Abstract:
BACKGROUND:The effect of age on adult brain arteriovenous malformation (AVM) outcomes after stereotactic radiosurgery (SRS) remains unclear. The aim of this study is to compare AVM outcomes between elderly (age ≥60 years) and nonelderly adult patients. METHODS:We retrospectively reviewed pooled data comprising patients who underwent SRS for AVMs between 1987 and 2014 at 8 centers participating in the International Gamma Knife Research Foundation. Adult (age ≥18 years) patients with ≥12 months follow-up were dichotomized into elderly and nonelderly cohorts, and matched in a 1:1 ratio. Favorable outcome was AVM obliteration without permanent symptomatic radiation-induced changes (RIC) or post-SRS hemorrhage. RESULTS:The study cohort consisted of 1845 patients (188 elderly vs. 1657 nonelderly) who met the inclusion criteria, and subsequent matching resulted in 181 patients in each cohort. In the matched cohorts, rates of obliteration (54.7% vs. 64.6%; P = 0.054) favorable outcome (51.4% vs. 61.3%; P = 0.056) were no different between the elderly and nonelderly cohorts. The rates of post-SRS hemorrhage (9.9% vs. 5.5%; P = 0.115), RIC (26.5% vs. 30.9%; P = 0.353), symptomatic RIC (9.4% vs. 9.4%; P = 1.000), and permanent symptomatic RIC (3.3% vs. 2.2%; P = 0.750) were also not significantly different between the elderly and nonelderly cohorts. Elderly patients with AVM did have a significantly higher rate of all-cause mortality (27.7% vs. 5.5%; P < 0.001). CONCLUSIONS:Advanced age does not seem to significantly affect obliteration or complication rates after SRS for AVMs. Although the decision to recommend intervention for AVMs in the elderly population is multifactorial, SRS may be a viable modality when treatment is deemed appropriate.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Chen CJ,Ding D,Kano H,Mathieu D,Kondziolka D,Feliciano C,Rodriguez-Mercado R,Sheehan DE,Grills IS,Barnett G,Lunsford LD,Sheehan JPdoi
10.1016/j.wneu.2018.07.178subject
Has Abstractpub_date
2018-11-01 00:00:00pages
e429-e440eissn
1878-8750issn
1878-8769pii
S1878-8750(18)31656-5journal_volume
119pub_type
杂志文章,多中心研究abstract:OBJECTIVE:There is sparse literature that investigates the adverse effects of postoperative pulmonary complication (PPCs) specifically in postcraniotomy tumor patients. In this study, we describe the rate of PPCs, determine predictive factors, and delineate associations with adverse outcomes. METHODS:The National Surg...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2019.03.058
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:To explore the effect and safety of transforaminal percutaneous endoscopic decompression for lower thoracic spinal stenosis. METHODS:We reviewed 6 patients receiving transforaminal percutaneous endoscopic thoracic decompression for sympathetic symptoms in the lower extremities. Pre- and postoperative Frankel...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2019.04.186
更新日期:2019-08-01 00:00:00
abstract:PURPOSE:To assess efficacy of immersive virtual reality (VR) surgical simulator training for pedicle screw placement (PSP) in surgical graduate students. METHODS:Sixteen inexperienced surgical graduate students were equally randomly assigned to an experimental group (VR group) and a control group (non-VR group). Stude...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2018.12.090
更新日期:2018-12-28 00:00:00
abstract:OBJECTIVE:The tumor microenvironment greatly influences tumor formation, invasion, and progression. The ESTIMATE (Estimation of STromal and Immune cells in MAlignant Tumor tissues) algorithm quantifies stromal and immune components in a tumor, reflecting the tumor microenvironment. This study aimed to explore key progn...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2019.08.253
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Recent changes in surgical training environments may have limited opportunities for trainees to gain proficiency in skill. Complex skills such as neurosurgery require extended periods of training. Methods to enhance surgical training are required to overcome duty-hour restrictions, to ensure the acquisition ...
journal_title:World neurosurgery
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.wneu.2017.08.123
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To report the comprehensive long-term functional and quality of life outcomes after craniectomy (CE) and craniotomy (CO) in individuals with traumatic brain injury (TBI). METHODS:Information on all individuals with TBI who had undergone CE or CO were extracted from the TBI Model Systems database from 2002 to...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2018.07.124
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To analyze the relationship between cognitive performance and white matter integrity in patients with temporal lobe epilepsy (TLE) to establish radiologic criteria to help with patient selection for surgery. METHODS:The study included 19 adults with temporal lobe epilepsy. A tractography analysis of fraction...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2020.03.103
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Global neurosurgery encompasses the social and surgical practices that effect the neurologic health of vulnerable and underserved populations in domestic and international resource-limited settings. Formal academic engagement in global neurosurgery is limited in residency programs. Here we explore the curren...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2020.06.039
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Microscopic training is essential for development of neurosurgical skills. A range of models is reported in the literature for this purpose, including live animals, exvivo, and synthetic material. Among the factors involved in selection and development of a training station, cost is a decisive one. METHODS:...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2019.06.089
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:Venous thromboembolism (VTE), which includes deep venous thrombosis and pulmonary embolism, is a serious and potentially fatal surgical complication. The goal of our study was to examine preoperative characteristics, incidence, and outcomes of patients with VTE after elective thoracic/thoracolumbar level spin...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2011.12.089
更新日期:2012-11-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2018.06.066
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Accurate assessment of therapeutic response in patients with brain abscess (BA) is essential to direct appropriate therapy. This study was performed with an aim to see the treatment-induced changes in diffusion tensor imaging (DTI) indices (i.e., fractional anisotropy [FA] and mean diffusivity [MD]) in follo...
journal_title:World neurosurgery
pub_type: 临床试验,杂志文章
doi:10.1016/j.surneu.2009.04.003
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:The aim of the study is to report the feasibility, safety, and outcomes associated with endovascular treatment (EVT) of unruptured intracranial aneurysms (UIAs) under local anesthesia. METHODS:Between March 2011 and December 2016, 184 consecutive patients with 198 UIAs were treated with coil embolization und...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2017.05.077
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Intracranial solitary fibrous tumor (SFT) is a rare occurrence and involvement of the fourth ventricle rarely reported. Because of its rarity, some characteristics of intracranial SFT seem to still remain uncertain. CASE DESCRIPTION:This study describes a very rare case of intracranial SFT in a 55-year-old ...
journal_title:World neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/j.wneu.2019.07.052
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:The aim of this systematic literature review is to evaluate recent attempts in creating a standardized multidisciplinary approach combining tumor treatment with current vertebral stabilization techniques for palliative treatment of vertebral metastasis in patients who do not fall into the NOMS (neurologic, on...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2019.05.042
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:Thalamic glioma is a type of midline glioma with poor outcomes. In the present study, we investigated the clinical and molecular features of thalamic gliomas in Chinese patients. METHODS:The data from 26 patients with thalamic glioma who had undergone surgery at Shanghai Huashan Hospital from January 2011 to...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2019.03.061
更新日期:2019-06-01 00:00:00
abstract::We here report findings on magnetic resonance imaging from a 60-year-old patient with an epithelioid glioblastoma of the corpus callosum treated with radiotherapy in combination with concomitant and adjuvant temozolomide. Neuropathology revealed a highly aggressive molecular subtype of the epithelioid glioblastoma wit...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2019.04.025
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:Surgical robotics present new and unique opportunities for the training and practice of neurosurgery, beyond the promise of the minimally invasive paradigm. METHODS:Robotic systems have been developed that simulate the sight, sound, and touch of surgery allowing surgical training to evolve past an apprentice...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2010.04.005
更新日期:2010-07-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2020.06.228
更新日期:2020-10-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.wneu.2015.06.005
更新日期:2015-10-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2018.12.014
更新日期:2018-12-20 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2020.11.060
更新日期:2020-11-18 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
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更新日期:2017-05-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2019.02.230
更新日期:2019-06-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章,多中心研究
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更新日期:2018-02-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2019.01.265
更新日期:2019-05-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Congenital spondylolytic spondylolisthesis of C2 vertebra resulting from deficient posterior element of the axis is rarely described in the literature. CASE DESCRIPTION:We describe a unique case of agenesis of posterior elements of C2 with craniovertebral junction anomalies consisting of osseous, vascular, ...
journal_title:World neurosurgery
pub_type: 杂志文章,评审
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更新日期:2016-11-01 00:00:00