Abstract：
:Background Head and neck surgical pathology has been shown to be prone to histopathologic diagnostic error that can adversely impact patient care due to inappropriate management. Sinonasal tumors, in particular, present a diagnostic challenge given the relative rarity and diversity in histology and thus may have higher rates of discordant histology. Objective The purpose of this study is to determine the rate of discrepancy between preoperative and postoperative diagnoses of sinonasal tumors. Methods Retrospective chart review was performed on 52 patients treated for sinonasal tumors between January 2013 and December 2016. Initial diagnosis on preoperative biopsy was compared to postoperative diagnosis rendered at a single tertiary care referral center. A discrepant diagnosis was regarded as any change in diagnosis that resulted in further refinement of therapy or prognosis. Results Eleven (21.2%) patients had discrepancy between the preliminary pathology and postsurgical diagnosis. Of these diagnoses, four involved a change from a benign to a more aggressive benign or malignant process, three involved reclassification of a malignant tumor to a more aggressive histology, and four involved change from an aggressive process to benign histology. In all 11 cases, alteration in management strategy was rendered. The majority of discordant diagnoses were of fibro-osseous lesions and small round blue cell tumors. Conclusion Sinonasal tumors exhibit a high degree of discordance from preoperative to postoperative diagnosis. Critical decision-making should be reserved until careful review of operative specimens is performed to minimize patient morbidity and unnecessary interventions.
journal_name
Am J Rhinol Allergyjournal_title
American journal of rhinology & allergyauthors
Ganti A,Tajudeen BA,Plitt MA,Rossi I,Gattuso P,Batra PSdoi
10.1177/1945892418762845subject
Has Abstractpub_date
2018-03-01 00:00:00pages
101-105issue
2eissn
1945-8924issn
1945-8932journal_volume
32pub_type
杂志文章abstract：BACKGROUND:Computed tomography (CT) of the paranasal sinuses is the diagnostic reference standard for chronic rhinosinusitis and related inflammatory sinus pathology. Nasal nitric oxide (nNO) levels have been investigated as a diagnostic tool in sinus disease because it decreases with sinus obstruction. OBJECTIVE:The ...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.1177/1945892418801389
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Respiratory epithelial adenomatoid hamartomas (REAH) are benign nose neoplasms found in the nasal cavity and sinuses. Symptoms include anosmia, nasal obstruction, facial pressure, and rhinorrhea. Although previously thought to be rare, these tumors are being increasingly recognized on pathology in patients u...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2016.30.4338
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to investigate the expression and distribution of superoxide anion, NADPH oxidase (NOX)1, and NOX4 in healthy, allergic nasal mucosa and nasal polyps to evaluate the possible influence of oxidative stress on the development of allergic rhinitis and nasal polyps. METHODS:The exp...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2009.23.3340
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND:Eosinophils are possibly the most important inflammatory cells in the pathogenesis of chronic rhinosinusitis with nasal polyposis. Eosinophilic nasal mucosal infiltration is characteristic of nasal polyposis. The aim of this work was to study the possibility of correlations between cytological and tissue eos...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2010.24.3549
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:Post-viral olfactory dysfunction is a common cause of both short- and long-term smell alteration. The coronavirus pandemic further highlights the importance of post-viral olfactory dysfunction. Currently, a comprehensive review of the neural mechanism underpinning post-viral olfactory dysfunction is lacking....
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.1177/1945892420957853
更新日期：2020-09-11 00:00:00
abstract：BACKGROUND:The greater palatine canal (GPC) local injection is used to limit posterior bleeding during sinus surgery in adults. Given the potential for causing iatrogenic damage to the intraorbital contents, this procedure is not commonly used in the pediatric population. No studies have described the anatomic developm...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2010.24.3496
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:Local allergic rhinitis (LAR) has been observed in patients without atopy. However, LAR is still underdiagnosed in patients with perennial or seasonal nasal symptoms. OBJECTIVE:The aim of this study was to determine the prevalence of LAR in young patients with a previous diagnosis of nonallergic rhinitis or...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2016.30.4369
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Endoscopic sinus surgery (ESS) is a safe and reliable procedure for the treatment of chronic rhinosinusitis (CRS) and nasal polyposis (NP). Although most cases of CRS with NP occur bilaterally, we occasionally encounter patients with unilateral sinus disease with NP. Because no study has been conducted on th...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2010.24.3482
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:Allergic rhinitis is commonly treated with antihistamines. Monitoring improvement of airway inflammation noninvasively using nasal nitric oxide (nNO) would be clinically useful. To determine the anti-inflammatory effect of oral levocetirizine dihydrochloride (LC), we measured nNO and nasal eosinophils (nEos...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章,随机对照试验
doi：10.2500/ajra.2011.25.3668
更新日期：2011-11-01 00:00:00
abstract：:Rhinitis is characterized by one or more of the following nasal symptoms: congestion, rhinorrhea (anterior and posterior), sneezing, and itching. It is classified as allergic or nonallergic, the latter being a diverse syndrome that is characterized by symptoms of rhinitis that are not the result of IgE-mediated events...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2013.27.3927
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:Skin prick test (SPT) or Phadiatop, a multi-allergen IgE screening test, was used as a tool for detecting aeroallergen sensitization. OBJECTIVE:To compare SPT and Phadiatop as a tool for diagnosis allergic rhinitis (AR) using the nasal provocation test (NPT) as a comparative standard. METHODS:Children aged...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.1177/1945892420938300
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Specific antibody deficiency may predispose patients to recurrent respiratory tract infections. There is limited literature assessing specific antibody deficiency in chronic rhinosinusitis (CRS). This study evaluated the role of specific antibody deficiency in patients with CRS who have failed medical therap...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2011.25.3653
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:Topical nasal sprays are commonly prescribed for sinonasal disease. Nasal drops applied in a head-down position are described alternatively to sprays. Multiple research methods have investigated the deposition pattern of intranasal medications, each with limitations. This pilot study analyzed the use of a co...
journal_title：American journal of rhinology & allergy
pub_type： 临床试验,杂志文章
doi：10.2500/ajra.2011.25.3569
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:Aspirin-exacerbated respiratory disease (AERD) affects 7% of asthmatics. Usual therapies are inadequate for asthma and/or nasal polyposis, leading to decreased quality of life. OBJECTIVE:Our objective was to evaluate the efficacy of dupilumab in AERD patients with uncontrolled, chronic rhinosinusitis with n...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.1177/1945892420961969
更新日期：2020-09-23 00:00:00
abstract：INTRODUCTION:Accountable care organizations (ACO) and alternative payment models are a sign of the change in reimbursement from fee-for-service to value-based reimbursement. The focus of health care under ACOs is represented by the Triple Aim: to improve the experience of health care, improve the health of populations,...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章,评审
doi：10.2500/ajra.2016.30.4348
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:There is a correlation between (18)F-fluorodeoxyglucose (FDG) uptake and the level of intracellular metabolic tumor activity, which in turn may be associated with active proliferation, invasion, and prognosis as well as distant metastases in head and neck cancer. This study was designed to assess whether tum...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2013.27.3848
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:The identification of anatomic landmarks in endoscopic skull base or revision sinus surgery can be challenging. Normal anatomy is significantly altered with many paranasal tumors. Traditional endoscopic surgical landmarks extrapolated from inflammatory disease, such as the superior turbinate, may have been p...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2010.24.3473
更新日期：2010-07-01 00:00:00
abstract：BACKGROUNDS:Diagnosis of allergic fungal rhinosinusitis (AFRS) is complicated because of the presence of fungi on mucosal surfaces of sinonasal passages. The objectives of this study were to define, using immunohistochemistry, lymphocyte populations associated with noninvasive fungal-related chronic rhinosinusitis (CRS...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2013.27.3882
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:MUC5AC, a major secreted mucin, is increased in chronic inflammatory airway disease. Spleen tyrosine kinase (SYK) is a mediator, which acts as an important regulator of intracellular signal transduction in the inflammatory response. SYK was originally identified in hematopoietic cells, and its expression in ...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2016.30.4276
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Multiple methods exist for nasal septoplasty. Proliferation of endoscopic technology has broadened these options. METHODS:Technical description of two techniques for endoscopic septoplasty. RESULTS:The endoscope can be utilized for visualization under the flaps after, a Killian or hemitransfixion incision,...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2017.31.4436
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:A foreign body (FB) penetrating intracranially after passing transorbitally or transnasally is a rare occurrence. However, otolaryngologists are increasingly being asked to participate in the care of these patients for both endoscopic removal of the object and repair of any skull base defects. OBJECTIVE:To ...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章,评审
doi：10.2500/ajra.2017.31.4421
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:The pterygopalatine fossa (PPF) can be entered endoscopically, but the endoscopic landmarks to localize the bony structures in the PPF are not well described. This study aimed to investigate the anatomy of the sphenopalatine foramen (SPF), vidian canal (VC), and foramen rotundum (FR) with regard to an endosc...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2011.25.3638
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:The nasal tip position and shape is critical to the overall view of the external nose and is significant in planning rhinoplasty procedures. This study was designed to review our experience in nasal tip surgery and to describe our own version of the suture technique in patients having endonasal rhinoplasty....
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2011.25.3678
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:The histopathology and microbiology associated with silent sinus syndrome (SSS) have not been well described. OBJECTIVE:This study details the histopathological and microbiological characteristics in addition to radiographic findings of SSS in comparison to those of chronic maxillary sinusitis (CRS). METHO...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.1177/1945892421989161
更新日期：2021-01-19 00:00:00
abstract：BACKGROUND:Nasal packing is usually performed to control bleeding after endoscopic sinus surgery (ESS). Although new packing materials have been developed, they still cause pain. This study was designed to evaluate the effect of lidocaine-soaked packs on pain after ESS. METHODS:A prospective, randomized, double-blind ...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章,随机对照试验
doi：10.2500/ajra.2013.27.3942
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Chronic rhinosinusitis with nasal polyps (CRSwNPs) is the most challenging form of CRS to treat. Clinical practices vary widely among physicians around the world, often with little evidence to support current therapies. METHODS:This study evaluates various medical and surgical treatments with a focus on the...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2013.27.3982
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Platelet-activating factor (PAF) is a lipid mediator produced by most inflammatory cells. Clinical and experimental findings suggest that PAF participates in allergic rhinitis (AR) pathogenesis. The aim was to assess the PAF ability to induce clinical response in nasal airway after local stimulation. METHOD...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2013.27.3856
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:Fibrinolytic components, their receptors, and inhibitors are considered to play an important role in inflammation and tissue remodeling including chronic rhinosinusitis (CRS). To clarify the relationship between these components and the pathology of CRS, we analyzed fibrinolytic components in sinonasal mucos...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2011.25.3537
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Epiphora has a significant impact on the patient's quality of life and is commonly caused by nasolacrimal duct obstruction. Dacryocystorhinostomy (DCR) has traditionally been performed via an external approach, which involves a skin incision. With the advent of endoscopes, the endonasal approach to DCR has g...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2018.32.4494
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Chronic rhinosinusitis (CRS) is a common illness, yet little is known about its pathogenesis, including the role played by respiratory viruses. METHODS:A transversal prospective study was conducted to analyze the seasonality of CRS using real-time polymerase chain reaction to detect respiratory virus genome...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2015.29.4129
更新日期：2015-01-01 00:00:00
