Prospective, Randomized, Controlled Comparison of Bupivacaine versus Liposomal Bupivacaine for Pain Management after Unilateral Delayed Deep Inferior Epigastric Perforator Free Flap Reconstruction.

Abstract:

:Effective postsurgical analgesia is a critical aspect of patient recovery. The goal of this prospective, randomized, controlled, blinded study was to examine the effect that liposomal bupivacaine delivered by means of a transversus abdominis plane block has on pain control in women undergoing unilateral deep inferior epigastric perforator flap reconstruction. Institutional review board approval was granted for this prospective study. Patients were eligible if they were undergoing unilateral, delayed deep inferior epigastric perforator flap reconstruction. Patients were randomized to one of three groups: liposomal bupivacaine transversus abdominis plane block, or bupivacaine pain pump. Charts were reviewed for demographics, length of stay, and postoperative narcotic use. There were eight patients in the liposomal bupivacaine and bupivacaine transversus abdominis plane block groups and five patients in the pain pump group. A retrospective cohort of six patients who did not receive any intervention was included. Patients who received a liposomal bupivacaine transversus abdominis plane block used statistically significantly less intravenous and total postoperative narcotics in milligrams and milligrams per kilogram per day compared with all other cohorts. They were able to get out of bed at an earlier time point. Overall hospital costs were similar among the groups. This is the first study to investigate liposomal bupivacaine delivered as a transversus abdominis plane block in a prospective, randomized, blinded study in women undergoing unilateral, delayed, abdominally based autologous breast reconstruction. The authors were able to demonstrate a significant reduction in intravenous and total narcotic use when a liposomal bupivacaine transversus abdominis plane block was used. Future studies are needed to prospectively investigate the effect that liposomal bupivacaine would have on immediate and bilateral reconstructions.

journal_name

Plast Reconstr Surg

authors

Gatherwright J,Knackstedt RW,Ghaznavi AM,Bernard S,Schwarz G,Moreira A,Gurunluoglu R,Djohan R

doi

10.1097/PRS.0000000000004360

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

1327-1330

issue

6

eissn

0032-1052

issn

1529-4242

pii

00006534-201806000-00004

journal_volume

141

pub_type

杂志文章,随机对照试验
  • Therapeutic value of intravenous heparin in microvascular surgery: an experimental vascular thrombosis study.

    abstract::In an attempt to decrease a 10 to 15 percent vascular thrombosis rate leading to graft occlusion, low-dose human-grade heparin was studied to determine if carefully monitored intravenous therapy would increase 7-day patency in a known potent thrombosis model. In New Zealand white rabbits, the type of infusate administ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198809000-00016

    authors: Greenberg BM,Masem M,May JW Jr

    更新日期:1988-09-01 00:00:00

  • Short-scar face lift with extended SMAS platysma dissection and lifting and limited skin undermining.

    abstract::In the past 8 years, short-scar cervicofacial rhytidectomy has been used with great success and a high level of patient satisfaction. The operation involves limited incisions in the sideburn and preauricular areas, extending just around the fold of the ear lobule. Extensive undermining of the superficial musculoaponeu...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.PRS.0000070945.35807.CE

    authors: Massiha H

    更新日期:2003-08-01 00:00:00

  • Refinements in the elevation of reconstructed auricles in microtia.

    abstract:BACKGROUND:In the treatment of microtia, the search has been for surgical techniques that prevent postoperative complications and realize sufficient and stable projection of the constructed ear. METHODS:Cartilage was fixed with absorbable synthetic thread instead of wire because wire has a high risk of exposure. A sub...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000225449.04098.94

    authors: Tai Y,Tanaka S,Fukushima J,Kizuka Y,Kiyokawa K,Inoue Y,Yamauchi T

    更新日期:2006-06-01 00:00:00

  • Congenital skin tube pedicle associated with the constriction band syndrome.

    abstract::A very rare case of congenital skin tube pedicle with congenital constriction band syndrome was presented. Only one report concerning this bizarre abnormality could be found in the available literature, and no consideration of its etiology has previously been published. In our case, the skin tube was accompanied by th...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199204000-00029

    authors: Nakamura K,Nanjyo B

    更新日期:1992-04-01 00:00:00

  • Acetyl-L-Carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome: A Double-Blind, Randomized, Controlled Trial.

    abstract:BACKGROUND:Carpal tunnel syndrome is very common. Although surgery is effective in mild and moderate cases, recovery is often incomplete in severe cases. Therefore, adjuvant therapy to improve nerve regeneration in those patients is much needed. Acetyl-L-carnitine has been shown to be effective in other neuropathies. T...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/PRS.0000000000005089

    authors: Curran MWT,Morhart MJ,Olson JL,Hachisuka A,Chan KM

    更新日期:2019-01-01 00:00:00

  • Acute hand compartment syndromes after closed crush: a reappraisal.

    abstract::Severe crush to the hand is associated with a poor prognosis. The authors investigated the hypothesis that compartment syndrome complicates such injuries. From 1996 to 2000, the authors retrospectively identified 11 patients who, after sustaining a closed crush injury, developed acute hand compartment syndrome. Diagno...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.PRS.0000025183.78057.9B

    authors: Del Piñal F,Herrero F,Jado E,García-Bernal FJ,Cerezal L

    更新日期:2002-10-01 00:00:00

  • A Formidable Foe Is Sabotaging Your Results: What You Should Know about Biofilms and Wound Healing.

    abstract:LEARNING OBJECTIVES:After reading this article, the participant should be able to: 1. Describe biofilm pathogenesis as it relates to problem wounds. 2. Understand the preclinical and clinical evidence implicating biofilm in problem wounds. 3. Explain the diagnostic and treatment challenges that biofilms create for prob...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000003325

    authors: Barker JC,Khansa I,Gordillo GM

    更新日期:2017-05-01 00:00:00

  • From birth to maturity: a group of patients who have completed their protocol management. Part I. Unilateral cleft lip and palate.

    abstract::The optimal management of the cleft lip and palate patient from birth to completion of treatment presents a formidable challenge to the plastic surgeon and the associated health care system. The multidisciplinary team approach for the management of these patients is widely accepted. However, a paucity of literature ex...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000105332.57124.89

    authors: Schnitt DE,Agir H,David DJ

    更新日期:2004-03-01 00:00:00

  • Xeroradiography for non-metallic foreign bodies.

    abstract::Xeroradiography can demonstrate many non-metallic foreign bodies that do not show by conventional radiography techniques. Two examples are shown. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Bowers DG Jr,Lynch JB

    更新日期:1977-09-01 00:00:00

  • Staged excision of lentigo maligna and lentigo maligna melanoma: a 10-year experience.

    abstract:BACKGROUND:The treatment of lentigo maligna and lentigo maligna melanoma presents a difficult problem for clinicians. Published guidelines recommend a 5-mm excision margin for lentigo maligna and a 1-cm margin for lentigo maligna melanoma, yet these are often inadequate. The authors' purpose is to report their 10-year ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181bcf002

    authors: Bosbous MW,Dzwierzynski WW,Neuburg M

    更新日期:2009-12-01 00:00:00

  • Pearls and pitfalls of needle aponeurotomy in Dupuytren's disease.

    abstract:BACKGROUND:Dupuytren's disease is a benign, progressive, fibroproliferative disease, and despite advances in basic science and technology, there remains no cure. To date, open fasciectomy procedures remain the criterion standard for the treatment of Dupuytren's disease despite a significant complication rate and recove...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0000000000000961

    authors: Morhart M

    更新日期:2015-03-01 00:00:00

  • Clinical and anatomical study of cervicopectoral superthin flaps.

    abstract:BACKGROUND:The authors have used cervicopectoral superthin flaps to reconstruct face, chin, and neck scar contractures. In the authors' clinical experience, three types of flaps could be harvested: (1) cutaneous pedicled flaps, (2) musculocutaneous pedicled flaps, and (3) muscle pedicled flaps. In the present study, th...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000256050.27716.03

    authors: Vinh VQ,Ogawa R,Iwakiri I,Hyakusoku H,Tanuma K

    更新日期:2007-04-15 00:00:00

  • The effect of human adipose-derived stem cells on healing of ischemic wounds in a diabetic nude mouse model.

    abstract:BACKGROUND:Among hundreds of pathophysiologic factors that impair healing of the diabetic foot, diminished perfusion and neovascularization are critical. This study aimed to show the effect of human adipose-derived stem cells on healing of ischemic wounds in diabetic nude mice and thus to estimate the possibilities of ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e31821e6de2

    authors: Kim EK,Li G,Lee TJ,Hong JP

    更新日期:2011-08-01 00:00:00

  • The identification of novel wound-healing genes through differential display.

    abstract::Effective methods to identify novel genes in complicated dynamic tissue processes are needed in molecular biology research. Traditional techniques primarily target known genes and are inefficient in the pursuit of unknown genes. Here we describe the use of a modified differential display polymerase chain reaction (DD-...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200209010-00011

    authors: Soo C,Sayah DN,Zhang X,Beanes SR,Nishimura I,Dang C,Freymiller E,Ting K

    更新日期:2002-09-01 00:00:00

  • Force-induced craniosynostosis in the murine sagittal suture.

    abstract:BACKGROUND:The cause of nonsyndromic craniosynostosis remains elusive. Although compressive forces have been implicated in premature suture fusion, conclusive evidence of force-induced craniosynostosis is lacking. The purpose of this study was to determine whether cyclical loading of the murine calvaria could induce su...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181bf806c

    authors: Oppenheimer AJ,Rhee ST,Goldstein SA,Buchman SR

    更新日期:2009-12-01 00:00:00

  • Late reconstruction of two total metacarpal bone defects using lengthening devices and a double-barrel osteocutaneous free parascapular flap.

    abstract::A case was presented in which the late reconstruction of left ring and little metacarpal bone defects was carried out using a lengthening device and a double-barrel osteocutaneous free parascapular flap. With this flap, up to 14 cm of nearly straight bone of a suitable width and length for the reconstruction of two me...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200007000-00019

    authors: Masaki F,Takehiro D,Ryuuichi M,Kumi M

    更新日期:2000-07-01 00:00:00

  • A comparative analysis of healing of surgical cleft lip corrected in utero and neonates.

    abstract::We studied the healing process in surgically created cleft lips in fetal mice and compared it with that in newborn mice with cleft lips. Our purpose was to determine the time for optimal healing, defined as minimal scarring, for a repaired cleft lip. Full-thickness paramedian lip incisions were made in NMRI mice in ut...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Boon L,Manicourt D,Marbaix E,Vandenabeele M,Vanwijck R

    更新日期:1992-01-01 00:00:00

  • Cranio-orbital correction for massive enlargement of the cranial vault.

    abstract::A case is reported in which an immense cranial vault was reduced as part of the rehabilitation of a patient with severe hydrocephalus who had preservation of the intellect. This patient was selected carefully, and we do not advocate such procedures on every hydrocephalic. This patient was recumbent and bedridden prior...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197904000-00004

    authors: Vries JK,Habal MB

    更新日期:1979-04-01 00:00:00

  • External distraction osteogenesis in the pediatric mandible.

    abstract:SUMMARY:Mandibular distraction osteogenesis is an effective tool with which to correct facial asymmetry, restore proper occlusion and, more importantly, create an appropriate airway in the micrognathic infant. As a component of many syndromes, micrognathia can impair feeding and speech development and can obstruct the ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e318193485e

    authors: Kaufman Y,Cole PD,McKnight A,Hatef DA,Hollier LH

    更新日期:2009-01-01 00:00:00

  • A novel device for the simple and efficient refinement of liposuctioned tissue.

    abstract::In short, our device allows a surgeon who is harvesting adipose tissue for autologous fat transplantation to immediately, easily, efficiently, and sterilely isolate adipose tissue from the unwanted waste components that are associated with primary liposuction effluent. It does so by "trapping" the fat tissue contained...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200102000-00047

    authors: Katz AJ,Hedrick MH,Llull R,Futrell JW

    更新日期:2001-02-01 00:00:00

  • Expression of bone morphogenetic proteins during membranous bone healing.

    abstract::For the reconstructive plastic surgeon, knowledge of the molecular biology underlying membranous fracture healing is becoming increasingly vital. Understanding the complex patterns of gene expression manifested during the course of membranous fracture repair will be crucial to designing therapies that augment poor fra...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200101000-00018

    authors: Spector JA,Luchs JS,Mehrara BJ,Greenwald JA,Smith LP,Longaker MT

    更新日期:2001-01-01 00:00:00

  • Expansion of the socket and orbit for congenital clinical anophthalmia.

    abstract:BACKGROUND:Congenital clinical anophthalmia requires fitting an artificial eye, achieving a pleasing aspect of the palpebral apparatus, and stimulating growth of the orbit, as well as of the entire midface. METHODS:Out of 25 patients with clinical anophthalmia, 22 were treated according to a new protocol (first descri...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000181653.38200.eb

    authors: Gundlach KK,Guthoff RF,Hingst VH,Schittkowski MP,Bier UC

    更新日期:2005-10-01 00:00:00

  • A methodological analysis of the plastic surgery cost-utility literature using established guidelines.

    abstract:BACKGROUND:Cost-utility studies, common in medicine, are rare within plastic surgery despite their capability of measuring the value of procedures by considering the societal costs of improving quality of life. The objectives of this study were to analyze the design quality of the plastic surgery cost-utility literatur...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000000004

    authors: Tessler O,Mattos D,Vorstenbosch J,Jones D,Winograd JM,Liao EC,Austen WG Jr

    更新日期:2014-04-01 00:00:00

  • Tracheostomal and cervical esophageal reconstruction with combined deltopectoral flap and microvascular free jejunal transfer after central neck exenteration.

    abstract:BACKGROUND:Combined defects of the skin, larynx, pharynx, and esophagus after central compartment exenteration of the neck can be extremely difficult to reconstruct. The objective of this article is to evaluate reconstruction of the central compartment using a combination of free jejunal transfer for pharyngoesophageal...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000156916.82294.98

    authors: McCarthy CM,Kraus DH,Cordeiro PG

    更新日期:2005-04-15 00:00:00

  • Adipose-Derived Stem Cells and Vascularized Lymph Node Transfers Successfully Treat Mouse Hindlimb Secondary Lymphedema by Early Reconnection of the Lymphatic System and Lymphangiogenesis.

    abstract:BACKGROUND:Secondary lymphedema is often observed in postmalignancy treatment of the breast and the gynecologic organs, but effective therapies have not been established in chronic cases even with advanced physiologic operations. Currently, reconstructive surgery with novel approaches has been attempted. METHODS:The h...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000003110

    authors: Hayashida K,Yoshida S,Yoshimoto H,Fujioka M,Saijo H,Migita K,Kumaya M,Akita S

    更新日期:2017-03-01 00:00:00

  • Long-Term Outcomes of Total Knee Arthroplasty following Soft-Tissue Defect Reconstruction with Muscle and Fasciocutaneous Flaps.

    abstract:BACKGROUND:Insufficient soft-tissue coverage following total knee arthroplasty jeopardizes prosthesis retention and may lead to significant complications. The aim of this study was to evaluate the natural history of total knee arthroplasty following flap reconstruction of soft-tissue defects. METHODS:A retrospective r...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000001929

    authors: Kwiecien GJ,Lamaris G,Gharb BB,Murray T,Hendrickson MF,Zins JE,Isakov R

    更新日期:2016-01-01 00:00:00

  • Bone grafts to the nose in Binder's syndrome (maxillonasal dysplasia): a follow-up of eleven patients with the use of profile roentgenograms.

    abstract::Bone grafts are used to lengthen the dorsum and elevate the tip of the nose in patients with Binder's syndrome. Disappointing long-term results in some patients generally have been assumed to be a result of resorption and/or displacement of the grafts. Treatment outcome was studied in 11 patients with the use of seria...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199802000-00005

    authors: Rune B,Aberg M

    更新日期:1998-02-01 00:00:00

  • Predictors of readmission after outpatient plastic surgery.

    abstract:BACKGROUND:Hospital readmissions have become a topic of focus for quality care measures and cost-reduction efforts. However, no comparative multi-institutional data on plastic surgery outpatient readmission rates currently exist. The authors endeavored to investigate hospital readmission rates and predictors of readmis...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000436833.11442.8d

    authors: Mioton LM,Buck DW 2nd,Rambachan A,Ver Halen J,Dumanian GA,Kim JYS

    更新日期:2014-01-01 00:00:00

  • Gastrocnemius transposition flap in conjunction with limb-sparing surgery for primary bone sarcomas around the knee.

    abstract::A primary gastrocnemius transposition flap is a useful technique for prosthetic coverage following extensive soft-tissue and bone resection for sarcomas of the knee joint. The gastrocnemius transposition flap is also a useful secondary procedure to treat local complications following attempted limb-sparing surgery. Th...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198405000-00004

    authors: Malawer MM,Price WM

    更新日期:1984-05-01 00:00:00

  • Prospective photographic measurement study of 196 cases of breast augmentation, mastopexy, augmentation/mastopexy, and breast reduction.

    abstract:BACKGROUND:Our understanding of breast shape and size changes after surgery is limited by a lack of measurement studies that evaluate and compare changes in breast dimensions after cosmetic breast procedures. This study was undertaken to remedy this deficiency. METHODS:Women undergoing primary vertical mastopexy, augm...

    journal_title:Plastic and reconstructive surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/PRS.0b013e3182865e20

    authors: Swanson E

    更新日期:2013-05-01 00:00:00