Tissue protein biomarker candidates to predict progression of esophageal squamous cell carcinoma and precancerous lesions.

abstract：:Calcium signaling plays a key role in bone turnover, regulating both osteoblasts and osteoclasts. Despite this the role of calmodulin, the primary intracellular calcium receptor regulatory protein, has received little attention. In this brief review, the function of Ca(2+)/calmodulin signaling in osteoclast developmen...

journal_title：Annals of the New York Academy of Sciences

authors： Williams JP,Micoli K,McDonald JM

更新日期：2010-03-01 00:00:00

abstract：:Increase in the dosage of cellular oncogenes by DNA amplification is a frequent genetic alteration of cancer cells. In neuroblastoma, amplification of the gene MYCN has been associated with aggressively growing cancers and is an indicator for poor prognosis. MYCN amplification is of predictive value in identifying pat...

journal_title：Annals of the New York Academy of Sciences

authors： Schwab M

更新日期：2002-06-01 00:00:00

abstract：:Twin and family studies have demonstrated that most cognitive traits are moderately to highly heritable. Neurodevelopmental disorders such as dyslexia, autism, and specific language impairment (SLI) also show strong genetic influence. Nevertheless, it has proved difficult for researchers to identify genes that would e...

journal_title：Annals of the New York Academy of Sciences

authors： Bishop DV

更新日期：2009-03-01 00:00:00

abstract：:Altered metabolism of the Alzheimer's amyloid precursor protein (APP) appears to be a key event in the pathogenesis of Alzheimer's disease (AD), and both altered phosphorylation and oxidative stress appear to affect the production of the toxic Abeta fragment. Our results show that altered processing of APP was observe...

journal_title：Annals of the New York Academy of Sciences

authors： Domingues SC,Henriques AG,Wu W,Da Cruz e Silva EF,Da Cruz e Silva OA

更新日期：2007-01-01 00:00:00

abstract：:2-Methoxyestradiol (2-ME) is an estradiol metabolite with antiangiogenic properties. It can be produced by granulosa cells and it is present in normal follicle at high concentrations. The identification of reactive oxygen species (ROS) role in the molecular pharmacology of 2-ME is an active area of research. The objec...

journal_title：Annals of the New York Academy of Sciences

authors： Basini G,Santini SE,Grasselli F

更新日期：2006-12-01 00:00:00

abstract：:Nitric oxide (NO) bioavailability is crucial for normal vascular endothelial function and health. Recent studies have demonstrated an endocrine role for NO equivalents that may be transported in the blood to peripheral tissue beds, where under hypoxic conditions they can liberate NO and cause vasodilation. Exercise tr...

journal_title：Annals of the New York Academy of Sciences

authors： Stabler T,Kenjale A,Ham K,Jelesoff N,Allen J

更新日期：2010-08-01 00:00:00

abstract：:Adhesive interactions are recognized requirements for cellular proliferation, migration and differentiation during normal morphogenesis as well as disease. By differential cloning, osteopontin was identified as an adhesive protein upregulated during vascular remodeling and neointima formation in both rat models and hu...

journal_title：Annals of the New York Academy of Sciences

authors： Giachelli CM,Liaw L,Murry CE,Schwartz SM,Almeida M

更新日期：1995-04-21 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2) are innate immune cells that respond rapidly to their environment through soluble inflammatory mediators and cell-to-cell interactions. As tissue-resident sentinels, ILC2 help orchestrate localized type 2 immune responses. These ILC2-driven type 2 responses are now recognized in di...

journal_title：Annals of the New York Academy of Sciences

authors： Schuijs MJ,Halim TYF

更新日期：2018-04-01 00:00:00

abstract：:The implications of recent precision Z-pole, W mass, and weak neutral current data for testing the standard electroweak model, constraining that t quark and Higgs masses, αs (MZ), and grand unification are discussed. A fit to all data yields sin(2)θw(MZ)= 0.2325 ± 0.0024 (on-shell), where the uncertainties are mainly ...

journal_title：Annals of the New York Academy of Sciences

authors： Langacker P

更新日期：1993-06-01 00:00:00

abstract：:Large quantities of polybrominated diphenyl ethers (PBDEs) have been used as flame retardants in clothing and plastic products since the 1970s. A small fraction of the PBDEs in manufactured products subsequently enters municipal wastewater. Nevertheless, the resistance of these compounds to chemical and biochemical tr...

journal_title：Annals of the New York Academy of Sciences

authors： Arnold RG,Teske S,Tomanek M,Engstrom J,Leung C,Zhang J,Banihani Q,Quanrud D,Ela WP,Sáez AE

更新日期：2008-10-01 00:00:00

abstract：:Nervous systems of helminths are highly peptidergic. Species in the phylum Nematoda (roundworms) possess at least 50 FMRFamide-related peptides (FaRPs), with more yet to be identified. To date, few non-FaRP neuropeptides have been identified in these organisms, though evidence suggests that other families are present....

journal_title：Annals of the New York Academy of Sciences

authors： Geary TG,Marks NJ,Maule AG,Bowman JW,Alexander-Bowman SJ,Day TA,Larsen MJ,Kubiak TM,Davis JP,Thompson DP

更新日期：1999-01-01 00:00:00

abstract：:Protein crystallography, which has a growing role in the human genome project, is one of the most powerful techniques in modern biology. However, it can only be applied providing suitable crystals can be obtained. The ability to produce suitable crystals is currently the major bottleneck to structure determination. Mi...

journal_title：Annals of the New York Academy of Sciences

authors： Chayen NE,Helliwell JR

更新日期：2002-10-01 00:00:00

abstract：:1. One can accurately predict the contribution of each inhibitor to the total inactivation of an enzyme in plasma once its pseudo-first-order reaction rate constant and concentration are known. 2. Because the mechanism of augmentation of the inactivation rate of an enzyme by ATIII occurs via formation of an ATIII-hepa...

journal_title：Annals of the New York Academy of Sciences

authors： Colman RW,Scott CF,Pixley RA,de la Cadena RA

更新日期：1989-01-01 00:00:00

abstract：:How can people adaptively analyze and "work through" negative feelings without ruminating? This paper will briefly review findings from an integrative program of research, which suggests that a critical factor determining whether people's attempts to adaptively reason about negative experiences succeed or fail is the ...

journal_title：Annals of the New York Academy of Sciences

authors： Kross E

更新日期：2009-06-01 00:00:00

abstract：:A decade of research on human embryonic stem cells (ESC) has paved the way for the discovery of alternative approaches to generating pluripotent stem cells. Combinatorial overexpression of a limited number of proteins linked to pluripotency in ESC was recently found to reprogram differentiated somatic cells back to a ...

journal_title：Annals of the New York Academy of Sciences

authors： Lengerke C,Grauer M,Niebuhr NI,Riedt T,Kanz L,Park IH,Daley GQ

更新日期：2009-09-01 00:00:00

abstract：:Osmotic opening of the blood-brain barrier (BBB) most likely is mediated by modification of interendothelial tight junctions, subsequent to shrinkage of cerebrovascular endothelial cells, and not by stimulation of transendothelial vesicular transport or by channel formation. This paper summarizes evidence for this con...

journal_title：Annals of the New York Academy of Sciences

authors： Rapoport SI,Robinson PJ

更新日期：1986-01-01 00:00:00

abstract：:MRI assessment of myocardial iron and function has revolutionized the treatment of thalassemia major patients. While knowledge of somatic iron stores is vital for iron chelation management, it does not adequately monitor cardiac risk. MRI monitoring of cardiac T2* allows preclinical recognition of myocardial iron, str...

journal_title：Annals of the New York Academy of Sciences

authors： Wood JC,Noetzli L

更新日期：2010-08-01 00:00:00

abstract：:We measured plasma concentration of alpha-melanocyte-stimulating hormone (alpha-MSH), a proopiomelanocortin derivative that modulates pyrogenic and proinflammatory effects of cytokines, in infectious and inflammatory disorders in humans to learn if changes in this peptide take place in naturally occurring disease. alp...

journal_title：Annals of the New York Academy of Sciences

authors： Catania A,Airaghi L,Garofalo L,Cutuli M,Lipton JM

更新日期：1998-05-01 00:00:00

abstract：:The purpose of this study was to quantify the changes in cell membrane conductance in response to electropermeabilization, which may elucidate the mechanisms of tissue injury resulting from high-voltage electrical shock. A high-speed, space-clamp and voltage-clamp experimental configuration was used. The pulse paramet...

journal_title：Annals of the New York Academy of Sciences

authors： Gowrishankar TR,Chen W,Lee RC

更新日期：1998-09-11 00:00:00

abstract：:The frequency of type 1 diabetes mellitus (T1DM)-associated HLA DQ alleles in the U.S. Pacific Northwest is as high as in Scandinavia, which has the highest T1DM incidence in the world. The high regional rate of islet autoimmunity observed among DPT-1 relatives supports this notion. Fortunately, Washington State archi...

journal_title：Annals of the New York Academy of Sciences

authors： Wion E,Brantley M,Stevens J,Gallinger S,Peng H,Glass M,Hagopian W

更新日期：2003-11-01 00:00:00

abstract：:Soluble decoy receptor 3 (DcR3), a member of the tumor necrosis factor receptor superfamily, has recently been reported to increase osteoclast (OC) differentiation. Its impact on the skeleton was reinforced by a study on DcR3 transgenic mice showing a decreased bone mass through the elevation of OC number, providing s...

journal_title：Annals of the New York Academy of Sciences

authors： Brunetti G,Oranger A,Mori G,Centonze M,Colaianni G,Rizzi R,Liso V,Zallone A,Grano M,Colucci S

更新日期：2010-03-01 00:00:00

abstract：:Here we briefly review our studies that have unraveled an important role for the calcium- and calmodulin-sensitive enzyme calcineurin (CN) in bone remodeling. We find that the genetic deletion of the calcineurin Aalpha isoform results in osteoporosis, which is recapitulated in humans following calcineurin inhibitor th...

journal_title：Annals of the New York Academy of Sciences

authors： Sun L,Zhu LL,Zaidi N,Yang G,Moonga BS,Abe E,Iqbal J,Epstein S,Blair HC,Huang CL,Zaidi M

更新日期：2007-11-01 00:00:00

abstract：:Within the past few years, developmental scientists have switched their attention from the study of DNA sequencing to the epigenetic state of the genome. Studying epigenetics could present the key to understanding gene expression changes without altering the basic structure of DNA. For example, the blastocyst, trophec...

journal_title：Annals of the New York Academy of Sciences

authors： Palini S,De Stefani S,Scala V,Dusi L,Bulletti C

更新日期：2011-03-01 00:00:00

abstract：:Our recently developed method, TranSIESTA, enables modelling of molecular electronic devices under operation conditions. The method is based on density functional theory, and calculates the self-consistent electronic structure of a nanostructure coupled to three-dimensional electrodes with different electrochemical po...

journal_title：Annals of the New York Academy of Sciences

authors： Stokbro K,Taylor J,Brandbyge M,Ordejón P

更新日期：2003-12-01 00:00:00

abstract：:A primary impairment of the kidney sodium excretion has been documented both in hypertensive patients (EH) and genetic animal models (Milan hypertensive rat [MHS]) carrying mutations of the cytoskeletal protein adducin and/or increased plasma levels of endogenous ouabain (EO). Ouabain (OU) itself induces hypertension ...

journal_title：Annals of the New York Academy of Sciences

authors： Ferrari P,Ferrandi M,Torielli L,Barassi P,Tripodi G,Minotti E,Molinari I,Melloni P,Bianchi G

更新日期：2003-04-01 00:00:00

abstract：:Mutations in the INSL3 and RXFP2 genes have been associated with human cryptorchidism but with contrasting data. We analyzed the frequency of mutations in these genes in 600 newborns with cryptorchidism (396 unilateral and 204 bilateral) and 300 noncryptorchid subjects. We found five RXFP2 mutations in five bilateral ...

journal_title：Annals of the New York Academy of Sciences

authors： Ferlin A,Zuccarello D,Garolla A,Selice R,Vinanzi C,Ganz F,Zanon GF,Zuccarello B,Foresta C

更新日期：2009-04-01 00:00:00

abstract：:Advanced glycation end products (AGEs) are the result of a nonenzymatic reaction of reducing sugars with primary amino groups of proteins (Maillard reaction). They accumulate in various tissues in the course of aging. Because AGEs induce protein cross-links and oxidative stress (radicals) within cells and tissues, the...

journal_title：Annals of the New York Academy of Sciences

authors： Simm A,Bartling B,Silber RE

更新日期：2004-06-01 00:00:00

abstract：:Pulmonary sarcoidosis is a disease characterized by increased numbers of T lymphocytes within the alveolar structures and the consequent spontaneous release of a variety of mediators relevant to the pathogenesis of this disorder. This phenomenon is associated with a different expansion of the T cell subpopulations pre...

journal_title：Annals of the New York Academy of Sciences

authors： Rossi GA,Sacco O,Cosulich E,Balbi B,Risso A,Ravazzoni C

更新日期：1986-01-01 00:00:00

abstract：:The induction of ornithine decarboxylase (ODC) during G1 phase of the cell cycle appears to be universal and essential for cell cycle progression. This induction has been demonstrated in at least 23 cell types in response to various growth stimuli. Further, specific inhibitors of ODC added to several of these cell lin...

journal_title：Annals of the New York Academy of Sciences

authors： Russell DH,Haddox MK

更新日期：1981-02-27 00:00:00

abstract：:Rapid advances in the biomedical sciences are producing new means of intervention against many of the major tropical diseases. The discovery of new drugs, vaccines and diagnostic tests, however, is only the first, though important, step down an often long and difficult road to their effective deployment in disease con...

journal_title：Annals of the New York Academy of Sciences

authors： Smith PG

更新日期：1989-01-01 00:00:00