Laser Ablation Therapy for Pediatric Patients with Intracranial Lesions in Eloquent Areas.

Abstract:

BACKGROUND:Laser interstitial thermal therapy (LITT) is an alternative, less-invasive, and, in some circumstances, effective treatment for patients with intracranial pathology including epilepsy and some tumors. For intracranial lesions in eloquent areas, resection by conventional craniotomy proves often to be a challenge, including in the care of pediatric patients. Herein, we reviewed our experience with magnetic resonance imaging (MRI)-guided LITT as treatment for pediatric patients with intracranial lesions in eloquent areas and evaluate neurologic function and clinical outcomes. METHODS:We retrospectively reviewed consecutive patients with intracranial lesions in eloquent speech and motor areas who underwent MRI-guided LITT. Clinical evaluation, including neurologic function and neuropsychological testing, was conducted according to clinical considerations. MRI pre- and postoperative imaging was reviewed to compare the change of lesion size. RESULTS:Five pediatric patients received MRI-guided LITT of intracranial lesions in eloquent cortex. One patient experienced complications secondary to MRI-guided LITT, but neither was discharged with a neurologic deficit. CONCLUSIONS:For intracranial lesions in the eloquent cortex, conventional craniotomy with surgical resection is a challenge for neurosurgeons, especially pediatric patients. MRI-guided LITT provides a less-invasive and potentially effective option for treatment in the management of pediatric epilepsy and tumors.

journal_name

World Neurosurg

journal_title

World neurosurgery

authors

Kuo CH,Feroze AH,Poliachik SL,Hauptman JS,Novotny EJ Jr,Ojemann JG

doi

10.1016/j.wneu.2018.09.074

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

e191-e199

eissn

1878-8750

issn

1878-8769

pii

S1878-8750(18)32120-X

journal_volume

121

pub_type

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