Tumor Volume Changes During and After Temozolomide Treatment for Newly Diagnosed Higher-Grade Glioma (III and IV).

Abstract:

BACKGROUND:A standard post-concomitant radiochemotherapy involving adjuvant temozolomide (TMZ) was stopped after 6 cycles for high-grade gliomas (HGG). Several studies demonstrated that prolonged TMZ treatment increased survival for these patients. METHODS:This retrospective study aimed to compare changes in tumor volume during and after adjuvant TMZ treatment and overall survival (OS). RESULTS:There were 90 patients were administered adjuvant TMZ treatment. Comparing average tumor volume changes during TMZ treatment and after TMZ was stopped, a significant decrease in tumor volume was observed during TMZ treatment in the total patient population, the anaplastic astrocytoma (AA) group, and the glioblastoma multiforme (GBM) group (P ≤ 0.001, P = 0.042, and P = 0.005, respectively). Median overall survival was 78.4 weeks, which was significant regarding the surgical tumor resection rate (r = 0.241; P = 0.04) and total TMZ treatment cycles (r = 0.631; P ≤ 0.001). CONCLUSIONS:During adjuvant TMZ treatment, tumor volume decreased significantly (P = 0.042, and P = 0.005, respectively) in patients with GBM and AA. Prolonged TMZ administration improved OS, without increased toxicity.

journal_name

World Neurosurg

journal_title

World neurosurgery

authors

Wang HC,Lin YT,Lin WC,Ho RW,Lin YJ,Tsai NW,Ho JT,Lu CH

doi

10.1016/j.wneu.2018.03.078

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

e766-e774

eissn

1878-8750

issn

1878-8769

pii

S1878-8750(18)30556-4

journal_volume

114

pub_type

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