Abstract:
INTRODUCTION:Morbidity and mortality due to tuberculosis are rising steadily. Despite having efficient drugs and treatment protocols, microbial drug resistance often leads to treatment failure. Efforts to bring novel drugs to combat this menace are hampered by several issues including problems in gaining industry support, motivation and ethical issues clinical trials. Bedaquiline and Delaminid are the only novel drugs approved in the last three decades for treating TB. A few more molecules and drug combinations are still in clinical trials. One such drug is the BM212, a potent anti-TB agent which acts by a novel mechanism of action. METHODS:In the present study, we used virtual screening method with a combination of molecular hybridization technique to design N-benzylated Indole Mannich bases as potent anti-TB agent based on BM212 pharmacophore. The library of designed molecules was prepared and screened using BM212 model. The top 5 'hit' molecules were selected (with good TC score >1.15), synthesized and screened for anti TB activity by MABA assay method. RESULTS AND CONCLUSION:All the compounds showed excellent anti TB activity, of which 4 compounds have shown MIC ≤12.5 µg/mL. Our protocol could help in the designing of newer anti-TB agents with better bioactivity profile.
journal_name
Curr Comput Aided Drug Desjournal_title
Current computer-aided drug designauthors
Kumar Muthyala MK,Jamullamudi RN,Sangeeta GPV,Kurre PNdoi
10.2174/1573409914666180423093049subject
Has Abstractpub_date
2018-01-01 00:00:00pages
200-206issue
3eissn
1573-4099issn
1875-6697pii
CAD-EPUB-89899journal_volume
14pub_type
杂志文章abstract::A new mathematical approach is proposed in the definition of molecular descriptors (MDs) based on the application of information theory concepts. This approach stems from a new matrix representation of a molecular graph (G) which is derived from the generalization of an incidence matrix whose row entries correspond to...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409911309020003
更新日期:2013-06-01 00:00:00
abstract::Diabetes accounts for high mortality rate worldwide affecting million of lives annually. Global prevalence of diabetes and its rising frequency makes it a key area of research in drug discovery programs. The research article describes the development of quantitative structure activity relationship model against PPARγ,...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409911666150610093611
更新日期:2015-01-01 00:00:00
abstract::For three random splits, one-variable models of oximes reactivation of sarin inhibited acetylcholinesterase (logarithm of the AChE reactivation percentage by oximes with concentration of 0.001 M) have been calculated with CORAL software. The total number of considered oximes was 42. Simplified molecular input line ent...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:
更新日期:2014-11-26 00:00:00
abstract::Chemical and molecular graphs have fundamental applications in chemoinformatics, quantitative structureproperty relationships (QSPR), quantitative structure-activity relationships (QSAR), virtual screening of chemical libraries, and computational drug design. Chemoinformatics applications of graphs include chemical st...
journal_title:Current computer-aided drug design
pub_type: 杂志文章,评审
doi:10.2174/1573409911309020002
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Chemotherapy and radiotherapy have negative effects on normal tissues and they are very expensive and lengthy treatments. These disadvantages have recently attracted researchers to the new methods that specifically affect cancerous tissues and have lower damage to normal tissues. One of these methods is the ...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409914666181012151242
更新日期:2020-01-01 00:00:00
abstract::PMD (p-menthane-3-8-diol) is an insect repellent that can be synthesized chemically or derived from a steam distillate residue of the leaves of lemon eucalyptus, Corymbia citriodora. It is one of the few natural product endorsed by the Center for Disease Control (USA) for topical application to protect against mosquit...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/15734099113099990021
更新日期:2013-09-01 00:00:00
abstract::The apparently paradoxical lack of correlation between the huge increase in the discovery of new potential drug targets made possible by the post-genomic sciences and new drugs development has stimulated many different interpretations. Here we illustrate the general principle of redundancy of biological pathways on ha...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/157340911796504297
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:The accuracy of molecular conformation for Quantitative Structure Activity Relationship (QSAR) studies is an important criteria, and the most favourable bioactive conformer selection is a tough task. Correct ligand alignment as input for 3D-QSAR is an important step that is prone to human biases. Multiple-di...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409913666170119115841
更新日期:2017-01-01 00:00:00
abstract::Induction of apoptosis by the activation of caspase 3 makes it a promising target for designing anticancer drugs hence an investigation for the essential structural features mandatory for caspase 3 activation has been carried out using a dataset comprising of caspase 3 activator candidate drug Azixa in phase II clinic...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409911666150701103342
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Unconventional Knoevenagel-type indoles have been the topic of interest of many synthetic chemists because of its promising efficacy in different diseases including cancer. OBJECTIVE:To explore the structural requirements of Knoevenagel-type cytotoxic indoles for higher efficacy. METHODS:Multi-QSAR modelin...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409913666170309150014
更新日期:2017-11-10 00:00:00
abstract::The most common mechanism of the so-called multidrug resistance (MDR), is mainly associated with an over expression of P-glycoprotein (Pgp). It is an ATP-dependent transport protein that limits the intracellular accumulation of a variety of structurally unrelated compounds within various organs and normal tissues such...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/157340991003150302231140
更新日期:2014-01-01 00:00:00
abstract::The role of molecular topology (MT) in the design and selection of new drugs is discussed. After an overview of the different in silico molecular design current technologies, the QSAR analysis is dealt in detail with particular emphasis in the use of topological indices as molecular descriptors. The results of the app...
journal_title:Current computer-aided drug design
pub_type: 杂志文章,评审
doi:10.2174/1573409911006040252
更新日期:2010-12-01 00:00:00
abstract::The paper is an attempt for QSAR modeling based on topological, electrostatic, quantum chemical, constitutional, geometrical and physicochemical indices computed from the structures of 59 set of synthesized chalcone derivatives tested for the cell cycle inhibition of mitotic G2/M phase using multiple linear regression...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409911666150702101559
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Thiadiazole not only acts as "hydrogen binding domain" and "two-electron donor system" but also as constrained pharmacophore. METHODS:The maleate salt of 2-((2-hydroxy-3-((4-morpholino-1, 2,5-thiadiazol-3-yl) oxy) propyl) amino)- 2-methylpropan-1-ol (TML-Hydroxy)(4) has been synthesized. This methodology in...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409915666190206142756
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Quantitative structure-activity relationship (QSAR) models could provide both statistical significance and useful chemical insights for drug design. The QSAR method has found applications for predicting diverse properties of organic compounds, including antiviral activities, toxicities and biological activit...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409913666170303113812
更新日期:2017-01-01 00:00:00
abstract::The QSAR and docking studies were performed on fifty seven steroids with binding affinities for corticosteroid-binding globulin (CBG) and eighty four steroids with binding affinities for sex hormone-binding globulin (SHBG). Since the steroidal compounds have binding affinity for both CBG and SHBG, multi-target QSAR ap...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/157340912803519642
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Quantitative structure-activity relationship (QSAR) models can be used as a predictive tool for virtual screening of chemical libraries to identify novel drug candidates. The aims of this paper were to report the results of a study performed for descriptor selection, QSAR model development, and virtual scree...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409912666160414104902
更新日期:2016-01-01 00:00:00
abstract:AIM AND OBJECTIVE:Isoflavone phytoestrogens, which commonly present in natural plants, are closely related to human health. The combination of them with estrogen receptors in the body can play a more important role in the prevention and treatment of cardiovascular diseases, cancer, and menopausal diseases. This researc...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409916666200712140245
更新日期:2020-07-12 00:00:00
abstract:INTRODUCTION:Machine Learning is a useful tool for the prediction of cell-penetration compounds as drug candidates. MATERIALS AND METHODS:In this study, we developed a novel method for predicting Cell-Penetrating Peptides (CPPs) membrane penetrating capability. For this, we used orthogonal encoding to encode amino aci...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409914666180925100355
更新日期:2019-01-01 00:00:00
abstract::Taking into consideration the high importance of the drug target 5-α-reductase (5αR) in prostate cancer in this work we are going first to review previous works and discuss works related to the computer aided drug design of 5αR inhibitors. We report new results in the in silico screening of natural 5αR inhibitors. Tra...
journal_title:Current computer-aided drug design
pub_type: 杂志文章,评审
doi:10.2174/157340911798260368
更新日期:2011-12-01 00:00:00
abstract::An important area of theoretical drug design research is quantitative structure activity relationship (QSAR) using structural invariants. The impetus for this research trend comes from various directions. Researchers in chemical documentation have searched for a set of invariants which will be more convenient than the...
journal_title:Current computer-aided drug design
pub_type: 杂志文章,评审
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更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Gefitinib (lressa) is the most prescribed drug, highly effective to treat nonsmall cell lung cancer; primarily it was considered that targeted therapy is a kinase inhibitor. The nonsmall cell lung cancer is caused by mutation in the Epithelial Growth Factor Receptor (EGFR) gene. Iressa works by blocking the ...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409914666180228111433
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Secreted Frizzled-Related Protein 4 (SFRP4) is a glycoprotein that acts as a competitor of both canonical and non-canonical Wnt pathways. SFRP4 is mostly expressed in ovary and plays a significant role as a target molecule to cure ovarian carcinoma. OBJECTIVE:Multiple chemical agonists are being used to cur...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409914666180112100122
更新日期:2018-01-01 00:00:00
abstract::The present work employs 152 benzene-carboxylic acid' esters having computed the toxicity within the range [2.251, 10.222] for fathead minnow fish (Pimephales promelas). Calibration set includes many pairs having very similar chemical structure, size, shape and hydrophilicity, but very different value of ECOSAR toxici...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409910666140410094056
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Development of resistance by the malaria parasite Plasmodium falciparum has created challenges in the eradication of this deadly infectious disease. Hence newer strategies are adopted to combat this disease and simultaneously new lead/hit identification is going on worldwide to develop new chemotherapeutic a...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409916666191226103000
更新日期:2019-12-25 00:00:00
abstract:INTRODUCTION:Acetyl-CoA Carboxylases (ACC) have been an important target for the therapy of metabolic syndrome, such as obesity, hepatic steatosis, insulin resistance, dyslipidemia, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), type 2 diabetes (T2DM), and some other diseases. METHODS...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409914666181109110030
更新日期:2019-01-01 00:00:00
abstract::Leflunomide (LFM) and its active metabolite, teriflunomide (TFM), have drawn a lot of attention for their anticancer activities, treatment of rheumatoid arthritis and malaria due to their capability to inhibit dihydroorotate dehydrogenase (DHODH) and Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) enzyme....
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409916666200527133126
更新日期:2020-05-27 00:00:00
abstract:BACKGROUND:The prevalence of multi-drug resistance S. aureus is one of the most challenging tasks for the treatment of nosocomial infections. Proteins and enzymes of peptidoglycan biosynthesis pathway are one among the well-studied targets, but many of the enzymes are unexplored as targets. MurE is one such enzyme feat...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409912666161010142943
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Trypanosoma brucei (T. brucei) is the cause of the deadly human African trypanosomiasis (HAT) with a case fatality ratio of 10%. OBJECTIVE:Targeting the essential Trypanosomal glucose metabolism pathway through the inhibition of phosphoglycerate kinase (PGK) and glyceraldehyde-3-phosphate dehydrogenase (GAP...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409916666200722140704
更新日期:2020-07-22 00:00:00
abstract:BACKGROUND:Various applications of nanosubstances in industrial and consumer goods sectors are growing rapidly because of their useful chemical and physical properties. OBJECTIVES:Assessment of hazard posed by exposure to nanosubstances is essential for the protection of human and ecological health. METHODS:We analyz...
journal_title:Current computer-aided drug design
pub_type: 杂志文章
doi:10.2174/1573409912666160824145722
更新日期:2016-01-01 00:00:00