Surgical experience following intervertebral discolysis with collagenase.

Abstract:

:Of 410 patients with refractory herniated lumbar disc disease treated with intradiscal collagenase, 82 (20%) did not respond to enzyme treatment and subsequently underwent surgery. Failure to improve in 6 to 8 weeks was the predominant cause for surgical intervention (53 patients). Increased pain (18 patients), progressing neurological deficit (10 patients), and disc-space infection (one patient) were the other indications for surgery. At surgery, extrusions and/or sequestrations were found in 46 patients, undigested protrusions in 16 patients, and other causes of treatment failure in 14 patients. Six patients had normal findings. There was no evidence of adverse enzyme activity on the surrounding structures. Surgical results showed an overall success rate of 87%, and did not appear to be compromised by the previous enzyme therapy.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Fisher RG,Bromley JW,Becker GL,Brown M,Mooney V

doi

10.3171/jns.1986.64.4.0613

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

613-6

issue

4

eissn

0022-3085

issn

1933-0693

journal_volume

64

pub_type

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