Matrix influence on the tumor cell stimulation of fibroblast collagenase production.

abstract：:The conversion of expandable liver progenitor cells into pancreatic beta cells would provide a renewable cell source for diabetes cell therapy. Previously, we reported the establishment of liver epithelial progenitor cells (LEPCs). In this work, LEPCs were modified into EGFP/Pdx-1 LEPCs, cells with stable expression o...

journal_title：Journal of cellular biochemistry

authors： Jin CX,Li WL,Xu F,Geng ZH,He ZY,Su J,Tao XR,Ding XY,Wang X,Hu YP

更新日期：2008-05-01 00:00:00

abstract：:Numerous studies have demonstrated the role of A3 adenosine receptor (A3AR) and signaling pathways in the multiple aspects of the tumor. However, there is a little study about the function of A3AR in the biological processes of cancer stem cells (CSCs). CSCs have a critical role in the maintenance and survival of brea...

journal_title：Journal of cellular biochemistry

authors： Jafari SM,Panjehpour M,Aghaei M,Joshaghani HR,Enderami SE

更新日期：2017-09-01 00:00:00

abstract：:Insects can effectively and rapidly clear microbial infections by a variety of innate immune responses including the production of antimicrobial peptides. Induction of these antimicrobial peptides in Drosophila has been well established to involve NF-kappaB elements. We present evidence here for a molecular mechanism ...

journal_title：Journal of cellular biochemistry

authors： Cornwell WD,Kirkpatrick RB

更新日期：2001-04-02 00:00:00

abstract：:We previously reported that 1α,25-dihydroxy-vitamin D(3) [1α,25(OH)(2)D(3)] induces non-transcriptional rapid responses through activation of Src and MAPKs in the skeletal muscle cell line C2C12. In the present study we investigated the modulation of Akt by the secosteroid hormone in C2C12 cells at proliferative stage...

journal_title：Journal of cellular biochemistry

authors： Buitrago CG,Arango NS,Boland RL

更新日期：2012-04-01 00:00:00

abstract：:Giant cell tumor of bone is a progressive, potentially malignant process which destroys skeletal tissue by virtue of its osteoclast complement. As a biological entity it provides a unique natural model of bone resorption by osteoclasts whose recruitment and development is controlled by a neoplastic population of fibro...

journal_title：Journal of cellular biochemistry

authors： Robinson D,Einhorn TA

更新日期：1994-07-01 00:00:00

abstract：:Endometrial carcinoma (EC) is one of the main gynecologic malignancies affecting women, but effective treatments are currently lacking. In the present study, we investigated the effect of sorafenib, a general kinase inhibitor, on several EC cell lines (HEC1A, HEC1B, and RL95-2). Sorafenib induced cell death in EC cell...

journal_title：Journal of cellular biochemistry

authors： Sun NK,Huang SL,Chang TC,Chao CC

更新日期：2013-08-01 00:00:00

abstract：:Acid-electrolyzed functional water (FW) is obtained through the electrolysis of sodium chloride solution. Stimulation of the human fibroblastic cell line HeLa by FW led to the augmented secretion of basic fibroblast growth factor (bFGF). Immunoprecipitation followed by Western blot analysis revealed that both high and...

journal_title：Journal of cellular biochemistry

authors： Motozawa K,Motoyoshi M,Saiki A,Sasaki H,Shimizu N,Asano M

更新日期：2018-09-01 00:00:00

abstract：:Nowadays, increased use of nanomaterials in industry and biomedicine poses potential risks to human health and the environment. Studying their possible toxicological effects is therefore of great significance. The present investigation was designed to examine the status of oxidative stress induced by nanoparticles (NP...

journal_title：Journal of cellular biochemistry

authors： Soltani A,Kahkhaie KR,Haftcheshmeh SM,Jalali Nezhad AA,Akbar Boojar MM

更新日期：2018-11-28 00:00:00

abstract：:The bone morphogenetic proteins were originally identified based on their ability to induce ectopic bone formation in vivo and have since been identified as members of the transforming growth factor-beta gene superfamily. It has been well established that the bone morphogenetic cytokines enhance osteogenic activity in...

journal_title：Journal of cellular biochemistry

authors： Gimble JM,Morgan C,Kelly K,Wu X,Dandapani V,Wang CS,Rosen V

更新日期：1995-07-01 00:00:00

abstract：:Fluorescent proteins have enabled the color-coding of cells growing in vivo. Noninvasive imaging of cells expressing fluorescent proteins has allowed the real-time determination of the behavior of cancer cells, the progression of infection, the differentiation of stem cells, and interaction of stromal and cancer cells...

journal_title：Journal of cellular biochemistry

authors： Hoffman RM

更新日期：2017-09-01 00:00:00

abstract：:A new method of protein nucleation and crystallization based on Langmuir-Blodgett technology is here utilized for the template stimulation of crystal growth of so far non-crystallized proteins. Microcrystals (60-120 microm) of bovine cytochrome P450scc and human protein kinase CKII alpha subunit were obtained with use...

journal_title：Journal of cellular biochemistry

authors： Pechkova E,Nicolini C

更新日期：2002-01-01 00:00:00

abstract：:The NAD-dependent deacetylase Sirtuin 1 (SIRT1) plays a vital role in leukemogenesis. Nicotinamide (NAM) is the principal NAD+ precursor and a noncompetitive inhibitor of SIRT1. In our study, we showed that NAM enhanced the sensitivity of chronic myeloid leukemia (CML) to doxorubicin (DOX) via SIRT1. We found that SIR...

journal_title：Journal of cellular biochemistry

authors： Pan S,Leng J,Deng X,Ruan H,Zhou L,Jamal M,Xiao R,Xiong J,Yin Q,Wu Y,Wang M,Yuan W,Shao L,Zhang Q

更新日期：2020-01-01 00:00:00

abstract：:Smoothened (SMO) is a significant signalling protein which functions as a key transducer for the hedgehog signalling pathway, an important signalling mechanism with key roles in development and oncogenesis. The correlation of expression dynamics of SMO with pancreatic and colorectal cancer genesis has been known but w...

journal_title：Journal of cellular biochemistry

authors： Niyaz M,Khan MS,Wani RA,Shah OJ,Besina S,Mudassar S

更新日期：2019-02-19 00:00:00

abstract：:Neuropathic pain is a kind of pain caused by primary or secondary impairment or dysfunction of peripheral or central nervous system. Patients with neuropathic pain were often with poor clinical outcome. We screened the differentially expressed genes between sciatic nerve injury and dorsal root ganglion gene in the sha...

journal_title：Journal of cellular biochemistry

authors： Yang JA,He JM,Lu JM,Jie LJ

更新日期：2018-06-01 00:00:00

abstract：:Ligamentum flavum (LF)-derived mesenchymal stem cells (MSCs) have been implicated in the pathogenesis of calcification of the ligamentum flavum (CLF) leading to the increased presence of chondrocyte-like cells and calcium deposition in CLF; however, the mechanisms of LF-MSCs in differentiation are not defined. In this...

journal_title：Journal of cellular biochemistry

authors： Zhang Q,Wang S,Sheng Y,Zhao S,Jiang Y,Zhou D,Yang H

更新日期：2019-03-01 00:00:00

abstract：:Poor prognosis and low survival are commonly seen in patients with glioblastoma multiforme (GBM). Due to the specific nature of solid tumors such as GBM, delivery of therapeutic agents to the tumor sites is difficult. So, one of the major challenges in the treatment of these tumors is a selection of appropriate method...

journal_title：Journal of cellular biochemistry

authors： Jabbarpour Z,Kiani J,Keshtkar S,Saidijam M,Ghahremani MH,Ahmadbeigi N

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:Hepatocarcinoma is one of the most lethal cancers, leading to a 5-year survival rate as low as 30% due to recurrence and metastasis. The treatment of liver cancer includes surgery and medication, of which, the former is more effective. However, surgical resection is applicable in less than 40% of patients. T...

journal_title：Journal of cellular biochemistry

authors： Shen X,Cui X,Cui H,Jin Y,Jin W,Sun H

更新日期：2019-04-01 00:00:00

abstract：:E-peptide of the pro-Insulin-like growth factor-I (pro-IGF-I) is produced from pre-pro-IGF-I by proteolytic cleavage in the post-translational processing. Previous in vitro studies conducted in our laboratory showed that Ea4-peptide of rainbow trout (rt) pro-IGF-I or Eb-peptide of human (h) pro-IGF-I exhibited activit...

journal_title：Journal of cellular biochemistry

authors： Chen MJ,Chiou PP,Lin P,Lin CM,Siri S,Peck K,Chen TT

更新日期：2007-08-01 00:00:00

abstract：:Vascular smooth-muscle cell (VSMC) proliferation plays a vital role in hypertension, atherosclerosis and restenosis. It has been reported that emodin, an active component extracted from rhubarb, can stop the growth of cancer cells; however, it is not known if emodin exerts similar anti-atherogenic effects in TNF-alpha...

journal_title：Journal of cellular biochemistry

authors： Heo SK,Yun HJ,Park WH,Park SD

更新日期：2008-09-01 00:00:00

abstract：:Osteopontin is a secreted glycoprotein with adhesive and migratory functions. Cellular interactions with osteopontin are mediated through integrin receptors which recognize the RGD domain. Recently, CD44, a non-integrin, multifunctional adhesion molecule was identified as an osteopontin receptor. CD44 is a ubiquitous ...

journal_title：Journal of cellular biochemistry

authors： Smith LL,Greenfield BW,Aruffo A,Giachelli CM

更新日期：1999-04-01 00:00:00

abstract：:Intact embryonic chick neural retina cells have at their surface an N-acetylgalactosaminyltransferase which catalyzes the incorporation of N-acetylgalactosamine from UDP-N-acetylgalactosamine into endogenous macromolecular acceptors. The enzyme along with its endogenous acceptors can be isolated as a particulate compl...

journal_title：Journal of cellular biochemistry

authors： Balsamo J,Pratt RS,Emmerling MR,Grunwald GB,Lilien J

更新日期：1986-01-01 00:00:00

abstract：:The current study was designed to explore the therapeutic effect and mechanism of different extraction, which came from hypoglycemic granule on diabetes-induced liver injury. The ethanol fraction (HGEF) and aqueous fraction (HGAF) from hypoglycemic granule were prepared and administered p.o. to diabetic mice for 17 we...

journal_title：Journal of cellular biochemistry

authors： Yang X,Zhang P,Zhang F,Ke Z,Chen Q,Liu C

更新日期：2020-06-01 00:00:00

abstract：:Cysteine-rich 61 (Cyr61) is a member of the CCN protein family that has been implicated in diverse biological processes such as cell adhesion, proliferation, angiogenesis, and tumorigenesis. Altered expression of Cyr61 is found to be associated with human cancers. Here we show that Cyr61 was up-regulated in prostate c...

journal_title：Journal of cellular biochemistry

authors： Lv H,Fan E,Sun S,Ma X,Zhang X,Han DM,Cong YS

更新日期：2009-03-01 00:00:00

abstract：:Muscular dystrophies are characterized by continuous cycles of degeneration and regeneration that result in extensive fibrosis and a progressive diminution of muscle mass. Cell surface heparan sulfate proteoglycans are found almost ubiquitously on the surface and in the extracellular matrix (ECM) of mammalian cells. T...

journal_title：Journal of cellular biochemistry

authors： Alvarez K,Fadic R,Brandan E

更新日期：2002-01-01 00:00:00

abstract：:Flavonoids are a group of naturally-occurring phenolic compounds in the plant kingdom, and many flavonoids are found with vascular protective properties. Nevertheless how the protective response is exerted by flavonoids is not well characterized. In view of the nuclear factor-kappaB (NFkappaB) may play a central role ...

journal_title：Journal of cellular biochemistry

authors： Tsai SH,Liang YC,Lin-Shiau SY,Lin JK

更新日期：1999-09-15 00:00:00

abstract：:Active nucleo-cytoplasmic transport is mediated by dynamic signal-mediated pathways. We investigated the effects of transcription inhibitors or fluorescent lectins on nuclear import mediated by nuclear localization signals (NLSs). Therefore, a novel experimental approach that allows the controlled sequential introduct...

journal_title：Journal of cellular biochemistry

authors： Stauber RH,Krätzer F,Schneider G,Hirschmann N,Hauber J,Rosorius O

更新日期：2001-01-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) increases steady-state mRNA levels of several extracellular matrix proteins in mineralized connective tissues. Bone sialoprotein (BSP) is a major constituent of the bone matrix, thought to initiate and regulate the formation of mineral crystals. To determine the molecular pat...

journal_title：Journal of cellular biochemistry

authors： Ogata Y,Niisato N,Furuyama S,Cheifetz S,Kim RH,Sugiya H,Sodek J

更新日期：1997-06-15 00:00:00

abstract：:Breast cancer resistance protein (BCRP) is an ATP-binding cassette multidrug transporter that confers resistance to various anticancer drugs like Mitoxantrone. Overexpression of BCRP confers multidrug resistance (MDR) in cancer cells and is a frequent impediment to successful chemotherapy. For stable reversal of BCRP-...

journal_title：Journal of cellular biochemistry

authors： Lv H,He Z,Liu X,Yuan J,Yu Y,Chen Z

更新日期：2007-09-01 00:00:00

abstract：:Fracture repair is a complex process involving timed cellular recruitment, gene expression, and synthesis of compounds that regenerate native tissue to restore the mechanical integrity, and thus function of injured bone. While the majority of fractures heal without complication, this takes time and a subset of patient...

journal_title：Journal of cellular biochemistry

authors： Komatsu DE,Warden SJ

更新日期：2010-02-01 00:00:00

abstract：:Platelets are critical regulators of liver regeneration, but the mechanisms are still not fully understood. Platelets have been shown to contain a wide variety of microRNAs (miRNAs) and play an important role in many diseases. However, the mechanism that how the platelet microparticles (PMPs)-derived miRNA regulate th...

journal_title：Journal of cellular biochemistry

authors： Xu Y,Li W,Liang G,Peng J,Xu X

更新日期：2020-07-21 00:00:00