Abstract:
:Colistin-resistance mediated by mobilisable and plasmid-borne mcr genes has emerged worldwide, threatening the efficacy of colistin, a last resort antibiotic increasingly used for treating human invasive infections by multidrug-resistant or extensively drug-resistant Enterobacteriaceae. In this study, we report the first evidence of mcr-1-mediated colistin resistance in four multidrug resistant (MDR) out of 324 Salmonella infantis from the Italian antimicrobial resistance (AMR) monitoring (2001-2017) in broilers and broiler meat. Two were also Extended Spectrum Beta-Lactamases (ESBL)-producing isolates. Characterization by whole genome sequencing (WGS), located mcr-1.1 on an incX4 plasmid. Phylogenetic analysis of these isolates with selected Italian S. Infantis previously isolated from animals, meat and human clinical cases with unknown epidemiological relationship, demonstrated that ESBL-producing, mcr-1-positive isolates belonged to the emerging pESI-like-positive-ESBL-producing clone described in Italy in 2015.
journal_name
Front Microbioljournal_title
Frontiers in microbiologyauthors
Carfora V,Alba P,Leekitcharoenphon P,Ballarò D,Cordaro G,Di Matteo P,Donati V,Ianzano A,Iurescia M,Stravino F,Tagliaferri T,Battisti A,Franco Adoi
10.3389/fmicb.2018.01880subject
Has Abstractpub_date
2018-08-17 00:00:00pages
1880issn
1664-302Xjournal_volume
9pub_type
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