Potential roles of microRNAs in redox state: An update.

Abstract:

:Oxidative stress is an important underlying cause of many disease processes and may arise due to either increasing free radical generation or decreasing antioxidant defense systems. MicroRNAs (miRs) are 22-nucleotide non-coding RNAs that may regulate many intracellular processes; and, more recently, they have been implicated in the pathways for free radical generation leading to oxidative stress. However, conversely, there is evidence that miRs may have an antioxidant effect, thus miR expression may be critical for the maintenance of the normal redox state and cell homeostasis. This review addresses these discrepant and opposing miR actions on how they may modify and regulate the oxidative balance.

journal_name

J Cell Biochem

authors

Yaribeygi H,Atkin SL,Sahebkar A

doi

10.1002/jcb.27475

subject

Has Abstract

pub_date

2018-08-30 00:00:00

eissn

0730-2312

issn

1097-4644

pub_type

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