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A MALDI-TOF Approach to Ubiquitin Ligase Activity.

Abstract：

:In this issue of Cell Chemical Biology,De Cesare et al. (2018) report the development of a high-throughput assay that measures E2/E3 enzyme activity by MALDI-TOF mass spectrometry and apply this to screen for small molecule E3 inhibitors. This assay potentially accelerates the drug discovery for the ubiquitin ligation pathway.

journal_name

Cell Chem Biol

journal_title

Cell chemical biology

authors

van Tol BDM,Geurink PP,Ovaa H

doi

10.1016/j.chembiol.2018.09.002

subject

Has Abstract

pub_date

2018-09-20 00:00:00

pages

1053-1055

issue

9

eissn

2451-9456

issn

2451-9448

pii

S2451-9456(18)30297-6

journal_volume

25

pub_type

评论,杂志文章

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