Abstract:
:We investigated the effect of irradiation on the kinetic characteristics of amino acid and glucose transport, and the effect on the activity of the cell membrane-bound enzyme 5'-nucleotidase and on the receptor-mediated stimulation of cyclic adenosine monophosphate synthesis by prostaglandin E1. Irradiation inhibited the sodium-dependent amino acid transport by a reduced binding of the amino acid to the transport unit. The transport of glucose, which appeared to be a sodium-independent process, was temporarily stimulated by increased maximal velocity of the transport. No effect was found on the binding to the transport unit. Irradiation increased the 5'-nucleotidase activity and decreased the prostaglandin E1-stimulated cyclic adenosine monophosphate synthesis 48 h after exposure to 20 Gy. It is concluded that irradiation decreases sodium-dependent transport by impairment of the transport unit, does not impair a sodium-independent process, and has opposite effects on membrane-bound enzyme activity and a receptor-mediated process.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Vegt GB,Wassenaar AM,Kawilarang-de Haas EW,Schütte PP,van der Linden M,Di Bon-de Ruijter M,Boon Asubject
Has Abstractpub_date
1985-12-01 00:00:00pages
317-28issue
3eissn
0033-7587issn
1938-5404journal_volume
104pub_type
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更新日期:1983-04-01 00:00:00
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更新日期:1991-11-01 00:00:00
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更新日期:1990-03-01 00:00:00
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更新日期:1992-07-01 00:00:00
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