[Therapeutic Concepts for Treatment of Patients with Non-infectious Uveitis Biologic Disease Modifying Antirheumatic Drugs].

Abstract:

:Biologic disease modifying antirheumatic drugs (bDMARDs) can be highly efficient in the treatment of various non-infectious uveitis entities. Currently, the TNF-α-inhibitor Adalimumab is the only in-label therapeutic option, whereas, all other bDMARDs need to be given as an off-label therapy. bDMARDs are indicated in diseases refractory to conventional synthetic DMARD therapy and/or systemic steroids, or in patients in whom treatment with those is not possible due to side effects. Therapeutic mechanisms currently employed are cytokine-specific (interferons, inhibition of TNF-α or of interleukin [IL]-1-, IL-6- or IL-17-signalling), inhibit T cell costimulation (CTLA-4 fusion protein), or act via depletion of B cells (anti-CD20). All bDMARDs need to be administered parenterally, and therapy is initiated by the treating internal specialist only after interdisciplinary coordination of all treating subspecialties and after exclusion of contraindications. Regular clinical and laboratory monitoring is mandatory for all patients while under bDMARD therapy. :Biologika stellen eine hochwirksame Therapieoption für verschiedene nicht infektiöse Uveitisformen dar. Einziges zugelassenes Biologikum ist der TNF-α-Inhibitor Adalimumab, alle anderen Präparate müssen im Rahmen einer Off-Label-Therapie gegeben werden. Die Indikation zur Therapieinitiierung mit einem Biologikum besteht, wenn die Erkrankung nicht ausreichend anspricht auf eine Behandlung mit systemischen Steroiden und/oder csDMARDs (konventionell-synthetischen disease modifying antirheumatic drugs) oder diese aufgrund von unerwünschten Wirkungen nicht gegeben werden können. Derzeit in der klinischen Anwendung befindliche biologische DMARD-Präparate wirken über zytokinspezifische Mechanismen (TNF-α-Inhibition, Interferone, Hemmung der Signaltransduktion von Interleukin-1 [IL-1], IL-6 und IL-17) sowie Hemmung der T-Zell-Kostimulation (CTLA-4-Fusionsprotein), oder B-Zell-Depletion (Anti-CD20). Alle Präparate müssen parenteral verabreicht werden. Die Einleitung einer Biologikatherapie sollte nach interdisziplinärer Abstimmung und Ausschluss von Kontraindikationen erfolgen. Ein regelmäßiges klinisches und laborchemisches Monitoring unter der Therapie ist erforderlich.

journal_name

Klin Monbl Augenheilkd

authors

Walscheid K,Pleyer U,Heiligenhaus A

doi

10.1055/a-0577-8006

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

553-561

issue

5

eissn

0023-2165

issn

1439-3999

journal_volume

235

pub_type

杂志文章
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    authors: Pau H

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  • [Results of Cüpper's "thread fixation" in squinters with inconstant angle (author's transl)].

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    doi:

    authors: Behrens-Baumann W,Wölz U

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  • [Special sound probe for foreign body localisation (author's transl)].

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    doi:

    authors: Till P

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  • [Luetic papilledema].

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    doi:

    authors: Bodechtel G,Lund OE

    更新日期:1979-12-01 00:00:00

  • [Iritis and optic nerve meningitis--initial symptoms of latent syphilis].

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    authors: Barthelmess-Mösler S,Völcker HE

    更新日期:1987-03-01 00:00:00

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    doi:

    authors: Plange H,Speiser P

    更新日期:1976-10-01 00:00:00

  • Bilateral peripapillary subretinal neovessel membrane associated with chronic papilledema: report of two cases.

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    authors: Nguyen C,Borruat FX

    更新日期:2005-03-01 00:00:00

  • [Anti-VEGF inhibitors and their role in the treatment of diabetic macular oedema].

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    authors: Kakkassery V,Winterhalter S,Joussen AM

    更新日期:2010-09-01 00:00:00

  • [Imaging of the Lacrimal Gland and the Lacrimal Drainage System].

    abstract::Die Tränendrüse kann von einer Vielzahl neoplastischer, infektiöser und autoimmunologischer Erkrankungen betroffen sein. Eine radiologische Charakterisierung der Veränderungen kann Hinweise für die differenzialdiagnostische Einordnung liefern. Erkrankungen der ableitenden Tränenwege, insbesondere Tränenwegsverschlüsse...

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    doi:10.1055/s-0033-1358102

    authors: Pieper CC,Thomas D

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  • [The value of preoperative calculation of intraocular lenses].

    abstract::In 82 cataract patients the power of the pseudophakos to be implanted was determined. Axial length and anterior chamber depth were measured by ultrasound. The results of keratometry and the echographic data were used for lens power calculation. For the accuracy of prediction the estimated post-operative anterior chamb...

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    doi:10.1055/s-2008-1055264

    authors: Hauff W

    更新日期:1982-11-01 00:00:00

  • Intravitreal triamcinolone injection for unresponsive cystoid macular oedema in probable Behçet's disease as an additional therapy.

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    doi:10.1055/s-2008-1027351

    authors: Oueghlani E,Pavésio CE

    更新日期:2008-05-01 00:00:00

  • [Current status of infrared photoablation of the cornea].

    abstract:BACKGROUND:IR-photothermal ablation has, for some time, been described as an alternative to UV photoablation with Excimer lasers. Both procedures are based on different laser-tissue-interactions. IR solid state lasers have cost advantages over UV laser technology and allow a broader clinical use. New beam shaping princ...

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    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1034776

    authors: Jean B,Bende T

    更新日期:1999-04-01 00:00:00

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    pub_type: 杂志文章

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    authors: Amstutz CA,Michel S,Thiel MA

    更新日期:2004-05-01 00:00:00

  • [Clinical experiences and results of application of mitomycin C in trabeculectomy].

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    authors: Laube T,Ritters B,Selbach M,Hudde T

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  • [Timolol in the treatment of glaucoma (author's transl)].

    abstract::Untolerated or insufficiently effective Therapy in 32 patients (63 eyes) with primary open-angle glaucoma was discontinued and substituted with Timolol, and all patients were followed up over a period of 60 weeks. Timolol was well tolerated in all cases without any local or systemic side effects. Either alone or in co...

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    doi:10.1055/s-2008-1057171

    authors: Strasser G,Haddad R,Wohlzogen FX

    更新日期:1981-02-01 00:00:00

  • [Timolol: long-term results, tolerance test and early-morning measurements (author's transl)].

    abstract::In a study lasting 16 months, Timolol was tested on 57 eyes of a group of selected patients with open-angle glaucoma. Patients whose IOP could not be stabilized with the 0.25% solution were treated with 0.5% drops twice a day. In five separate cases, where regulation was inadequate, pilocarpine 2% twice a day was pres...

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    pub_type: 临床试验,杂志文章

    doi:

    authors: Strempel I

    更新日期:1979-11-01 00:00:00

  • [Chemical and thermal eye burns in the residential area of RWTH Aachen. Analysis of accidents in 1 year using a new automated documentation of findings].

    abstract:BACKGROUND:Until now there were no statistical data on the incidence and the prevalence of eye burns. Therefore we studied all patients coming to our hospital from the area of Aachen with eye burns during the time from September 1990 until August 1991. PATIENTS AND METHODS:All patients underwent a standardized examina...

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    pub_type: 杂志文章

    doi:10.1055/s-2008-1045646

    authors: Kuckelkorn R,Luft I,Kottek AA,Schrage NF,Makropoulos W,Reim M

    更新日期:1993-07-01 00:00:00

  • [Closure of the central artery of the retina in progressive scleroderma (author's transl)].

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    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Berndt K,Hoffmann A

    更新日期:1977-10-01 00:00:00

  • [Visual evoked potentials in the evaluation of suspected simulation and aggravation].

    abstract::Visual evoked potentials (VEP) with checkerboard stimulation are good reference for the function of the visual pathways. Normal VEP are registered from simulants and better than expected VEP are noted from aggravants. However an exact objective determination of the visual acuity is limited, due to the low correlation ...

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    doi:10.1055/s-2008-1057538

    authors: Wildberger H,Huber C

    更新日期:1980-04-01 00:00:00

  • [Ultrasound microscopy findings of artificial lenses].

    abstract::Acoustic microscopy permits a native, nondestructive and artefact-free analysis of the surface of intraocular lenses with regard to manufacturing defects, biologic cellular and membranaceous layers, and signs of degradation. Furthermore, it enables structures below the surface to be evaluated, so that inclusions, pore...

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    doi:10.1055/s-2008-1046419

    authors: Rochels R,Lieb W,Ganz S,Hoppe M

    更新日期:1989-08-01 00:00:00

  • [Arteriovenous malformation of the orbit].

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    doi:10.1055/s-2008-1046343

    authors: Witschel H,Grannemann D

    更新日期:1989-02-01 00:00:00

  • [Lens changes following pneumatic retinopexy: preliminary results of linear densitometry image analysis of Scheimpflug photographs two months after operation].

    abstract::The small degree of morbidity and a better postoperative visual acuity are the advantages of pneumatic retinopexy in comparison to encircling procedures in the treatment of retinal detachment. The injection of air or gas into the vitreous cavity can theoretically induce a cataract postoperatively. Two months after pne...

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    doi:10.1055/s-2008-1046024

    authors: Koch F,Hockwin O,Böker T,Mougharbel M

    更新日期:1991-06-01 00:00:00

  • [Notes on a modification of Cüpper's Faden operation (the "false faden") (author's transl)].

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    pub_type: 杂志文章

    doi:

    authors: Kaufmann H

    更新日期:1981-03-01 00:00:00

  • [Keratoconus in Mulvihill-Smith syndrome].

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    authors: Rau S,Duncker GI

    更新日期:1994-07-01 00:00:00

  • [Near heterophoria with a description of the heterometer].

    abstract::The examination of near heterophoria with a heterometer using a large series of test plates presented "free-sighted" (i.e., not hindered by optical or mechanical means) enables a more comprehensive analysis to be made than has so far been achieved with other instruments. The principal components of the instruments are...

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    pub_type: 杂志文章

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    authors: Littan KE

    更新日期:1988-05-01 00:00:00

  • Strabismus Surgery of Consecutive Exotropia.

    abstract:PURPOSE:The purpose of this study was to determine the surgical outcome, dose-effect (DE), and degree of binocularity in patients undergoing surgery for consecutive exotropia following initial surgery of esotropia. PATIENTS/METHODS:Twenty-one patients were identified. We analyzed the mean angle of deviation pre- and p...

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    pub_type: 杂志文章

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    authors: Janeschitz-Kriegl L,Roulez F,Wipf MM,Palmowski-Wolfe A

    更新日期:2020-04-01 00:00:00

  • [Retinopathy of prematurity].

    abstract::This review summarizes the knowledge and highlights recent advances in clinical research of retinopathy of prematurity (ROP). This disease is still important, because improvements in neonatal intensive care during the last years have increased the survival of the most immature newborns, but did not diminish the ROP fr...

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  • [An approach to diabetic retinopathy].

    abstract::Presentation of ophthalmological taking in charge program of the diabetic patients, program elaborated during a symposium in London under the supervision of the World's Health Organisation and the International Federation of Diabetes. A calendar of the necessary controls is worked out. A scheme of the proposed treatme...

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    doi:10.1055/s-2008-1045832

    authors: Ducrey N

    更新日期:1992-05-01 00:00:00

  • [Significance of the corneal thickness in non-contact tonometry].

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    doi:10.1055/s-2008-1046068

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  • [Minimally invasive lacrimal duct surgery with a multimodal concept for functional lacrimal stenosis].

    abstract:PURPOSE:The aim of this study was to evaluate the long-term success rates of a multimodal concept for treating functional nasolacrimal duct obstruction (FNLDO) consisting of minimally invasive lacrimal duct surgery and additional treatment of the conjunctiva, the puncta or the lids if necessary. METHODS:Clinical outco...

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