High resolution propagation-based imaging system for in vivo dynamic computed tomography of lungs in small animals.

abstract：:Sparse-view CT reconstruction algorithms via total variation (TV) optimize the data iteratively on the basis of a noise- and artifact-reducing model, resulting in significant radiation dose reduction while maintaining image quality. However, the piecewise constant assumption of TV minimization often leads to the appea...

journal_title：Physics in medicine and biology

authors： Niu S,Gao Y,Bian Z,Huang J,Chen W,Yu G,Liang Z,Ma J

更新日期：2014-06-21 00:00:00

abstract：:All radiation therapy treatment planning relies on accurate dose calculation. Uncertainties in dosimetric prediction can significantly degrade an otherwise optimal plan. In this work, we introduce a robust optimization method which handles dosimetric errors and warrants for high-quality IMRT plans. Unlike other dose e...

journal_title：Physics in medicine and biology

authors： Nohadani O,Seco J,Martin BC,Bortfeld T

更新日期：2009-06-07 00:00:00

abstract：:Although field area and object thickness are important parameters in comparisons of techniques for optimal reduction of scattered radiation to the image, they are in practice seldom varied. For this reason, we suggest that contrast degradation (CDF) and contrast improvement (CIF) factors be more frequently used and ap...

journal_title：Physics in medicine and biology

authors： Carlsson GA,Carlsson CA,Nielsen B,Persliden J

更新日期：1986-07-01 00:00:00

abstract：:The aim of this study was to systematically investigate the influence of the inter- and intra-observer segmentation variation of tumors and organs at risk on the simulated temperature coverage of the target. CT scans of six patients with tumors in the pelvic region acquired for radiotherapy treatment planning were use...

journal_title：Physics in medicine and biology

authors： Aklan B,Hartmann J,Zink D,Siavooshhaghighi H,Merten R,Putz F,Ott O,Fietkau R,Bert C

更新日期：2017-05-08 00:00:00

abstract：:Intraoperative x-ray radiography/fluoroscopy is commonly used to assess the placement of surgical devices in the operating room (e.g. spine pedicle screws), but qualitative interpretation can fail to reliably detect suboptimal delivery and/or breach of adjacent critical structures. We present a 3D-2D image registratio...

journal_title：Physics in medicine and biology

authors： Uneri A,De Silva T,Goerres J,Jacobson MW,Ketcha MD,Reaungamornrat S,Kleinszig G,Vogt S,Khanna AJ,Osgood GM,Wolinsky JP,Siewerdsen JH

更新日期：2017-04-21 00:00:00

abstract：:Several methods of flip angle mapping for magnetic resonance imaging have been proposed. We evaluated the accuracy of five methods of flip angle measurement in the presence of measurement noise. Our analysis was performed in a closed form by propagation of probability density functions (PDFs). The flip angle mapping m...

journal_title：Physics in medicine and biology

authors： Morrell GR,Schabel MC

更新日期：2010-10-21 00:00:00

abstract：:In fully three-dimensional PET imaging, iterative image reconstruction techniques usually outperform analytical algorithms in terms of image quality provided that an appropriate system model is used. In this study we concentrate on the calculation of an accurate system model for the YAP-(S)PET II small animal scanner,...

journal_title：Physics in medicine and biology

authors： Cecchetti M,Moehrs S,Belcari N,Del Guerra A

更新日期：2013-10-07 00:00:00

abstract：:Inverse treatment planning in intensity modulated particle therapy (IMPT) with scanned carbon-ion beams is currently based on the optimization of RBE-weighted dose to satisfy requirements of target coverage and limited toxicity to organs-at-risk (OARs) and healthy tissues. There are many feasible IMPT plans that meet ...

journal_title：Physics in medicine and biology

authors： Burigo LN,Ramos-Méndez J,Bangert M,Schulte RW,Faddegon B

更新日期：2019-01-04 00:00:00

abstract：:Speed of sound (SOS) measurements, typically made using 1 MHz broadband pulses, are increasingly used in the clinical diagnosis of bone disorders. Previous in vitro studies indicate that broadband ultrasound pulses are susceptible to distortion in cancellous bone, leading to imprecise arrival time and SOS measurements...

journal_title：Physics in medicine and biology

authors： Pollintine P,Haddaway MJ,Davie MW

更新日期：2000-07-01 00:00:00

abstract：:In the IAEA TRS-381 protocol, k(cel) and p(cel) account for the central electrode perturbation during the air kerma chamber calibration and the in-phantom measurements. The values of these correction factors are based mainly on Monte Carlo simulations. In the present work experimental data on k(cel) and p(cel) for the...

journal_title：Physics in medicine and biology

authors： Palm A,Mattsson O

更新日期：1999-05-01 00:00:00

abstract：:The National Physical Laboratory (NPL) provides a high-energy photon calibration service using 4-19 MV x-rays and 60Co gamma-radiation for secondary standard dosemeters in terms of absorbed dose to water. The primary standard used for this service is a graphite calorimeter and so absorbed dose calibrations must be con...

journal_title：Physics in medicine and biology

authors： Nutbrown RF,Duane S,Shipley DR,Thomas RA

更新日期：2002-02-07 00:00:00

abstract：:Micro-CT is widely used in preclinical studies, generating substantial interest in extending its capabilities in functional imaging applications such as blood perfusion and cardiac function. However, imaging cardiac structure and function in mice is challenging due to their small size and rapid heart rate. To overcome...

journal_title：Physics in medicine and biology

authors： Holbrook M,Clark DP,Badea CT

更新日期：2018-01-09 00:00:00

abstract：:Medulloblastoma treatment involves irradiation of the entire central nervous system, i.e. craniospinal irradiation (CSI). This is associated with the significant exposure of large volumes of healthy tissue and there is growing concern regarding treatment-associated side effects. The current study compares out-of-field...

journal_title：Physics in medicine and biology

authors： De Saint-Hubert M,Verellen D,Poels K,Crijns W,Magliona F,Depuydt T,Vanhavere F,Struelens L

更新日期：2017-07-07 00:00:00

abstract：:In previous work we demonstrated the potential of positron emission tomography (PET) detectors with depth-of-interaction (DOI) encoding capability based on phosphor-coated crystals. A DOI resolution of 8 mm full-width at half-maximum was obtained for 20 mm long scintillator crystals using a delayed charge integration ...

journal_title：Physics in medicine and biology

authors： Roncali E,Phipps JE,Marcu L,Cherry SR

更新日期：2012-10-21 00:00:00

abstract：:A near-field probe is described that enables high spatial resolution imaging with terahertz (THz) pulses. The spatial resolution capabilities of the system lie in the range of few microns and we demonstrate a resolution of 7 microm using broad-banded THz pulses with an intensity maximum near 0.5 THz. We present a stud...

journal_title：Physics in medicine and biology

authors： Federici JF,Mitrofanov O,Lee M,Hsu JW,Brener I,Harel R,Wynn JD,Pfeiffer LN,West KW

更新日期：2002-11-07 00:00:00

abstract：:Avoiding toxicities in radiotherapy requires the knowledge of tolerable organ doses. For new, experimental fractionation schemes (e.g. hypofractionation) these are typically derived from traditional schedules using the biologically effective dose (BED) model. In this report we investigate the difficulties of establish...

journal_title：Physics in medicine and biology

authors： Perkó Z,Bortfeld T,Hong T,Wolfgang J,Unkelbach J

更新日期：2018-02-05 00:00:00

abstract：:The purpose of this study was to determine the performance of a single lutetium oxy-orthosilicate (LSO) crystal layer High Resolution Research Tomograph (HRRT) positron emission tomography (PET) scanner. The HRRT is a high resolution PET scanner designed for human brain and small animal imaging. The scanner consists o...

journal_title：Physics in medicine and biology

authors： Boellaard R,Buijs F,de Jong HW,Lenox M,Gremillion T,Lammertsma AA

更新日期：2003-02-21 00:00:00

abstract：:Silicon photomultipliers (SiPMs) are widely used in positron emission tomography (PET), however, SiPMs from different vendors vary in their performance characteristics. In addition, the specifications provided by the manufacturers are measured under different operating conditions and using different test setups, makin...

journal_title：Physics in medicine and biology

authors： Du J,Bai X,Cherry SR

更新日期：2019-08-07 00:00:00

abstract：:Four-dimensional computed tomography (4D-CT) requires breathing information from the patient, and for this, several systems are available. Testing of these systems, under realistic conditions, requires a phantom with a moving target and an expandable outer contour. An anthropomorphic phantom was developed to simulate ...

journal_title：Physics in medicine and biology

authors： Vásquez AC,Runz A,Echner G,Sroka-Perez G,Karger CP

更新日期：2012-05-07 00:00:00

abstract：:Three-dimensional reconstruction of cardiac vasculature from angiographic C-arm CT (rotational angiography) data is a major challenge. Motion artefacts corrupt image quality, reducing usability for diagnosis and guidance. Many state-of-the-art approaches depend on retrospective ECG-gating of projection data for image ...

journal_title：Physics in medicine and biology

authors： Schwemmer C,Rohkohl C,Lauritsch G,Müller K,Hornegger J

更新日期：2013-06-07 00:00:00

abstract：:Rheumatoid arthritis is one of the most common epidemic diseases in the world. For some patients, the treatment with steroids or nonsteroidal anti-inflammatory drugs is not effective, thus necessitating physical removal of the inflamed synovium. Alternative approaches other than surgery will provide appropriate diseas...

journal_title：Physics in medicine and biology

authors： Wu J,Chang SJ,Chuang KS,Hsueh YW,Yeh KC,Wang JN,Tsai WP

更新日期：2007-03-21 00:00:00

abstract：:The aim of the study is to verify the fundamental assumption in the monitor source method, i.e. uniform fractional count loss across the field of view (FOV), and to introduce a revised monitor source method for SPECT deadtime correction that minimally interferes with the clinical protocol. SPECT images of non-uniform ...

journal_title：Physics in medicine and biology

authors： Siman W,Silosky M,Kappadath SC

更新日期：2015-02-07 00:00:00

abstract：:Cardiac resynchronization therapy (CRT) is an effective procedure for patients with heart failure but 30% of patients do not respond. This may be due to sub-optimal placement of the left ventricular (LV) lead. It is hypothesized that the use of cardiac anatomy, myocardial scar distribution and dyssynchrony information...

journal_title：Physics in medicine and biology

authors： Ma YL,Shetty AK,Duckett S,Etyngier P,Gijsbers G,Bullens R,Schaeffter T,Razavi R,Rinaldi CA,Rhode KS

更新日期：2012-05-21 00:00:00

abstract：:We describe a radiation therapy treatment plan optimization method that explicitly considers the effects of interfraction organ motion through optimization on the clinical target volume (CTV), and investigate how it compares to conventional planning using a planning target volume (PTV). The method uses simulated treat...

journal_title：Physics in medicine and biology

authors： Fredriksson A,Engwall E,Andersson B

更新日期：2020-12-21 00:00:00

abstract：:Ultraviolet (UV) treatment dose is determined by the length of time that a patient spends in a phototherapy cabin. The output from UV fluorescent lamps declines with use and a method is needed to compensate for the change in irradiance and to identify and replace any lamps that fail. The decline in lamp output with ag...

journal_title：Physics in medicine and biology

authors： Amatiello H,Martin CJ

更新日期：2006-01-21 00:00:00

abstract：:In order to optimize external-beam conformal radiotherapy, patient movement during treatment must be minimized. For treatment on the upper torso, the target organs are known to move substantially due to patient respiration. This paper deals with the technical aspects of gating the radiotherapy beam synchronously with ...

journal_title：Physics in medicine and biology

authors： Kubo HD,Hill BC

更新日期：1996-01-01 00:00:00

abstract：:In this letter the authors highlight the presence of an error appearing in the discussion of the note 'The use of the Henyey-Greenstein phase function in Monte Carlo simulations in biomedical optics' previously published by them (Binzoni et al 2006 Phys. Med. Biol. 51 N313). In the light of this error, the discussion ...

journal_title：Physics in medicine and biology

authors： Binzoni T,Leung TS,Gandjbakhche AH,Rüfenacht D,Delpy DT

更新日期：2006-11-21 00:00:00

abstract：:Histotripsy is a therapeutic ultrasound modality under development to liquefy tissue mechanically via bubble clouds. Image guidance of histotripsy requires both quantification of the bubble cloud activity and accurate delineation of the treatment zone. In this study, magnetic resonance (MR) and diagnostic ultrasound i...

journal_title：Physics in medicine and biology

authors： Anthony GJ,Bollen V,Hendley S,Antic T,Sammet S,Bader KB

更新日期：2019-05-02 00:00:00

abstract：:The goals of this study were (1) to characterize the optical artefacts affecting measurement accuracy in a volumetric liquid scintillator detector, and (2) to develop methods to correct for these artefacts. The optical artefacts addressed were photon scattering, refraction, camera perspective, vignetting, lens distort...

journal_title：Physics in medicine and biology

authors： Robertson D,Hui C,Archambault L,Mohan R,Beddar S

更新日期：2014-01-06 00:00:00

abstract：:We present a comparison of simulated low-frequency electromagnetic fields in the human body, calculated by means of the electro-quasistatic formulation. The geometrical data in these simulations were provided by an anatomically realistic, high-resolution human body model, while the dielectric properties of the various...

journal_title：Physics in medicine and biology

authors： Barchanski A,De Gersem H,Gjonaj E,Weiland T

更新日期：2005-10-07 00:00:00