Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline.

Abstract:

OBJECTIVE:To examine associations of orthostatic hypotension (OH) with dementia and long-term cognitive decline and to update previously published results in the same cohort for stroke with an additional 16 years of follow-up. METHODS:We analyzed data from 11,709 participants without a history of coronary heart disease or stroke who attended the baseline examination (1987-1989) of the prospective Atherosclerosis Risk in Communities (ARIC) study. OH was defined as a drop in systolic blood pressure (BP) of at least 20 mm Hg or a drop in diastolic BP of at least 10 mm Hg on standing. Dementia was ascertained via examination, contact with participants or their proxy, or medical record surveillance. Ischemic stroke was ascertained via cohort surveillance of hospitalizations, cohort follow-up, and linkage with registries. Both outcomes were adjudicated. Cognitive function was ascertained via 3 neuropsychological tests administered in 1990 to 1992 and 1996 to 1998 and a full battery of tests in 2011 to 2013. Scores were summarized and reported as SDs. We used adjusted Cox regression and linear mixed models. RESULTS:Over ≈25 years, 1,068 participants developed dementia and 842 had an ischemic stroke. Compared to persons without OH at baseline, those with OH had a higher risk of dementia (hazard ratio [HR] 1.54, 95% confidence interval [CI] 1.20-1.97) and ischemic stroke (HR 2.08, 95% CI 1.65-2.62). Persons with OH had greater, although nonsignificant, cognitive decline over 20 years (SD 0.09, 95% CI -0.02 to 0.21). CONCLUSIONS:OH assessed in midlife was independently associated with incident dementia and ischemic stroke. Additional studies are needed to elucidate potential mechanisms for these associations and possible applications for prevention.

journal_name

Neurology

journal_title

Neurology

authors

Rawlings AM,Juraschek SP,Heiss G,Hughes T,Meyer ML,Selvin E,Sharrett AR,Windham BG,Gottesman RF

doi

10.1212/WNL.0000000000006027

subject

Has Abstract

pub_date

2018-08-21 00:00:00

pages

e759-e768

issue

8

eissn

0028-3878

issn

1526-632X

pii

WNL.0000000000006027

journal_volume

91

pub_type

杂志文章
  • Widening spectrum of congenital hemiplegia: Periventricular venous infarction in term neonates.

    abstract::MRI in five term children with congenital hemiplegia without clinically apparent prenatal or perinatal difficulties showed a focal or porencephalic enlargement of the lateral ventricle and periventricular T2 prolongation, which were identical to findings of periventricular venous infarction seen in preterm children. S...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/01.wnl.0000079370.28310.ea

    authors: Takanashi J,Barkovich AJ,Ferriero DM,Suzuki H,Kohno Y

    更新日期:2003-08-26 00:00:00

  • Incidence of contrast nephropathy from cerebral CT angiography and CT perfusion imaging.

    abstract::The incidence of contrast-induced nephropathy was examined in 1,075 patients receiving routine CT angiography and CT perfusion brain imaging at a single institution. Fifty-two patients had a creatinine rise of > or =0.5 mg/dL. In four patients (0.37%), the administration of IV contrast medium possibly contributed to r...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.WNL.0000161845.69114.62

    authors: Josephson SA,Dillon WP,Smith WS

    更新日期:2005-05-24 00:00:00

  • Practice parameter: risk of driving and Alzheimer's disease (an evidence-based review): report of the quality standards subcommittee of the American Academy of Neurology.

    abstract::Studies of automobile accident frequency among drivers with AD have yielded conflicting results about the risk of accidents. To develop a practice parameter regarding driving and AD the authors performed a systematic review of the literature. The authors identified well-designed, controlled studies of driving and AD u...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.54.12.2205

    authors: Dubinsky RM,Stein AC,Lyons K

    更新日期:2000-06-27 00:00:00

  • Angioplasty and stenting for stroke prevention: good questions that need answers.

    abstract::Extracranial and intracranial angioplasty and stenting of the cerebral vessels are being performed more frequently. One clinical trial demonstrated equivalent outcomes between extracranial carotid angioplasty and carotid endarterectomy, but the results in both groups were suboptimal. Concerns remain about the iatrogen...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.59.5.664

    authors: Chaturvedi S,Fessler R

    更新日期:2002-09-10 00:00:00

  • Connections between intrinsically photosensitive retinal ganglion cells and TBI symptoms.

    abstract::The majority of patients with traumatic brain injury (TBI) are classified as having a mild TBI. Despite being categorized as mild, these individuals report ongoing and complex symptoms, which negatively affect their ability to complete activities of daily living and overall quality of life. Some of the major symptoms ...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/WNL.0000000000010830

    authors: Elenberger J,Kim B,de Castro-Abeger A,Rex TS

    更新日期:2020-11-03 00:00:00

  • Linking MRI to daily life experience: the example of poststroke depression.

    abstract:OBJECTIVE:The state-of-the-art tools of neurology, in particular modern neuroimaging techniques, have yet to benefit from the revolution in mobile technologies that provide new insights into the mechanisms underlying clinical syndromes. This study demonstrates the manner in which mobile technologies may provide informa...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31824528b2

    authors: Lassalle-Lagadec S,Allard M,Dilharreguy B,Schweitzer P,Swendsen J,Sibon I

    更新日期:2012-01-31 00:00:00

  • Plasma exchange and immunosuppressive drug treatment in the Lambert-Eaton myasthenic syndrome.

    abstract::We undertook serial clinical and electromyographic muscle action potential (MAP) amplitude assessments in nine patients with the Lambert-Eaton myasthenic syndrome (LEMS) over 0.5 to 2.5 years who received plasma exchange (PE; 5 to 15 exchanges over 4 to 19 days) and immunosuppressive drug (IS) treatment (prednisolone ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.4.480

    authors: Newsom-Davis J,Murray NM

    更新日期:1984-04-01 00:00:00

  • Association of circulating metabolites in plasma or serum and risk of stroke: Meta-analysis from seven prospective cohorts.

    abstract:OBJECTIVE:To conduct a comprehensive analysis of circulating metabolites and incident stroke in large prospective population-based settings. METHODS:We investigated the association of metabolites with risk of stroke in seven prospective cohort studies including 1,791 incident stroke events among 38,797 participants in...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000011236

    authors: Vojinovic D,Kalaoja M,Trompet S,Fischer K,Shipley MJ,Li S,Havulinna AS,Perola M,Salomaa V,Yang Q,Sattar N,Jousilahti P,Amin N,Satizabal CL,Taba N,Sabayan B,Vasan RS,Ikram MA,Stott DJ,Ala-Korpela M,Jukema JW,Sesh

    更新日期:2020-12-02 00:00:00

  • Magnetic resonance imaging of thoracic epidural venous dilation in Hirayama disease.

    abstract::Hirayama disease is a nonprogressive, asymmetric amyotrophy of the hands and forearms, possibly caused by compression of the lower cervical cord on neck flexion. The authors used phase-contrast MR angiography to study a patient with this disorder and observed abnormal spinal epidural venous dilation on neck flexion. I...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000120665.81001.40

    authors: Baba Y,Nakajima M,Utsunomiya H,Tsuboi Y,Fujiki F,Kusuhara T,Yamada T

    更新日期:2004-04-27 00:00:00

  • Neurofilament protein levels in CSF are increased in dementia.

    abstract::The neurofilament is the major cytoskeletal structure of myelinated axons. In this study, CSF levels of the light subunit of the neurofilament protein (NFL) were increased in patients with vascular dementia (VAD), AD, and frontotemporal dementia (FTD) compared with neurologically healthy individuals. Because NFL is lo...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.52.5.1090

    authors: Rosengren LE,Karlsson JE,Sjögren M,Blennow K,Wallin A

    更新日期:1999-03-23 00:00:00

  • Autosomal dominant progressive external ophthalmoplegia: distribution of multiple mitochondrial DNA deletions.

    abstract:OBJECTIVE:To relate signs and symptoms to morphologic changes and presence of multiple mitochondrial DNA (mtDNA) deletions in a patient with autosomal dominant progressive external ophthalmoplegia (adPEO) and mitochondrial myopathy. BACKGROUND:An etiologic association between the somatic multiple mtDNA deletions in ad...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.53.1.79

    authors: Moslemi AR,Melberg A,Holme E,Oldfors A

    更新日期:1999-07-13 00:00:00

  • Intracranial Wegener's granulomatosis.

    abstract::We describe an atypical neurologic presentation of Wegener's granulomatosis (WG) with striking meningeal and cerebral involvement, responding to immunosuppressive therapy. WG may cause treatable intracranial complications in the absence of nasal or renal disease and without cerebral angiographic abnormalities, CSF ple...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.43.9.1831

    authors: Weinberger LM,Cohen ML,Remler BF,Naheedy MH,Leigh RJ

    更新日期:1993-09-01 00:00:00

  • Cervical puncture to deliver nusinersen in patients with spinal muscular atrophy.

    abstract:OBJECTIVE:To report our experience delivering intrathecal nusinersen through cervical puncture in patients with spinal muscular atrophy (SMA) with no lumbar access. BACKGROUND:SMA is a neuromuscular disorder characterized by profound muscle weakness, atrophy, and paralysis due to degeneration of the anterior horn cell...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000006006

    authors: Veerapandiyan A,Pal R,D'Ambrosio S,Young I,Eichinger K,Collins E,Westesson PL,Kwon J,Ciafaloni E

    更新日期:2018-08-14 00:00:00

  • Primary Sjögren's syndrome in patients with multiple sclerosis.

    abstract::The relationship between multiple sclerosis (MS) and primary Sjögren's syndrome (PSS) is ambiguous; it was suggested that some patients diagnosed with MS may instead have PSS. In a recent epidemiologic study, the prevalence of PSS was 2.7% in southern Sweden. We randomly selected 30 patients with definite MS from our ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.42.4.845

    authors: Sandberg-Wollheim M,Axéll T,Hansen BU,Henricsson V,Ingesson E,Jacobsson L,Larsson A,Lieberkind K,Manthorpe R

    更新日期:1992-04-01 00:00:00

  • Electroclinical features of absence seizures in childhood absence epilepsy.

    abstract:OBJECTIVE:To accurately define the electroclinical features of absence seizures in children with newly diagnosed, untreated childhood absence epilepsy (CAE). METHODS:The authors searched an EEG database for absence seizures in normal children with new onset untreated absence epilepsy. Seventy consecutive children were...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000228257.60184.82

    authors: Sadleir LG,Farrell K,Smith S,Connolly MB,Scheffer IE

    更新日期:2006-08-08 00:00:00

  • Validation of the Alzheimer Disease Dementia Conversion-Related Pattern as an ATN Biomarker of Neurodegeneration.

    abstract:OBJECTIVE:To determine whether the Alzheimer's disease dementia conversion-related pattern (ADCRP) on [18F]FDG PET can serve as a valid predictor for the development of Alzheimer's disease dementia, the individual expression of the ADCRP (subject score) and its prognostic value were examined in subjects with mild cogni...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000011521

    authors: Blazhenets G,Frings L,Ma Y,Sörensen A,Eidelberg D,Wiltfang J,Meyer PT,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2021-01-06 00:00:00

  • The treatment of postprandial hypotension in autonomic failure with 3,4-DL-threo-dihydroxyphenylserine.

    abstract::Postprandial hypotension occurs commonly in patients with autonomic failure and may be due to attenuation of the normal sympathetic nervous system activation in response to meal ingestion. In a randomized, double-blind, placebo-controlled study, we investigated the therapeutic effect of the norepinephrine precursor 3,...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/wnl.47.6.1414

    authors: Freeman R,Young J,Landsberg L,Lipsitz L

    更新日期:1996-12-01 00:00:00

  • Paraparesis in hereditary multiple exostoses: case report.

    abstract::The authors report a case of hereditary multiple exostoses (HME) with neurologic complications, and review the literature. A 23-year-old man exhibited a worsening spastic paraparesis with sphincter dysfunction. The cranial nerves and the exteroceptive and deep sensations were apparently undamaged. The family history, ...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.29.7.973

    authors: Ferrari G,Taddei L,Vivenza C,Rossi G

    更新日期:1979-07-01 00:00:00

  • SPECT imaging of the dopamine transporter in juvenile-onset dystonia.

    abstract::Juvenile-onset dystonia that improves after levodopa may occur in both dopa-responsive dystonia (DRD) and juvenile parkinsonism (JP), clinically similar conditions with different prognoses and management goals. The authors show normal striatal uptake of the dopamine transporter ligand FP-CIT with SPECT in a clinically...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.56.2.266

    authors: O'Sullivan JD,Costa DC,Gacinovic S,Lees AJ

    更新日期:2001-01-23 00:00:00

  • Network dysfunction predicts speech production after left hemisphere stroke.

    abstract:OBJECTIVE:To investigate the role of multiple distributed brain networks, including the default mode, fronto-temporo-parietal, and cingulo-opercular networks, which mediate domain-general and task-specific processes during speech production after aphasic stroke. METHODS:We conducted an observational functional MRI stu...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000002537

    authors: Geranmayeh F,Leech R,Wise RJS

    更新日期:2016-04-05 00:00:00

  • Assessment of the interaction of age and sex on 90-day outcome after intracerebral hemorrhage.

    abstract:OBJECTIVE:Because age affects hormonal production differently in women compared with men, we sought to define sex and age interactions across a multiracial/ethnic population after intracerebral hemorrhage (ICH) to uncover evidence that loss of gonadal hormone production would result in loss of the known neuroprotective...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1212/WNL.0000000000004255

    authors: James ML,Langefeld CD,Sekar P,Moomaw CJ,Elkind MSV,Worrall BB,Sheth KN,Martini SR,Osborne J,Woo D,ERICH Investigators.

    更新日期:2017-09-05 00:00:00

  • Vagus nerve stimulation for epilepsy: randomized comparison of three stimulation paradigms.

    abstract::Vagus nerve stimulation (VNS) is an effective adjunctive treatment for intractable epilepsy. However, the optimal range of device duty-cycles [on/(on + off times)] is poorly understood. The authors performed a multicenter, randomized trial of three unique modes of VNS, which varied primarily by duty-cycle. The results...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1212/01.wnl.0000168899.11598.00

    authors: DeGiorgio C,Heck C,Bunch S,Britton J,Green P,Lancman M,Murphy J,Olejniczak P,Shih J,Arrambide S,Soss J

    更新日期:2005-07-26 00:00:00

  • Effect of tryptophan depletion on symptoms of motion sickness in migraineurs.

    abstract::Seven hours after 39 migraineurs and 37 controls consumed an amino acid drink that contained or omitted l-tryptophan (thereby reducing brain serotonin synthesis), motion sickness was provoked by the visual illusion of movement. Tryptophan depletion boosted dizziness, nausea, and the illusion of movement in controls to...

    journal_title:Neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1212/01.wnl.0000172339.15577.a6

    authors: Drummond PD

    更新日期:2005-08-23 00:00:00

  • Steroid-sparing maintenance immunotherapy for MOG-IgG associated disorder.

    abstract:OBJECTIVE:Myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG) associated disorder (MOGAD) often manifests with recurrent CNS demyelinating attacks. The optimal treatment for reducing relapses is unknown. To help determine the efficacy of long-term immunotherapy in preventing relapse in patients with MOGAD, w...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000009758

    authors: Chen JJ,Flanagan EP,Bhatti MT,Jitprapaikulsan J,Dubey D,Lopez Chiriboga ASS,Fryer JP,Weinshenker BG,McKeon A,Tillema JM,Lennon VA,Lucchinetti CF,Kunchok A,McClelland CM,Lee MS,Bennett JL,Pelak VS,Van Stavern G,Adesina

    更新日期:2020-07-14 00:00:00

  • Conjugal amyotrophic lateral sclerosis: a report on two couples from southern France.

    abstract::We report two conjugal cases of amyotrophic lateral sclerosis (ALS) occurring between 1977 and 1991 in southern France (Languedoc-Roussillon). Although conjugal ALS may occur by chance, the description of two cases in the same area points to a role of environmental or genetic factors in the etiology of the disease. ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.44.3_part_1.547

    authors: Camu W,Cadilhac J,Billiard M

    更新日期:1994-03-01 00:00:00

  • The frequency of CD5+ B lymphocytes in the peripheral blood of patients with myasthenia gravis.

    abstract::A subset of human B lymphocytes expresses Leu-1 (CD5), a pan-T cell marker, which is the equivalent of the murine Lyt-1 molecule. CD5+ B cells produce autoantibodies in vitro; therefore, they may play a role in the pathogenesis of autoimmune disorders. In myasthenia gravis (MG), autoantibodies are directed against the...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.40.7.1120

    authors: Ragheb S,Lisak RP

    更新日期:1990-07-01 00:00:00

  • Socioeconomic status and disability progression in multiple sclerosis: A multinational study.

    abstract:OBJECTIVE:To examine the association between socioeconomic status (SES) and disability outcomes and progression in multiple sclerosis (MS). METHODS:Health administrative and MS clinical data were linked for 2 cohorts of patients with MS in British Columbia (Canada) and South East Wales (UK). SES was measured at MS sym...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000007190

    authors: Harding KE,Wardle M,Carruthers R,Robertson N,Zhu F,Kingwell E,Tremlett H

    更新日期:2019-03-26 00:00:00

  • Plasma exchange for acute attacks of CNS demyelination: Predictors of improvement at 6 months.

    abstract:BACKGROUND:Plasma exchange (PE) is used to treat severe episodes of CNS demyelination unresponsive to corticosteroids. Predictors of long-term response are not well known. METHODS:We retrospectively reviewed the medical records of 41 patients consecutively treated by PE between January 1995 and July 2007. The primary ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181b879be

    authors: Llufriu S,Castillo J,Blanco Y,Ramió-Torrentà L,Río J,Vallès M,Lozano M,Castellà MD,Calabia J,Horga A,Graus F,Montalban X,Saiz A

    更新日期:2009-09-22 00:00:00

  • Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells.

    abstract:BACKGROUND:Natalizumab is an antibody directed against integrin alpha4 that reduces disease activity in patients with multiple sclerosis (MS) by blocking migration of T and B cells into the CNS. The goal of this study was to characterize the effects of natalizumab treatment on cytokine production and expression of acti...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181a8266f

    authors: Kivisäkk P,Healy BC,Viglietta V,Quintana FJ,Hootstein MA,Weiner HL,Khoury SJ

    更新日期:2009-06-02 00:00:00

  • Preclinical detection in studies of the etiology, natural history, and treatment of Parkinson's disease.

    abstract::The development of reliable preclinical detection procedures for idiopathic Parkinson's disease may be the fundamental advance required for the establishment of the cause, the natural history, and ultimately, the prevention of this neurodegenerative disorder. The usefulness of these preclinical markers in efforts to b...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.41.5_suppl_2.14

    authors: Ellenberg JH

    更新日期:1991-05-01 00:00:00