Abstract:
:The respiratory network of the preBötzinger complex (preBötC), which controls inspiratory behavior, can in normal conditions simultaneously produce two types of inspiration-related rhythmic activities: the eupneic rhythm composed of monophasic, low-amplitude, and relatively high-frequency bursts, interspersed with sigh rhythmic activity, composed of biphasic, high-amplitude, and lower frequency bursts. By combining electrophysiological recordings from transverse brainstem slices with computational modeling, new advances in the mechanisms underlying sigh production have been obtained during prenatal development. The present review summarizes recent findings that establish when sigh rhythmogenesis starts to be produced during embryonic development as well as the cellular, membrane, and synaptic properties required for its expression. Together, the results demonstrate that although generated by the same network, the eupnea and sigh rhythms have different developmental onset times and rely on distinct network properties. Because sighs (also known as augmented breaths) are important in maintaining lung function (by reopening collapsed alveoli), gaining insight into their underlying neural mechanisms at early developmental stages is likely to help in the treatment of prematurely born babies often suffering from breathing deficiencies.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Thoby-Brisson Mdoi
10.1152/jn.00314.2018subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1162-1172issue
3eissn
0022-3077issn
1522-1598journal_volume
120pub_type
杂志文章,评审abstract::N-arachidonoyldopamine (NADA) is an endogenous molecule found in the nervous system that is capable of acting as a vanilloid agonist via the TRPV1 receptor and as a cannabinoid agonist via the CB1 receptor. Using anesthetized rats, we investigated the neural correlates of behavioral thermal hyperalgesia produced by NA...
journal_title:Journal of neurophysiology
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
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更新日期:2003-06-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1152/jn.1989.62.5.997
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journal_title:Journal of neurophysiology
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journal_title:Journal of neurophysiology
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journal_title:Journal of neurophysiology
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
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