Complications of Treatments for Pediatric Rheumatic Diseases.

Abstract:

:Medications to treat children with rheumatic disease include disease-modifying antirheumatic drugs, glucocorticosteroids, and biologic response modifiers that target mediators and cells involved in autoimmunity and inflammation. Although usually well-tolerated, such medications have many possible side effects, of which primary care and emergency providers should be aware. Both disease and immunosuppression contribute to susceptibility to unusual and opportunistic infections, in addition to usual childhood infections for which these children should receive all applicable nonlive vaccines. Close coordination between the rheumatologist and other medical care providers is essential, because medication side effects, infections, and disease flares are difficult to distinguish, and may occur together.

journal_name

Pediatr Clin North Am

authors

Higgins GC

doi

10.1016/j.pcl.2018.04.008

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

827-854

issue

4

eissn

0031-3955

issn

1557-8240

pii

S0031-3955(18)30047-6

journal_volume

65

pub_type

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