Abstract:
:In contrast to other countries with predominantly white populations, Russian smoking-related lung cancers (LC) are mainly squamous cell carcinomas and approximately half lung adenocarcinomas (AdCa) are not related to tobacco consumption. Given that smoking significantly influences the probability of presence of actionable mutations in LC, one would expect that Russian lung AdCa patients would differ from other white populations in distribution of EGFR, ALK, KRAS and BRAF mutations. Herein, 2,336 consecutive lung AdCa cases, including 1,203 patients with known smoking status, were subjected to sequential testing for the above mutations. One quarter of lung AdCa patients carried either EGFR or ALK mutation with combined prevalence of 42% in those who had never smoked but only 8% in smokers. There was only a moderate difference in KRAS mutation frequency between ever- and never-smokers in EGFR/ALK-negative cases (31% vs. 23%), and this was mainly attributed to increased prevalence of G12C substitution in the former group. The occurrence of BRAF V600E mutation was 1.7% and 4% in EGFR/ALK/KRAS mutation-negative ever- and never-smokers, respectively. ALK testing of 470 EGFR-mutated tumors revealed only 1 (0.2%) instance of translocation. Similarly, KRAS testing identified 1 (1.25%) mutation in 80 EGFR-mutated AdCa and none in 48 ALK-rearranged AdCa. Therefore, concurrent actionable mutations in lung adenocarcinoma are exceptionally rare and sequential gene testing can be regarded as a reliable option.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Mitiushkina NV,Kholmatov MM,Venina AR,Tiurin VI,Yanus GA,Sokolova TN,Yatsuk OS,Zaitseva OA,Ivantsov AO,Kuligina ES,Togo AV,Imyanitov ENdoi
10.4149/neo_2018_171225N843subject
Has Abstractpub_date
2018-11-15 00:00:00pages
972-979issue
6eissn
0028-2685issn
1338-4317pii
171225N843journal_volume
65pub_type
杂志文章相关文献
NEOPLASMA文献大全abstract:UNLABELLED:Breast cancer is one of the most common cancer affecting women and the recent research is focused on identifying new genetic and epigenetic prognostic and predictive factors. Glutathione S-transferase P1 (GSTP1) is abiotransformation enzyme expressed in normal breast epithelial cells which can be epigenetica...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2010_01_035
更新日期:2010-01-01 00:00:00
abstract::Resistance to chemotherapy significantly affects the treatment results in various cancers. Multidrug resistance caused by P-glycoprotein expression is now widely studied in human malignancies. We present the results of P-glycoprotein expression examination in 91 tumor tissue samples obtained from children treated for ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::Acyclic nucleotide analogs (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) were phosphorylated in the presence of ribonucleoside 5'-triphosphates by the crude extract from mouse leukemia cells L1210 affording the respective mono- and diphosphoryl derivatives. T...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::Up to 19--20 fractions of separate RNA species and groups have been revealed in malignant tumors of the stomach and mucous membrane of patients with stomach cancer, ulcer and polyposis of the stomach by means of the method of analytical and preparative electrophoresis in 2.5% polyacrylamide gel. A more intensive incor...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::The levels of nicotinamide adenine dinucleotide (NAD) and NADH in blood of patients with cancer in various stages of development as well as their modification after glucose administration were determined in 188 respectively 77 cases. NAD was significantly decreased in patients with cervix and breast carcinoma but unal...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::To explore how Tim-3 is expressed and how its expression influences invasion and metastasis of colorectal cancer (CRC) cells. A total of 188 CRC patients were prospectively collected for this study. Meanwhile, 135 normal controls were incorporated during the same period. Intestinal samples of the CRC radical cancerous...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2017_112
更新日期:2017-01-01 00:00:00
abstract::Relative content of membrane sectors of ATPase complex in rat liver and Zajdela hepatoma mitochondria and the ability of mitochondrial membrane of the two sources to bind isolated soluble (F1) ATPase were examined. Approximately equal concentrations of oligomycin were required for 50% inhibition of ATPase activity in ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract:UNLABELLED:The study was aimed at detecting the expression of a newly found oncogene, astrocyte elevated gene-1 (AEG-1), in renal cell carcinoma (RCC) and its correlation with histopathologic features and the survival of patients. Real-time reverse transcription-PCR and Western blot showed markedly higher expression of...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2010_06_522
更新日期:2010-01-01 00:00:00
abstract::During the last 30 years the trends in cancer mortality in Europe significantly changed. In 1970 the male and female cancer mortality (all ages) was higher in the Western Europe than in the "socialist" Central and Eastern Europe. After 1970 in most Western countries decrease or no change of male premature (0-64 years)...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Leukemia-associated phenotypes have been suggested to be a valuable tool for the detection of minimal residual disease in acute leukemia patients, as they allow to distinguish leukemic blasts from normal hematopoietic progenitor cells. The aim of the present study was to analyze the proportion of acute leukemia patien...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::The levels of carcinoembryonic antigen (CEA) and the activities of creatine kinase isoenzyme BB (CK-BB) were assessed in 84 patients with primary lung carcinoma and in 20 patients with nonmalignant lung diseases. The level of CEA was measured by the immunoenzymatic method using monoclonal antibodies (Abbott). The acti...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Sentinel node biopsy becomes a standard diagnostic and therapeutic tool in breast cancer in certain indications, while in other indications its validity is still reviewed. The authors present their experience with this method. In the years 2000-2006 700 patients underwent surgery. 704 sentinel node biopsies were perfo...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::C-band heteromorphism was studied in 106 females, including 71 patients with breast cancer or ovarian cancer. Size heteromorphism and localization variants (inversions) were scored separately. Compared to 22.86% of controls, 70.42% of the cancer patients were heteromorphic for the size of C-band. The localization vari...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Several parameters for an optimal treatment scheme of a soluble BCG fraction (F70) were investigated. Among lung cancer patients treated with F70 a restricted selection was made of patients treated with small doses (5--10 U) every second or third month (sparing scheme) and of patients treated every month with sharply ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::The effects of the specific active cancer immunotherapy utilizing autologous tumor tissue particles polymerized with ethylchlorformiate on the immune system of the host were evaluated in DBA/2 mice bearing a malignant mast cell tumor, mastocytoma (P-815 X 2), with the special emphasis placed on the morphologic changes...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::Increasing evidences have proved that circular RNAs (circRNAs), identified as a specific kind of non-coding RNAs, play a potential critical role in tumorigenesis including prostate cancer. However, the function of circRNAs in human prostate cancer remain largely unknown. In this study, we demonstrated that the express...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2019_190213N116
更新日期:2020-01-01 00:00:00
abstract::HCC (hepatocellular carcinoma), which can be induced by cirrhosis and viral hepatitis infection, is the most frequent form of liver cancer. This study is performed to investigate the mechanisms of HCC. GSE57957 was obtained from Gene Expression Omnibus database, including 39 HCC samples and 39 adjacent non-tumorous sa...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_161215N642
更新日期:2018-01-01 00:00:00
abstract::Age over 65 years is a risk factor per se for doxorubicin administration, and coexisting diseases pose additional problems. There is still controversy whether chemotherapy regimens for elderly patients with aggressive NHL should be full-dose doxorubicin containing or whether development of non-anthracycline containing...
journal_title:Neoplasma
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1999-01-01 00:00:00
abstract::Immunohistochemistry (IE) and polymerase chain reaction (PCR) are tools enabling to find small number of tumor cells in lymph nodes (LNs) or peripheral blood. Perhaps these methods will allow early detection of cell dissemination and refine risk group within papillary thyroid cancer (PTC) that might benefit from more ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::Transplacental effect of benzo(a)pyrene was studied in organ cultures of embryonic lung tissue explanted from mouse donors injected by the carcinogen. Hyperplastic alteration of epithelium, followed by adenomatous changes were seen in embryonic lung tissue cultures from donor mice injected by benzo(a)pyrene. No altera...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::A series of seven monoclonal antibodies recognizing cell surface antigens of similar distribution on a panel of leukemia/lymphoma and lymphoblastoid human cell lines was prepared by hybridoma technique after immunization with non-T, non-B acute lymphoblastic leukemia cell line REH. Immune reactivity of these monoclona...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::The aim of our work was to develop a fast, reliable and sensitive PCR method to detect K-ras mutations in various clinical samples. There is a need for an unimpeachable method for early diagnosis and/or screening of pancreatic cancer (PC). We optimized and subsequently analyzed four methods based on mutant-enriched PC...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Two simple spectrophotometric assays have been employed for the measurement of dopa oxidase activity and ceruloplasmin polyphenol oxidase activity in the sera from normal hamsters and hamsters bearing melanotic melanoma. Both activities were found to be augmented in tumor animals, the dopa oxidase activity much more p...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::Activity of chromatin-bound protease of rat liver and Morris hepatoma 7777 was studied. Proteolytic enzyme was copurified with histones during extraction of chromatin with 0.25 M HCl. Total histone was fractionated by Oliver's et al. method. Histone fractions were incubated in 0.01 M Tris-HCl buffer (pH 7.6) at 37 deg...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::Molecular targeted therapy based on tyrosine kinase inhibitors, directed at the epidermal growth factor receptor (EGFR) is one of novel options for management of NSCLC. Erlotinib is EGFR tyrosine kinase inhibitor used for treatment of the advanced NSCLC. This presented study is focused on comparison of erlotinib and c...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2013_017
更新日期:2013-01-01 00:00:00
abstract::The response of different stages of spermatogenesis to heat have been assessed by scoring the cell types in testis tubules at 14, 28 and 35 days after treatment. Deficiencies in spermatids at these times can be related back to the stage that the precursor would have been in 14 and 28 days earlier. On the 35th day the ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::Weanling ICRC female mice were given syngeneic neonatal thymus graft under renal capsule and two weeks later whole-body gamma-radiation (group ITR). The findings on ITR were compared with three controls--untreated (C), thymus grafted (IT) and irradiated (IR). In ITR group 15/15 developed generalized neoplasms of retic...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::The aim of this study was a contemporaneous measurement of plasma cells proliferative and apoptotic activity in patients examined at the time of multiple myeloma (MM) diagnosis before initiation of chemotherapy, focussed on the following aspects: determination of prognostic significance of plasma cell propidium iodide...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::The aim was to analyze morphologico-functional characteristics of ductal carcinoma in situ (DCIS) in breast MRI to assess signs correlating with the degree of nuclear atypia. From 636 malignant lesions, 114 were DCIS (17.92%): 44 cases of high-grade (38.60%), 37 intermediate (32.45%), 33 low-grade (28.95%). MRI charac...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_170509N333
更新日期:2018-03-14 00:00:00
abstract::The aim of this study was a contemporaneous measurement and a mutual comparison of plasma cells proliferative activity and grade of apoptosis in patients with monoclonal gammopathy of undetermined significance (MGUS) and various phases of MM i.e. smoldering (SMM), stable/plateau and active (progression/relapse) forms ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00