negative urgency, defined as a tendency to act rashly under extreme negative emotion, is strongly associated with tobacco use. Despite the robust evidence linking negative urgency and tobacco use and accumulating evidence suggesting that localized, segregated brain regions such as the nucleus accumbens (NAcc), insula,...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-019-00136-1
更新日期：2020-10-01 00:00:00
abstract：:The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium brings together researchers from around the world to try to identify the genetic underpinnings of brain structure and function, along with robust, generalizable effects of neurological and psychiatric disorders. The recently-formed ENIGMA Br...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-021-00450-7
更新日期：2021-01-27 00:00:00
abstract：:Chronic Traumatic Encephalopathy (CTE) is a neurodegenerative disease thought to be caused, at least in part, by repetitive brain trauma, including concussive and subconcussive injuries. It is thought to result in executive dysfunction, memory impairment, depression and suicidality, apathy, poor impulse control, and e...
journal_title：Brain imaging and behavior
pub_type： 杂志文章,评审
doi：10.1007/s11682-012-9164-5
更新日期：2012-06-01 00:00:00
abstract：:Dementia with Lewy bodies (DLB) is often associated with occipital hypometabolism or hypoperfusion, as well as deficits in cholinergic neurotransmission. In this study, 11 mild DLB, 16 mild AD and 16 age-matched controls underwent arterial spin-labeled perfusion MRI (ASL-pMRI) and neuropsychological testing. Patterns ...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-010-9108-x
更新日期：2011-03-01 00:00:00
abstract：:Joint analysis of genetic and neuroimaging data, known as Imaging Genetics (IG), offers an opportunity to deepen our knowledge of the biological mechanisms of neurodevelopmental domains. There has been exponential growth in the literature on IG studies, which challenges the standardization of analysis methods in this ...
journal_title：Brain imaging and behavior
pub_type： 杂志文章,评审
doi：10.1007/s11682-016-9663-x
更新日期：2017-12-01 00:00:00
abstract：:The association between gray matter (GM) density and neurophysiologic changes is still unclear in amyotrophic lateral sclerosis (ALS). We evaluated the relationship between GM density and motor system integrity combining voxel-based morphometry (VBM) and transcranial magnetic stimulation (TMS) in ALS. We included 17 A...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-018-9841-0
更新日期：2018-12-01 00:00:00
abstract：:The level and richness of consciousness depend on information integration in the brain. Altered interregional functional interactions may indicate disrupted information integration during anesthetic-induced unconsciousness. How anesthetics modulate the amount of information in various brain regions has received less a...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-018-9886-0
更新日期：2019-04-01 00:00:00
abstract：:Neuroscientific and psychological research posits that there are two transdiagnostic facets of anxiety: anxious arousal and anxious apprehension. Though these two facets of anxiety are distinct, they are often subsumed into one domain (e.g., trait anxiety). The primary goal of the current study was to delineate the re...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-017-9772-1
更新日期：2018-08-01 00:00:00
abstract：:Genome-wide association studies (GWAS) opened new horizons in genomics and medicine by discovering novel genetic factors in numerous health conditions. The analogous analysis of the correlations of large quantities of psychological and brain imaging measures may yield similarly striking results in the brain science. S...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-018-9937-6
更新日期：2019-10-01 00:00:00
abstract：:D-amphetamine (dAMPH) and methylphenidate (MPH) are stimulants used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Preclinical studies have shown that in healthy animals, dAMPH induces dopamine (DA) dysfunction, as evidenced for instance by loss of DA levels and its transporters. It has also been...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-014-9350-8
更新日期：2015-12-01 00:00:00
abstract：:How and when the known genetic risk allele, apolipoprotein E-epsilon4 (APOEepsilon4), confers risk to Alzheimer's disease has yet to be determined. We studied older adults and found that APOEepsilon4 carriers had greater neural activation in the medial frontal and parahippocampal gyrus during a memory task (cluster-co...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-010-9097-9
更新日期：2010-06-01 00:00:00
abstract：:Recent evidence from neurophysiological and functional imaging research has demonstrated that semantically congruent sounds can modulate the identification of a degraded visual object. However, it remains unclear how different integration regions interact with each other when only a visual object was obscured. The pre...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-019-00134-3
更新日期：2020-08-01 00:00:00
abstract：:Classification of individuals based on patterns of brain activity observed in functional MRI contrasts may be helpful for diagnosis of neurological disorders. Prior work for classification based on these patterns have primarily focused on using a single contrast, which does not take advantage of complementary informat...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-014-9292-1
更新日期：2015-06-01 00:00:00
abstract：:Protracted abstinence (PA) and Methadone maintenance treatment (MMT) are two main types of heroin addiction treatment, however, the effects of both measures on the functional connectivity (FC) of the brain in heroin dependents in the drug cue event-related response are unclear. Functional magnetic resonance imaging (f...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-020-00447-8
更新日期：2021-01-27 00:00:00
abstract：:The neurobiological mechanisms that underlie facial affect recognition deficits after traumatic brain injury (TBI) have not yet been identified. Using functional magnetic resonance imaging (fMRI), study aims were to 1) determine if there are differences in brain activation during facial affect processing in people wit...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-015-9415-3
更新日期：2016-06-01 00:00:00
abstract：:Genetic variation in the kidney and brain expressed protein (KIBRA) rs17070145 gene has been linked to episodic memory and cognitive aging; yet, the neural mechanism underlying this association remains to be fully understood. Using the magnetic resonance imaging (MRI) technique, this study investigated the effect of K...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-019-00047-1
更新日期：2020-10-01 00:00:00
