Abstract:
:Though smokers have poor clinical outcomes after treatment for fractures, the skeletal effects of smoking are still debated. Our results showed that female smokers had 33% higher cortical bone porosity. Smoking targets cortical compartment microstructure and mechanics, and micron-scale variables are essential to better understand the specific effects of smoking. PURPOSE:Smokers have poor outcomes in the clinic after treatment for fractures. However, skeletal effects of smoking are still debated. Inconsistencies in published data are likely due to macro-scale variables used to characterize bone differences due to smoking. Therefore, our goal was to characterize distal radius microstructure and macrostructure differences between smokers and non-smokers, and determine the degree to which smoking is associated with compartment-specific mechanical differences resulting from compromised cortical-trabecular microstructure. METHODS:Data were acquired from 46 female smokers (35 to 64 years old), and 45 age- and body mass-matched female non-smokers. Distal radius microstructure and mechanical variables were determined from high-resolution peripheral quantitative computed tomography (HR-pQCT) images and multiscale finite element analysis. Distal radius macro-scale variables (bone volume, bone mineral content, volumetric bone mineral density [vBMD]) were determined from low-resolution images. RESULTS:Age- and body mass index-adjusted results showed that cortical porosity was 33% higher (p < 0.01), and that cortical vBMD and stiffness were 3% and 8% lower, respectively (p < 0.05), among smokers. We also observed unloading of the cortical compartment in smokers. There were no differences in the macro-scale variables. Average HR-pQCT-derived vBMD was 8% lower (p < 0.05) in smokers corresponding to 5 years of postmenopausal loss. CONCLUSION:Skeletal effects of smoking become evident at the micron level through a structurally and mechanically compromised cortical compartment, which partially explains the inconsistent results observed at the macro-level, and the poor clinical outcomes. Smoking may also compound postmenopausal effects on bone potentially placing women having undergone menopause at a greater risk for fracture.
journal_name
Arch Osteoporosjournal_title
Archives of osteoporosisauthors
Johnson JE,Troy KLdoi
10.1007/s11657-018-0504-ysubject
Has Abstractpub_date
2018-08-23 00:00:00pages
89issue
1eissn
1862-3522issn
1862-3514pii
10.1007/s11657-018-0504-yjournal_volume
13pub_type
杂志文章abstract::The publisher has retracted this article [1] from Archives of Osteoporosis in order to publish in Osteoporosis International as originally intended by the authors and the Editors of Osteoporosis International. Springer Nature apologizes to readers and the authors. ...
journal_title:Archives of osteoporosis
pub_type: 已发布勘误,撤回出版物
doi:10.1007/s11657-019-0614-1
更新日期:2019-07-08 00:00:00
abstract:OBJECTIVES:Many studies have explored the association between neuropathy and osteoporosis in patients with diabetes mellitus. However, the results still remain inconsistent and controversial. We aimed to estimate the association between diabetic neuropathy and osteoporosis. METHODS:Databases, including PubMed, Embase,...
journal_title:Archives of osteoporosis
pub_type: 杂志文章,meta分析
doi:10.1007/s11657-020-00804-6
更新日期:2020-08-10 00:00:00
abstract::We have characterised 997 hip fracture patients from a representative 45 Spanish hospitals, and followed them up prospectively for up to 4 months. Despite suboptimal surgical delays (average 59.1 hours), in-hospital mortality was lower than in Northern European cohorts. The secondary fracture prevention gap is unaccep...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-018-0515-8
更新日期:2018-09-14 00:00:00
abstract::The microstructure of autologous bone grafts from men over 50 years old and postmenopausal women undergoing spinal fusion were evaluated using micro-CT. We demonstrated postmenopausal women, especially those with osteoporosis (OP) presented more serious microarchitectural deterioration of bone grafts. PURPOSE:This st...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-018-0422-z
更新日期:2018-03-05 00:00:00
abstract::In this study, we attempted to determine the epidemiology and clinical characteristics of hip fracture in the elderly. We find that elderly people with hip fracture have multiple comorbidities and suffer numerous complications. INTRODUCTION:We attempted to explore the epidemiology and clinical characteristics of hip ...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0580-7
更新日期:2019-03-12 00:00:00
abstract::In November 2008, the "2nd Summit on Osteoporosis-Central and Eastern Europe (CEE)" was held in Warsaw, Poland. Discussions at this meeting focused on the identification and discussion of diagnostic, preventive, and therapeutic measures used in CEE. Evaluated information was used to identify issues regarding diagnosis...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-009-0028-6
更新日期:2009-12-01 00:00:00
abstract::Older men who participated in a sporting activity were less likely to sustain any fracture or major osteoporotic fracture over a 6-year follow-up period. PURPOSE:Regular weight-bearing physical activity can reduce fracture risk through an increase in bone strength, as well as reducing falls risk by improving muscle s...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-018-0459-z
更新日期:2018-04-19 00:00:00
abstract::MrOS MsOS (Hong Kong) studies year 14 follow-up shows for subjects without baseline osteoporotic vertebral deformity, women's incident vertebral fracture (VF) rate was twice that of men. For subjects with vertebral deformity of baseline ≥ 20% height loss, counting subject, women's incident VF rate was three times high...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-020-00845-x
更新日期:2020-11-07 00:00:00
abstract:UNLABELLED:It is unknown whether osteoporosis is socially patterned. Using data from the Hertfordshire Cohort Study we found no consistent evidence for social inequalities in prevalent or incident fracture, bone mineral density or loss rates, or bone strength. Public health strategies for prevention of osteoporosis sho...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-012-0069-0
更新日期:2012-01-01 00:00:00
abstract::This analysis was performed in Zambian children who had a high prevalence of hypervitaminosis A, defined as > 1.0 μmol retinol/g liver. Bone parameters included markers of bone formation (P1NP), bone resorption (CTX), parathyroid hormone, calcium, vitamin A, and vitamin D. Low dietary vitamin A intake increased P1NP. ...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0617-y
更新日期:2019-06-28 00:00:00
abstract::The effects of gluteal implants on bone mass remain unclear. Transgender women with ILS presented higher BMD in the hip compared with transgender women without implants, while no difference was observed in other sites. These results may be artifactual and suggest using spine/forearm sites for DXA in individuals with I...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-020-00824-2
更新日期:2020-09-22 00:00:00
abstract::This study aimed to investigate the correlation between bone mineral density (BMD) with hemoglobin and ferritin levels in Palestinian patients suffering from various types of hemoglobinopathies. The study revealed the thresholds of hemoglobin and ferritin to protect against low BMD in these patients. PURPOSE:Iron ove...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-020-00853-x
更新日期:2020-11-13 00:00:00
abstract::To ensure meaningful results in a clinical audit, as many hospitals as possible should participate. To optimise participation, the data collection process should either be performed by additional staff or be automated. Active participation may be promoted by offering relevant external parties insight into the actual q...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0652-8
更新日期:2019-11-21 00:00:00
abstract::This study aims to determine the awareness of osteoporosis and factors that determine awareness of osteoporosis. Results showed that osteoporosis awareness was associated with age (p = 0.006) and occupation (p < 0.001) but not gender, marital status, and level of education. There is therefore need for educational inte...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-017-0342-3
更新日期:2017-12-01 00:00:00
abstract:UNLABELLED:Calf circumference has significant predictive value for bone mineral density (BMD) at hip and spine and for fracture at spine in both genders and hence may be used as a clinical risk factor for fracture when BMD is not available. INTRODUCTION:Lean muscle mass and higher regular physical ability has been sho...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-015-0221-8
更新日期:2015-01-01 00:00:00
abstract::Giant cell tumor (GCT) of the bone, also called osteoclastoma, is a rare complication of Paget's bone disease. We report a patient from Southern Italy who developed a GCT infiltrating the neighboring tissues. The natural history and the therapeutic outcomes of this unique complication of Paget's bone disease are prese...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-009-0027-7
更新日期:2009-12-01 00:00:00
abstract::In pre-pubertal girls, nutrient intakes and non-aquatic organized activity were evaluated as factors in vertebral body bone mass, structure, and strength. Activity, vitamin B12, and dietary fiber predicted bone outcomes most consistently. Exercise and vitamin B12 appear beneficial, whereas high fiber intake appears to...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-017-0312-9
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:Medical treatment of osteoporosis should preferably be both effective and have minimal side effects. The aim of the present study was to examine long-term benefits and risks of parathyroid hormone (PTH) treatment in compliant patients. METHODS:This is a nationwide retrospective cohort study based on national r...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-018-0444-6
更新日期:2018-05-02 00:00:00
abstract:UNLABELLED:This survey describes the epidemiology of approximately 1800 low-energy humeral fractures seen in a large emergency department in Northern Italy over 7 years (2007-2013), highlighting the differences from previous Italian studies. PURPOSE:The purpose of this study was to determine the incidence of humeral f...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-015-0228-1
更新日期:2015-01-01 00:00:00
abstract:UNLABELLED:Minimal data on bone mineral density changes are available from populations in developing countries. Using calcaneal quantitative ultrasound (QUS) techniques, the current study contributes to remedying this gap in the literature by establishing a normative data set on the indigenous Shuar and non-Shuar Colon...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-011-0056-x
更新日期:2011-01-01 00:00:00
abstract:UNLABELLED:Black women are generally regarded as being less prone to the development of osteoporosis. This study reports a similar prevalence of morphometric vertebral fractures in black (9.1 %) and white (5.0 %) South African women. Clinical risk factors and bone strength parameters contributed differently to fracture...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-015-0203-x
更新日期:2015-01-01 00:00:00
abstract:UNLABELLED:Osteoporosis is common, and physical activity is important in its prevention and treatment. Of the categories of historical physical activity (PA) examined, we found that weight-bearing and very hard physical activity had the strongest relationships with areal bone mineral density (aBMD) throughout growth an...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-015-0239-y
更新日期:2015-01-01 00:00:00
abstract::While adherence to osteoporosis treatment is low, patients' preference for osteoporosis treatment is unknown in Chinese patients. Chinese patients are willing to receive treatments with higher clinical efficacy and lower out-of-pocket cost. In addition, annual intravenous infusion and 6-month subcutaneous injection ar...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0624-z
更新日期:2019-07-31 00:00:00
abstract::One hundred and eighty patients with incident fragility hip fracture admitted to a tertiary care center in Sri Lanka were followed up for 12 months. When compared with those survived, patients who died were older and had higher comorbidity and physical impairment, before fracture and at discharge from the hospital. I...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-020-00769-6
更新日期:2020-06-25 00:00:00
abstract:INTRODUCTION:Hyperparathyroidism often presents with asymptomatic hypercalcemia or minimal, unspecific symptoms and the middle-age female is the predominant population. CASE REPORT:We reported a young Vietnamese female with primary hyperparathyroidism presented with chronic low back pain of about 1 year duration, simi...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-012-0072-5
更新日期:2012-01-01 00:00:00
abstract::Awareness and knowledge about any disease is the first step to prevent and treat it, so this study evaluates osteoporosis awareness and knowledge in university students. Our results showed a high awareness and good knowledge of osteoporosis. Females were better informed than males. Knowledge increased with increasing ...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0560-y
更新日期:2019-01-14 00:00:00
abstract::Osteocalcin, the osteoblast-derived protein, has been shown to be modulated in patients with problematic glucose metabolism. Our systematic review and meta-analysis found that in humans, higher blood osteocalcin level is associated with lower body indices of fat. PURPOSE/INTRODUCTION:Osteocalcin (OC) was found to be ...
journal_title:Archives of osteoporosis
pub_type: 杂志文章,meta分析
doi:10.1007/s11657-020-00812-6
更新日期:2020-09-18 00:00:00
abstract::A workflow tool for measurements of vertebral heights on lateral spine radiographs based on automated placements of 6 points per vertebra was evaluated. The tool helps to standardize point placement among operators. Its success rate is very good in normal vertebrae but lower in vertebrae with more severe fractures. Ma...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0577-2
更新日期:2019-02-11 00:00:00
abstract:INTRODUCTION:We report a case of a patient sustaining multiple simultaneous vertebral fractures 5 months after Roux-en-Y gastric bypass (RYGB) surgery. Obesity is associated with increased rates of morbidity and mortality and obesity rates globally continue to rise. Bariatric surgical procedures are successful in induc...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-018-0471-3
更新日期:2018-05-02 00:00:00
abstract::This cross-sectional study among members of public showed that people generally had good knowledge and awareness about vitamin D. However, inconsistencies between awareness and attitudes were observed. Our findings reinforce the need of educating people to improve attitude and practices toward vitamin D consumption. ...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0671-5
更新日期:2019-11-22 00:00:00