Effect of T1-mapping technique and diminished image resolution on quantification of infarct mass and its ability in predicting appropriate ICD therapy.

Abstract:

PURPOSE:Myocardial infarct (MI) may consist of an infarct core (IC) and a heterogeneous, semi-viable border zone (BZ). Patients with chronic MI in the left ventricular (LV) myocardium are at increased risk of developing ventricular arrhythmias, and may therefore qualify for implantable cardioverter defibrillator (ICD) therapy. Indices based on MI mass, as determined by cardiac magnetic resonance (CMR) imaging, are shown to be sensitive in predicting adverse ventricular arrhythmic events. However, several factors, such as imaging technique and spatial resolution affect the accuracy of MI mass quantification. The aim of this study was to compare the MI masses determined by T1-mapping CMR techniques to those of conventional late Gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) using inversion recovery fast gradient echo (IR-FGRE). We additionally aimed to investigate the effect of diminishing image resolution on quantification of the MI mass and its ability to predict appropriate ICD therapy. METHODS:Thirty-eight patients with known MI underwent acquisitions of three CMR imaging techniques: the multicontrast late enhancement (MCLE) and modified look-locker inversion recovery (MOLLI) T1-mapping techniques, and conventional inversion recovery fast gradient echo (IR-FGRE) about 20 min after double-dose injection of Gadolinium. We postprocessed images to quantify IC and BZ masses determined by each CMR technique using a full-width half-maximum (FWHM) approach in IR-FGRE images and a fuzzy c-means clustering algorithm for T1-mapping images. To determine the impact of spatial resolution in sensitivity of predicting ICD events, we artificially diminished resolution of MCLE images acquired from a separate group of 27 patients who had been followed up for ICD therapy and compared the MI masses estimated from the original and downsampled MCLE images. RESULTS:Twelve patients out of 27 (44%) received ICD therapy (i.e., one or more delivered shock) during the follow-up stage. Between each of the three imaging methods, IC masses were not significantly different. Conversely, BZ masses determined by MOLLI were larger compared to those determined by MCLE and IR-FGRE (P value = 0.0022 and 0.0003, respectively). The BZ masses determined by MCLE were not significantly different from those determined by IR-FGRE; however, BZ masses determined by the downsampled MCLE were significantly larger than those determined by IR-FGRE and original MCLE (P value = 0.0033 and 0.0003, respectively). The BZ mass estimated by original MCLE was larger in patients who had received ICD therapy compared to those who did not (P value = 0.044). However, when the spatial resolution of the MCLE images was diminished to that of MOLLI, BZ masses were not significantly different between patients with and without ICD therapy. CONCLUSIONS:While estimated IC masses were consistent among all three techniques, the estimated BZ masses were not consistent, especially when spatial resolution of images differed between the techniques. In particular, our study showed that diminished image resolution caused an increase in estimation of the BZ mass, likely due to partial volume effects, which led to a reduced sensitivity in the prediction of appropriate ICD therapy.

journal_name

Med Phys

journal_title

Medical physics

authors

Farrag NA,Ramanan V,Wright GA,Ukwatta E

doi

10.1002/mp.12840

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

1577-1585

issue

4

eissn

0094-2405

issn

2473-4209

journal_volume

45

pub_type

杂志文章
  • Optimization of power deposition and a heating strategy for external ultrasound thermal therapy.

    abstract::The purpose of this paper is to examine the thermal dose distribution, to configure the optimal absorbed power deposition, and to design an appropriate heating strategy for ultrasound thermal therapy. This work employs simulation programs, which are based on the transient bio-heat transfer equation and an ideal absorb...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1406516

    authors: Lin WL,Liang TC,Yen JY,Liu HL,Chen YY

    更新日期:2001-10-01 00:00:00

  • Mineralization in calcified plaque is like that of cortical bone--further evidence from ultrashort echo time (UTE) magnetic resonance imaging of carotid plaque calcification and cortical bone.

    abstract:PURPOSE:This study aims to investigate carotid plaque calcification (CPC) using two-dimensional (2D) and 3D ultrashort echo time (UTE) magnetic resonance imaging (MRI) sequences and compare T1, T2*, water concentration, and bone mineral density (BMD) of CPC with those of cortical bone. METHODS:Twelve carotid plaque sp...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4819944

    authors: Du J,Peterson M,Kansal N,Bydder GM,Kahn A

    更新日期:2013-10-01 00:00:00

  • An experimentally validated couch and MLC tracking simulator used to investigate hybrid couch-MLC tracking.

    abstract:PURPOSE/OBJECTIVE:Couch and MLC tracking are two novel techniques to mitigate intrafractional tumor motion on a conventional linear accelerator, but both techniques still have residual dosimetric errors. Here, we first propose and experimentally validate a software tool to simulate couch and MLC tracking, and then use ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.12104

    authors: Toftegaard J,Hansen R,Ravkilde T,Macek K,Poulsen PR

    更新日期:2017-03-01 00:00:00

  • Lung morphometry using hyperpolarized 129 Xe multi-b diffusion MRI with compressed sensing in healthy subjects and patients with COPD.

    abstract:PURPOSE:To demonstrate the feasibility of compressed sensing (CS) to accelerate the acquisition of hyperpolarized (HP) 129 Xe multi-b diffusion MRI for quantitative assessments of lung microstructural morphometry. METHODS:Six healthy subjects and six chronic obstructive pulmonary disease (COPD) subjects underwent HP 1...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.12944

    authors: Zhang H,Xie J,Xiao S,Zhao X,Zhang M,Shi L,Wang K,Wu G,Sun X,Ye C,Zhou X

    更新日期:2018-07-01 00:00:00

  • Novel methods of measuring single scan dose profiles and cumulative dose in CT.

    abstract::Computed tomography dose index (CTDI) is a conventional indicator of the patient dose in CT studies. It is measured as the integration of the longitudinal single scan dose profile (SSDP) by using a 100-mm-long pencil ionization chamber and a single axial scan. However, the assumption that most of the SSDP is contained...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1835571

    authors: Nakonechny KD,Fallone BG,Rathee S

    更新日期:2005-01-01 00:00:00

  • Iodine quantification in limited angle tomography.

    abstract:PURPOSE:To develop and test the feasibility of a two-pass iterative reconstruction algorithm with material decomposition designed to obtain quantitative iodine measurements in digital breast tomosynthesis. METHODS:Contrast-enhanced mammography has shown promise as a cost-effective alternative to magnetic resonance ima...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.14400

    authors: Michielsen K,Rodríguez-Ruiz A,Reiser I,Nagy JG,Sechopoulos I

    更新日期:2020-10-01 00:00:00

  • Metal artifact correction for x-ray computed tomography using kV and selective MV imaging.

    abstract:PURPOSE:The overall goal of this work is to improve the computed tomography (CT) image quality for patients with metal implants or fillings by completing the missing kilovoltage (kV) projection data with selectively acquired megavoltage (MV) data that do not suffer from photon starvation. When both of these imaging sys...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4901551

    authors: Wu M,Keil A,Constantin D,Star-Lack J,Zhu L,Fahrig R

    更新日期:2014-12-01 00:00:00

  • Design for an accelerator-based orthogonal epithermal neutron beam for boron neutron capture therapy.

    abstract::This paper is concerned with the proposed Birmingham accelerator-based epithermal neutron beam for boron neutron capture therapy (BNCT). In particular, the option of producing a therapy beam at an orthogonal direction to the incoming protons is considered. Monte Carlo radiation transport simulations, both with and wit...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.598479

    authors: Allen DA,Beynon TD,Green S

    更新日期:1999-01-01 00:00:00

  • Fast contour propagation for MR-guided prostate radiotherapy using convolutional neural networks.

    abstract:PURPOSE:To quickly and automatically propagate organ contours from pretreatment to fraction images in magnetic resonance (MR)-guided prostate external-beam radiotherapy. METHODS:Five prostate cancer patients underwent 20 fractions of image-guided external-beam radiotherapy on a 1.5 T MR-Linac system. For each patient,...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.13994

    authors: Eppenhof KAJ,Maspero M,Savenije MHF,de Boer JCJ,van der Voort van Zyp JRN,Raaymakers BW,Raaijmakers AJE,Veta M,van den Berg CAT,Pluim JPW

    更新日期:2020-03-01 00:00:00

  • The use of modified single pencil beam dose kernels to improve IMRT dose calculation accuracy.

    abstract::Intensity modulated radiation therapy (IMRT) is used to deliver highly conformal radiation doses to tumors while sparing nearby sensitive tissues. Discrepancies between calculated and measured dose distributions have been reported for regions of high dose gradients corresponding to complex radiation fluence patterns. ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1812851

    authors: Bergman AM,Otto K,Duzenli C

    更新日期:2004-12-01 00:00:00

  • Correcting magnetic resonance k-space data for in-plane motion using an optical position tracking system.

    abstract:PURPOSE:Motion is a major confound of image quality in MRI. A method of retrospectively correcting the effects of rotations and translations on the acquired k-space data is presented. METHODS:In two phantom experiments of well-controlled translation and rotation, two MRI-compatible infrared cameras recorded motion dat...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3254189

    authors: Marxen M,Marmurek J,Baker N,Graham SJ

    更新日期:2009-12-01 00:00:00

  • Poster - Thur Eve - 77: Coordinate transformation from DICOM to DOSXYZnrc.

    abstract::DICOM format is the de facto standard for communications between therapeutic and diagnostic modalities. A plan generated by a treatment planning system (TPS) is often exported to DICOM format. BEAMnrc/DOSXYZnrc is a widely used Monte Carlo (MC) package for beam and dose simulations in radiotherapy. It has its own defi...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4740186

    authors: Zhan L,Jiang R,Osei EK

    更新日期:2012-07-01 00:00:00

  • Proliferative diabetic retinopathy characterization based on fractal features: Evaluation on a publicly available dataset.

    abstract:PURPOSE:Diabetic retinopathy (DR) is one of the most widespread causes of preventable blindness in the world. The most dangerous stage of this condition is proliferative DR (PDR), in which the risk of vision loss is high and treatments are less effective. Fractal features of the retinal vasculature have been previously...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.12627

    authors: Orlando JI,van Keer K,Barbosa Breda J,Manterola HL,Blaschko MB,Clausse A

    更新日期:2017-12-01 00:00:00

  • A Laplace transform pair model for spectral reconstruction.

    abstract::A four-parameter Laplace transform pair model, which accurately reconstructs an experimental bremsstrahlung spectrum from attenuation data, is presented. Computed spectral values with both aluminum and copper attenuators generally agree with experimental 70-kVp data to better than 2%. Reconstructed spectra at other kV...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.595193

    authors: Archer BR,Wagner LK

    更新日期:1982-11-01 00:00:00

  • The generalized geometry of eye plaque therapy.

    abstract::A calculation is described that enables the rapid assessment of dose rate at various points of interest within the eye (lens, optic nerve, etc.) for the treatment of choroidal melanoma by plaque therapy. 125I seeds are used as the radiation source. The location of the plaque and its associated seeds relative to the ey...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.596234

    authors: Kepka AG,Johnson PM,Kline RW

    更新日期:1988-05-01 00:00:00

  • Correcting and reweighting false label masks in brain tumor segmentation.

    abstract:PURPOSE:Recently, brain tumor segmentation has made important progress. However, the quality of manual labels plays an important role in the performance, while in practice, it could vary greatly and in turn could substantially mislead the learning process and decrease the accuracy. We need to design a mechanism to comb...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.14480

    authors: Cheng G,Ji H,He L

    更新日期:2020-09-24 00:00:00

  • Calculation of the radiological depth.

    abstract::The concept of the radiological depth is central to all algorithms which calculate radiation dose in a heterogeneous medium. For a discrete heterogeneous medium, consisting of regions of inhomogeneity, the radiological depth is usually presented as the sum over segments of the product of the segment length and the inh...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.595739

    authors: Siddon RL

    更新日期:1985-01-01 00:00:00

  • Intensity inhomogeneity correction for magnetic resonance imaging of human brain at 7T.

    abstract:PURPOSE:To evaluate the performance and efficacy for intensity inhomogeneity correction of various sequences of the human brain in 7T MRI using the extended version of the unified segmentation algorithm. MATERIALS:Ten healthy volunteers were scanned with four different sequences (2D spin echo [SE], 3D fast SE, 2D fast...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4860954

    authors: Uwano I,Kudo K,Yamashita F,Goodwin J,Higuchi S,Ito K,Harada T,Ogawa A,Sasaki M

    更新日期:2014-02-01 00:00:00

  • Spatial and temporal performance of 3D optical surface imaging for real-time head position tracking.

    abstract:PURPOSE:The spatial and temporal tracking performance of a commercially available 3D optical surface imaging system is evaluated for its potential use in frameless stereotactic radiosurgery head tracking applications. METHODS:Both 3D surface and infrared (IR) marker tracking were performed simultaneously on a head pha...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4823757

    authors: Wiersma RD,Tomarken SL,Grelewicz Z,Belcher AH,Kang H

    更新日期:2013-11-01 00:00:00

  • Simultaneous super-resolution and contrast synthesis of routine clinical magnetic resonance images of the knee for improving automatic segmentation of joint cartilage: data from the Osteoarthritis Initiative.

    abstract:PURPOSE:High resolution three-dimensional (3D) magnetic resonance (MR) images are well suited for automated cartilage segmentation in the human knee joint. However, volumetric scans such as 3D Double-Echo Steady-State (DESS) images are not routinely acquired in clinical practice which limits opportunities for reliable ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.14421

    authors: Neubert A,Bourgeat P,Wood J,Engstrom C,Chandra SS,Crozier S,Fripp J

    更新日期:2020-10-01 00:00:00

  • Noninvasive eye localization in ocular proton therapy through optical eye tracking: A proof of concept.

    abstract:PURPOSE:Over the last four decades, Ocular Proton Therapy has been successfully used to treat patients affected by intraocular lesions. For this, treatment geometry verification is routinely performed using radiographic images to align a configuration of fiducial radiopaque markers implanted on the sclera outer surface...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.12841

    authors: Via R,Hennings F,Fattori G,Fassi A,Pica A,Lomax A,Weber DC,Baroni G,Hrbacek J

    更新日期:2018-05-01 00:00:00

  • Monte Carlo and experimental dosimetry of an 1251 brachytherapy seed.

    abstract::We have performed a comprehensive dosimetric characterization of the Oncura model 6711 125I seed using both experimental [LiF thermoluminscent dosimetry (TLD)] and theoretical (Monte Carlo photon transport) methods. In addition to determining the dosimetric parameters of the 6711, this report quantified: (1) the angul...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2388158

    authors: Dolan J,Lia Z,Williamson JF

    更新日期:2006-12-01 00:00:00

  • Resolution of pinhole collimators used with gamma cameras.

    abstract::The line spread function (LSF) of an imaging system incorporating a pinhole of 0.275 cm radius and a scintillation camera has been measured and its full width at half maximum (FWHM) compared to the values predicted by an expression based on the resolution index of Anger. In most cases, the actual resolution of the sys...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.594755

    authors: Goulet P,Joy ML

    更新日期:1980-09-01 00:00:00

  • Minimizing image noise in on-board CT reconstruction using both kilovoltage and megavoltage beam projections.

    abstract::We studied a recently proposed aggregated CT reconstruction technique which combines the complementary advantages of kilovoltage (kV) and megavoltage (MV) x-ray imaging. Various phantoms were imaged to study the effects of beam orientations and geometry of the imaging object on image quality of reconstructed CT. It wa...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2768862

    authors: Zhang J,Yin FF

    更新日期:2007-09-01 00:00:00

  • Ultrafast treatment plan optimization for volumetric modulated arc therapy (VMAT).

    abstract:PURPOSE:To develop a novel aperture-based algorithm for volumetric modulated are therapy (VMAT) treatment plan optimization with high quality and high efficiency. METHODS:The VMAT optimization problem is formulated as a large-scale convex programming problem solved by a column generation approach. The authors consider...

    journal_title:Medical physics

    pub_type: 信件

    doi:10.1118/1.3491675

    authors: Men C,Romeijn HE,Jia X,Jiang SB

    更新日期:2010-11-01 00:00:00

  • A methodology to determine margins by EPID measurements of patient setup variation and motion as applied to immobilization devices.

    abstract::Assessment of clinic and site specific margins are essential for the effective use of three-dimensional and intensity modulated radiation therapy. An electronic portal imaging device (EPID) based methodology is introduced which allows individual and population based CTV-to-PTV margins to be determined and compared wit...

    journal_title:Medical physics

    pub_type: 临床试验,杂志文章

    doi:10.1118/1.1800712

    authors: Prisciandaro JI,Frechette CM,Herman MG,Brown PD,Garces YI,Foote RL

    更新日期:2004-11-01 00:00:00

  • SU-E-T-203: Development of a QA Software Tool for Automatic Verification of Plan Data Transfer and Delivery.

    abstract:PURPOSE:Consistency verification between the data from treatment planning system (TPS), record and verification system (R&V), and delivered recorder with visual inspection is time consuming and subject to human error. The purpose of this work is to develop a software tool to automatically perform such verifications. M...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4735263

    authors: Chen G,Li X

    更新日期:2012-06-01 00:00:00

  • Best estimate of luminal cross-sectional area of coronary arteries from angiograms.

    abstract::We have reexamined the problem of estimating the luminal area of an elliptically shaped coronary artery cross section from two or more radiographic diameter measurements. The expected error is found to be much smaller than the maximum potential error. In the cases of two orthogonal views, closed form expressions have ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.596296

    authors: Lee PL,Selzer RH

    更新日期:1988-07-01 00:00:00

  • Effect of beam number on organ-at-risk sparing in dynamic multileaf collimator delivery of intensity modulated radiation therapy.

    abstract::Due to practical limitations such as inter- and intraleaf transmission, nondivergent leaf end design, and leaf scatter, multileaf collimators (MLCs) are unable to accurately produce the ideal fluence patterns generated by inverse planning systems. Consequently, low dose regions receive substantially more radiation tha...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2779862

    authors: Popple RA,Fiveash JB,Brezovich IA

    更新日期:2007-10-01 00:00:00

  • Carpal tunnel syndrome diagnosis by a self-normalization process and ultrasound compound imaging.

    abstract:PURPOSE:Carpal tunnel syndrome (CTS) is the common entrapment neuropathy that occurs due to compression of the median nerve at the wrist. Ultrasound images have been used to highlight anatomical variants of the median nerve, and CTS is thought to be associated to enlargement of the cross-sectional area (CSA) of the med...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4767754

    authors: Liao YY,Wu CC,Kuo TT,Chen JP,Hsu YW,Yeh CK

    更新日期:2012-12-01 00:00:00