Challenges for the Sustainability of University-Run Biobanks.

Abstract:

:Most university biobanks begin like other university research projects, that is, with an idea conceived by an individual researcher in pursuit of his/her own research interests, publications, funding, and career. Some biobanks, however, come to have scientific value that goes beyond the projects that were initially responsible for the collection of the samples and data they contain. Such value may derive from among other things the uniqueness of the samples in terms of their sheer volume, the quality of the samples, the ability to link the samples with information retrieved in disease registries, or the fact that the samples represent very rare diseases. This article focuses on biobanks of this kind, and the special obligations that publicly funded universities have to ensure the sustainability of biobanks with continued scientific value. We argue that universities should adopt policies to deal with the various, diverse issues which may arise during the lifecycle of a biobank. The policies should be flexible, accommodate the freedoms of individual researchers, and reflect the multifaceted nature of biobanks. Yet they should be specific enough to provide guidance and robust enough to safeguard legal norms and ethical values. The article sets out concrete recommendations which universities should consider and act upon.

journal_name

Biopreserv Biobank

authors

Kongsholm NCH,Christensen ST,Hermann JR,Larsen LA,Minssen T,Pedersen LB,Rajam N,Tommerup N,Tupasela A,Schovsbo J

doi

10.1089/bio.2018.0054

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

312-321

issue

4

eissn

1947-5535

issn

1947-5543

journal_volume

16

pub_type

杂志文章
  • The challenge of sustaining a hospital-based biobank and core molecular laboratory: the Beaumont experience.

    abstract::The Beaumont Health System BioBank was established in 2008, not only to leverage the potential to collect biospecimens for translational research, but to undertake such research in a seamless facility that combined high quality biobanking with state-of-the-art laboratory platforms geared towards biospecimen-based rese...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2014.0049

    authors: Wilson GD,D'Angelo K,Pruetz BL,Geddes TJ,Larson DM,Akervall J

    更新日期:2014-10-01 00:00:00

  • Comparison Between an Animal-Derived Product Medium and a Chemically Defined Medium for Ram Sperm Cryopreservation.

    abstract::Animal-derived products are widely used in sperm cryopreservation for their cryoprotective properties. These components, however, tend to be replaced because of sanitary risks. STEMALPHA.CRYO3 (Ref. 5617; Stem Alpha, Saint-Genis-l'Argentière, France), called "CRYO3," is a chemically defined preservation medium current...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2018.0067

    authors: Gavin-Plagne L,Commin L,Bruyère P,Buff S,Joly T

    更新日期:2019-01-01 00:00:00

  • Improving Ribosomal RNA Integrity in Surgically Resected Human Brain Tumor Biopsies.

    abstract:BACKGROUND:Biopsies extracted from brain cancer patients often display degraded ribosomal RNA, which makes them unusable in transcriptomic experiments. This has not been properly documented in previous works aimed at refining the molecular classification of brain cancer. OBJECTIVE:To determine RNA integrity in a large...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2015.0086

    authors: Castells Domingo X,Ferrer-Font L,Davila M,Candiota AP,Simões RV,Fernández-Coello A,Gabarrós A,Boluda S,Barceló A,Ariño J,Arús C

    更新日期:2016-04-01 00:00:00

  • Severe Acute Respiratory Syndrome Coronavirus 2 and Coronavirus Disease 2019: A Clinical Overview and Primer.

    abstract::Following its emergence in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused what rapidly became a global pandemic. The precise origin and subsequent path of transmission have not yet been established-but like the other novel coronaviruses that it closely resembles, it appears to have ...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章,评审

    doi:10.1089/bio.2020.0066

    authors: Knight TE

    更新日期:2020-12-01 00:00:00

  • Mesenchymal stem cell isolation from human umbilical cord tissue: understanding and minimizing variability in cell yield for process optimization.

    abstract::Human tissue banks are a potential source of cellular material for the nascent cell-based therapy industry; umbilical cord (UC) tissue is increasingly privately banked in such facilities as a source of mesenchymal stem cells for future therapeutic use. However, early handling of UC tissue is relatively uncontrolled du...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2013.0027

    authors: Iftimia-Mander A,Hourd P,Dainty R,Thomas RJ

    更新日期:2013-10-01 00:00:00

  • Oocyte Cryopreservation Based in Sheep: The Current Status and Future Perspective.

    abstract::The establishment of a cryopreservation procedure for sheep oocytes will enhance the development of long-term conservation of sheep female genetic resources and the advancement of sheep embryonic biotechnology. However, higher cytoplasmic lipid content and complex subcellular structures affect the relatively higher se...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章,评审

    doi:10.1089/bio.2017.0074

    authors: Quan G,Wu G,Hong Q

    更新日期:2017-12-01 00:00:00

  • Cryopreservation and storage effects on cell numbers and DNA damage in human lymphocytes.

    abstract::The comet assay measures DNA damage in individual cells (usually lymphocytes) and is widely used in biomonitoring studies. Lymphocytes are harvested and are usually cryopreserved for batch testing. We investigated cell loss during harvesting, cryopreservation, thawing, and washing of human peripheral lymphocytes and c...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2011.0024

    authors: Ho CK,Choi SW,Siu PM,Benzie IF

    更新日期:2011-12-01 00:00:00

  • Targeting Future Customers: An Introductory Biobanking Course for Undergraduate Students of Life Sciences.

    abstract:INTRODUCTION:Biobanking is a relatively new concept in the Arab region. Targeting different stakeholders to introduce the concept of biobanking and develop an acceptance of it among them is important for the growth of biobanking in the region. Undergraduate students of life sciences represent an important segment of st...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2016.0111

    authors: Abdelhafiz AS,Fouda MA,El-Jaafary SI,Farghly MI,Salem M,Tammam A,Gabr H

    更新日期:2017-08-01 00:00:00

  • Integrating Molecular Control to Improve Cryopreservation Outcome.

    abstract::Cryopreservation (CP) is a critical component in enabling on-demand access to biological material (macromolecules, cells, and tissues), yet CP has evolved little over the last several decades. Today's CP processes often yield a suboptimal "product," which has slowed progression in areas such as cell therapy and stem c...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章,评审

    doi:10.1089/bio.2016.0119

    authors: Baust JG,Snyder KK,Van Buskirk R,Baust JM

    更新日期:2017-04-01 00:00:00

  • Biobanking in the COVID-19 Era and Beyond: Part 2. A Set of Tool Implementation Case Studies.

    abstract::The COVID-19 era has brought about a number of novel challenges for the global biobanking community. An array of diverse tools (e.g., standards, best practices, and plans) exists to support quality and fitness-for-purpose in biobank operations. The International Society for Biological and Environmental Repositories (I...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2020.0083

    authors: Allocca CM,Snapes E,Albert M,Bledsoe MJ,Castelhano MG,De Wilde M,Furuta K,Kozlakidis Z,Martin D,Martins A,McCall SJ,Schacter B

    更新日期:2020-12-01 00:00:00

  • The Montpellier Leishmania Collection, from a Laboratory Collection to a Biological Resource Center: A 39-Year-Long Story.

    abstract::We report the development of a laboratory collection of Leishmania that was initiated in 1975 and, after 39 years, has become an international Biological Resource Center (BRC-Leish, Montpellier, France, BioBank No. BB-0033-00052), which includes 6353 strains belonging to 36 Leishmania taxa. This is a retrospective ana...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2015.0101

    authors: Pratlong F,Balard Y,Lami P,Talignani L,Ravel C,Dereure J,Lefebvre M,Serres G,Bastien P,Dedet JP

    更新日期:2016-12-01 00:00:00

  • Effect of Synergism Between Carboxylated Poly-l-Lysine and Glycerol on Freezability of Nili-Ravi Buffalo (Bubalus bubalis) Semen.

    abstract::Carboxylated poly-l-lysine (CPLL), an ampholytic polymer, has remarkable cryoprotective properties. It was hypothesized that CPLL will reduce/replace glycerol in extender and improve the freezability of buffalo semen. The objective was to evaluate various combinations of CPLL and glycerol in extenders for any synergis...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2019.0120

    authors: Akhter S,Awan MA,Arshad J,Rakha BA,Ansari MS,Iqbal S

    更新日期:2020-10-01 00:00:00

  • Human Adipose Tissue Cryopreservation: Impact of Different Calf Serum Concentrations on Tissue Viability.

    abstract::Adipose tissue, which is harvested in large quantities during liposuction, has no blood supply and becomes necrotic within a few hours, if not immediately transplanted. Cryopreservation of adipose tissue allows these samples to be stored and used in diverse fundamental experiments, especially in fat-grafting animal te...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2020.0038

    authors: Gu L,Sun Y,Wang P,Liu L,Gu J

    更新日期:2020-10-09 00:00:00

  • Impact of a Permission to Contact (PTC) platform on biobank enrollment and efficiency.

    abstract::The consent process involves three steps; referral for contact, preliminary interview, and informed consent discussion. We propose that the efficiency and frequency of the consent process for individual biobank related projects increases when the referral for contact is conducted by an independent "Permission to Conta...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2013.0004

    authors: LeBlanc J,Dee S,Braun L,Daudt H,Cheah S,Watson PH

    更新日期:2013-06-01 00:00:00

  • Ethical Legal and Social Issues of Biobanking: Past, Present, and Future.

    abstract::The past 15 years has seen considerable changes in the research environment. These changes include the development of new sophisticated genetic and genomic technologies, a proliferation of databases containing large amount of genotypic and phenotypic data, and wide-spread data sharing among many institutions, national...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章,评审

    doi:10.1089/bio.2017.0030

    authors: Bledsoe MJ

    更新日期:2017-04-01 00:00:00

  • Increased Cell Survival of Human Primary Conjunctival Stem Cells in Dimethyl Sulfoxide-Based Cryopreservation Media.

    abstract::Glycerol and dimethyl sulfoxide (DMSO) are widely used cryoprotectants for freezing human cell cultures. During the manufacturing process of ocular stem cell-based autographs, ex vivo cultivated ocular cells are cryopreserved for quality control purposes in accordance with regulatory requirements. The efficiency of th...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2020.0091

    authors: van Velthoven AJH,Bertolin M,Barbaro V,Sthijns MMJPE,Nuijts RMMA,LaPointe VLS,Dickman MM,Ferrari S

    更新日期:2020-11-13 00:00:00

  • Changing the Culture of Tumor Tissue Biobanking in a Tertiary Referral Hospital Using an Audit and Feedback Strategy.

    abstract::We examined whether the introduction of an audit and feedback strategy applied to specimens dissected at the John Hunter Hospital anatomical pathology department improved the number of formalin fixed tumor specimens sampled by anatomical pathology registrars for the Hunter Cancer Biobank. During the audit period (1/7/...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2018.0100

    authors: King S,Walker M,Neilsen S,O'Brien M

    更新日期:2019-01-01 00:00:00

  • Practical electronic information system and printed recording promote management accuracy in an early-stage small-scale non-automatic biobank.

    abstract::It is particularly necessary for biomedical researchers to obtain applicable biosamples accurately and efficiently, especially from a biobank with multiple-disease catalogs. To optimize the retrieval procedure, especially in the early stages of a non-automatic biobank, we developed a procedure that combined the electr...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2014.0102

    authors: Gao Z,Gu Y,Lv Z,Yu G,Zhou J

    更新日期:2015-02-01 00:00:00

  • Consent to a Postmortem Tissue Procurement Study: Distinguishing Family Decision Makers' Knowledge of the Genotype-Tissue Expression Project.

    abstract::Tissues from postmortem transplantation donors are a viable and productive option for genomic research. This entails obtaining authorization from the family decision makers (FDMs) of deceased donors. This study examined best practices for making such requests within the context of the Genotype-Tissue Expression (GTEx)...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2017.0115

    authors: Siminoff LA,Wilson-Genderson M,Gardiner HM,Mosavel M,Barker KL

    更新日期:2018-06-01 00:00:00

  • Standardized Serum-Free Cryomedia Maintain Peripheral Blood Mononuclear Cell Viability, Recovery, and Antigen-Specific T-Cell Response Compared to Fetal Calf Serum-Based Medium.

    abstract::The ability to analyze cryopreserved peripheral blood mononuclear cells (PBMCs) from biobanks for antigen-specific T-cell immunity is necessary to evaluate responses to immune-based therapies. Comprehensive studies have demonstrated that the quality of frozen PBMCs is critical and the maintenance of cell viability and...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2010.0033

    authors: Germann A,Schulz JC,Kemp-Kamke B,Zimmermann H,von Briesen H

    更新日期:2011-09-01 00:00:00

  • Factors associated with willingness to participate in biospecimen research among Chinese Americans.

    abstract::A paucity of information exists on the recruitment of Asian Americans for biospecimen research. Although studies show that Chinese Americans are at high risk for hepatitis B virus (HBV) infection, little is known about their willingness to participate in HBV-related biospecimen research and how knowledge, attitudes, a...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2013.0081

    authors: Gao W,Ma GX,Tan Y,Fang C,Weaver J,Jin M,Lai P

    更新日期:2014-04-01 00:00:00

  • Organization of BBMRI.pl: The Polish Biobanking Network.

    abstract::In Poland storage of human biological samples takes place at most universities and scientific institutions conducting research projects in the field of biomedicine. The First International Biobanking Conference organized by the Ministry of Science and Higher Education in 2014 shed a light on the situation of Polish bi...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2016.0091

    authors: Witoń M,Strapagiel D,Gleńska-Olender J,Chróścicka A,Ferdyn K,Skokowski J,Kalinowski L,Pawlikowski J,Marciniak B,Pasterk M,Matera-Witkiewicz A,Kozera Ł

    更新日期:2017-06-01 00:00:00

  • The influence of tissue procurement procedures on RNA integrity, gene expression, and morphology in porcine and human liver tissue.

    abstract::The advent of molecular characterization of tissues has brought an increasing emphasis on the quality of biospecimens, starting with the tissue procurement process. RNA levels are particularly affected by factors in the collection process, but the influence of different pre-analytical factors is not well understood. H...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2014.0076

    authors: Kap M,Sieuwerts AM,Kubista M,Oomen M,Arshad S,Riegman P

    更新日期:2015-06-01 00:00:00

  • Short-term stability study of RNA at room temperature.

    abstract::The quality of RNA preserved in different stabilization matrices was investigated after 2 weeks of storage at room temperature. RNA samples in RNAstable (Biomatrica), GenTegra (IntegenX), and RNAshell (Imagene) were compared to RNA stored at -80°C (the current gold standard for RNA preservation) and with liquid or dri...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章,多中心研究

    doi:10.1089/bio.2012.0030

    authors: Mathay C,Yan W,Chuaqui R,Skubitz AP,Jeon JP,Fall N,Betsou F,Barnes M,ISBER Biospecimen Science Working Group.

    更新日期:2012-12-01 00:00:00

  • Chinese biobanking initiatives.

    abstract::Due to the requirement for comprehensive clinical research efforts in China, the importance of biobanking in modern clinical research is outlined in this overview. Hospitals, universities, and research institutes have been well organized as fundamental resources for Chinese biobanking initiatives and the resulting bio...

    journal_title:Biopreservation and biobanking

    pub_type: 历史文章,杂志文章

    doi:10.1089/bio.2014.0096

    authors: Gan R,Wang H,Song Y,Fan J,Xiong Y

    更新日期:2015-02-01 00:00:00

  • Repository Planning, Design, and Engineering: Part I--Infrastructure.

    abstract::This is a two-part review describing the planning, engineering, and design considerations for building a new repository for biological and environmental samples. Part I addresses the physical infrastructure requirements for a repository; Part II will cover equipment and costing. Planning for construction of a new repo...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章,评审

    doi:10.1089/bio.2015.0084

    authors: Baird PM,Gunter EW

    更新日期:2016-04-01 00:00:00

  • Bacterial Contamination of Blood DNA Samples is Associated with Donor's Health Condition.

    abstract::Bacterial contamination often occurs in human blood DNA samples, possibly due to bacteremia or an inappropriate procedure during sample preparation. This study aimed at analyzing the clinical significance of bacterial DNA contamination in human blood DNA samples and to assess its influence on experimental data. DNA sa...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2010.0012

    authors: Lee JE,Hong EJ,Shim SM,Kim JW,Bae GR,Cho YS,Jeon JP,Han BG

    更新日期:2010-09-01 00:00:00

  • The use of biospecimens in population-based research: a review of the National Cancer Institute's Division of Cancer Control and Population Sciences grant portfolio.

    abstract::Over the past two decades, researchers have increasingly used human biospecimens to evaluate hypotheses related to disease risk, outcomes and treatment. We conducted an analysis of population-science cancer research grants funded by the National Cancer Institute (NCI) to gain a more comprehensive understanding of bios...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章,评审

    doi:10.1089/bio.2014.0009

    authors: Carrick DM,Mette E,Hoyle B,Rogers SD,Gillanders EM,Schully SD,Mechanic LE

    更新日期:2014-08-01 00:00:00

  • Long-Term Room Temperature Storage of Dry Ribonucleic Acid for Use in RNA-Seq Analysis.

    abstract::RNA is an essential biological material for research in genomics and translational medicine. As such, its storage for biobanking is an important field of study. Traditionally, long-term storage in the cold (generally freezers or liquid nitrogen) is used to maintain high-quality (in terms of quantity and integrity) RNA...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2017.0024

    authors: Li Q,Wang X,Liu X,Liao Q,Sun J,He X,Yang T,Yin J,Jia J,Li X,Colotte M,Bonnet J

    更新日期:2017-12-01 00:00:00

  • Advancing Professionalization of Biobank Business Operations: Performance and Utilization.

    abstract::Biobanks are now in the spotlight as key enablers supporting preclinical, clinical, and environmental research. Awareness of their value has increased along with the need for these infrastructures to be sustained through business-focused practices. Following our 2017 pilot survey on biobank business planning, we initi...

    journal_title:Biopreservation and biobanking

    pub_type: 杂志文章

    doi:10.1089/bio.2019.0005

    authors: Henderson MK,Goldring K,Simeon-Dubach D

    更新日期:2019-06-01 00:00:00