[Tunnelled central venous catheter infection during treatment with epoprostenol].

Abstract:

INTRODUCTION:Pulmonary arterial hypertension is a pulmonary vascular disease with a poor prognosis. Continuous intravenous treatment with prostacyclin analogues requires the placement of a tunnelled catheter. The occurrence of catheter-related infections in this context is unusual due to the alkaline pH of the prostacyclin analogue solutions. OBSERVATION:A 50-year-old patient with inherited pulmonary artery hypertension, treated with bosentan, sildenafil and epoprostenol, experienced generalized malaise associated with a weight loss of 9kg over a 12-month period without evidence of a source of infection or malignancy. There was no evidence of hemodynamic disturbance. The diagnosis was made after 1 year of follow-up, when the patient presented with a 38° fever and a biological inflammatory syndrome. Repeated peripheral blood cultures were positive for Dietzia, an alkalophilic coryneform bacillus. The patient's condition responded favourably to antibiotic therapy. CONCLUSION:Infection of a tunneled intravenous catheter should be considered in the case of non-specific symptoms or where there is evidence of sepsis, in patients treated with intravenous prostacyclin analogues administered intravenously. In this context, the laboratory should be warned to search for slow-growing organisms.

journal_name

Rev Mal Respir

authors

Koszutski M,Faure M,Guillaumot A,Gomez E,Mercy M,Chabot F,Chaouat A

doi

10.1016/j.rmr.2017.03.037

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

324-327

issue

3

eissn

0761-8425

issn

1776-2588

pii

S0761-8425(17)30296-6

journal_volume

35

pub_type

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