Liraglutide Activates the Nrf2/HO-1 Antioxidant Pathway and Protects Brain Nerve Cells against Cerebral Ischemia in Diabetic Rats.

Abstract:

:This study aimed to determine the effect of liraglutide pretreatment and to elucidate the mechanism of nuclear factor erythroid 2-related factor (Nrf2)/heme oxygenase-1 (HO-1) signaling after focal cerebral ischemia injury in diabetic rats model. Adult male Sprague-Dawley rats were randomly divided into the sham-operated (S) group, diabetes mellitus ischemia (DM + MCAO) group, liraglutide pretreatment normal blood glucose ischemia (NDM+MCAO+L) group, and liraglutide pretreatment diabetes ischemia (DM + MCAO + L) group. At 48 h after middle cerebral artery occlusion (MCAO), neurological deficits and infarct volume of brain were measured. Oxidative stress brain tissue was determined by superoxide dismutase (SOD) and myeloperoxidase (MPO) activities. The expression levels of Nrf2 and HO-1 of brain tissue were analyzed by western blotting. In the DM + MCAO + L group, neurological deficits scores and cerebral infarct volume seemed to decrease at 48 h after MCAO cerebral ischemia compared with those in DM + MCAO group (P < 0.05). In addition, the expression of Nrf2 and HO-1 increased in 48 h at liraglutide pretreatment groups after MCAO cerebral ischemia if compared with those in the DM + MCAO group (P < 0.05). Furthermore, the DM + MCAO + L group has no significant difference compared with the NDM + MCAO + L group (P > 0.05). To sum up, alleviating effects of liraglutide on diabetes complicated with cerebral ischemia injury rats would be related to Nrf2/HO-1 signaling pathway.

journal_name

Comput Intell Neurosci

authors

Deng C,Cao J,Han J,Li J,Li Z,Shi N,He J

doi

10.1155/2018/3094504

subject

Has Abstract

pub_date

2018-02-12 00:00:00

pages

3094504

eissn

1687-5265

issn

1687-5273

journal_volume

2018

pub_type

杂志文章
  • Channel Projection-Based CCA Target Identification Method for an SSVEP-Based BCI System of Quadrotor Helicopter Control.

    abstract::The brain-computer interface (BCI) plays an important role in assisting patients with amyotrophic lateral sclerosis (ALS) to enable them to participate in communication and entertainment. In this study, a novel channel projection-based canonical correlation analysis (CP-CCA) target identification method for steady-sta...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2019/2361282

    authors: Gao Q,Zhang Y,Wang Z,Dong E,Song X,Song Y

    更新日期:2019-12-16 00:00:00

  • A Time-Series Water Level Forecasting Model Based on Imputation and Variable Selection Method.

    abstract::Reservoirs are important for households and impact the national economy. This paper proposed a time-series forecasting model based on estimating a missing value followed by variable selection to forecast the reservoir's water level. This study collected data from the Taiwan Shimen Reservoir as well as daily atmospheri...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2017/8734214

    authors: Yang JH,Cheng CH,Chan CP

    更新日期:2017-01-01 00:00:00

  • Characterization of Visual Scanning Patterns in Air Traffic Control.

    abstract::Characterization of air traffic controllers' (ATCs') visual scanning strategies is a challenging issue due to the dynamic movement of multiple aircraft and increasing complexity of scanpaths (order of eye fixations and saccades) over time. Additionally, terminologies and methods are lacking to accurately characterize ...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2016/8343842

    authors: McClung SN,Kang Z

    更新日期:2016-01-01 00:00:00

  • Prognostics of Lithium-Ion Batteries Based on Wavelet Denoising and DE-RVM.

    abstract::Lithium-ion batteries are widely used in many electronic systems. Therefore, it is significantly important to estimate the lithium-ion battery's remaining useful life (RUL), yet very difficult. One important reason is that the measured battery capacity data are often subject to the different levels of noise pollution....

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2015/918305

    authors: Zhang C,He Y,Yuan L,Xiang S,Wang J

    更新日期:2015-01-01 00:00:00

  • A fuzzy logic system for seizure onset detection in intracranial EEG.

    abstract::We present a multistage fuzzy rule-based algorithm for epileptic seizure onset detection. Amplitude, frequency, and entropy-based features were extracted from intracranial electroencephalogram (iEEG) recordings and considered as the inputs for a fuzzy system. These features extracted from multichannel iEEG signals wer...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2012/705140

    authors: Rabbi AF,Fazel-Rezai R

    更新日期:2012-01-01 00:00:00

  • Construction Project Safety Performance Management Using Analytic Network Process (ANP) as a Multicriteria Decision-Making (MCDM) Tool.

    abstract::The paper addresses the context in which the construction industry is considered risky, as the intense labor and machine environment interacts with acceleration and overlapping activities. This situation results in accidents and fatalities. A high number of accidents and fatalities leads to additional costs and delays...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2020/2610306

    authors: Gunduz M,Khader BK

    更新日期:2020-02-25 00:00:00

  • A red-light running prevention system based on artificial neural network and vehicle trajectory data.

    abstract::The high frequency of red-light running and complex driving behaviors at the yellow onset at intersections cannot be explained solely by the dilemma zone and vehicle kinematics. In this paper, the author presented a red-light running prevention system which was based on artificial neural networks (ANNs) to approximate...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2014/892132

    authors: Li P,Li Y,Guo X

    更新日期:2014-01-01 00:00:00

  • Embedding Undersampling Rotation Forest for Imbalanced Problem.

    abstract::Rotation Forest is an ensemble learning approach achieving better performance comparing to Bagging and Boosting through building accurate and diverse classifiers using rotated feature space. However, like other conventional classifiers, Rotation Forest does not work well on the imbalanced data which are characterized ...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2018/6798042

    authors: Guo H,Diao X,Liu H

    更新日期:2018-11-01 00:00:00

  • An Energy Storage Performance Improvement Model for Grid-Connected Wind-Solar Hybrid Energy Storage System.

    abstract::This study introduces a supercapacitor hybrid energy storage system in a wind-solar hybrid power generation system, which can remarkably increase the energy storage capacity and output power of the system. In the specific solution, this study combines the distributed power generation system and the hybrid energy stora...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2020/8887227

    authors: Zhu R,Zhao AL,Wang GC,Xia X,Yang Y

    更新日期:2020-08-28 00:00:00

  • Driving Fatigue Detection from EEG Using a Modified PCANet Method.

    abstract::The rapid development of the automotive industry has brought great convenience to our life, which also leads to a dramatic increase in the amount of traffic accidents. A large proportion of traffic accidents were caused by driving fatigue. EEG is considered as a direct, effective, and promising modality to detect driv...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2019/4721863

    authors: Ma Y,Chen B,Li R,Wang C,Wang J,She Q,Luo Z,Zhang Y

    更新日期:2019-07-14 00:00:00

  • HDEC: A Heterogeneous Dynamic Ensemble Classifier for Binary Datasets.

    abstract::In recent years, ensemble classification methods have been widely investigated in both industry and literature in the field of machine learning and artificial intelligence. The main advantage of this approach is to benefit from a set of classifiers instead of using a single classifier with the aim of improving the pre...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2020/8826914

    authors: Ostvar N,Eftekhari Moghadam AM

    更新日期:2020-12-14 00:00:00

  • Neural Basis of Intrinsic Motivation: Evidence from Event-Related Potentials.

    abstract::Human intrinsic motivation is of great importance in human behavior. However, although researchers have focused on this topic for decades, its neural basis was still unclear. The current study employed event-related potentials to investigate the neural disparity between an interesting stop-watch (SW) task and a boring...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2015/698725

    authors: Jin J,Yu L,Ma Q

    更新日期:2015-01-01 00:00:00

  • The Brainarium: An Interactive Immersive Tool for Brain Education, Art, and Neurotherapy.

    abstract::Recent theoretical and technological advances in neuroimaging techniques now allow brain electrical activity to be recorded using affordable and user-friendly equipment for nonscientist end-users. An increasing number of educators and artists have begun using electroencephalogram (EEG) to control multimedia and live a...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2016/4204385

    authors: Grandchamp R,Delorme A

    更新日期:2016-01-01 00:00:00

  • EEGLAB, SIFT, NFT, BCILAB, and ERICA: new tools for advanced EEG processing.

    abstract::We describe a set of complementary EEG data collection and processing tools recently developed at the Swartz Center for Computational Neuroscience (SCCN) that connect to and extend the EEGLAB software environment, a freely available and readily extensible processing environment running under Matlab. The new tools incl...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2011/130714

    authors: Delorme A,Mullen T,Kothe C,Akalin Acar Z,Bigdely-Shamlo N,Vankov A,Makeig S

    更新日期:2011-01-01 00:00:00

  • Gaze Estimation Method Using Analysis of Electrooculogram Signals and Kinect Sensor.

    abstract::A gaze estimation system is one of the communication methods for severely disabled people who cannot perform gestures and speech. We previously developed an eye tracking method using a compact and light electrooculogram (EOG) signal, but its accuracy is not very high. In the present study, we conducted experiments to ...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2017/2074752

    authors: Sakurai K,Yan M,Tanno K,Tamura H

    更新日期:2017-01-01 00:00:00

  • Automatic Construction and Global Optimization of a Multisentiment Lexicon.

    abstract::Manual annotation of sentiment lexicons costs too much labor and time, and it is also difficult to get accurate quantification of emotional intensity. Besides, the excessive emphasis on one specific field has greatly limited the applicability of domain sentiment lexicons (Wang et al., 2010). This paper implements stat...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2016/2093406

    authors: Yang X,Zhang Z,Zhang Z,Mo Y,Li L,Yu L,Zhu P

    更新日期:2016-01-01 00:00:00

  • RnRTD: Intelligent Approach Based on the Relationship-Driven Neural Network and Restricted Tensor Decomposition for Multiple Accusation Judgment in Legal Cases.

    abstract::The use of intelligent judgment technology to assist in judgment is an inevitable trend in the development of judgment in contemporary social legal cases. Using big data and artificial intelligence technology to accurately determine multiple accusations involved in legal cases is an urgent problem to be solved in lega...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2019/6705405

    authors: Guo X,Zhang H,Ye L,Li S

    更新日期:2019-07-07 00:00:00

  • An Improved DSA-Based Approach for Multi-AUV Cooperative Search.

    abstract::Multi-AUV cooperative target search problem in unknown 3D underwater environment is not only a research hot spot but also a challenging task. To complete this task, each autonomous underwater vehicle (AUV) needs to move quickly without collision and cooperate with other AUVs to find the target. In this paper, an impro...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2018/2186574

    authors: Ni J,Yang L,Shi P,Luo C

    更新日期:2018-12-02 00:00:00

  • Robust SAR Automatic Target Recognition Based on Transferred MS-CNN with L2-Regularization.

    abstract::Though Synthetic Aperture Radar (SAR) Automatic Target Recognition (ATR) via Convolutional Neural Networks (CNNs) has made huge progress toward deep learning, some key issues still remain unsolved due to the lack of sufficient samples and robust model. In this paper, we proposed an efficient transferred Max-Slice CNN ...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2019/9140167

    authors: Zhai Y,Deng W,Xu Y,Ke Q,Gan J,Sun B,Zeng J,Piuri V

    更新日期:2019-11-15 00:00:00

  • A Reweighted Scheme to Improve the Representation of the Neural Autoregressive Distribution Estimator.

    abstract::The neural autoregressive distribution estimator(NADE) is a competitive model for the task of density estimation in the field of machine learning. While NADE mainly focuses on the problem of estimating density, the ability for dealing with other tasks remains to be improved. In this paper, we introduce a simple and ef...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2018/6401645

    authors: Wang Z,Wu Q

    更新日期:2018-12-23 00:00:00

  • Predictive Modeling in Race Walking.

    abstract::This paper presents the use of linear and nonlinear multivariable models as tools to support training process of race walkers. These models are calculated using data collected from race walkers' training events and they are used to predict the result over a 3 km race based on training loads. The material consists of 1...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2015/735060

    authors: Wiktorowicz K,Przednowek K,Lassota L,Krzeszowski T

    更新日期:2015-01-01 00:00:00

  • Effectiveness of Serious Games for Leap Motion on the Functionality of the Upper Limb in Parkinson's Disease: A Feasibility Study.

    abstract::The design and application of Serious Games (SG) based on the Leap Motion sensor are presented as a tool to support the rehabilitation therapies for upper limbs. Initially, the design principles and their implementation are described, focusing on improving both unilateral and bilateral manual dexterity and coordinatio...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2018/7148427

    authors: Oña ED,Balaguer C,Cano-de la Cuerda R,Collado-Vázquez S,Jardón A

    更新日期:2018-04-11 00:00:00

  • Large-Truck Safety Warning System Based on Lightweight SSD Model.

    abstract::Transportation is an important link in the mining process, and large trucks are one of the important tools for mine transportation. Due to their large size and small driving position, large trucks have a blind spot, which is a hidden danger to the safe transportation of mines and has a great impact on production effic...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2019/2180294

    authors: Xiao D,Li H,Liu C,He Q

    更新日期:2019-10-13 00:00:00

  • Augmenting weak semantic cognitive maps with an "abstractness" dimension.

    abstract::The emergent consensus on dimensional models of sentiment, appraisal, emotions, and values is on the semantics of the principal dimensions, typically interpreted as valence, arousal, and dominance. The notion of weak semantic maps was introduced recently as distribution of representations in abstract spaces that are n...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2013/308176

    authors: Samsonovich AV,Ascoli GA

    更新日期:2013-01-01 00:00:00

  • Software Development Effort Estimation Using Regression Fuzzy Models.

    abstract::Software effort estimation plays a critical role in project management. Erroneous results may lead to overestimating or underestimating effort, which can have catastrophic consequences on project resources. Machine-learning techniques are increasingly popular in the field. Fuzzy logic models, in particular, are widely...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2019/8367214

    authors: Nassif AB,Azzeh M,Idri A,Abran A

    更新日期:2019-02-20 00:00:00

  • Inclusion of Neuropsychological Scores in Atrophy Models Improves Diagnostic Classification of Alzheimer's Disease and Mild Cognitive Impairment.

    abstract::Brain atrophy in mild cognitive impairment (MCI) and Alzheimer's disease (AD) are difficult to demarcate to assess the progression of AD. This study presents a statistical framework on the basis of MRI volumes and neuropsychological scores. A feature selection technique using backward stepwise linear regression togeth...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2015/865265

    authors: Goryawala M,Zhou Q,Barker W,Loewenstein DA,Duara R,Adjouadi M

    更新日期:2015-01-01 00:00:00

  • Fuzzy Classification of High Resolution Remote Sensing Scenes Using Visual Attention Features.

    abstract::In recent years the spatial resolutions of remote sensing images have been improved greatly. However, a higher spatial resolution image does not always lead to a better result of automatic scene classification. Visual attention is an important characteristic of the human visual system, which can effectively help to cl...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2017/9858531

    authors: Li L,Xu T,Chen Y

    更新日期:2017-01-01 00:00:00

  • Saliency Mapping Enhanced by Structure Tensor.

    abstract::We propose a novel efficient algorithm for computing visual saliency, which is based on the computation architecture of Itti model. As one of well-known bottom-up visual saliency models, Itti method evaluates three low-level features, color, intensity, and orientation, and then generates multiscale activation maps. Fi...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2015/875735

    authors: He Z,Chen X,Sun L

    更新日期:2015-01-01 00:00:00

  • Chaos Quantum-Behaved Cat Swarm Optimization Algorithm and Its Application in the PV MPPT.

    abstract::Cat Swarm Optimization (CSO) algorithm was put forward in 2006. Despite a faster convergence speed compared with Particle Swarm Optimization (PSO) algorithm, the application of CSO is greatly limited by the drawback of "premature convergence," that is, the possibility of trapping in local optimum when dealing with non...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2017/1583847

    authors: Nie X,Wang W,Nie H

    更新日期:2017-01-01 00:00:00

  • A Db-Scan Binarization Algorithm Applied to Matrix Covering Problems.

    abstract::The integration of machine learning techniques and metaheuristic algorithms is an area of interest due to the great potential for applications. In particular, using these hybrid techniques to solve combinatorial optimization problems (COPs) to improve the quality of the solutions and convergence times is of great inte...

    journal_title:Computational intelligence and neuroscience

    pub_type: 杂志文章

    doi:10.1155/2019/3238574

    authors: García J,Moraga P,Valenzuela M,Crawford B,Soto R,Pinto H,Peña A,Altimiras F,Astorga G

    更新日期:2019-09-16 00:00:00